Stem Cell Markers

8/14/2019 Stem Cell Markers

1/3

Stem Cell MarkersStem cell biology, the study of mechanisms causing the undifferentiated embryonicor adult stem cells to differentiate, is one of the fastest growing areas in biologytoday. Cell Signaling Technology's goal is to accelerate stem cell research bydeveloping the highest quality, most rigorously validated antibodies for the study ofstem cell markers, epigenetic regulation and stem cell signaling.

Ternary complex of the DNA binding domains of Oct1 (red) and Sox2 (yellow) boundto cognate DNA (in this case a region of the HoxB1 regulatory element).

New No. Antibody Application Reactivity Lineage Stage Description

new 3663

CD133(C24B9)Rabbit

mAb

W, IP, IHC-P,F

H

earlyembryo,mesoderm,

ectoderm

blastocyst,hematopoieticstem cells,neuronal stem

cells

Five-transmembraneglycosylated cell-surfaceprotein initially described asa hematopoietic stem cellmarker. Also expressed in

and used to identifyneuronal, cancer andembryonic stem cells.

new 2750Oct-4Antibody

W, IHC-P,IF-IC, F

Hearlyembryo

blastocyst

Transcription factorexpressed in undifferentiatedpluripotent embryonic stemcells and germ cells duringnormal development.Together with Sox2 andNanog, is necessary for themaintenance of pluripotentpotential.

new 2273SCFAntibody

W, IHC-P Hearlyembryo

blastocyst

Mediates biological effects by

binding to and activating c-kit. Promotes proliferation ofembryonic stem cells andhematopoetic stem cells.Essential for hematopoiesis,melanogenesis and fertility.

new 2748Sox2Antibody

W, IP H, Mearlyembryo

blastocyst

Transcription factorexpressed in undifferentiatedpluripotent embryonic stemcells and germ cells duringdevelopment. Together withOct-4 and Nanog, is

necessary for themaintenance of pluripotentpotential.

new 3670

GFAP(GA5)MousemAb

W, IP, IHC-P,IF-F

H, M, R ectoderm

neural stemcell/ectodermalprogenitor

Marker protein specificallyexpressed in astrocytes.

new 4706Integrin 1Antibody

WH, M, R,Mk, Hm

ectoderm

bulge stemcell/mesenchymalstem cell

Cell-adhesion moleculeimportant in cell adhesionand migration. Markerexpressed on mesenchymalstem cells, bulge stem cellsand during development of

the liver.new 2274 MELK

AntibodyW, IP H, M ectoderm neural stem

cellImplicated in stem cellrenewal, cell cycle
http://products/3663.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/2750.htmlhttp://products/2750.htmlhttp://products/2750.htmlhttp://products/2273.htmlhttp://products/2273.htmlhttp://products/2273.htmlhttp://products/2748.htmlhttp://products/2748.htmlhttp://products/2748.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/4706.htmlhttp://products/4706.htmlhttp://products/4706.htmlhttp://products/2274.htmlhttp://products/2274.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/3663.htmlhttp://products/2750.htmlhttp://products/2750.htmlhttp://products/2750.htmlhttp://products/2273.htmlhttp://products/2273.htmlhttp://products/2273.htmlhttp://products/2748.htmlhttp://products/2748.htmlhttp://products/2748.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/3670.htmlhttp://products/4706.htmlhttp://products/4706.htmlhttp://products/4706.htmlhttp://products/2274.htmlhttp://products/2274.htmlhttp://products/2274.html


2/3


progression and pre-mRNAsplicing. Marker for neuralprogenitors.

new 2154MusashiAntibody

W, IF-F H, M, R ectodermneural stemcell

RNA-binding protein thatregulates the translation oftarget mRNA during

asymmetric cell division ofectodermal precursor cells.Marker for proliferatingneural precursor cells.Expressed in epithelial stemcells including intestinal andmammary gland stem cells.

new 2137AFPAntibody

W, IP H, M endodermhematopoieticstem cell

Glycoprotein found in serumof mammalian fetal liver, yolksac and GI tract. Expressedduring development of theprimitive endoderm. Markerfor endodermal differentiationfrom pluripotent stem cells.

new 2158VE-CadherinAntibody

W, IP, IF-IC H, B mesodermhematopoieticstem cell

Adhesion moleculeexpressed in embryonic (notadult) hematopoietic stemcells. Also expressed invascular smooth musclecells.

new 3569

CD34(ICO115)MousemAb

IHC-P, F H mesodermhematopoieticstem cell

Transmembraneglycophosphoproteinexpressed in hematopoieticskin cells, vascularendothelium and some

fibroblasts.

new 4115CDCP1Antibody

W, IP, IF-IHC H mesodermhematopoieticstem cell

Multidomain membraneglycoprotein highlyexpressed in some humancancer cells and in bothtypical and atypical(cancerous) colon. May beepigenetically regulated.Putative hematopoetic stemcell marker.

new 3392c-KitAntibody

W, IP H, M mesodermhematopoieticstem cell

new 3308c-Kit(Ab81)MousemAb

W, IP, F H mesodermhematopoieticstem cell

new 3310

c-Kit(Ab81)MousemAb (Alexa

Fluor 488Conjugate)

IF-IC, F H mesodermhematopoieticstem cell

Receptor tyrosine kinase thatplays a critical role in cell

growth and proliferation inhematopoietic stem cells,mast cells, melanocytes andgerm cells. Binding of itsligand (SCF) to c-kit initiatesproliferation anddifferentiation ofhematopoietic progenitorcells. Hematopoietic stemcell marker.

new 2266PU.1Antibody

W, IP, IHC-P,IF-IC, F

H, M, (Mk) mesodermhematopoieticstem cell

new 2258PU.1 (9G7)RabbitmAb

W, IP, IHC-P,IF-IC, F

H, M, (Mk) mesodermhematopoieticstem cell

new 2216 PU.1 (9G7) F H, M mesoderm hematopoietic

Member of the Ets family oftranscription factors that

plays a pivotal role in thedifferentiation of myeloidcells and lymphocytes.Expressed in several
http://products/2154.htmlhttp://products/2154.htmlhttp://products/2154.htmlhttp://products/2137.htmlhttp://products/2137.htmlhttp://products/2137.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/4115.htmlhttp://products/4115.htmlhttp://products/4115.htmlhttp://products/3392.htmlhttp://products/3392.htmlhttp://products/3392.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/2266.htmlhttp://products/2266.htmlhttp://products/2266.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2216.htmlhttp://products/2154.htmlhttp://products/2154.htmlhttp://products/2154.htmlhttp://products/2137.htmlhttp://products/2137.htmlhttp://products/2137.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/2158.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/3569.htmlhttp://products/4115.htmlhttp://products/4115.htmlhttp://products/4115.htmlhttp://products/3392.htmlhttp://products/3392.htmlhttp://products/3392.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3308.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/3310.htmlhttp://products/2266.htmlhttp://products/2266.htmlhttp://products/2266.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2258.htmlhttp://products/2216.htmlhttp://products/2216.html


3/3


RabbitmAb (Alexa

Fluor 488Conjugate)

stem cell

new 2240

PU.1 (9G7)

RabbitmAb (Alexa

Fluor 647Conjugate)

F H, M mesodermhematopoieticstem cell

hematopoietic cells includingB lymphocytes,macrophages, neutrophils,mast cells, early erythroidcells and megakaryocytes.Critical for both

determination ofhematopoietic cell lineageand regulation ofdifferentiation vs. stem cellproliferation.

new 4119

TWIST1

Antibody W, IP H, Mk

neural crest

stem cell

Basic helix-loop-helixtranscription factor thatfunctions as a masterregulator of embryonicmorphogenesis. Playsessential roles inmesenchymal differentiationand osteogenic

determination. Also playscritical role in neural crestformation and is a marker forneural crest stem cells.Upregulated in varioushuman tumors and may playa role in EMT andmetastasis.
http://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/4119.htmlhttp://products/4119.htmlhttp://products/4119.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2216.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/2240.htmlhttp://products/4119.htmlhttp://products/4119.htmlhttp://products/4119.html

Stem Cell Markers

Documents

Transcript of Stem Cell Markers