Starch/PVA Blended hydro gel For Wound Dressing

ARJUN K GOPI & SUHAIL K S – M.Sc. Biopolymer Science

CENTRE FOR BIOPOLYMER SCIENCE AND TECHNOLOGY(CBPST), KOCHI

INTRODUCTION HOW TO DRESS THE WOUND WITH HYDROGELPREPARATION OF HYDROGELABSTRACT

MATERIALS USED FOR PREPARING HYDROGEL

REFERENCES

CONTACT

Hydrogels are hydrophilic natured three-dimensionalnetworks, held together by chemical or physicalbonds. Hydrophilic groupssuch as hydroxyl (OH) and carboxyl (COOH) onthe polymer chains absorb and store water.

The design and development of novel membrane ofhydrogels prepared by crosslinking of polyvinyl alcohol with heat-treated corn-starch suspension was attempted.

Hydrogels save the wound from fluid loss, are capableof providing the lesion with additional moisture,and securely protect it against external noxae.

Provides instant cooling and soothing relief for burns. Absorbs wound drainage to help prevent infection. This hydrating dressing allows the wound to heal without adhering to it. Breathable.

Fifty ml of 10% (w/v) PVA solution was taken

in a beaker. To the PVA solution, 50ml of 5%

(w/v) starch dispersion in water prepared by

heating at 100oC, was added with constant

stirring to get a homogeneous mixture.

To this mixture GA reagent (10.55ml) was

added with constant stirring. Care was taken to

eliminate entrapment of air bubbles during

mixing and the mixture was used to obtain a

membrane by the conventional solution

casting method. The membrane was dried at

room temperature.

The membrane so obtained was transparent

and was named as HT. The membrane was

washed thoroughly with distilled water to wash

off hydrochloric acid and GA, if any. Then the

membrane was dried at room temperature.

Potato starch (PS),

Ethanol

Glutaraldehyde (GA)

Polyvinyl alcohol (PVA), mol. wt. 125000.

Hydrochloric acid 35% pure

Double distilled water was used

throughout the study.

MTT dye

GA reagent was prepared by mixing

0.5ml of GA in a solution mixture of 10ml

ethanol and 0.05ml Hydrochloric acid.

Hydrogels are hydrophilic natured three

dimensional networks, held together by

chemical or physical bonds. Water

absorbed by hydrogel is not released

under ordinary pressure. Hydrophilic

groups such as hydroxyl (OH) and carboxyl

(COOH) on the polymer chains absorb and

store water.

This is the quality that brings about the

specific benefit of hydrogels in wound

treatment. They immediately function as

moist wound dressings. At the same

time they are capable of absorbing

contaminated exudates and safely

retaining them within the gel structure. The

absorption of secretions causes an

expansion of the cross-links in the polymer

chains, making room for the inclusion of

foreign bodies such as bacteria, detritus,

and odour molecules that

are irreversibly taken up along with the

liquid. The basic physical features of

hydrogel dressings can be specifically

modified, according to the properties

of the polymers used.

Hydrogels save the wound from fluid

loss, are capable of providing the lesion

with additional moisture, and securely

protect it against external noxae.

http://www.smithnephew.com/professional/p

roducts/advanced-wound-

management/intrasite-gel/

http://www.researchgate.net

ARJUN K GOPI, M.Sc BIOPOLYMER SCIENCE,

CENTRE FOR BIOPOLYMER SCIENCE AND

TECHNOLOGY(CBPST), KOCHI

Email: arjunkgopi@gmail.com

SUHAIL K.S, M.Sc BIOPOLYMER SCIENCE,

CENTRE FOR BIOPOLYMER SCIENCE AND

TECHNOLOGY(CBPST), KOCHI

Email: suhailksiddique@gmail.com

WOUND DRESSING USING HYDROGEL

STEP 1

Remove secondary dressing. Irrigate wound

with sterile saline solution to clean wound site.

STEP 2

Remove blue protective cap from the nozzle.Swab

the snap-off tip and nozzle of the pack with a

suitable antiseptic swab. Snap the patterned tip off

the nozzle.

STEP 3

Keeping the nozzle tip clear of the wound surface,

gently press the bowl of the pack to dispense gel into

the wound. Smooth Gel over surface of wound to a

depth of approximately 5mm (0.2in.). Discard any

unused gel.

STEP 4

Cover with a secondary dressing.

STEP 5

Gel can be removed from the wound by rinsing

with sterile saline solution