SRTTD July 30, 2010 Brooks Adams Executive Director & President Accelerating Commercialization in...
-
Upload
evelyn-west -
Category
Documents
-
view
218 -
download
1
Transcript of SRTTD July 30, 2010 Brooks Adams Executive Director & President Accelerating Commercialization in...
SRTTDJuly 30, 2010
Brooks AdamsExecutive Director & President
Accelerating Commercialization in Nanobiotechnology
We promote innovation & commercialization in nanobiotechnology & nanomedicine to enable future economic growth & improve human life.
COIN
Key facts
Nonprofit 501c3 launched June 2009 $2.6 million funds committed 4 full-time staff Outsource finance, marketing, & IT University intern program (4 - 5) 8 Board members & 6 on SAB Annual operating budget ~ $800K to 1MM Based in Triangle; frequently in Triad &
Charlotte and beyond
“Human health has always been determined on the nanometer scale…where the structure & properties of the machines of life work in every one of the cells in every living thing. The practical impact of nanosciences on human health will be huge.”
Dr. Richard Smalley, Nobel Laureate
The opportunity
Nanobiotechnology
Application of nanotechnology materials, tools, & processes in the life sciences & medicine:
Commercial applications: Therapeutics & diagnostics Medical technology & devices Medical/life science research Non human health-care related
Versatile structure of carbon nanotubes enables use for variety of tasks in the body
The promise & challenge
Nanotech is a tool box not an industry Many potential high value applications Nanotech centers are forming globally &
industry clusters grow around them Requisite capabilities/resources:
Research, infrastructure, talent, money, & a conducive business environment are needed
A few major centers will develop
“A Roadmap for Nanotechnology in NC’s 21st Century Economy,” March 2006
Nanobiotech global market
2009 nanomedicine healthcare market largest in N America at $4.75 billion followed by Europe at $3.65 billion
Nano-enabled drug delivery largest segment with expected CAGR of 21.7% to ~ $16 billion by 2014 Biocompatible implants & coatings and diagnostics
estimated growth of 42% & 21.8%, respectively through 2014
Global clusters: US, Singapore, Canada, Australia, Germany, China, UK, & Israel
US hubs: Boston, San Francisco, Houston, & RTP US academic centers of excellence: NC, Mass.,
California, Ohio, & Texas
Sources: Business Insights (Jan 2010), Pew Charitable Trusts, COIN database
Nanomedicine patents
3% 3%8%
14%
15%
57%
Active Implants
Drugs and Therapies
Biomaterials
Imaging
In vitro Diagnostics
Drug Delivery
Provided by Wake Forest Univ. Center for Translational Nanomedicine
.
Vision for NC
Assets to succeed lie in Charlotte, Triad, & Triangle Mix of nanotech research activity, medical centers, related
large/emerging companies, and investors To be nationally competitive, must promote projects in
this corridor leveraging resident assets
NC nanobiotech ecosystem overview
Building from thriving, mature biotech industry & infrastructure, emerging nanobiotech sector is gaining rapid traction
NC strong in 3 of highest-growth nanotech sectors: Medicine & healthcare Tools/instruments Materials
NC repeatedly recognized as leader in nanotech 2009 survey (PEN) ranked NC 8th in US & Raleigh metro area 4th
2009 US University Report & Rankings by Small Times placed NCSU 3rd in for nanotech commercialization and UNC-CH 5th & NCSU 10th for nanotech research
Positive political-business climate in support of biotech, low-cost of doing business, & high quality of life NC Innovation Council
NC nanobiotech ecosystem overview
Industry > 70 nanotech companies & 35 nanobiotech companies
> 280 US nanobiotech companies & additional 150 int’l nanobiotech companies University & college resources
30 university research centers Two nanotech PhD programs (only 36 in world) Among 1st in nation to offer nanotech associates degree
Supportive infrastructure 7 major research parks across NC 3 major nonprofit research institutes 108 medical products CRO’s Active, engaged VC & angel investment NC Department of Commerce NC Biotechnology Center Centers of Innovation: COIN, ibiliti (med tech), Drug Discovery COI NC Regional Partnerships
Community resources CED SBTDC
NC among nano-enabled drug delivery research university leaders
1. University Texas2. Harvard University3. MIT4. University of Michigan5. Johns Hopkins University6. University of Illinois7. Northwestern University8. University of Washington9. Purdue University10. University of Utah11. Georgia Institute of
Technology12. Washington University13. University of Florida14. University Pennsylvania15. Cornell University16. University of California at
Berkeley17. University of Massachusetts18. University of California at
San Francisco19. University of Minnesota20. NCI
21. Rice University22. Ohio State University23. University of California at
Los Angeles24. University of California at
Santa Barbara25. University Nebraska26. University of North
Carolina27. University of Wisconsin28. Penn State University29. Massachusetts General
Hospital30. University of Kentucky31. Stanford University32. University of Maryland33. University of Southern
California34. University of Pittsburgh35. University of California at Davis36. Emory University37. SUNY Buffalo38. University of California at San
Diego
39. Northeastern University40. Carnegie Mellon University41. North Carolina State
University42. Vanderbilt University43. Case Western Reserve
University44. Duke University45. Brown University46. CALTECH47. Arizona State University48. Columbia University49. Rutgers State University50. University of Delaware
Source: COIN study (based on publications)
Leading NC nanobio companies
Liquidia: Series B VC funding, entering clinical trials
XinRay: Major partnership with Siemens Pioneer Surgical Orthobiologics:
Product on market Biodelivery Sciences: Publicly traded;
$56.69 MM market cap
Innovation Management involves two major, increasingly resource intensive, business processes
Product DevelopmentTechnology Development
Termed stage-gate processes, each stage is intended to provide decisionmakers with enough additional information about a particular technology / product development project before committing additional resources to its next stage.
$$$$
Develop
Demo Quality
Concept
Plan
Design
Test Launch
Idea
Burgeoning field with challenges
Shortage of qualified personnel Education of workforce for future Limited funding for early-stage innovation Lack of pre-clinical/clinical testing guidance &
facilities Development of GMP capabilities / manufacturing
scale up Need for more:
Low-cost, flexible research space Multidisciplinary research partnerships Business development connections
COIN offers
Innovators & entrepreneurs Resources to build relationships crucial for
technology translation & business development
Industry partners Single point of entry to nanobiotech sectors in
NC and access to innovators & entrepreneurs
Service providers Resources to develop nanobiotech project
pipeline
COIN goals
BUILD a community of practice of NC nanobiotechinnovators & industry players focused on commercialization
CONNECT innovators with promising nanobiotechnology with industry partners, resources, & collaborators
GROW nanobiotech infrastructure in NC
DRIVE new product development by reducing barriers to commercialization
INCREASE the profile of NC nanobiotech activity globally
COIN programs
Events & seminars to build, connect, & inform the community: Nanobiotech Executive Roundtable Annual NC Nanotech Commercialization Conference: Nanobio track
Membership services including knowledge-rich web portal: Business intelligence RFP scouting service
Innovation services that address specific obstacles to commercialization: Grant writing Incubation partners Connections for pre-clinical testing
NC resources for pre-clinical testing
synthesis
•WFU Nanotech Center
•Nanotech Labs (Yadkinville, NC)
Characterization
•WFU Nanotech Center, JSNN, Forsyth Tech, Murdoch
In Vitro
•Murdoch, Biomedical Innovation Network, JSNN, ECU, RTI
In Vivo
•Murdoch, Biomedical Innovation Network, JSNN, UNC . RTI
Clinical Trials
•Duke, UNC, WFU , ECU med schools
•RTI, CROs
COIN clients & collaborators
University researchers & tech transfer offices
Pharma/biotech, specialty pharma, drug delivery companies
Startups VC, angel, & public
funding sources
Equipment & software companies
National nanobiotech research institutes
Trade groups Law & accounting
firms Economic
development & policy makers
“…to increase its share of nanotechnology activity nationally and internationally, the (Southeast) region needs to take specific steps in achieving a leadership role…with a focus on improved collaborations and increasing the number and growth of nanotechnology companies.”
Working together
Source: “Connecting the Dots,” 2006, Southern Growth Policies Board, Georgia Tech, Oak Ridge Nat’l Lab
Creating a Southern nanotechnology strategy
Establish Southern Nanotech Network, a membership network to increase awareness of industry among South’s citizens, governments, & businesses and: Offer opportunities for collaborative interaction between the public and private sectors Identify policy advocates Have each Southern Growth state put advancement of nanotech as a primary economic
development goals Develop/execute branding strategy for Southern nanotech to promote South’s assets within
region, nationally & internationally Coordinate collaborative trips to CA, NY, and MA to promote linkages between region &
other major centers Establish Southern Nanotechnology Institute, based on resources of Oak Ridge &
others to: Develop nanotech business incubation capacity for all Southern states Increase funding opportunities for Southern institutions including state matching funds for
SBIR and other federal grants with specific focus and development of equity funds for nanotech companies
Enhance availability & affordability of research tools Develop survey of nano-equipment in region’s universities & research labs, so other users
may gain access & subsidize their expenses through user agreements Other considerations
More in-depth look at commercialization including development process, South’s market niches, & role of various funding sources
Explore opportunity/need for equipment cooperatives with vendors
Source: “Connecting the Dots,” 2006, Southern Growth Policies Board, Georgia Tech, Oak Ridge Nat’l Lab
Summary
Technology knows no borders Together we can accelerate
commercialization in nanobiotechnology: Foster nano-size solutions for life science
research & medicine for the benefit of mankind Bridge research community with business &
funding sources to create R&D collaborations, new companies, and products
BROOKS ADAMSExecutive Director & President
[email protected]: 804-363-9574Assistant: Clare Valcore / 919-782-1991, Ext. 302
1
Major categories of nanomaterials
Type Definition ExampleSolid nanoparticles Ultrafine solid particles on
nanoscale, including crystals & nanopowders
Synthetic bone made from calcium & phosphate particles manipulated at molecular level
Hollow nanoparticle Hollow nanoscale particles, including nanotubes & other kinds such as nanohorns & nanocapsules
Drug delivery systems or bundle & detonate for cancer detection
Nanoscale thin film coatings
Coatings with thickness &/or internal structures measured in units of 100 nm or less
Antimicrobial coatings applied to surgical dressing or medical devices
Nano structured monolithic
Bulk solids that have macroscale external dimensions but nanoscale internal structure (could be metal or alloys)
High strength medical implants using nanostructured pure titanium
Nanocomposites Mixture of 2 or more dissimilar components, at least one of which has nanoscale dimensions
Devices with increased responsiveness to pressure for MIS techniques
Source: BCC research
Major categories of nanomaterials
Nanotools: Device enabling viewing/manipulation of nanoscale
objects E.g., scanning probe microscope on market today
Nanodevices Nanomachines to do useful work in medicine E.g., nanorobots injected into blood to destroy cancer
cells;medical nanosensors incorporating nanoengineered structures, e.g., spintronic sensors that incorporate nanoscale thin films or next generation nanomedical sensors, e.g., respiratory gas sensors (going soon to market)
Source: BCC research