T o d ay ’ s I n n o v at I o n s T o m o r r o w ’ s H e a lt H C a r e

Story Chair Supports Colorectal Research

Gratitude Moves Leah Adamski to Send Gift

Fodors Endow Endocrinology Chair

Koch Family Golf Outing Supports Crohn’s Research

Liselotte Martin Funds Lupus Database

Cancer Genetics Explored with Support of Hardis Chair

Goldbergs Bank on Crohn’s Disease Research

Mary Sterle Treasures the “Gem on the Lake”

News at Cleveland Clinic

Campaign Update

C a m p a i g n f o r C l e v e l a n d C l i n i c

Inside

Weiders’ Exercise in Philanthropy Helps Heart Patients

Joe and Betty Weider are health and fitness pioneers. Mr. Weider is the publishing magnate and fitness icon who founded many publications that promoted health and fitness such as Muscle and Fitness, Men’s Fitness, and Shape. Mrs. Weider, who co-founded Shape with her husband, is known for her worldwide magazine columns on women’s fitness.

It is appropriate, then, that when the Sydell and Arnold Miller Family Pavilion opens as the home of Cleveland Clinic’s Heart and Vascular Institute, the gym in the Center for Preventive Cardiology will bear the names of Joe and Betty Weider. The couple’s $1 million gift will support new, state-of-the-art exercise equipment and a highly trained staff to assist recovering heart patients.

Mr. Weider has earned numerous accolades, including having July 9 officially declared Joe Weider Day in the state of California by his protégé, current California Gov. Arnold Schwarzenegger.

Mr. Weider is perhaps proudest of an honor he received in 1991, the Boy Scouts’ Distin-guished Citizen Award, presented to him for his role as the “Father of Fitness.”

The Weiders express pride in having their names associated with Cleveland Clinic.

“I think Cleveland Clinic is the finest clinic in the world,” Mrs. Weider says. “They don’t just look at one aspect of your disease. They look at the whole person, including the effects of lifestyle on the patient’s health. Cleveland Clinic is in the forefront of healthcare with its emphasis on wellness and prevention, and Joe and I want to support this effort. We hope that Cleveland Clinic’s approach will influence the entire field of medicine and that the medicine of the future will focus on preventing disease.”

Mr. Weider also praises Cleveland Clinic’s emphasis on wellness and prevention.

“I learned a long time ago that one of the most important things in the world is activity,” he says. “My earliest philosophy was that people have to live by activity, good nutrition, fresh air and sunshine.”

Joe and Betty Weider

Volume 6 | Issue 1 spring 2008

2

4

5

6

7

8

9

10

11

12Continued on page 2

0803392 12pg-02.indd 3 3/27/2008 4:28:52 AM

Joey Story expresses gratitude for many things, including her husband of 22 years, three lovely stepdaughters, an exciting life traveling in the Far East, and good health.

She credits colorectal surgeon Feza Remzi, MD, with the latter. To show their appreciation, Mr. and Mrs. Story have established the Ed and Joey Story Endowed Chair in Colorectal Surgery at Cleveland Clinic, and Dr. Remzi is to be the first chair holder.

Mrs. Story, 57, has had colitis, a form of inflammatory bowel disease, since she was 28. For many years, she says she “never suffered greatly” because she took excellent care of herself through proper diet and exercise.

However, this changed in January 2003 when a colonoscopy revealed a problem that required removal of her colon. A surgeon in Houston, where the couple lives, opted to perform a one-step, J-pouch surgery, in which the colon is removed and an internal pouch is created from the small intestine. The intent of one-step surgery is to avoid the need for further operations. However, Mrs. Story had serious surgical complications that led to 21 additional procedures.

When it was recommended that she go to Cleveland Clinic for corrective surgery, she was reluctant. Her father, a patient at Cleveland Clinic for five years, had died there when she was 12 years old and living in Kentucky.

“I hadn’t been back to Cleveland since then,” she says. “My sisters and friends wanted me to go. I looked at it as, ‘Cleveland killed him.’ But my sisters looked at it as, ‘Cleveland kept him alive for five years.’”

Her views changed when, coincidentally, the only day that Dr. Remzi was available to perform her surgery was the 41st anniversary of her father’s death. She calls this “a blessing in disguise,” because she now associates that date with something positive. Since her surgery, Mrs. Story says, she has had no problems or pain. “And now, I have a love of Cleveland,” she says.

Before endowing the chair, the Storys had made a gift to Cleveland Clinic for research “to keep what happened to me from happening to others,” she says. The new endowed chair will further that effort by sup-porting research on the J-pouch procedure, including the expansion of the pelvic pouch database.

Dr. Remzi’s compassionate approach to patient care and his interest in research and education impressed the couple from the start, Mr. Story says.

“ I saw that, eventually, maybe the whole world would begin to recognize the importance of exercise, proper nutrition and a healthy lifestyle.” – Joe Weider

2 Catalyst

Continued from page 1

Growing up in Canada during the Depres-sion, Mr. Weider was a poor, skinny youngster who sometimes was bothered by bullies. At age 13, he purchased a used copy of a magazine on healthy living and bodybuilding that inspired him to change his life by strengthening his body and building his self-confidence. However, bodybuilding was not sociably acceptable then, and barbells were difficult to find. Gyms were practically nonexistent. A scrap yard foreman soldered together locomotive parts for him, creating his first set of barbells.

Story Chair Supports Colorectal Research

“Nobody could have deterred me,” he says. “I saw that, eventually, maybe the whole world would begin to recognize the importance of exercise, proper nutrition and a healthy lifestyle.”

After transforming his own body, mind and perception of how to be healthy, he embarked on a lifelong personal crusade to share this information with the world. Among his many accomplishments were founding Weider Publications, published in more than 17 languages, and Weider Nutrition International.

“Because heart disease often is prevent-able, we felt that we could do more good by giving to heart disease and to heart patients’ recovery,” Mrs. Weider says. “Not only can you promote greater heart health by changing your lifestyle, but you also will be happier mentally and physically. We feel that we’ve been very fortunate and blessed in our lives to be able to do what we’ve done, and one of our greatest joys is to be able to share with others something that we feel is worthwhile.”

Feza Remzi, MD

0803392 12pg-02.indd 4 3/27/2008 4:28:55 AM

“We think Dr. Remzi is a brilliant surgeon, a great leader and a great person,” he says.

Dr. Remzi says he and his department are grateful for the gift. “The chair will provide the resources to conduct our studies and explore issues related to ulcerative colitis and the ileal pouch procedure, as well as education.”

Education includes spreading the word that patients who need an ileal pouch procedure “have the best chance when it’s done right the first time,” he says. “It’s very prudent to have these procedures done in centers where any complications can be handled – tertiary care centers that do a high volume of these procedures.”

Cleveland Clinic performs approximately 150 to 200 ileal pouch procedures per year and has done more than 3,000 total. “We have the highest volume in the world, and we share our outcomes with our patients and the scientific community,” Dr. Remzi says.

3clevelandclinic.org /giving

Joey Story, left, and Ed Story, right, enjoy riding elephants at the Four Seasons Tented Camp, Golden Triangle, Thailand.

The Storys once again are enjoying their travels. Mr. Story is founder, President and Chief Executive of Soco International, an oil and gas exploration and production company headquartered in London. His business often takes the couple to Vietnam. They also own a condominium in Mongolia, and their favorite place to visit is Bangkok, Thailand.

“We both love traveling, hotels and room service,” Mrs. Story says. They also have fun riding elephants in Thailand, where Mr. Story is a fierce competitor in elephant polo.

While Cleveland may not be the focus of their travels, Mrs. Story now receives all of her healthcare at Cleveland Clinic. She believes that this particular destination helps make all of her other travels possible.

“I have a wonderful life!” she says and smiles broadly.

While Cleveland may not be the focus of their travels, Mrs. Story now receives all of her healthcare at Cleveland Clinic. She believes that this particular destination helps make all of her other travels possible.

0803392 12pg-02.indd 5 3/27/2008 4:29:00 AM

As her letter indicates, Mrs. Adamski has had a long relation-ship with Cleveland Clinic. Her mother, who passed away in 1987, was treated for lung cancer at Cleveland Clinic and, at the age of 80, had a lung removed. The surgery helped extend her life, Mrs. Adamski says.

“It gave her six more years of traveling. She went to Ireland and Las Vegas. She loved playing the quarter slots!” Mrs. Adamski says. “She saw more grandchildren and great grandchildren born and had a wonderful life.”

She has poignant memories of her mother’s care at Cleveland Clinic. For instance, she recalls that when her mother declined an experimental procedure, “the doctor put his arm around me and said to my mother, ‘Is she a good daughter?’ She said, ‘Yes.’ He said, ‘Then why don’t you want to stay with her longer?’ She then agreed to have the procedure. I thought it was the sweetest thing! He didn’t argue with her or anything. He was a good doctor.”

She remembers how, in the evenings, after exhausting days spent taking her mother from place to place for tests, exams and treatments, she would head downstairs at the Cleveland Clinic Inn (now the site of Cleveland Clinic’s Surgical Center) to listen to musicians play piano and bass fi ddle.

Gratitude Moves Leah Adamski to Send Gift

Catalyst

“I’d let the music soothe my cares away,” she says. “It was just what I needed. Every part of Cleveland Clinic has touched me.”

Some years later, Mrs. Adamski’s husband, Ed, who passed away six years ago, was treated at Cleveland Clinic for emphysema. He partici-pated in the National Emphysema Treatment Trial (NETT), and Cleve-land Clinic worked closely with his healthcare providers in Buffalo and Florida, Mrs. Adamski says. Good care extended his life, she says.

“They were wonderful; so kind to him,” she says. “He wasn’t just a number. They knew who he was.”

In late 2006, Mrs. Adamski also relied on Cleveland Clinic. Now living in Winter Haven, Fla., she was alarmed by the diagnosis of a local physician who wanted to perform what he considered life-saving kidney surgery. Concerned that such surgery instead would hasten her demise, she immediately made an appointment for a second opinion at Cleve-land Clinic. She says she is grateful to her Cleveland Clinic physician, who advised against the surgery.

The Florida physician’s opinion was that, without the surgery, “I wasn’t supposed to be alive by Christmas. But I’m still here!” she says.

Gratitude for all of these experiences led to her quick response to the letter, she says. “I couldn’t possibly say ‘no.’ ”

4

Leah Adamski responded quickly to a letter seeking her three-year commitment to Cleveland Clinic’s Heart and Vascular Institute:

Dear Dr. Cosgrove,

Your request for a pledge for 3 years concerns me. Cleveland

Clinic helped my mother many years ago. ‘They’ treated my

mother like their mother.

A few years after that, my husband was in the ‘NETT’ program,

and he was treated as if I were taking care of him.

Last year, I came to Cleveland Clinic myself for help and again

you gave me wonderful care and help.

Now to my concern. I’m 81 years old and not sure I have three

years left. So, I’ll send the full amount now to be sure I care for

you and treat you well in return.

Sincerely,

Leah AdamskiLeah Adamski

0803392 12pg-02.indd 6 3/27/2008 4:29:03 AM

Louis and Patricia Fodor’s map of the world, displayed on a wall of their home overlooking Lake Erie, is crowded with pins designating the 175 countries they have visited. Mr. Fodor also set a record in 1963 with his friend Sam Miller for the fastest trip around the world via a carefully planned series of commercial airline flights.

There were articles written on this trip in every language. He has saved a World Almanac that lists their accomplishment.

Although the Fodors greatly enjoy their travels, they remain firmly rooted in the Cleveland area, which is Mr. Fodor’s birthplace and Mrs. Fodor’s adopted home since she emigrated from Scotland years ago. In 1916, Mr. Fodor’s father founded Fodor Realty, now Fodor Companies, which Mr. Fodor has run since his father’s death 53 years ago.

The Fodors support several local institu-tions, and one of their longest and closest relationships is with Cleveland Clinic. Mr. Fodor’s parents were Cleveland Clinic patients, and he has been receiving medical care there since the 1940s. Mrs. Fodor has been a Cleveland Clinic patient since 1985.

In appreciation for the care they receive, the couple has established the Patricia and Louis Fodor Endowed Chair in Endocrinology. Robert Zimmerman, MD, acting Chairman of the Department of Endocrinology, will be the first to hold the chair, which supports thyroid research.

The couple took more than a year to consider “the best way to give” before endowing the chair, Mr. Fodor says. “We liked the idea of a teaching chair, which provides income for a researcher.”

Mrs. Fodor says she selected the endocri-nology area because her mother, who passed away, struggled with the illness. She says she hopes that their contribution to research will lead to new treatments.

“This endowment gives us a sense of satisfaction,” she says. “It’s a privilege to give to something of this caliber.”

“We can see where our money is going,” Mr. Fodor adds. “That’s very important to us.”

Several research projects on thyroid disease are under way at Cleveland Clinic, Dr. Zimmerman says. One recent study resulted in a change in recommended care for

patients with thrombocytopenia (low blood platelet count). Other research explores new ways to detect thyroid cancer and its recurrence. Also new is a thyroid cancer patient database that will help determine the effectiveness of current treatments.

The Fodors’ endowed chair will expedite these and other research efforts, Dr. Zimmerman says.

“It’s a tremendous honor for me to be the first chair holder, and I am extraordinarily grateful to the Fodors for their generosity,” he says. “We have conducted a large number of research studies over the last several years without a lot of resources, and having extra support will greatly help the quality and quantity of studies that we can do.”

For their part, the Fodors express excite-ment about the new chair and what it might mean for patients in the future.

“This was one of the best decisions we’ve ever made,” Mr. Fodor says. “It was the right thing to do.”

Fodors Endow Endocrinology Chair

Gratitude Moves Leah Adamski to Send Gift

clevelandclinic.org /giving

Patricia and Louis Fodor

5

0803392 12pg-02.indd 7 3/27/2008 4:29:05 AM

Catalyst

A family determined to honor their youngest daughter and sister’s battle with Crohn’s disease through an annual family golf outing has raised hundreds of thousands of dollars to advance research and education, which, they hope, may lead to a cure.

At 8, Lucy Ambrosi was diagnosed with Crohn’s disease, an incurable, chronic inflammation of the digestive tract usually affecting the colon and rectum. There is no cure for Crohn’s disease, and among its severe symptoms are loss of bowel control, daily nausea, pain and extreme fatigue. For Mrs. Ambrosi, the disease controlled every minute of her life.

“I just existed day to day,” she says. “I wasn’t living life.”She could not sit in the middle of a row of seats in a theater or on a plane, attend an outdoor concert or travel long distances without the tremendous anxiety of being far away from a restroom. Although she excelled in a competitive, all-girls’ college preparatory school, her drive to attend college also was overshadowed by the disease.

”At 18, instead of starting my college career, I found myself at home hooked up to a machine all day to intravenously infuse my nutrition. I realized I was not moving forward. It was time to remove my diseased colon and have an ileostomy created,” Mrs. Ambrosi says.

With the support of her five siblings and with her parents, George and Helen Koch, by her side, she set out on a hospital tour to find the best place for treating Crohn’s disease. When the family met Victor Fazio, MD, now Chairman of the Digestive Disease Institute, their tour ended.

“I’ve seen hundreds of doctors, and I’d never encountered any physician like Dr. Fazio,” Mrs. Ambrosi says. “His warmth, caring and willingness to explain everything to me was just miraculous, especially knowing how busy he must have been.”

Koch Family Golf Outing Supports Crohn’s Research

6

Since having her colon removed 20 years ago, Mrs. Ambrosi has traveled to Cleveland Clinic hundreds of times, where she had 28 additional surgeries. Even though she lives at a distance, in Charlottesville, Va., she says that she would never consider going anywhere else for care.

“Cleveland Clinic comes up with all the answers to keep me going,” she says. “Each time it’s a different puzzle, and each time, they put it together – correctly.”

She is now 40, married, and an enterostomal nurse, trained to help ostomy patients. To the surprise of many physicians, she also has three healthy children, all of whom were born at Cleveland Clinic. She named her first daughter Victoria, in honor of Dr. Fazio.

Koch Family ClassicIn 1994, Mrs. Ambrosi’s father and a brother, Bobby, initiated the Koch Family Cleveland Clinic Classic golf outing to raise money for Crohn’s disease research.

More than 140 golfers participate in the annual Koch Family Classic, which nets a minimum of $100,000 annually to fund research and other priorities for Cleveland Clinic’s Department of Colorectal Surgery. It takes place at the Woodmont Country Club in Rockville, Md., which also is host to the sectional qualifying matches for the U.S. Golf Open.

Mrs. Ambrosi says she is humbled by her family’s dedication.

“It started as teenage siblings supporting a sister who was sick all of the time. They could have been resentful of the time stolen away from their parents and the inconvenience my disease created for the family, but they weren’t. The opposite happened,” she says.

Bobby Koch is glad to help.

“What we’ve been able to do is call attention to this very special health challenge,” he says. “Hopefully, our modest contribution can speed the day for a cure to be found, and lead to better educational programs, for those who treat and those who have Crohn’s.”

For more information about the Koch Family Cleveland Clinic Classic, please email golf@kochclassic.com or call 202.408.0870.

From left: Bobby Koch, Lucy Ambrosi and George Koch

0803392 12pg-02.indd 8 3/27/2008 4:29:10 AM

clevelandclinic.org /giving

Liselotte Martin Funds Lupus Database

“The lupus came up again and again,” says Mrs. Martin of her struggles with the disease. “But I am very determined. I keep going.”

Her difficulties with lupus recently motivated Mrs. Martin to fund the start-up of a research database at Cleveland Clinic to expand knowledge of the disease and, she hopes, lead to new treatments. She made the gift in honor of her long-time rheumatologist, John D. Clough, MD, who retired in December. Rheumatologist and researcher Soumya Chatterjee, MD, directs the database.

The Martins immigrated to Ohio from Germany in 1953. The young couple found jobs with General Electric, started a family, and were doing well until the mid-1960s, when Mrs. Martin began having health problems. She sought help at Cleveland Clinic, where her lupus was diagnosed.

Through the years, despite recurring bouts of illness, Mrs. Martin persevered. She attended night school while working full time and raising her daughter, majoring in accounting at Cleveland State University and graduating with honors. She earned her master’s degree in library science at Case Western Reserve University and became head of General Electric’s research library.

Mr. Martin, who passed away in 2002, changed jobs in 1968 and became Superintendent of Holden Arboretum in Kirtland. At the family’s home in Chardon, he nurtured gardens with more than 200 rhododendrons, a waterfall and ponds, alpine rock and prairie gardens. Though her life is restricted by illness, Mrs. Martin continues to enjoy the beautiful view from her home and indulge in her passion for classical music.

Just as their gardens grew from vision to reality, Mrs. Martin would like to see the newly formed Cleveland Clinic Lupus Database one day become a substantial resource. “It is my hope that it will motivate more people to give,” she says.

7

Dr. Clough says he believes that the database will help better define lupus, improving physicians’ ability to diagnose it. “Lupus is so complex and manifests itself in so many different ways that people wonder if it’s all the same disease. Clinical observations carefully reported are very important.”

Both Dr. Clough and Dr. Chatterjee express deep appreciation for Mrs. Martin’s gift.

“I am very grateful for her willingness to support research into the disease because her gift will benefit many people,” Dr. Clough says. “Lupus is more common than people realize.”

Dr. Chatterjee agrees. “A database or registry is essential. Federal dollars are scarce, and the funding from Mrs. Martin really is essential. It’s very important to collect demographic, clinical and investigation data and information on the treatment patients receive over time. With Cleveland Clinic, alone, going back five to 10 years, there would be close to 3,000 patients. It’s a big undertaking, and a great gesture on Mrs. Martin’s part.”

Liselotte Martin of Chardon Township, Ohio, used to love skiing and swimming. She yearned to take her daughter, Sonya, to the beach and to travel abroad with her husband, Winfried. Severe lupus, a debilitating autoimmune disease, though, frequently forced her to change her plans.

Liselotte Martin and her pet corgi, Willy

0803392 12pg-02.indd 9 3/27/2008 4:29:16 AM

Through their recent gift of an endowed chair in cancer genomic medicine, Mr. and Mrs. Hardis are hoping that the first chair holder, Charis Eng, MD, PhD, Chair of Lerner Research Institute’s Genomic Medicine Institute and Director of the Center for Personalized Genetic Healthcare, will discover the answer to that question.

Mr. and Mrs. Hardis are longtime, enthusi-astic Cleveland Clinic supporters. In 2003, they established an endowed chair in oncology research, with Tarek Mekhail, MD, of the Taussig Cancer Institute as the chair holder. They also are committed volunteers. Mr. Hardis has been an active member of Cleveland Clinic’s Board of Trustees and the Executive Committee for 23 years. Mrs. Hardis is co-chair of Lerner Research Institute’s fundraising campaign.

“We’re involved with Cleveland Clinic because it’s a superb medical facility for research and patient care,” Mrs. Hardis says. “We both receive care there, as do several members of our family.”

Dr. Eng says she is honored to hold the new cancer genomics research chair and is excited about the future of her work.

“The sky’s the limit,” Dr. Eng says. “Eventually, we want to use genomics to keep healthy people healthy.”

Sondra J. and Stephen R. Hardis would like to help solve a mystery: How do you differentiate a single piece of hay from the rest of the haystack? Specifically, how can the new field of genetics and genomics help personalize cancer care, such as in identifying genetic markers that could predict a person’s risk of developing thyroid or breast cancer?

Her research will help create what she calls “new genomic medicine toolboxes” to solve the cancer puzzle.

“Many cancers occur sporadically – that is, are not inherited,” she says. “But a subset of all cancers is caused by faulty genes, which can be passed down to subsequent generations. An inherited cancer may look just like a noninherited cancer. So, how does one look for a single piece of hay in a haystack? By looking at the genes in the genome.”

The human genome (all of an individual’s DNA) has approximately 30,000 genes. Dr. Eng compares a single gene to an encyclopedia of instructions. “When a severe typographical error occurs in a vital sentence – a genetic mutation – the book of life begins giving out incorrect instructions, and the cells go awry and become a cancer.”

Her lab is dedicated to finding the spectrum of errors to differentiate inherited from sporadic breast and thyroid cancers.

“These tools facilitate highly accurate predictions of whether and which family members will develop inherited cancers, which can lead to personalized screening strategies to detect very early cancers when they are curable or to tailoring preventive strategies before the cancer can develop.”

8 Catalyst

Cancer Genetics Exploredwith Support of Hardis Chair

An endowed chair is important, she says. “It means that Cleveland Clinic has acknowledged outstanding research. Also, an endowed chair is unencumbered by traditional funding. You can use it to invest in cutting-edge, paradigm- shifting research.”

Paul E. DiCorleto, PhD, Lerner Research Institute Chair, agrees.

“We are extremely grateful for Stephen and Sondra’s personal involvement in helping to guide the Lerner Research Institute’s (LRI) philanthropic efforts,” he says. “Gifts such as this help the LRI to recruit and retain the best medical researchers in the world. Dr. Eng is a world-renowned geneticist whose breakthrough discoveries in the genetic causes of cancer will lead to new diagnostic tests and new therapies for cancer patients. Someday, we may be able to keep cancers from developing in the first place, or to provide personalized care for people who do develop cancer. Unlocking the genetic basis of cancer today will improve patient care and quality of life now and in the future.”

Sondra and Stephen Hardis

0803392 12pg-02.indd 10 3/27/2008 4:29:22 AM

Goldbergs Bank on Crohn’s Disease Research

As bankers, father and son Gerald and Peter Goldberg understand the value of a wise investment. As philanthropists, they view support of medical research as an investment in the next generation.

Gerald Goldberg, Co-chairman of Amtrust Bank, and Peter Goldberg, President of Amtrust Bank, are passionate supporters of Cleveland Clinic’s research into the causes and treatment of Crohn’s disease, a debilitating inflammatory bowel disease (IBD).

Crohn’s affects an estimated 1 million Americans. There is no known cure. However, medical treatment can help keep the disease in remission.

Peter Goldberg, his sister, Betsy, and a cousin all have Crohn’s. The highest incidence of Crohn’s occurs in siblings.

“Crohn’s has the strongest evidence of genetic influence, more than any other disease at the moment,” says Claudio Fiocchi, MD, Professor of Molecular Medicine, Lerner College of Medicine, whose team is conducting research into the causes of IBD. The specific cause of the disease still is unknown, he says. “The current belief is that essentially all people with IBD and Crohn’s have an underlying genetic defect that, combined with environmental factors, triggers the disease.”

In a healthy person, the body’s immune system is switched on when defending against disease and returns to its normal resting state once the threat is gone. With Crohn’s, it never turns off. “Either the ‘bad guy’ is not eliminated, or the mechanism of the immune system is not working well, or a combination of both,” Dr. Fiocchi says.

Robert Silverman, Ph.D., is the first to hold the Mal and Lea Bank Chair.

9clevelandclinic.org /giving

Gerald Goldberg’s reason for his gift and for devoting himself to learning about the disease, meeting with researchers, and attending medical conferences is simple: “I have two children with Crohn’s, and my grandchildren will have 20 times the probability of having Crohn’s as the average person,” he says.

He often thinks of his deceased father, Leo Goldberg, the bank’s president in the 1950s who started a philanthropic foundation.

“When we talk about where the money should go, I say, ‘What would my father do if he was here and found out that three of his grandchildren have Crohn’s and there is a high probability that his great-grandchildren will have Crohn’s, too?’ ” he says. “I’m guessing that he would be thinking what I’m thinking.”

Research already is making a difference for people with Crohn’s, says Peter Goldberg’s gastroenterologist, Aaron Brzezinski, MD. “I think that in the past five years, advancement and understanding in the treatment of Crohn’s has been greater than for the preceding 50 years.”

Crohn’s often is misdiagnosed, Dr. Brzezinski says. “The length of time between the onset of symptoms and diagnosis is variable. It can be several years.” Through further genetic research, he says, physicians eventually may be able to identify the particular type of Crohn’s disease that a patient has and then predict disease behavior and provide treatment. “I hope that with better understanding of the genetic abnormalities in a given patient, we’ll be able to customize the treatment.”

Continued on page 10

From left: Peter and Gerald Goldberg

0803392 12pg-02.indd 11 3/27/2008 4:29:33 AM

Mary Sterle Treasures the “Gem on the Lake”

Mary Sterle’s role as a volunteer for Euclid Hospital, a Cleveland Clinic hospital, began 18 years ago. She retired from her long and successful career as a designer buyer, first for Halle’s Department Store and then Higbee’s, and found that she missed the daily structure of being employed.

“After you’ve been working for 40-some years, you feel a little useless if you’re not doing something,” she says.

She considered the idea of volunteering “somewhere,” and talked about this with a neighbor, the obstetrician who delivered her sons. He urged her to volunteer at Euclid

Hospital, an idea that had not crossed her mind. Once she started, she knew that it was the right decision.

“I had the time since my children were grown, and I wanted to give back to the community. The great thing about volun-teering is the more you do it, the more you want to get involved,” she says.

The wide variety of volunteer opportunities appeals to her, including chairing fundrais-ing events such as the fashion shows, which, she says, are “right up my alley,” as well as reverse raffles and bake sales. Every Thursday, she can be found in her blue volunteer’s uniform working in the surgical waiting area, where she helps comfort patients’ family members and answers their questions.

“People get a little anxious, especially when the surgery goes a little longer than they expected, and I help calm them down and reassure them,” she says.

Mrs. Sterle also has found joy in supporting the hospital financially. She helped create the hospital’s healing garden and donated a bench for the garden in her and her late husband, Richard’s, names.

She and her husband also have a room named for them in the newly expanded emergency department.

As much as Euclid Hospital benefits from her gifts and efforts, she believes that she is the privileged one. She likes the fact that the hospital is not too large and that it is easy to get to know people who work there. She also enjoys her relationship with the other volunteers, some of whom also have been there for many years.

Mrs. Sterle lives only 11 blocks from Euclid Hospital, known as the “Gem on the Lake,” which celebrated its 100th anniversary in 2007. She gave birth to both of her sons at the hospital, and she and her whole family continue receiving their care at the hospital and its adjacent medical building. She is proud and protective of Euclid Hospital. With other community hospitals closing in recent years, she says, this one is even more important to local residents.

“There is something to be said for a community hospital,” she says. “Even the mayor, who grew up near me, gets his care there. We need this hospital.”

10 Catalyst

New(s) at Cleveland ClinicThe Goldbergs’ grant focuses specifically on research into the role of two genes in the development of Crohn’s, Interleukin 23R and PTPN2, both of which are involved in the regulation of immunity and inflammation. These are genes identified by national and international consortia of researchers investigating the genetics of IBD. Gerald Goldberg is especially hopeful that one of the results of his family’s gift will be Cleveland Clinic researchers sharing their new findings with outside researchers, such as these consortia.

In deciding to help support Cleveland Clinic’s research, Peter Goldberg says, he and his father grappled with the question, “What is a realistic dollar amount?”

After exploring this question extensively, they decided on a total gift of $1.25 million, to be distributed over five years – the equivalent of an average National Institutes of Health research grant. The gift was made in the names of both of Peter’s parents, Gerald and Nancy Goldberg.

The Goldbergs’ gift extends beyond the grant. Gerald Goldberg considers himself “value added” as he combines his knowledge and passion about Crohn’s research with a lifetime of business and networking skills to engage other potential research supporters.

“Our goal is to get something going and to have the ability to attract others to give,” he says.

Continued from page 9

Crohn’s affects an estimated 1 million Americans. There is no known cure. However, medical treatment can help keep the disease in remission.

Mary Sterle

0803392 12pg-02.indd 12 3/27/2008 4:29:37 AM

11clevelandclinic.org /giving

Dr. Wexner Named Chief Academic Officer of Cleveland Clinic in FloridaCleveland Clinic has appointed colorectal surgeon Steven Wexner, MD, as the first Chief Academic Officer at Cleveland Clinic in Florida. Dr. Wexner began his career at Cleveland Clinic in Florida in 1988. He has served as Chairman of the Department of Colorectal Surgery since 1993 and Chief of Staff since 1997. In his new role, Dr. Wexner will oversee all institutional research and educational activities, which include graduate medical education, allied health and professional staff academic affairs.

Cleveland Clinic Abu Dhabi GroundbreakingThe groundbreaking for Cleveland Clinic Abu Dhabi (CCAB) took place Jan. 28. Scheduled to open in 2011, CCAD will be a 360-bed, multispecialty hospital on Al Sowa Island, across from the Abu Dhabi Mall. CCAD is an initiative led by Mubadala Healthcare, the division of Mubadala dedicated to investment in projects that enhance the private healthcare infrastructure of Abu Dhabi and the United Arab Emirates. The hospital, an extension of the Cleveland Clinic model, will be a physician-led medical facility served by

U.S.-trained, board-certified physicians.

New(s) at Cleveland Clinic

Cleveland Clinic / West Virginia Urological Partnership’s 20th YearCleveland Clinic and the Charleston Area Medical Center, based in Charleston, W.Va., recently celebrated the 20th anniversary of a joint renal transplant and urology program and completion of 800 kidney transplants. This is the only program of its kind in West Virginia and was the first outreach initiative undertaken by Cleveland Clinic outside the state of Ohio. It is staffed by two full-time Cleveland Clinic transplant urologists, Bashir Sankari, MD, and Larry Wyner, MD, who live and work in Charleston. In addition to kidney transplants, the center also provides subspecialty urological care.

Cleveland Clinic Co-sponsors Arab Health Congress 2008The Arab Health Congress took place Jan. 28-31 in Dubai. In addition to Cleveland Clinic sponsorship, President and CEO Toby Cosgrove, MD, and eight other Cleveland Clinic physi-cians and professionals spoke to more than 50,000 attendees at the region’s leading medical event.

First Single-port Laparoscopic Colon ResectionFeza Remzi, MD, and Daniel Geisler, MD, Colorectal Surgery, recently performed the world’s first colon resection (partial removal of the colon) entirely through a single incision in the navel. The conventional laparoscopic approach to colon resection for polyps or cancer entails three to five abdominal wall incisions.

0803392 12pg-02.indd 13 3/27/2008 4:29:37 AM

Soon, Cleveland Clinic supporters can exchange their hardhats for party hats in anticipation of fall openings for the Sydell and Arnold Miller Family Pavilion and Glickman Tower buildings.

Approximately 500 workers are installing the finishes in the buildings, including ceilings, wall covering, painting, flooring, millwork and casework, says Ronald Lawson, Senior Owner’s Representative, Operations Administration. “The buildings are beginning to look finished on the inside,” he says.

In 2007, nearly 20,000 supporters contributed $176 million toward Today’s Innovations, Tomorrow’s Healthcare: Campaign for Cleveland Clinic. To date, more than 70,000 supporters have contributed $986 million to the campaign.

Those gifts have made possible the construction of these innovative new buildings. They also are essential in supporting other renovation projects, as well as patient care, basic and clinical research, and medical education.

With this outstanding support, the Today’s Innovations, Tomorrow’s Healthcare campaign has reached $986 million. To learn more about the campaign, visit ClevelandClinic.org/giving.

Campaign Momentum Rises Along with New Buildings

2

4

5

6

7

8

9

10

11

12

T o d ay ’ s I n n o v at I o n s T o m o r r o w ’ s H e a lt H C a r e

C a m pa I g n H a p p e n I n g sGenerous Support Fuels Progress

Today’s Innovations, Tomorrow’s Healthcare: Campaign for Cleveland Clinic has drawn generous support. Cleveland Clinic’s financial donors are contributing to new construction and advances in patient care, research and education, all of which will help determine the future of healthcare.

Campaign attainment as of march 7, 2008:$986 million

Campaign fund progress:

• Innovative patient care: $156 million raised Goal: $235 million

• Basic and clinical research: $221 million raised Goal: $300 million

• medical education: $149 million raised Goal: $275 million

• Campus master plan: $460 million raised Goal: $440 million

For information on giving, go to clevelandclinic.org/giving or call 216.444.1245.

managing ediTor: elaine derosaConTribuTing wriTer: natalie sobonyadesign: epstein design Partners, inc.PhoTograPhy: Cleveland Clinic department of Photography; mike Potthast; douglas seifert

Cleveland Clinic Catalyst is published three times a year by institutional relations and development for friends and supporters of Cleveland Clinic.

Cleveland Clinic, founded in 1921, integrates clinical and hospital care with research and education in a private, not-for-profit group practice. Cleveland Clinic depends on the generosity of in-dividuals, families, corporations and foundations to ensure its continued excellence in patient care, medical research and education.

Cleveland Clinic realizes that individuals would like to learn more about its particular programs, services or developments. at the same time, we fully respect the privacy of our patients. if you do not wish to receive any materials containing this information, please write to us at: institutional relations and development, Cleveland Clinic, 3050 science Park drive, aC/322, beachwood oh 44122.

The Cleveland Clinic FoundationInstitutional Relations & Development9500 Euclid Avenue AC / 322Cleveland, OH 44195

Volume 6 | Issue 1 spring 2008

0803392 12pg-03.indd 2 3/27/2008 5:24:59 PM