Sponsorship and Advertising Prospectus

Join experts from science, medicine, government, industry, and more at the Carnegie Institution for Science in Washington, DC, for a silo-busting conversation that targets chronic, non-communicable diseases of aging.

www.metabesity2019.com

David Keith Photography

2 TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC

Learn from ExpertsStay up on the latest developments in the field with keynote talks by leaders in medical policy and government regulation. Broaden your understanding of the current challenges and opportunities through sessions on disease, longevity, foundations, insurance, capital markets, and more.

Engage the CommunityConnect with professionals who are highly involved in all aspects of research, development, and patient care. Take advantage of discussion opportunities, networking breaks and sponsored social events to stand out as a leader in targeting metabesity challenges.

Advance your MissionSupporting the conference will demonstrate your organization’s commitment to finding real-world solutions to metabesity and will showcase the impact of your products and services in this evolving field.

Invitation from the Co-ChairsGrowing scientific evidence suggests that most of the major diseases of our time (including diabetes, cardiovascular and neurodegenerative diseases, cancer, and the aging process itself ) have common metabolic roots, and thus may be susceptible to common solutions.

But the challenges of targeting this constellation of interconnected conditions, which we call “metabesity,” are not just technical: regulatory agencies today don’t have a clear pathway for a drug that is aimed at delaying aging; companies and financiers are uninterested in paying for clinical trials that may take more time and money than those for disease treatment; payers are reluctant to pay for products and services today for which decades may be required to reap the benefits.

TARGETING METABESITY 2019 focuses on some of the most important issues in healthcare today: shifting the emphasis from treatment to prevention, and going beyond managing individual diseases to extending healthy lifespan.

Gathering will be stellar speakers and participants from science and medicine, government regulation and policy, healthcare organizations, industry (drugs, devices, nutritional, and digital products), capital markets, patient advocacy, and other fields. Metabesity 2019 is a silo-busting examination of the challenges affecting the health and quality of life of billions of people. Creative solutions will be devised that could improve wellbeing and save trillions of healthcare dollars. We cordially invite all who have an interest in this conversation to join us in Washington, DC, in October 2019.

Alexander Fleming, MD Executive Chairman,

Kinexum

Lawrence Steinman, MD Professor of Neurology

and Neurological Sciences, Pediatrics and

Genetics, Stanford

TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC 3

Who Should Sponsor METABESITY 2019?This is the ideal venue for anyone with a stake in defining tractable steps for a better aproach to treating diabetes, obesity, other metabolic or endocrine disorders, cardiovascular and neurodegenerative diseases, cancer and the aging process itself. Members of this community are involved in multiple disciplines, including:

Life ScienceMedicineGovernmentPublic PolicyReimbursementIndustryCapital MarketsPatient Advocacyand others

Target Audience• Leaders and advisors involved in the future of healthcare, particularly in

prevention and delay of illness and aging

• Industry, including startups, developing pharmaceutical, digital health, nutrition, new business model and other approaches to disease prevention and healthy aging

• Scientists involved in metabolic, cancer, dementia, cardiovascular and aging-related research

• Clinical investigators and healthcare providers involved in chronic non-communicable disease care and prevention

• Government regulators and policy makers

• Funders, payers and investors (including capital markets, philanthropies, government and insurers) in disease prevention and healthy aging

• Federal and local health organization executives

• Epidemiologists, social scientists, economists, bioethicists, patient advocates, journalists and others thinking about how to harness emerging science behind Metabesity for global public health

4 TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC

High-Profile SponsorshipsSponsor PackagesAll prices are in U.S. Dollars (USD)

Platinum $20,000

Gold $10,000

Silver $5,000

Bronze $2,500

Number of delegate registrations 6 4 2 1

Logo, brief description, and link on mobile app sponsor page

Logo on back cover of printed program

Logo on signage at the venue

Advertisement in printed program Full page color1 Full page color Half page color

Flier inserted in delegate tote bag

Twitter announcement with your logo and link2 2 1

1. First registered Platinum Sponsor receives ad placement on the inside back cover.2. Metabesity 2019 will announce your support of the conference on Twitter

and include your logo and link.

Advertising OpportunitiesPrinted Program AdvertisementsKeep your message in the hands of all conference delegates long after the conference ends!

• Full page, color: $600 (one is included in Platinum and Gold Sponsorships)

• Half page, color: $450 (one is included in Silver Sponsorship)

• Full Page, black & white: $300• Half Page, black & white: $200

Info-CircleReservations and artwork are due 5 September 2019.

A registration form is on page 8.

All prices are in U.S. Dollars (USD)

Before You Print: Your signage, decorations, fliers, and/or gifts must be reviewed by Metabesity 2019 before you have them printed.

Logo Submission: Email high-resolution logo to mowens@custommanagement.com by 5 September 2019 to be included in all materials. File formats accepted: .ai, .eps, .pdf, .png, .psd, .jpg, or .tif, at least 300dpi.

Advertisements: Email high-resolution PDF in full color (CMYK) to mowens@custommanagement.com by 5 September 2019 to be included in print program. Full page (portrait/vertical): 5.5 in. wide x 8.5 in. high (140 mm x 215 mm) plus 1/8 in (5mm) bleed on all sides. Half page: (landscape/horizontal): 5.5 in. wide x 4 in. high (140 mm x 102 mm), no bleed.

Questions? Contact Lynne Valentic: lvalentic@custommanagment.com +1 434.977.4788

Not able to use all of your registrations? Donate one or more

as a delegate sponsorship and we will give you special recognition in the printed

and mobile programs.

TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC 5

Exclusive Event SponsorshipsWelcome Reception | $7,500 | limit 1Networking is made easier in the relaxed atmosphere of the coctail reception on Tuesday evening that brings together speakers and participants.• Your logo will be featured on the mobile event listing and in

the printed program• Opportunity to display branded signage, decorations

and tableware (must be reviewed before printing)

Networking Lunch | $5,000 | limit 2• Your logo will be featured on the mobile event listing• Opportunity to display branded signage and decorations

during a conference lunch (must be reviewed before printing)

Networking Beverage Break | $2,500 | limit 4• Your logo will be featured on the mobile event listing• Opportunity to display branded signage and decorations during

one of the beverage breaks (must be reviewed before printing)

Sponsorships that Focus on DelegatesSponsor a Delegate | $1,499 per delegateExtend your engagement at the conference by making it possible for others to participate too. Receive special recognition in the printed and mobile programs for delegate sponsorship.

Tote Bags | $6,000 | ExclusiveYour logo will be featured on the tote bag that delegates use during and after the conference! Submit a high-quality logo and Metabesity 2019 will handle production.

Lanyards | $2,500 | ExclusiveMake an impact with your company’s name or logo on lanyard for the badge that all delegates are required to wear to conference sessions and events. Metabesity 2019 can handle production as needed.

Distribution of Delegate Gift | $500Metabesity 2019 will distribute a small gift imprinted with your logo that you provide for delegates. Suggested gifts include:

• Notepad & Pen• Thumb Drive• Ear Buds

• First Aid Kit• Hand Sanitizer• Pill Case

• Lip Balm• Luggage Tag• Stress Ball

Info-CircleReservations and artwork are due 5 September 2019.

A registration form is on page 8.

All prices are in U.S. Dollars (USD)

Before You Print: Your signage, decorations, fliers, and/or gifts must be reviewed by Metabesity 2019 before you have them printed.

Logo Submission: Email high-resolution logo to mowens@custommanagement.com by 5 September 2019 to be included in all materials. File formats accepted: .ai, .eps, .pdf, .png, .psd, .jpg, or .tif, at least 300dpi.

Questions? Contact Lynne Valentic: lvalentic@custommanagment.com +1 434.977.4788

David Keith Photo

graphy

6 TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC

Preliminary Program | Day 1 | Tuesday, 15 October 2019THE SCIENCE AND THE SCIENTIFIC INFRASTRUCTURE FOR TARGETING METABESITY

REGISTRATION & CONTINENTAL BREAKFAST

SESSION 1 | KEYNOTESRichard Hodes, MD, Director of the National Institute on Aging (NIH), USA

Janet Woodcock, MD, Director of FDA Center for Drug Evaluation and Research, USA

SESSION 2 | LONGEVITYMatt Kaeberlein, PhD, Director of the Healthy Aging and Longevity Research Institute, University of Washington, USA

Brian Kennedy, PhD, Director of the Centre for Healthy Ageing at the National University Health System, Singapore

David Sinclair, PhD, co-Director of Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, USA

Richard Hodes, MD, Director of the National Institute on Aging (NIH), USA

SESSION 3 | CANCER, NEURODEGENERATIVE DISEASES AND CARDIOVASCULAR DISEASESBrian Leyland-Jones, MB, BS, PhD, VP, Molecular and Experimental Research of Avera Cancer Institute, USA

Jennifer Ligibel, MD, Director, Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana Farber Cancer Institute, USA

Lawrence Steinman, MD, Professor of Neurology Neurology and Neurological Sciences, Pediatrics and Genetics, Stanford, USA - Co-Chair

Others invited

LUNCH AND POSTER PRESENTATIONS

SESSION 4 | DIABETES, OBESITY AND OTHER METABOLIC DISEASESJohn Buse, MD, PhD, Professor of Medicine, Director of Diabetes Care Center of University of North Carolina, USA

Will Cefalu, MD , CSO of American Diabetes Association (ADA), USA

Ralph DeFronzo, MD, Professor of Medicine, University of Texas Health Science Center, San Antonio, USA

Professor Philip Home, MA DPhil DM FRCP, Professor of Diabetes Medicine, University of Newcastle, UK

SESSION 5 | NUTRITION, LIFESTYLE AND SOCIAL APPROACHESKenneth Cooper, MD, MPH, Founder of The Cooper Institute, USA

Chef Karl Guggenmos, WACS Global Master Chef, USA

Lucy Rose, Founder and President of The Cost of Loneliness Project, USA ; Former Director, Division of Drug Advertising and Marketing, CDER, FDA, USA

Others invited

SUMMARY OF DAY 1 AND LOOK AHEAD TO DAY 2

COCKTAIL RECEPTION

TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC 7

Preliminary Program | Day 2 | Tuesday, 16 October 2019TRANSLATION OF METABESITY SCIENCE TO PEOPLE

REGISTRATION & CONTINENTAL BREAKFAST

SESSION 6 | KEYNOTESSusan Mayne, PhD, Director of FDA Center for Food Safety and Applied Nutrition, USA

Other invited

SESSION 7 | CLINICAL DEVELOPMENT ISSUES – CHALLENGES AND OPPORTUNITIES Nir Barzilai, MD, Director of Institute for Aging Research, Albert Einstein College of Medicine, USA

Brian Harvey, MD, PhD, EVP of Global Liver Institute, USA

Alex Zhavoronkov, PhD, CEO of InSilico Medicine, USA

Others invited

SESSION 8 | PAYERS AND PROVIDERSModerator: Jeffrey Berkowitz, CEO and Director of Real Endpoints; Former EVP of UnitedHealth/Optum, USA

Others invited

SESSION 9 | INDUSTRY: MORE ESTABLISHED COMPANIES Moderator: Joe Cook, Jr., Executive Chairman and President of NuSirt Biopharma; Former Chairman and CEO of Amylin, USA

Stephen Gough, MD, FRCP, SVP Global Chief Medical Officer of Novo, Denmark

Maha Radhakrishnan, MD, Senior Vice President Head of Medical Affairs for Primary Care of Sanofi, France

Antonio Tataranni, MD, Deputy Chief Scientific Officer, PepsiCo, USA

LUNCH AND POSTER PRESENTATIONS

SESSION 10 | INDUSTRY: EMERGING COMPANIESModerator: Ed Saltzman, Executive Chairman, Cello Health BioConsulting, USA

Nora Khaldi, PhD, Founder and CSO, Nuritas, Ireland

Joan Mannick, MD, Co-Founder and CMO of resTORbio, USA

Sree Kant, Head of Business Development, Life Biosciences, USA

SESSION 11 | A VIEW FROM THE CAPITAL MARKETSModerator: Dennis Purcell, Founder and Senior Advisor of Aisling Capital, USA

Laura Deming, Founder and Partner of The Longevity Fund, USA

James Peyer, PhD, Founder and Managing Partner, Apollo Ventures, USA

Others invited

SESSION 12 | FOUNDATIONS, PATIENTS AND GOVERNMENTStephanie Lederman, Executive Director of American Federation for Aging Research (AFAR) Board of Directors, USA

Others invited

SESSION 13 | SUMMATION AND TRENDS, QUESTIONS FOR THE NEXT CONFERENCEModerated multilogue/town hall among speakers and delegates.

8 TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC

Sponsorship and Advertising Registration FormContact Information (please print)Contact Name (to receive correspondence): ______________________________________________________________

Contact E-mail: __________________________________________Contact Telephone: _________________________

Company Name (as it should appear in print/on screen): ________________________________________________

Street Address: ____________________________________________________________________________________

City, State/Province: __________________________ Postcode: ___________ Country: _________________________

Company Telephone: _________________________ Company E-mail: _______________________________________

Company Website: _________________________________________________________________________________ (as it should be linked from the conference website and mobile app)

High-Profile Sponsorship Platinum Sponsor $20,000

Gold Sponsor $10,000

Silver Sponsor $5,000

Bronze Sponsor $2,500

Donate ____ registration(s) as delegate sponsorship(s)

Sponsorships that Focus on Delegates Sponsor Delegate(s) Number: ____ @ $1,499 each

Delegate Tote Bags - Exclusive $6,000

Lanyards - Exclusive $2,500

Distribution of Delegate Gift $500 Describe your gift: _________________________________________ Examples: notepad and pen; stress ball; thumb drive

Printed Program Advertisements Full page, color* $600 (one is included for Platinum & Gold sponsors)

First registered Platinum Sponsor receives ad placement on the inside back cover.

Half page, color** $450 (one is included for Silver sponsor)

Full page, black & white* $300

Half page, black & white** $200

* Full page: portrait (vertical), full bleed

** Half page: landscape (horizontal), no bleedDetails about your sponsorship and advertising selections will be provided after your completed form is received.

Sponsors: please email a 250-word company description to lvalentic@custommanagement.com.

Payment InformationPlease complete this form and send it to one of the addresses below. We will invoice you for the items you selected.

Email: lvalentic@custommanagement.com Fax: +1 434.977.1856Mail: Lynne Valentic; Metabesity 2019 Conference Services; 154 Hansen Rd, Suite 201; Charlottesville, VA 22911 USA

Exclusive Event Sponsorship Welcome Reception (limit 1) $7,500

Networking Lunch (limit 2) $5,000

Networking Beverage Break (limit 4) $2,500

All amounts are in U.S. Dollars (USD)

Rules and Regulations I agree to the General Conditions, Rules, and Regulations on page 9.

Reservations and artwork are due 5 September 2019.See addresses below.

TARGETING METABESITY 2019 15-16 OCTOBER 2019 WASHINGTON, DC 9

General Conditions, Rules, and RegulationsMetabesity 2019 Conference Services: Custom Management Group (CMG) is providing conference and sponsorship services under the name of Metabesity 2019 Conference Services. Communications, agreements and payments regarding these services that are made through CMG are binding.

All communications regarding sponsorship and advertising at Metabesity 2019 shall be directed to:

Lynne Valentic Metabesity 2019 Conference Services 154 Hansen Rd, Suite 201 Charlottesville, VA 22911 USA lvalentic@custommanagement.com What the Fee Includes: Please see pages 4–5 for details and rates.

Payment Schedule: Exhibit registration with full payment and description (not exceeding 250 words) must be received by Metabesity 2019 Conference Services by 5 September 2019 to be printed in the official conference program. Information submitted after the cut-off date will not be included in printed materials. Payment and remittance must be made to Metabesity 2019 in U.S. Dollars. Payment may be made by check or credit card (American Express, MasterCard or Visa), or wire transfer. Transfer fees may apply. A $25 surcharge will be assessed to cover any collection fees.

Activities Permitted: Sponsor’s and Advertiser’s promotional activities are limited to the spaces, times and materials included in the sponsorship/advertising options that have been reserved and paid in full. Any other promotional activity that is not included in the paid option, such as displays, presentations, and distribution of fliers or other materials to delegates on the conference premises, is not allowed.

Displays, Materials, and Signage: All displays, materials and signage must be approved by and coordinated with Metabesity 2019 Conference Services.

Liability/Hold Harmless: Sponsor/Advertiser hereby agrees to and does indemnify, hold harmless, and defend Custom Management Group (dba Metabesity 2019 Conference Services) and the conference organizer, Kinexum, from and against any and all liability, responsibility, loss, damage, cost or expense of any kind whatsoever, regardless of any events beyond the conference organizer’s control, including, but not limited to, the outbreak of war, terrorist activity, riots, governmental or other obstacles for the freedom of travel, union actions, or natural disasters, that take place during the Conference.

Terms and Conditions: By checking off the box on the registration form, you hereby authorize Metabesity 2019 Conference Services to reserve space and order materials for use by the above company or organization. The undersigned acknowledges receipt of and agrees to abide by the General Conditions, Rules, and Regulations available in this prospectus and on the Metabesity 2019 website at www.metabesity2019.com and to all conditions under which exhibit space is leased to the conference organizers. Metabesity 2019 Conference Services reserves the absolute right, at any time, to determine the eligibility of any company or product for inclusion in the exhibit. The undersigned acknowledges that space assignments shall be acceptable unless Metabesity 2019 Conference Services is notified in writing within fifteen (15) days of the date of assignment notification. The undersigned specifies that the products or services listed in your description are those to be exhibited.

Cancellation/Partial Refund: Cancellations must be made in writing by 15 August 2019 to receive a 75% refund. No refunds will be made after 15 August 2019. Metabesity 2019 may, at its discretion, refund part or all of a fee in the case that the conference is canceled altogether.

Sponsor/Advertiser Checklist Reservation form sent to lvalentic@custommanagement.com Sponsor’s company description (max 250 words) sent to lvalentic@custommanagement.com Sponsor’s Logo (high-resolution) sent to mowens@custommanagement.com Advertisement Artwork (high resolution PDF) sent to mowens@custommanagement.com

Metabesity 2019 Conference ServicesCustom Management Group (CMG)

154 Hansen Road, Suite 201; Charlottesville, VA 22911 USA

cmg@custommanagement.com +1 434-971-4788

David Keith Photography