SPIE Medical Imaging 2013

LocationDisney Coronado Springs ResortLake Buena Vista (Orlando Area)Florida, USA

Conferences& Courses9–14 February 2013

spie.org/micallpdf

Call for PapersSubmit your abstractby 30 July 2012

Call for Papers

Technologies• Physics of medical imaging• Image processing• Computer-aided diagnosis• Image-guided procedures,

robotic interventions, and modeling

• Biomedical applications in molecular, structural, and functional imaging

• Image perception, observer performance, and technology assessment

• Advanced PACS-based imaging informatics and therapeutic applications

• Ultrasonic imaging, tomography, and therapy

• Digital pathology

Present your work at the premier event for medical scientists and practitioners in the fi eld of imaging

Conferences & Courses: 9–14 February 2013Disney Coronado Springs ResortLake Buena Vista (Orlando Area)Florida, USA

+1 360 676 3290 • [email protected] • twitter (#SPIEMI) 1

Submit your abstract todayspie.org/micallpdfAbstract Due Date: 30 July 2012

SPIE would like to express its deepest appreciation to the symposium chairs, conference chairs, program committees, session chairs, and authors who have so generously given their time and advice to make this symposium possible.

The symposium, like our other conferences and activities, would not be possible without the dedicated contribution of our participants and members.

Plan to Participate SPIE Medical Imaging is the internationally recognized premier forum for reporting state-of-the-art research and development. We invite contributions that address topics ranging from underlying fundamental scientifi c principles to clinical evaluations. The symposium covers the full range of medical imaging modalities with special emphasis on medical image acquisition, display, processing, analysis, perception, decision support, imaging informatics, and more.

We encourage contributions from you and your colleagues. The SPIE copyright policy grants authors the right to submit their Medical Imaging Proceedings papers to peer-reviewed journals or magazines of their choice.

2013 Symposium Chairs

Ehsan SameiDuke Univ. (USA)

Nico KarssemeijerRadboud Univ. Nijmegen Medical Ctr. (Netherlands)

Submit your Medical Imaging manuscripts in parallel to the Journal of Biomedical Optics and Journal of Electronic Imaging See page 15 for details.

2 SPIE Medical Imaging 2013 Call for Papers • spie.org/micallpdf

MI101 Physics of Medical Imaging (Nishikawa, Whiting) . . . . . . . . . . . 3

MI102 Image Processing (Ourselin, Haynor) . . . . . . . . . . . . . . . . . . . . . 4

MI103 Computer-Aided Diagnosis (Novak, Aylward) . . . . . . . . . . . . . . 5

MI104 Image-Guided Procedures, Robotic Interventions, and Modeling (Holmes, Yaniv) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

MI105 Biomedical Applications in Molecular, Structural, and Functional Imaging (Weaver, Molthen) . . . . . . . . . . . . . . . . . . . . 7

MI106 Image Perception, Observer Performance, and Technology Assessment (Abbey, Mello-Thoms) . . . . . . . . . . . . 8

MI107 Advanced PACS-based Imaging Informatics and Therapeutic Applications (Law, Boonn) . . . . . . . . . . . . . . . 9

MI108 Ultrasonic Imaging, Tomography, and Therapy (Bosch, Doyley) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

MI109 Digital Pathology (Gurcan, Madabhushi) . . . . . . . . . . . . . . . . . 11

Poster Session Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Abstract Submission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Sponsorship Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Contents

Cooperating Organizations AAPM—American Association of Physicists in Medicine

APS—American Physiological Society

CARS—Computer Assisted Radiology and Surgery

MIPS—Medical Image Perception Society

RSNA—Radiological Society of North America

SIIM—Society for Imaging Informatics in Medicine

WMIS—World Molecular Imaging Society

The DICOM Standards Committee

Photos Courtesy of Ken Hanson

Abstract Due Date: 30 July 2012


Call for PapersPhysics of Medical Imaging (MI101)Conference Chairs: Robert M. Nishikawa, The Univ. of Chicago (USA); Bruce R. Whiting, Univ. of Pittsburgh (USA)Cochair: Christoph Hoeschen, Helmholtz Zentrum München GmbH (Germany)Program Committee: Hilde Bosmans, UZ Leuven (Belgium); Guang-Hong Chen, Univ. of Wisconsin School of Medicine and Public Health (USA); Mats E. Danielsson, Royal Institute of Technology (Sweden); Maria Drangova, Robarts Research Institute (Canada); Thomas G. Flohr, Siemens Medical Solutions GmbH (Germany); Stephen J. Glick, Univ. of Massachusetts Medical School (USA); Michael Grass, Philips Technologie GmbH (Germany); Marc Kachelriess, German Cancer Research Ctr. (DKFZ) (Germany); Karim S. Karim, Univ. of Waterloo (Canada); Hee-Joung Kim, Yonsei Univ. (Korea, Republic of); Despina Kontos, The Univ. of Pennsylvania Health System (USA); Iacovos S. Kyprianou, U.S. Food and Drug Administration (USA); Joseph Y. Lo, Duke Univ. (USA); Norbert Pelc, Stanford Univ. (USA); Jinyi Qi, Univ. of California, Davis (USA); John A. Rowlands, Thunder Bay Regional Research Institute (Canada); John M. Sabol, GE Healthcare (USA); Taly G. Schmidt, Marquette Univ. (USA); Jeffrey H. Siewerdsen, Johns Hopkins Univ. (USA); Anders Tingberg, Scanias Univ. Hospital (Sweden); John Yorkston, Carestream Health Technology and Innovation Ctr. (USA)

This conference will cover all aspects of image for-mation in medical imaging including systems using ionizing radiation (x-rays, gamma rays) or non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, or magnetic particle imaging). Papers of a theoretical nature or papers reporting new experi-mental results are invited. Topics of particular interest include experimental methods and results regarding image performance, image reconstruction, detec-tor materials and electronic design, analytical and computer modeling of imaging systems, and novel methods for image formation. The conference will cover predicted and measured system performance including image noise and contrast, spatial and temporal resolution, and inherent artifacts. Systems of interest include those producing projection, tomo-graphic, volumetric, dynamic, or time resolved studies along with systems using specialized approaches for depth or tissue discrimination. Work directed toward the imaging of human subjects, small animals, or tis-sue specimen are welcome. Original papers are especially requested in the following areas:

Imaging Science• Physics of signal detection and image formation • Object characterization and contrast mechanisms • Characterization of detector and system

performance (MTF, NPS, DQE, task- and observer-based)

Technology• Novel medical imaging systems and methods • Properties of scintillating, photoconductive, or

other sensor materials • Novel sources of radiation • Image reconstruction methods (e.g., for CT,

tomosynthesis, SPECT and PET, optical imaging, MRI, etc.)

• Multi-energy (spectral) x-ray and CT imaging • Computer simulation of imaging systems

including models for radiation sources, imaged objects, physical interactions, and detectors

• Phantoms (physical and numerical) • Radiation (e.g., optical) and signal transport • Radiation dose, dosimetry, and dose effects (risk)

Devices and Applications• Advanced multi-slice or cone beam CT systems • Advanced radiographic, fl uoroscopic, or

angiographic systems (including phase contrast and diffraction)

• Advanced applications (clinical, translational, preclinical, basic science, biomarkers)

• Non-ionizing radiation systems (ultrasound, MRI, optical, thermal, magnetic particle imaging)

• Small animal imaging systems • Megavoltage imaging devices • Multi-modality imaging devices • Low-cost imaging devices with global health

applications • Imaging applications in therapy (e.g., radiation

therapy, surgery, interventions)

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process. Please select in order of importance.• ALG - Algorithmic developments, simulations,

calibration, classifi cation, etc. (for CT and tomosynthesis reconstruction use dedicated categories)

• APPS - Applications, e.g. cardiovascular, oncology, image guided interventions (for breast imaging use dedicated category)

• CT - All conventional CT topics (for reconstruction, cone beam, and multi-energy use dedicated category)

• CTCB - Cone beam CT • CTME - Multi-energy CT • CTREC - CT image reconstruction • DET - Detector technology; scintillators,

photoconductors, diodes, TFT • DOSE - radiation dose, dosimetry, and dose effects • MAM - Imaging of the breast (any device) • METR - Measurement methods (MTF, NPS, DQE,

eDQE, gDQE, Spectra, ...) • MICRO - Devices/techniques for microscopic or

small animal imaging • IMG - Imaging methods including optical, MR,

nuclear, etc. (for x-ray based methods use dedicated categories)

• PER - Observer or perception-based performance evaluations of systems

• PHT - Work involving development of phantoms or anatomical simulation models

• PHS - Phase contrast imaging• RADT - Radiation Transport Calculations• RECON - Image reconstruction including SPECT,

PET, OCT, and tomosynthesis • SYS - Reports on complete systems, prototypes,

products • TSY - Tomosynthesis (for tomosynthesis

reconstruction use dedicated category) • TSYREC - Tomosynthesis reconstruction • XIM - X-ray imaging, x-ray sources, techniques,

scatter (for detectors, mammography, and reconstruction use dedicated categories)

• XME - Multi-energy radiography or mammography (for CT use CTME instead)

• OTHER - Other technical areas

Extended Abstract Due Date: 6 August 2012All submissions must include: a 250-word abstract and a two- to four-page supplemental fi le (see Submission Guidelines for detailed instructions).


Image Processing (MI102)Conference Chairs: Sebastien Ourselin, Univ. College London (United Kingdom); David R. Haynor, Univ. of Washington (USA)Program Committee: Mostafa Analoui, The Livingston Group, LLC (USA); Elsa D. Angelini, Telecom ParisTech (France); Kyongtae T. Bae, Univ. of Pittsburgh Medical Ctr. (USA); Christian Barillot, IRISA / INRIA Rennes (France); Benoit M. Dawant, Vanderbilt Univ. (USA); Baowei Fei, Emory Univ. (USA); Aaron Fenster, Robarts Research Institute (Canada); Bernd Fischer, Univ. Luebeck (Germany); Alejandro F. Frangi, Univ. Pompeu Fabra (Spain); Mona K. Garvin, The Univ. of Iowa (USA); James C. Gee, Univ. of Pennsylvania (USA); Guido Gerig, The Univ. of Utah (USA); Tobias Heimann, Deutsches Krebsforschungszentrum (Germany); Bennett A. Landman, Vanderbilt Univ. (USA); Tianhu Lei, Univ. of Pittsburgh Medical Ctr. (USA); Boudewijn Lelieveldt, Leids Univ. Medisch Ctr. (Netherlands); Murray Loew, The George Washington Univ. (USA); Cristian Lorenz, Philips Medizin Systeme GmbH (Germany); Frederik Maes, Katholieke Univ. Leuven (Belgium); Vincent A. Magnotta, The Univ. of Iowa Hospitals and Clinics (USA); Sunanda D. Mitra, Texas Tech Univ. (USA); Kensaku Mori, Nagoya Univ. (Japan); Nassir Navab, Technische Univ. München (Germany); Mads Nielsen, Univ. of Copenhagen (Denmark); Wiro J. Niessen, Erasmus MC (Netherlands); Josien P. Pluim, Univ. Medical Ctr. Utrecht (Netherlands); Jerry L. Prince, Johns Hopkins Univ. (USA); Sonia Pujol, Brigham and Women’s Hospital (USA) and Harvard Medical School (USA); Daniel Rueckert, Imperial College London (United Kingdom); Punam K. Saha, The Univ. of Iowa (USA); Olivier Salvado, Commonwealth Scientifi c and Industrial Research Organisation (Australia); Julia A. Schnabel, Univ. of Oxford (United Kingdom); Colin Studholme, Univ. of Washington (USA); Martin A. Styner, The Univ. of North Carolina at Chapel Hill (USA); Philippe Thévenaz, Ecole Polytechnique Fédérale de Lausanne (Switzerland); Jayaram K. Udupa, The Univ. of Pennsylvania Health System (USA); Tomas Vrtovec, Univ. of Ljubljana (Slovenia); Andreas Wahle, The Univ. of Iowa (USA)

Original papers are invited on all aspects of the processing and analysis of medical, small animal, or cellular images, with applications in medicine, biological, and pharmaceutical research. Of inter-est are algorithms applied to all imaging modalities, including x-ray, DSA, CT, MRI, nuclear medicine, optical, ultrasound, macroscopic, and microscopic imaging. Papers dealing with the challenges of bring-ing advances in research laboratories into clinical application are particularly welcomed. Papers typically involve research that includes one or more of the following categories (in alpha-betical order):

Categories• Analysis/processing of DTI, fMRI, connectivity

data • Atlases • Active shape and appearance models, manifold

learning • Classifi cation • Compressive sensing/sparse reconstruction

methods • Deformable geometry • Developments in open software for medical

image processing and translational research • Image compression • Image computing for mobile devices • Image restoration and enhancement • Mathematical morphology • Motion/time series analysis • Multiresolution and wavelets • Pattern recognition • Population/clinical studies • Registration • Segmentation • Shape

• Stereoscopic x-ray processing and visualization • Texture • Validation, including creation of ‘ground truth’

image repositories • Voxel-based morphometry

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the list above to assist in the review process.

Abstract Due Date: 30 July 2012All submissions must include: a 250-word abstract and a two- to four-page supplemental fi le (see Submission Guidelines for detailed instructions).

SPIE Medical Imaging 2013


Call for Papers

Computer-Aided Diagnosis (MI103)Conference Chairs: Carol L. Novak, Siemens Corporate Research (USA); Stephen Aylward, Kitware, Inc. (USA)Program Committee: Samuel G. Armato III, The Univ. of Chicago Medical Ctr. (USA); Susan Astley, The Univ. of Manchester (United Kingdom); Kyongtae T. Bae, Univ. of Pittsburgh Medical Ctr. (USA); Matthew S. Brown, Univ. of California, Los Angeles (USA); Heang-Ping Chan, Univ. of Michigan Health System (USA); Marleen de Bruijne, Erasmus MC (Netherlands); Thomas M. Deserno, RWTH Aachen (Germany); Catalin Fetita, TELECOM & Management SudParis (France); Hiroshi Fujita, Gifu Univ. School of Medicine (Japan); Maryellen L. Giger, The Univ. of Chicago Medical Ctr. (USA); Hayit Greenspan, Tel Aviv Univ. (Israel); Lubomir M. Hadjiiski, Univ. of Michigan Health System (USA); Horst K. Hahn, Fraunhofer MEVIS (Germany); Jong Hyo Kim, Seoul National Univ. College of Medicine (Korea, Republic of); Marius G. Linguraru, Children’s National Medical Ctr. (USA); Joseph Y. Lo, Duke Univ. (USA); Michael F. McNitt-Gray, Univ. of California, Los Angeles (USA); Kensaku Mori, Nagoya Univ. (Japan); Janne J. Nappi, Massachusetts General Hospital (USA); Meindert Niemeijer, The Univ. of Iowa Hospitals and Clinics (USA); Noboru Niki, Univ. of Tokushima (Japan); Nicholas A. Petrick, U.S. Food and Drug Administration (USA); Ronald M. Summers, National Institutes of Health (USA); Kenji Suzuki, The Univ. of Chicago (USA); Georgia Tourassi, Oak Ridge National Lab. (USA); Bram van Ginneken, Radboud Univ. Nijmegen (Netherlands); Rafael Wiemker, Philips Research (Germany); Axel Wismueller, Univ. of Rochester Medical Ctr. (USA)

This conference will provide a forum for research-ers involved in development and application of computer-aided diagnosis and detection systems. Original papers are requested on all aspects of CAD, including segmentation, pattern recognition, feature extraction, classifi er design, workstation design, human interaction, database construction, and evaluation. CAD methods involving any medical imaging modality are welcome, including x-ray, CT, MRI, nuclear medicine, molecular imaging, optical, ultrasound, endoscopy, macroscopic and micro-scopic imaging, and multi-modality technologies.

LIVE DEMONSTRATIONS WORKSHOP: A workshop featuring real-time demonstrations of algorithms and systems will be held during the conference. This workshop is intended to be a forum for developers to exhibit their creations, fi nd new collaborators, and inspire the attendees. All participants of SPIE Medical Imaging are in-vited to submit a proposal for a demonstration. More information will be provided at a later date.

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics (one Applications, and up to two others) from the following list to assist in the review process. Choose one or more applications topic from the following list:• Applications: Breast • Applications: (Cardio-)Vascular • Applications: Colon and other Gastrointestinal

Tract • Applications: Eye (including retina) • Applications: Head and Neck • Applications: Liver • Applications: Lung • Applications: Microscopy and Histopathology • Applications: Multiple Organ Systems • Applications: Musculoskeletal • Applications: Oncology • Applications: Prostate • Applications: Novel Applications • Applications: Other Organ Systems

Choose up to two topics from the following list:• Detection • Characterization and staging • Machine learning • Classifi er design • Risk assessment • CAD system quality assessment • Segmentation • False positive reduction • Feature extraction • Quantitative analysis • Database design • Content-Based Image Retrieval • Reference libraries • Visualization and interaction • Validation • Observer studies• Human factors in CAD• Decision support systems• Comparative evaluation of different CAD

systems • Combining or fusing different CAD systems • Other, please specify



Image-Guided Procedures, Robotic Interventions, and Modeling (MI104)Conference Chairs: David R. Holmes III, Mayo Clinic (USA); Ziv R. Yaniv, Children’s National Medical Ctr. (USA)Program Committee: Purang Abolmaesumi, The Univ. of British Columbia (Canada); Alexandre X. Falcão, Univ. Estadual de Campinas (Brazil); Baowei Fei, Emory Univ. (USA); Gabor Fichtinger, Queen’s Univ. (Canada); George J. Grevera, Saint Joseph’s Univ. (USA); Steven L. Hartmann, Medtronic Navigation (USA); David R. Haynor, Univ. of Washington (USA); William E. Higgins, The Pennsylvania State Univ. (USA); Pierre Jannin, Univ. de Rennes 1 (France); David M. Kwartowitz, Clemson Univ. (USA); Michael Miga, Vanderbilt Univ. (USA); Terry Peters, Robarts Research Institute (Canada); Frank Sauer, Siemens Corporate Research (USA); Eric J. Seibel, Univ. of Washington (USA); Guy Shechter, Philips Medical Systems (USA); Robert J. Webster III, Vanderbilt Univ. (USA); Jay B. West, Accuray, Inc. (USA); Ivo Wolf, Deutsches Krebsforschungszentrum (Germany); Kenneth H. Wong, Virginia Polytechnic Institute and State Univ. (USA)

This conference is primarily concerned with applica-tions of medical imaging data in the engineering of therapeutic systems. Original papers are requested in the following topic areas:• 3D visualization • Augmented, virtual, and enhanced reality • Mathematical modeling to guide and understand

therapy • Techniques in population-specifi c and patient-

specifi c model generation • Image-based models for characterization of

tissue and disease properties • Novel interfaces for therapy and visualization of

data • Image-guided procedures • Minimally invasive surgery • Computer-assisted therapy and therapy

planning • Robotic interventions and surgical tools • Medical image based simulation • Localization technologies and navigation

systems • Tracking and calibration • Intraoperative imaging • Intraoperative patient-to-image/-model

registration • Modeling of intraprocedural changes • Validation/evaluation • Telemedicine systems and their applications • Clinical applications and technology integration • High performance computing for real-time

modeling and/or large dataset visualization • Modeling and analysis of procedures • Safety and standards for image-guided and

robotic procedures • Other related areas.

Papers from student authors are particularly encour-aged; there is a competition for the best student paper and limited student travel awards are also available. Submissions that cross over between this conference and others at SPIE Medical Imaging, and which would be appropriate for combined sessions, are also welcomed.

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process.• Abdominal Procedures • Calibration • Cardiac Procedures • Pelvic Procedures • Diagnosis • Disease Characterization • Localization and Tracking Technologies • Endoscopic Procedures • Enhanced Reality • Image-Guided Therapy • Data Integration for the Clinic/OR • Intraoperative Imaging • Medical Robotics • Modeling • Monitoring and Feedback • Multimodality Display • Neurosurgical Procedures • Registration • Segmentation • Surgical Simulation • Therapy Planning • Treatment Planning • Ultrasound Guidance • Validation/Evaluation • Visualization • Human Factors • Stereoscopic Display • Other, please specify




Biomedical Applications in Molecular, Structural, and Functional Imaging (MI105)Conference Chairs: John B. Weaver, Dartmouth Hitchcock Medical Ctr. (USA); Robert C. Molthen, Medical College of Wisconsin (USA)Program Committee: Amir A. Amini, Univ. of Louisville (USA); Thorsten M. Buzug, Univ. zu Lübeck (Germany); Juan R. Cebral, George Mason Univ. (USA); Yu Chen, Univ. of Maryland, College Park (USA); Anne Clough, Marquette Univ. (USA); Andreas H. Hielscher, Columbia Univ. (USA); Xiaoping P. Hu, Emory Univ. (USA); Xavier Intes, Rensselaer Polytechnic Institute (USA); Andrzej Krol, SUNY Upstate Medical Univ. (USA); John F. LaDisa, Marquette Univ. (USA); Armando Manduca, Mayo Clinic College of Medicine (USA); Erik L. Ritman, Mayo Clinic (USA); Merryn H. Tawhai, The Univ. of Auckland (New Zealand); Nicholas J. Tustison, Univ. of Virginia (USA); Axel Wismueller, Univ. of Rochester Medical Ctr. (USA)

This conference will cover all aspects of measuring and quantifying molecular, structural and functional parameters from biomedical images. Descriptions of work based on any imaging technology, includ-ing multidimensional and multimodality, are invited. Techniques, methods, and systems for evaluation and interpretation of structure-function relationships and interrelationships from images of intact, living tissues, are of particular interest. Work in emerging areas such as novel contrast agents, small animal imaging, optical or electrical impedance tomogra-phy, and dual-modality imaging is also of specifi c interest. Original papers are requested in, but not limited to, the following areas:

• Imaging methods • Small animal imaging, molecular imaging • Nanoparticle biosensors and magnetic particle

imaging (MPI)• Optical, electrical impedance, terahertz or

microwave imaging • Novel physiological imaging agents/

probes: quantum dots, nanoparticles, radiopharmaceuticals

• Pulmonary function: perfusion, ventilation, mechanics, and modeling

• Vessels and airways: detection, modeling, trees, reactivity

• Cardiac electrophysiology • Functional neuro-imaging and brain mapping • Soft tissue deformation: analysis and

quantifi cation • Biomechanical modeling and imaging: cardiac,

orthopedic, fi nite-element models • Physiologic modeling: metabolism, receptor-

ligand binding • Pharmacokinetic models • Multimodality imaging • Hybrid imaging

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process.• Physiological modeling/computational

physiology • Imaging methods • Small-animal imaging • Optical imaging • Electrical impedance, terahertz or microwave

imaging • Imaging agents/molecular probes: receptor-

ligand binding / pharmacokinetic models • Magnetic particle imaging (MPI) • Nanoparticle imaging: sensing/therapy • Neuro-imaging and brain mapping • Soft tissue imaging • Cardiac electrophysiology • Detection, segmentation, mapping: vessels and

airways • Biomechanical modeling/structure • Pulmonary function: perfusion, ventilation,

mechanics, and modeling

Call for Papers


Critical DatesAbstract Due Date: 30 July 2012 (Check Conferences for Extended Due Date)

Manuscript Due Date: 14 January 2013Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.


Image Perception, Observer Performance, and Technology Assessment (MI106)Conference Chairs: Craig K. Abbey, Univ. of California, Santa Barbara (USA); Claudia R. Mello-Thoms, Univ. of Pittsburgh (USA)Program Committee: François Bochud, Ctr. Hospitalier Univ. Vaudois (Switzerland); Jovan G. Brankov, Illinois Institute of Technology (USA); Darrin C. Edwards, The Univ. of Chicago (USA); Alastair G. Gale, Loughborough Univ. (United Kingdom); Howard C. Gifford, Univ. of Massachusetts Medical School (USA); Stephen L. Hillis, Iowa City VA Medical Ctr. (USA); Elizabeth A. Krupinski, The Univ. of Arizona (USA); Matthew A. Kupinski, The Univ. of Arizona (USA); Anthony J. Maeder, Univ. of Western Sydney (Australia); Maciej A. Mazurowski, Duke Univ. (USA); Mark F. McEntee, The Univ. of Sydney (Australia); Berkman Sahiner, U.S. Food and Drug Administration (USA); David L. Wilson, Case Western Reserve Univ. (USA); Federica Zanca, UZ Leuven (Belgium)

This conference focuses on a broad understanding of medical image perception, observer-performance measurement, and the application of these methods to evaluation of medical technology. Areas of tradi-tional interest include - but are not limited to - opti-mizing image acquisition, display and workstations, psychophysical and vision-science based models of human observer performance, factors that affect the diagnostic process, eye-movement studies, observer performance methodologies, human-CAD interaction, optimal decision-making strategies, statistical models for evaluation of observer perfor-mance, and observer variability assessment. The conference welcomes new areas of research as well. Original papers and posters are requested in the following areas:

• Technology assessment • Diagnostic-performance evaluation

methodologies (ROC, FROC and alternatives) • Observer performance evaluation of new

technologies (Acquisition devices, CAD, display devices etc)

• Cognitive aspects of image interpretation• Perceptual and performance factors in

diagnostic workstation and environmental design

• Perceptual and performance factors in new modalities (e.g., digital pathology and telemedicine)

• Models of detection, discrimination, and localization

• The nature of reader expertise • Sources of observer variance

TOPIC AREAS: For this conference only To assist the reviewers, choose up to three keywords in order of relevance from the following list.• Image Display • Image Perception • Observer Performance Evaluation • ROC Methodology • Model Observers • Technology Assessment• Technology Impact• Other (please specify)



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Advanced PACS-based Imaging Informatics and Therapeutic Applications (MI107)Conference Chairs: Maria Y. Law, Hong Kong Sanatorium and Hospital (Hong Kong, China); William Boonn, Univ. of Pennsylvania Health System (USA)Program Committee: James Chen, Univ. of California, San Diego (USA); Janice C. Honeyman-Buck, Univ. of Florida (USA); Steven C. Horii, Univ. of Pennsylvania Health System (USA); Woojin Kim, Univ. of Pennsylvania Health System (USA); Heinz U. Lemke, Computer Assisted Radiology and Surgery (Germany); Brent J. Liu, The Univ. of Southern California (USA); Khan M. Siddiqui, Higi Corp. (USA); Eliot L. Siegel, Univ. of Maryland Medical Ctr. (USA); John B. Strauss, Microsoft Corp. (USA); Wyatt Tellis, Univ. of California, San Francisco (USA); Jianguo Zhang, Shanghai Institute of Technical Physics (China); Stefan L. Zimmerman, Johns Hopkins Univ. (USA)

Rapid developments in imaging and information technology have led to signifi cant changes in the design and implementation of Picture Archiving and Communication Systems (PACS) and related imaging and healthcare information management systems. A new focus on the Digital Operating Room (OR) will be added for this year. The contin-ued emphasis on system integration, workfl ow and globalization of information management has led to a need for more sophisticated imaging informatics techniques. In addition, the role of imaging infor-matics is bridging gaps between the diagnosis and treatment/therapy continuums. The conference will include, but is not necessarily limited to, the follow-ing general session topics:

Digital Operating RoomThis is a new session focusing the application of im-aging informatics in the operating room. Suggested topics include surgical workfl ow, digital operating room ergonomics, therapy imaging and model management systems, surgical PACS, DICOM and IHE in surgery, management and assessment of OR system integration and architecture of ORs and imaging suites

Medical Image Sharing and Exchange This session includes the application of cloud com-puting technology in imaging informatics related to healthcare.and the use of mobile devices in radiology. Suggested topics include image sharing applications, distributed image processing, and design, implementation, and challenges in cloud storage architecture as well as mobile application development, security and networking challenges, mobile display performance, and imaging workfl ow performance utilizing mobile devices.

Systems Integration and Standards Integration of radiology-based imaging with the electronic medical record and multi-media informa-tion from other specialties can positively impact the diagnostic and treatment process but must meet the demands for enterprise-wide access and distribu-tion of image-intensive data. In addition, enterprise level PACS design and implementation, extending to all clinical areas and patient care settings can be achieved through the utilization of standards such as DICOM, HL7 along with the IHE initiatives. This section will also cover topics including Fault-Toler-ance, Data Security, and Data Integrity. Research developed utilizing DICOM-SR and other Imaging Informatics standards (eg, XML, HTML, XDS, etc) will be covered within this session.

Quantitative Analysis and Diagnostics, Knowledge, Search and Data MiningResearch in database development, database aggrega-tion, and knowledge base will be covered along with data mining tools, such as CBIR methodologies, and the development of other tools to mine data. Medical Imaging search related topics including web, local, and image based search engines, indexing, ranking algorithms and NLP integration will be included. Also invited are research on business intelligence and data mining applications for quality and patient safety within imaging informatics including radiation dose monitor-ing and tracking, productivity and effi ciency, and other performance metrics and integration of CAD and PACS.

Advanced PACS-based Radiology Workfl ow With the advent of thin-slice volumetric imaging, the need for research in more effi cient methods to analyze and navigate through the crucial clinical data becomes more apparent. Clinical experiences, workfl ow issues, system performance, multimodal-ity image display and navigation, and new intelligent display technologies will be discussed in this session.

Therapeutic Applications and Extending Imaging Informatics beyond RadiologyOther image-intensive therapeutic applications (eg, Sur-gery, Radiation Therapy, Chemotherapy, Rehabilitation) will be discussed in this session. System integration within the Radiation Oncology department in addition to research advancement in the utilization of DICOM-RT objects will be covered. Advancements in system integration for Optical Imaging and Imaging in Pathol-ogy will be included in this session. Research involving the integration of multi-media data in new areas such as physical therapy and rehabilitative sciences are also included. Topics relating to research work performed based on DICOM WG26 are encouraged as well.

Imaging Informatics in Translational Research This session will discuss the extension of imaging informatics to translational research. Research advancements towards personalized medicine will be investigated from genomic-related Imaging Infor-matics to small animal imaging to functional and/or whole body imaging and any imaging informatics tools developed to link the fi elds of research.

TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process.• Digital Operating Room• Medical Image Sharing and Exchange • Systems Integration and Standards • Quantitative Analysis and Diagnostics,

Knowledge, Search and Data Mining • Advanced PACS-based Radiology Workfl ow • Therapeutic Applications and Extending Imaging

Informatics beyond Radiology • Imaging Informatics in Translational Research

Call for Papers



Ultrasonic Imaging, Tomography, and Therapy (MI108)Conference Chairs: Johan G. Bosch, Erasmus Univ. Rotterdam (Netherlands); Marvin M. Doyley, Univ. of Rochester (USA)Program Committee: Jeffrey C. Bamber, The Royal Marsden NHS Foundation Trust (United Kingdom); Jan D’Hooge, Katholieke Univ. Leuven (Belgium); Neb Duric, Karmanos Cancer Institute (USA) and Delphinus Medical Technologies (USA); Stanislav Y. Emelianov, The Univ. of Texas at Austin (USA); James F. Greenleaf, Mayo Clinic (USA); Michael F. Insana, Univ. of Illinois at Urbana-Champaign (USA); Jørgen A. Jensen, Technical Univ. of Denmark (Denmark); Roman Maev, Univ. of Windsor (Canada); Stephen A. McAleavey, Univ. of Rochester (USA); Nicole V. Ruiter, Karlsruher Institut für Technologie (Germany); K. Kirk Shung, The Univ. of Southern California (USA); Kai E. Thomenius, General Electric Co. (USA); William F. Walker, Univ. of Virginia (USA)

This conference provides a forum for in-depth dis-cussion of all aspects related to medical ultrasound imaging: physics of ultrasound wave propagation, image reconstruction strategies, hardware and system design, new imaging modalities, contrast agents, biological and biomedical applications of new ultrasound modalities. In addition, the 2013 conference will put special emphasis on ultrasound tomography (methodology, technology, application). A joint session with the Image-guided Procedures, Robotic Interventions, and Modeling conference will be held in order to have a high-level discussion on the state-of-the-art in ultrasound guidance of surgi-cal interventions.



TOPIC AREAS: For this conference only During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process.• Physics and computer simulation • Transducers and beam forming • Novel imaging approaches • Ultrasound tomography • Ultrasound therapy • Ultrasound image analysis• Ultrasound functional imaging • Motion and deformation estimation • Contrast imaging • Tissue characterization • Photoacoustic imaging • High frequency imaging• Acoustic microscopy • New applications of ultrasound in medicine and

biology • Other, please specify.


Digital Pathology (MI109)Conference Chairs: Metin N. Gurcan, The Ohio State Univ. Medical Ctr. (USA); Anant Madabhushi, Rutgers, The State Univ. of New Jersey (USA)Program Committee: Eric Cosatto, NEC Labs. America, Inc. (USA); M. Murat Dundar, Indiana Univ.-Purdue Univ. Indianapolis (USA); Andinet Enquobahrie, Kitware, Inc. (USA); Michael D. Feldman, The Univ. of Pennsylvania Health System (USA); David J. Foran, Univ. of Medicine & Dentistry of New Jersey (USA); Brandon D. Gallas, U.S. Food and Drug Administration (USA); Marios A. Gavrielides, U.S. Food and Drug Administration (USA); Leo Grady, Siemens Corporate Research (USA); Stephen M. Hewitt, National Cancer Institute/NIH (USA); Elizabeth A. Krupinski, The Univ. of Arizona (USA); Richard M. Levenson, Univ. of California, Davis Medical Ctr. (USA); Olivier Lezoray, Univ. de Caen Basse-Normandie (France); Anne L. Martel, Univ. of Toronto (Canada); James P. Monaco, Rutgers, The State Univ. of New Jersey (USA); Tim W. Nattkemper, Univ. Bielefeld (Germany); Daniel Racoceanu, Univ. Pierre and Marie Curie (France); Nasir M. Rajpoot, The Univ. of Warwick (United Kingdom); Badrinath Roysam, Univ. of Houston (USA); Berkman Sahiner, U.S. Food and Drug Administration (USA); Olcay Sertel, Ventana Medical Systems, Inc. (USA); John E. Tomaszewski, SUNY at the Univ. at Buffalo (USA); Martin J. Yaffe, Sunnybrook Research Institute (Canada); Bulent Yener, New Jersey Institute of Technology (USA)

This conference will address digital pathology, from acquisition of pathology data to its management, analysis, and interpretation by observers. The use of digital pathology data, by both the human and computer, is growing in importance with the recent advent of whole slide scanners and novel instru-mentation for multispectral, multiparametric tissue imaging. There is potential for digital pathology to improve diagnosis and grading of cancer and other pathology tasks, but there are still limitations and challenges that must be addressed before it can be incorporated in the clinical workfl ow. Although there has been great progress in the development and application of digital pathology over recent years, there are a number of signifi cant computational challenges specifi c to pathology imaging that distinguish it from its radiological coun-terpart. There are also unique challenges in terms of how digitized pathology specimens and correlated data are presented to, modifi ed and interpreted by clinicians. We invite submissions that address specific problems related to image acquisition, computer-aided diagnosis, and quantitative image analysis of pathology specimens. We particularly welcome contributions that identify and address challenges encountered in digital pathology imaging as well as in new approaches for image capture and analysis.

TOPIC AREAS: For this conference only.During the submission process, you will be asked to choose no more than three topics from the following list to assist in the review process.

Image Acquisition• Acquisition, storage, and processing of

microscopy images, including histopathology, cytology, immunohistochemistry, and immunofl uorescence,

• Image mosaicking of nontraditional near-real-time microscopy (OCT, confocal)

• Multispectral imaging• Multi-focus volume imaging

Quantitative Image Analysis• Computer-aided diagnosis and prognosis• Automated quantifi cation of tissue biomarkers• Grading and classifi cation of pathology images• Segmentation of cellular and tissue structures • Shape analysis and morphology in pathology

imaging• Architectural feature extraction and

quantifi cation• Multispectral- and volume-based segmentation• Content-based image retrieval, machine-

learning, semantic annotation, and visualization of pathology image databases

• High-performance computing for whole-slide tissue image analysis

Information Fusion• Radiology-pathology registration and fusion• Registration of multiply stained tissue

microscopy images• Integration of digital image features with “omics”

data for fused diagnostics

Others• Remote consultation• Metrics, variability and standardization issues

unique to digital pathology• Methodologies for the objective technical

assessment of digital pathology systems• Observer performance, human factors and

diagnostic interpretation issues• Optical probe tracking and visualization tools• PACS and new DICOM standards for

histopathology• Other, Please specify.

Call for Papers



Participate in a Poster SessionGain valuable feedback and one-on-one networking with colleagues.

Each conference review committee recognizes a selected poster at the cum laude level for best poster presentation in their conference. Congratulations to the following who received this award in 2012.

Congratulations to the 2012 Poster Award WinnersPhysics of Medical ImagingLocal spectral adaptive multitaper method with bilateral fi ltering for spectrum analysis of mammographic images . . . . . . .Paper 8313-170Authors: Gang Wu, Sunnybrook Research Institute (Canada) and Univ. of Toronto (Canada); James G. Main-prize, Sunnybrook Research Institute (Canada); Martin J. Yaffe, Sunnybrook Research Institute (Canada) and Univ. of Toronto (Canada)

Image ProcessingInitial compressed sensing reconstruction results for phase contrast CT . . . . . . . . .Paper 8314-168Authors: Thomas Gaass, Zentralinstitut für Medizintech-nik, Technische Univ. München (Germany); Martin Bech, Julia Herzen, Peter B. Noël, Arne Tapfer, Marian S. Willner, Franz Pfeiffer, Technische Univ. München (Ger-many); Axel Haase, Zentralinstitut für Medizintechnik, Technische Univ. München (Germany)

Computer-Aided DiagnosisGleason grading of prostate histology utilizing statistical shape model of manifolds (SSMM) . . . . . . . . . . . . . . . . . . . . . .Paper 8315-54Authors: Rachel E. Sparks, Anant Madabhushi, Rutgers, The State Univ. of New Jersey (USA)

Image-Guided Procedures, Robotic Interven-tion, and ModelingFeature identifi cation for image-guided transcatheter aortic valve implantation . . . . . . . . . . . . . . . . .Paper 8316-106Authors: Pencilla Lang, Martin Rajchl, A. Jonathan McLeod, Michael Chu, Terry M. Peters, The Univ. of Western Ontario (Canada)

Biomedical Applications in Molecular, Structural, and Functional ImagingA novel shape similarity based elastography system for prostate cancer assessment . . . . . . . . . . . . . . . . . .Paper 8317-77Authors: Haisu Wang, Seyed Reza Mousavi, Abbas Samani, The Univ. of Western Ontario (Canada)

Image Perception, Observer Performance, and Technology AssessmentA potential method to identify poor breast screening performance . . . . . . . . .Paper 8318-44Authors: Leng Dong, Yan Chen, Alastair G. Gale, Loughborough Univ. (UK); Dev P. Chakraborty, Univ. of Pittsburgh (USA)

Advanced PACS-based Imaging Informatics, and Therapeutic ApplicationsMedCast: a discussion support system for cooperative work . . . . . . . . . . . . . .Paper 8319-37Authors: Ramon A. Moreno, Instituto do Coração do Hospital das Clínicas (Brazil); Vinicius Lima, Isidro Lopes, Fundacao CPqD (Brazil); Marco A. Gutierrez, Instituto do Coração do Hospital das Clínicas (Brazil)

Ultrasonic Imaging, Tomography, and TherapySpeckle tracking without fully developed speckle . . . . . . . . . . . . . . . . . . . . . .Paper 8320-43Authors: Narges Afsham, Mohammad Najafi , Purang Abolmaesumi, Robert Rohling, The Univ. of British Columbia (Canada)


Congratulations to the 2012 Student Paper Award Recipients

2013 Student Paper Awards InformationATTENTION STUDENTS

Below are the submission instructions and eligibility requirements for the 2013 Student Paper Awards.

Submissions Due: 10 December 2012

The winners of this award will be students: • without a doctoral degree • who are the principal authors of the paper in the current program • selected by the review committee.

A fi rst place winner and runner-up will be recognized with a cash prize and a certifi cate during the plenary session at the meeting. To be considered, students must submit electronic copies of: • the full manuscript to the Conference Programs Coordinator ([email protected])

- no later than 10 December 2012. • a signed letter from the student’s advisor stating that the principal contribution to the

work described was made by the student.

NOTE: This manuscript will be used for review purposes only. A separate manuscript must be submitted for publication by the manuscript due date.

The best student paper award was presented to:Ryan D. Datteri, Vanderbilt Univ. (USA)Estimation of rigid-body registration quality using registration networks . . . . . . . . . [8314-44]

Coauthored with Benoit M. Dawant, Vanderbilt Univ. (USA)

The runner-up student paper award was presented to:Raymond J. Acciavatti, The Univ. of Pennsylvania Health System (USA)Optimization of continuous tube motion and step-and-shoot motion in digital breast tomosynthesis systems with patient motion . . . . . . . . . . . . . . . . . . . . . . . . . . . . [8313-5]

Coauthored with Andrew D. Maidment, The Univ. of Pennsylvania Health System (USA)

Call for Papers


SPIE is the international society for optics and photonics, a not-for-profi t organization founded in 1955 to advance light-based technologies. The Society serves nearly 225,000 constituents from approximately 150 countries, offering conferences, continuing education, books, journals, and a digital library in support of interdisciplinary information exchange, professional growth, and patent precedent. SPIE provided over $2.5 million in support of education and outreach programs in 2011.

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RegistrationSPIE Medical Imaging registration will be available October 2012

All participants, including invited speakers, con-tributed speakers, session chairs, cochairs, and committee members, must pay a registration fee. Authors, coauthors, program committee members, and session chairs are accorded a reduced sympo-sium registration fee. Fee information for conferences, courses, a regis-tration form, and technical and general information will be available on the SPIE website in October 2012.

Hotel InformationOpening of the hotel reservation process for SPIE Medical Imaging 2013 is scheduled for the begin-ning of October 2012. SPIE will arrange special discounted hotel rates for conference attendees. The website will be kept current with any updates: spie.org/micallpdf

Student Travel GrantsA limited number of SPIE student travel grants will be awarded based on need. Applications must be received no later than 3 December 2012. Eligible applicants must present an accepted paper at this meeting. Offer applies to undergraduate/graduate students who are enrolled full-time and have not yet received their PhD.

Clearance InformationIf government and/or company clearance is required to present and publish your presenta tion, start the process now to ensure that you receive clearance if your paper is accepted.

Important News for All Visitors from Outside the United StatesFind important requirements for visiting the United States on the SPIE Medical Imaging website. There are steps that ALL visitors to the United States need to follow.Online at: spie.org/visa

General Information


Submission of AbstractsCritical DatesAbstract Due Date: 30 July 2012 (Check Conferences for Extended Due Date)

Manuscript Due Date: 14 January 2013Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.

By submitting an abstract, I agree to the following conditions: An author or coauthor (including keynote, invited, oral, and poster presenters) will:• Register at the reduced author registration rate (cur-

rent SPIE Members receive an additional discount on the registration fee).

• Attend the meeting.• Make the presentation as scheduled in the program.• Submit a full-length manuscript (6 pages minimum)

for publication in the SPIE Digital Library, Proceed-ings of SPIE, and CD-ROM compilations.

• Obtain funding for their registration fees, travel, and accommodations, independent of SPIE, through their sponsoring organizations.

• Ensure that all clearances, including government and company clearance, have been obtained to present and publish. If you are a DoD contractor in the USA, allow at least 60 days for clearance. .

Submit an abstract and summary online at http://spie.org/micallpdf• Please submit a 250-word text abstract for technical

review purposes that is suitable for publication. SPIE is authorized to circulate your abstract to confer-ence committee members for review and selection purposes.

• Please also submit a 100-word text summary suitable for early release. If accepted, this summary text will be published prior to the meeting in the online or printed programs promoting the conference.

• Identify the topics appropriate to the specifi c con-ference. During the submission process you will be asked to choose no more than three topics from a predefi ned list and/or add a topic not included on the list. (See individual conference Call for Papers for topic categories.)

• Prepare your 2-4 page supplemental MS Word or PostScript fi le. Supplemental fi le instructions can be found online. For full consideration this fi le must include the paper title, authors, 250-word abstract text, and the following supplemental information: - Description of purpose - Method(s) - Results - New or breakthrough work to be presented - Conclusions - Whether the work is being, or has been, submitted

for publication or presentation elsewhere, and, if so, indicate how the submissions differ.

- This fi le may contain supporting images/tables/fi gures

- Failure to follow these guidelines may disqualify your submission.

• Only original material should be submitted.• Abstracts should contain enough detail to clearly

convey the approach and the results of the research.

• Commercial papers, papers with no new research/development content, and papers where supporting data or a technical description cannot be given for proprietary reasons will not be accepted for presen-tation in this conference.

• Please do not submit the same, or similar, abstracts to multiple conferences.

Review, Notifi cation, and Program Placement Information• To ensure a high-quality conference, all submissions

will be assessed by the Conference Chair/Editor for technical merit and suitability of content.

• Conference Chair/Editors reserve the right to reject for presentation any paper that does not meet con-tent or presentation expectations.

• The contact author will receive notifi cation of ac-ceptance and presentation details by e-mail no later than 12 October 2012.

• Final placement in an oral or poster session is subject to the Chairs’ discretion.

Proceedings of SPIE and SPIE Digital Library Information• Conference Chair/Editors may require manuscript

revision before approving publication and reserve the right to reject for publication any paper that does not meet acceptable standards for a scientifi c publication. Conference Chair/Editors’ decisions on whether to allow publication of a manuscript is fi nal.

• Manuscript instructions are available from the “Au-thor/Presenter Information” link on the conference website.

• Authors must be authorized to transfer copyright of the manuscript to SPIE, or provide a suitable publication license.

• Only papers presented at the conference and received according to publication guidelines and timelines will be published in the conference Pro-ceedings of SPIE and SPIE Digital Library.

• Published papers are indexed in leading scientifi c databases including INSPEC, Ei Compendex, Chemi-cal Abstracts, International Aerospace Abstracts, ISI Index to Scientifi c and Technical Proceedings and NASA Astrophysical Data System, and are searchable in the SPIE Digital Library. Full manuscripts are avail-able to SPIE Digital Library subscribers worldwide.

When submitting your manuscript to the proceed-ings, we encourage you to consider also submitting it to the SPIE peer-reviewed Journals, Journal of Biomedical Optics (JBO) and Journal of Electronic Imaging (JEI). Manuscripts submitted to these jour-nals will go through the normal peer-review process. No reformatting is necessary for initial submission to the journals, but manuscripts intended to be reviewed must adhere to the generally higher stan-dards of content required of a refereed journal. For more information, please visit the Author Information at http://spie.org/journals


Conference Sponsorship OpportunitiesSPIE Medical Imaging conference sponsorships provide a unique opportunity to interact with the leading professionals in the fi eld and gain high-profi le visibility before, during, and after the event.

Interested in sponsoring an event, advertising with SPIE? Learn more:

spie.org/mi13Sponsor

Sponsor Packages:

‘Gold’ Sponsor Level – $5000 (2 Available)

‘Silver’ Sponsor Level – $2000 (5 Available)

Event Specifi c SponsorshipsStudent Networking Luncheon $2,500 (Exclusive)

Best Student Paper $1,250 (Exclusive)

Poster Sessions $1,250 (Exclusive each day)

Workshops $1,250 (2 Available)

Conference Sponsor $1,250 (Exclusive, one sponsor per conference)

Conference Bags 1,$500 (Exclusive)

Advertising Opportunities

Print and Web Ads $280 – $1,960

Contact Al Ragan, +1 360 685 5539 Fax: +1 360 647 1445 or [email protected]

Gain visibility at the premier international forum on medical imaging

2013

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• Present a paper and participate in the conference

• Receive feedback from your peers

• Hear the latest research

• Network with your colleagues

• Publish your work

Plus enjoy the fl exibility and freedom of staying at the Disney Coronado Springs Resort. The resort refl ects the cultural infl uence of the Mexican and American Southwest areas, and the overall atmosphere is casual and relaxed. Lago Dorado, a 15-acre lake, acts as a centerpiece and includes a full marina, located between Disney's Animal Kingdom theme park and Disney's Hollywood Studios theme park.

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