SOPHIA GIRLS’ COLLEGE, AJMER · Sem Paper Code Nomenclature Contact Hours Credits Total Marks...

SOPHIA GIRLS’ COLLEGE,AJMER

(AUTONOMOUS)

SYLLABUS

(Batch)2018-19

FOR

MASTER OF SCIENCECHEMISTRY

SEMESTER – III

Sem PaperCode

Nomenclature ContactHours

Credits Total Marks Max.Marks

Min. Pass

Marks

Duration

PerSem

PerWeek

Internal External

III CHEM -301

Spectroscopy 90 06 06 30 70 100 40 3 hrs

CHEM-302

Photochemistryand Solid StateCheemistry

90 06 06 30 70 100 40 3 hrs

CHEM -303

Environmental Chemistry

90 06 06 30 70 100 40 3 hrs

CHEM -304

Bioinorganic chemistry

90 06 06 30 70 100 40 3 hrs

CHEM -305

Practicals 180 12 06 30 70 100 40 6 hrs

Sophia Girls’ College, Ajmer (Autonomous)M. Sc. Chemistry Semester – III (2019-20 Batch)

Max. Marks : 100(Ext:70, Int:30) Min. Marks: 40Time : 3 Hrs

CHEM – 301: SPECTROSCOPY

Learning Outcomes: On successful completion of the course student will be able to- Analyse 13C - NMR spectroscopy. Elaborate the mass spectroscopy. Determine the structure of different organic compounds with the help of spectroscopic data.

Unit – I

13C NMR Spectroscopy Difficulties and solution for recording 13C - NMR spectra, recording of 13C- NMR spectra- scale, solvent, solvent signals and their positions, multiplicity, 13C -1H coupling constant- proton coupled and decoupled, 13C spectra- broad band decoupling, off resonance technique. Chemical shifts in 13C spectra- chemical shift calculations for alkanes, alkenes, alkynes and aromatic compounds. Nuclear Overhauser Effect, 13C-DEPT Spectra- differentiation in primary, secondary and tertiary carbons by Dept-45, Dept-90, Dept-135 Spectra.

Unit - II

Mass Spectroscopy Introduction, ion production- EI, CI, FD and FAB, factors affecting fragmentation, ion analysis abundance. Mass spectral fragmentation of organic compounds, common functional groups, molecular ion peak, metastable peak, Mc Lafferty rearrangement, Nitrogen rule, High Resolution Mass Spectrometry. Examples of mass spectral fragmentation of organic compoundswith respect to their structure determination.

Unit - III

Applications of spectroscopy UV-Visible, IR, 1H- NMR, 13C- NMR, MASS-interpretation of common organic compounds.

Reference Books :

1. Infrared and Raman Spectra : Inorganic and Cooradination Compounds, K. Nakamoto, Wiley.

2. Inorganic Electronic Spectroscopy, A.P.B Leaver, Elsevier. 3. NMR, NQR, EPR and Mossbauer Spectroscopy in Inorganic Chemistry,

R.V.Parish, Ellis Horwood.4. Practical NMR Spectroscopy, M.L. Martin, J.J. Delpeuch and G.J. Martyin, 5. Spectrometric identification of Organic Compounds, R.M. Silverstein, G.C. Bassler and T.C,

Morrill, John Wiley.6. Introduction to NMR Spectroscopy, R.J. Abraham, J. Fisher and P. Loftus Wiley. 7. Application of Spectroscopy of organic Compounds. J.R. Dyer, Prentice Hall. 8. Spectroscopic Methods in Organic Chemistry. D.H. Williams, I Fleming TataMcGraw Hill.

Sophia Girls’ College, Ajmer (Autonomous)

M. Sc. Chemistry Semester – III (2018-19 Batch)

Max. Marks: 100(Ext:70, Int:30) Min. Marks: 40Time : 3 Hrs

CHEM – 302 PHOTOCHEMISTRY AND SOLID STATE CHEMISTRY

Learning Outcomes: On successful completion of the course student will be able to- Explain the solid state chemistry. Analyse photochemical reactions. Elaborate the photochemistry of various organic compounds.

Unit - I

1. Electronic Properties and Band TheoryMetals, insulators and semiconductors, electronic structure of solids- band theory. Band structure of metals, insulators and semiconductors. Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junction.

2. Super conductors- Definition types and BCS theory Optical properties- photoconduction- photoelectric effects. Magnetic Properties- Classification of materials-magnetic domains, hysteresis.

Unit – II

1. Photochemical Reactions Interaction of electromagnetic radiation with matter, type of excitations, fate of excited molecule, quantum yield, transfer of excitation energy, actinometry.

2. Determination of Reaction Mechanism Classification, rate constants and life time of reactive energy state- determination of rate constants of reactions. Effect of light intensity on the rate of photochemical reactions. Type of photochemical reactions- photodissociation, gas-phase photolysis.

3. Photochemistry of Alkenes. Intramolecular reactions of the olefinic bond-geometrical isomerism cyclisation reaction, rearrangement of 1,4-and 1,5-dienes.

Unit – III1. Photochemistry of Carbonyl Compounds

Intermolecular reactions of the carbonyl compounds- saturated, cyclic and acyclic, α,β- unsaturated, cyclohexadienones, Intermolecular cycloaddition reaction-dimerisation and oxetane formation.

2. Photochemistry of Aromatic Compounds Isomerisations, additions and substitutions.

3. Miscellaneous Photochemical Reactions Photo-Fries reactions of anilides. Photo-Fries rearrangement. Barton reaction. Singlet molecular oxygen reactions. Photochemical formation of smog. Photo Degradation of polymers.

Reference Books :

1. Structural Methods in Inorganic Chemistry, E.A.V. Ebsworth, D.W.H. Rakin and S. Cradock,EIBS.

2. Progress in Inorganic Chemistry vol., 8th ed., F.A Cotton, vol., 15, ed, S.J. Lippard, Wiley.3. Transition Metal Chemistry ed. R.L. Carlin vol.3 Dekker. 4. Inorganic Electronic Spectroscopy, A.P.B. Lever Elsevir. 5. Fundamentals of Photochemistry, K.K Rohtagi- Mukherji, Wiley-Eastern. 6. Essentials of Molecular Photochemistry A. Gilbert and J.Baggott, Blackwell Scientific

Publication. 7. Molecular Photochemistry, N.J. Turro, W.A. Benjamin. 8. Introductory Photochemistry, A Cox and T.Chap. Mc-Graw Hill. 9. Photochemistry. R.IP. Kundall and A Gilbert, Thomson Nelson.10. Organic Photochemistry, J. Coxon and B. Halton, Cambridge University Press.

Sophia Girls’ College, Ajmer (Autonomous)M. Sc. Chemistry Semester –III (2019-20 Batch)


CHEM – 303 ENVIRONMENTAL CHEMISTRYLearning Outcomes: On successful completion of the course student will be able to- Elaborate the principle and concept of green chemistry. Illustrate application of greener alternative approaches. Analyse the various aspects of pollution.

Unit IIntroduction, Principle and concept of green chemistry: Introduction and need of green chemistry, green chemistry in day to day life, Basic principles of green chemistry, concept of atom economy, designing green synthesis using these principles.

Unit IIApplication of greener alternative approachesDifferent approaches to green synthesis : Use of green reagents-dimethyl carbonate, polymer supported reagents- (per acids and chromic acids), green solvents, Synthetic organic transformations under microwave- Fries reaarangement, Diels-Alder reaction, decarboxylation, Saponification of esters, alkylation of reactive methylene compounds, heterocyclic synthesis : 3-alkyl coumarins, flavones, 3-aryl-2H-1,4- benzoxazines.

Unit III

Analysis of pollution: Sampling procedures and monitoring of water pollutants, determination of total dissolved solids, conductivity , acidity, alkalinity, hardness, chloride, Free (Residual) chlorine, sulphate, fluoride, phosphate, phenols, pesticides and surfactants, determination of DO, BOD, COD and microorganism. Water quality parameters, standards and laws.

Reference Books :

1. Environmental Chemistry, S.E. Mannahan, Lewis Publishers. 2. Environmental Chemistry, Sharma & Kaur, Krishna Publishers. 3. Environmental Chemistry, A.K. De, Wiley Eastern. 4. Environmental Pollution Analysis, S.M. Khopkar, Wiley Eastern.5. Standard Method of Chemical Analysis. F.J. Welcher Vol.III Van Nostrand Reinhold Co.6. Element Analysis of Airborne Particles, Ed.S. Landsbergeer and M. Creatchman,Gordon and

Breach Science Publication. 7. Environmental Chemistry, C Baird, W.H. Freeman.8. Green Chemical Syntheses and Processes: Edited by Paul T. Anastas, Lauren G. Heine &

Tracy C. Williamson, ACS Symposium Series.9. Green Chemistry: Environment Friendly Alternatives, Edited by Rashmi Sanghi, M. M.

Srivastava, Narosa Publishing House, New Delhi. 10. Green Chemistry: Frontiers in Benign Chemical Synthesis and Processes, Edited by Paul T.

Anastas & Tracy C. Williamson, Oxford University Press



CHEM – 304 Bioinorganic chemistry

Learning Outcomes: On successful completion of the course student will be able to- Review of bioenergetics and nitrogen fixation. Illustrate metalloenzymes and metals in medicine. Analyse haemoglobin and myoglobin in oxygen transport mechanism.

Unit-I1. Role of bulk and trace metals ions in biological processes with special reference to Ca, Mg,

Mn, Fe, Co, Na and K. Na+/K+ Pump.2. Bioenergetics

Standard free energy change in biochemical reactions, exergonic, endergonic, Hydrolysis of ATP, synthesis of ATP from ADP.

3. Nitrogen fixation: Biological nitrogen fixation and its mechanism, nitrogenase, chemical nitrogen fixation and other nitrogenase model systems.

Unit-II1. Metalloenzymes and their role in biological systems

Zinc enzymes- carboxypeptidase A and carbonic anhydrase. Iron enzyme- oxygenases, cytochrome P-450, catalase and peroxidase. Copper enzyme- superoxide dismutase. Molybdenum enzyme- xanthine oxidase. Vitamin B12.

2. Metals In MedicineMetals deficiency and disease, toxic effects of metals, metals used for diagnosis and chemotherapy with particular reference to anticancer drugs based on Pt.

Unit-III Oxyen transport and oxygen uptake proteins. Haemoglobin (Hb) and Myoglobin (Mb) in oxygen transport mechanism. Structural feature of Heme group in Hb and Mb. Functions of Hb and Mb. Characteristics of oxygen binding interactions with Hb and Mb.Reference Books :

1. Bioinorganic Biochemistry, Berttini, H.B. Gray, S.J. Valentine, University Science Books.2. Principles of Bioinorganic Chemistry, S.J. Lippard and J.M. Berg, University Science Books.3. Inorganic Biochemistry vols I and II. ed. G.L. Eichhorn Elsevier. 4. Progress in Inorganic Chemistry, Vols 18 and 38 ed. J.J. Lippard, Wiley.5. Bioinorganic Chemistry, Vol II, R.R. Chirchton.


Max. Marks : 100(Ext:70, Int:30) Min. Marks: 40 Time : 6 Hrs

CHEM –305 Practicals

Learning Outcomes: On successful completion of the course the student will be able to- Understand the practical applications of various aspects of chemistry

A.INORGANIC PREPARATIONS ( At least seven preparations) 1. Prepare sodium amide 2. Prepare calcium oxalate 3. Prepare magnesium oxalate 4. Prepare sodium tetrathionate Na2S4O6

5. Prepare vanadyl acetylacetonate Vo (acac)2

6. Prepare Fe (acac)2

7. Prepare R2Sn(acac)2

8. Prepare Cr(acac)2

9. Prepare Cu (acac)2 H2O 10. Prepare Al(acac)3

11. Prepare tris (acetyl acetanato) manganese(II) 12. Prepare Fe (II) chloride 13. Prepare ferrocene 14. Prepare copper glycine complex.

B. ORGANIC CHEMISTRY (At least seven mixtures) Qualitative Analysis Separation and identification of the compound of mixture of three organic compounds (three solids and/or two solids and liquid) by Water, NaHCO3, NaOH. Prepare derivatives, wherever possible.

C.PHYSICAL (Perform at least seven experiments)

1. Determine the partial molar volume of solute and solvent in a binary mixture 2. Study the effect of addition of an electrolyte on the solubility of an organic acid. 3. Determine the composition of binary mixture containing K2Cr2O7 and KMnO4 using

spectrophotometer. 4. Determine the heat of neutralization of hydrochloric acid by sodiUM hydroxide. 5. Determine the heat neutralization of two acids eg HCl and CH3COOH and hence their

relative strengths. 6. Study the adsorption of iodine form alcoholic solution on charcoal 7. Study the adsorption of certain dyes such as methyl violet, picric acid or malachite green on

charcoal. 8. Find the specific rotation and molecular rotation of cane sugar polarimetrically and also find

the concentration of the unknown solution (concentration lies 1% and 5%). Calculate intrinsic rotation for cane sugar.

9. Study the influence of added impurity on rotation of a solute. 10. Investigate the inversion of cane sugar in the presence of an acid say HCl at 30 degree

Celsius

11. Calculate the molecular weight of a high molecular weight polymer by means of viscosity measurements.

12. Study the complex formation and find the formula of silver amine complex by partition method.

13. Determine the solubility product of calcium hydroxide using common ion effect of sodium hydroxide or of any other strong alkali.

14. Determine the transition temperature of sodium sulphate dechydrate by solubility method. 15. Determine the rate constant of a reaction between acetone and iodine in presence of mineral

acid and a catalyst and to show that this reaction is of zero order with respect to iodine. 16. Estimate the amino acid using ninhydrin method 17. Study the kinetics of reaction between glycolic acid and ceric ammonium sulphate. 18. Determine the effect of concentration of salt on the reaction between glycolic acid and ceric

ammonium sapphire. 19. Determine Na and K in a mixture by flame photometry 20. Determine Na and K in mixture by flame photometry 21. Determine Li, Na and K individually in three different solutions by flame photometry.22. Verify Beer's law for the solubility and determine the concentration of the given unknown

aqueous solution of KMnO4

23. Determine the solubility of various salts like NaCl, KCl, KNO3. NaNO3 at the different temperature and draw solubility curve.

Books Suggested (Laboratory Courses)1. J. Bassett, R.C. Denney, GH. Jeffery and J. Mendham, Vogel’s Textbook of QuantitativeAnalysis, revised, ElBS. 2. W.L. Jolly, Synthesis and Characterization of Inorganic Compounds, Prentice Hall.3. D.Past, C.Johnson and M. Miller, Experiments and Techniques in Organic Chemistry,Prentice Hall. 4. K.L. Williamson, Macroscale and Miicroscale Organic Experiments, D.C. Health. 5. H. Mideleton, Systematic Qualitative Organic Analysis, Adward Arnold.6. H. Clark, Handbook of Organic Analysis-Qualitative and Quantitative, Adward Arnold. 7.A.R. Tatchell Vogel’s Textbook of Practical Organic Chemistry, John Wiley. 8. A.M. James and F.E. Prichard, Practical Physical Chemistry, Longman. 9. B.P. Levitt, Findley’s Practical Physical Chemistry, Longman.10. R.C. Das and B. Behera, Experiments in Physical Chemistry, Tata McGraw Hill.

INSTRUCTIONS FOR PRACTICALS- Marks

A. Inorganic Preperations- 15B. Organic -

Qualitative analysis 20C. Physical- 15D. Viva 10E. Record 10

SEMESTER – IV

Sem Group

PaperCode

Nomenclature ContactHours

Credits Total Marks Max.Marks

Min. Pass

Marks

Duration

PerSem

PerWeek

Internal External

IV A CHEM-401(A)

OrganometallicChemistry

90 06 06 30 70 100 40 3 hrs

CHEM-402(A)

SupramolecularChemistry

90 06 06 30 70 100 40 3 hrs

CHEM-403(A)

Inorganic Polymers

90 06 06 30 70 100 40 3 hrs

B CHEM-401(B)

Organometallics and Disconnections

90 06 06 30 70 100 40 3 hrs

CHEM-402(B)

Heterocyclic Chemistry

90 06 06 30 70 100 40 3 hrs

CHEM-403(B)

Natural Products 90 06 06 30 70 100 40 3 hrs

A,B CHEM-404

Elective I-Dissertation

90 06 06 30 70 100 40

Elective II-AnalyticalChemistry

90 06 06 30 70 100 40 3 hrs

CHEM-405

Practicals 180 12 06 30 70 100 40 6 hrs

Sophia Girls’ College, Ajmer (Autonomous)M. Sc. Chemistry Semester – IV (2018-19 Batch)

GROUP A – INORGANIC CHEMISTRY

Max. Marks: 100(Ext: 70, Int: 30) Min. Marks: 40Time : 3 Hrs

CHEM – 401(A): ORGANOMETALLIC CHEMISTRY

Learning Outcomes: On successful completion of the course student will be able to- Summarize the basic concepts of organo transition metal complexes. Elaborate the chemistry of organo transition metal complexes. Illustrate application of organometallic compounds in homogenous catalysis.

Unit – I

An Introduction to Organometallic CompoundsIntroduction, Classification and Nomenclature of Organometallic Compounds, Bonding: Stable electron Configuration, Electron Count Preference, Electron Counting and Oxidation states, Reactionof Organometallic Compounds- Ligand Subsituition, Oxidative addition and Reductive elimination, σbond metathesis, 1, 1- Migratory insertion, 1, 2- insertions and β hydride elimination and Cyclometallations. Concept of Isolability and Isolobal analogies,

Unit - II

Organometallic compounds of Transition metalsPreperation, Properties, Nature of Bonding and Structural features of σ bonded Transition metal complexes and Complexes with unsaturated organic molecules alkenes, alkynes, allyland diene,

Unit - III

Application of Organometallic Compounds as homogenous Catalysts1. Hydrogenation of Alkene2. Hydroformation3. Wacker process4. Alkene Metathesis5. Pd catalysed C-C Bond forming reactions6. Methanol Carbonylation- ethanoic acid synthesis

Reference Books:1. J.P. Collman, L.S. Hegdus, J.R. Norton and R.G. Finke, Principles and Application of

Organotransition Metal Chemistry, University Science Books. 2. A.J. Pearson, Metallo-Organic Chemistry, Wiley. 3. R.C. Mehrotra and A. Singh, Organometallic Chemistry, New Age International. 4. D.F. Shriver, P.W. Atkins and C.H. Longford: Inorganic Chemistry, ELBS with Oxford University5. Ajai Kumar, Organometallic and Bioinorganic Chemistry,Aaryush Education



CHEM – 402(A): SUPRAMOLECULAR CHEMISTRY

Learning Outcomes: On successful completion of the course student will be able to- Analyse different aspects of supra molecular chemistry. Assess supramolecular reactivity and catalysis. Elaborate about various supramolecular devices.

Unit – I

1. Introduction- Definition and development of Supramolecular Chemistry, Classification of Supramolecular Host- Guest Compunds, receptors, Coordination and the lock nad key analogy, Nature of Supramolecular Interactions- Ion-Ion Interactions, Ion-dipole Interactions, Dipole- Dipole interaction, , Hydrogen bonding, Cation- interaction, Anion- interactions, - interactions, vander wall forces and Crystal Close packing, Closed shell Interactions

2. Molecular recognition: Introduction to recognition, information and complementarity, Principle of molecular receptor designs, Spherical recognition, Tetrahedral recognition, Recognition of ammonium ions and neutral molecules, multiple recognition by coreceptor molecules.

Unit – II1. Supra molecular reactivity and catalysis-Introduction, Catalysis by cation , anion and

metalloreceptor molecules, catalysis with Cyclophane type receptors, Co catalysi- synthetic reaction catalysis, Bimolecular and abiotic catalysis.

2. Transport processes and carrier design- carrier mediated transport, cation, anion transport process,coupled transport process, electron coupled, proton coupled and light coupled transport.

3. Supramolecular assemblies- Introduction, Supramolecular solid materials, molecular recognition at surfaces, molecular and supramolecular morphogenesis.

Unit – III

1. Supra molecular photochemistry- Light conversion and energy transfer devices, photosensitive molecular receptors, photinduced electron transfer in photoactive devices, photoinduced reactions in supramolecular devices, Non linear optical properties of supramolecular species, Supramolecular effects in photochemical hole burning.

2. Molecular and Supra molecular electronic and ionic devices, switching devices and signals

Reference Books:1. J.M.Lehn, Supramolecular Chemistry, VCH. 2. Dr. AK Goswami & Dr. Rekha Dashora, Supramolecular and Bioinorganic Chemistry, Pragati

Prakashan 3. J.W. Steed,J.L. Atwood,Supramolecular Chemistry, John wiley and Sons4. P.S. Kalsi, J.P. Kalsi, Bio-organic, Bio-inorganic and Supramolecular Chemistry, New age

International5. Ajay Kumar Bhagi, G.R. Chatwal, Bioinorganic and Supramolecular Chemistry, Himalaya

Publishing House.



CHEM – 403(A) INORGANIC POLYMERS

Learning Outcomes: On successful completion of the course student will be able to- Elaborate basic concepts and synthesis of Inorganic polymers. Analyse the Chemical nature of polymers. Summarize the Properties of Inorganic Polymers.

Unit-I1. Basics Concepts

Definition, Classifications by Connectivities, Classifications by Dimensionality, the Metal/Backbone Classification of Metal-Containing Polymers.

2. Inorganic Polymer SynthesisStep Growth synthesis, Chain Polymerization, ring opening polymerization, Reductive coupling and other Redox Polymerisation reactions.

Unit-II

1. Inorganic Polymer CharacterizationAverage Molecular Masses and Degrees of Polymerization, Methods of Characterizing Average Molecular Masses- Gel Permeation Chromatography, Viscosity, Universal Calibration, Colligative Properties (Vapor Pressure Lowering, Boiling Point Elevation, Melting Point Lowering, and OsmoticPressure), End-Group Analysis, Mass Spectroscopy, Ultracentrifugation.

2. Analysis and. testing of polymersChemical analysis of polymers, spectroscopic methods. X-ray diffraction study, microscopy. thermal analysis and physical testing-tensile strength. Fatigue, impact, tear resistance. hardness and abrasion resistance.

Unit-III

1. Polymers based on Boron – Borides, Carborane Polymers, Borazine, Boron Nitride2. Polymers based on Silicon- Silicones- Preparation and properties of Silicones, Silicone Fluids, Silicone Rubbers, Silicone

Resins, Modification of Silicones Polysilanes and related polymers- Structure, Synthesis, Physical and electronic properties of

polysilanes, Chemical modification of Polysilanes, Other Silicon Containing Polymers

Reference Books:1. F.W. Billmeyer Jr, Text book of Polymer Science, Wiley. 2. V.R. Gowarikar, N.V. Viswanathan and J. Srcedhar, Polymer Science, Wiley- Eastern. 3. Ronald D. Archer, Inorganic nad Organometallic Polymers, Wiley-VCH4. M.F. Lappert, G.J. Leigh, Developments in Inorganic Polymer Chemistry, ACS Publications5. G.R. Chatwal, Inorganic Polymers, Himalaya Publishing House.6. James E. Mark, Harry R. Allcock, Robert West, Inorganic Polymers, Oxford University Press


GROUP B


CHEM – 401 (B) ORGANOMETALLICS AND DISCONNECTIONS

Learning Outcomes: On successful completion of the course student will be able to- Analyse organometallic reagents of transition metals. Elaborate disconnection approach. Implement the application of disconnection approach in the synthesis of complex organic

compounds.

Unit I

1. Organometallic Reagents Principles, preparations, properties and applications of the following in organic synthesis with mechanistic details.

Transition Metal organic compounds Cu, Pd, Ni, Fe, Co, Rh, Cr and Ti Compounds.

2. Protecting Groups Principle of Protection of alcohol, amine, carbonyl and carboxyl group.

Unit-II

1. One Group C-C Disconnections Alcohols and carbonyl compounds, regioselectivity. Alkene Synthesis, use of acetylenes and aliphatic nitro compounds in organic synthesis.

2. Two Group C-C Disconnections Diels-Alder reactions 1,3-difunctionalised compounds. - unsaturated carbonyl compounds, control in carbonyl condensations, 1,5-difunctionalized compounds . Micheal addition and Robinson annelation.

Unit-III

Synthesis of Some Complex Molecules Application of disconnection approach in the synthesis of following compounds : Camphor, Longifoline, Cortisone, Reserpine, Vitamin D, Juvabione, Aphidicolin and Fredericamycin A. Reference Books:1. H.O House, Modern Synthetic Reactions, Benjamin Cummings Pub. Co.2. W. Carruthers, Some modern methods of Organic Synthesis, Cambridge Univ. Press.3. J. March, Advanced organic Chemistry, Reactions Mechanisms and Structure, John Wiley. 4. R.O.C. Norman and J.M. Coxon, Principles of Organic Synthesis, Blackie Academic & Professional.

5. F.A. Carey and R.J. Sundberg, Advanced Organic Chemistry Part B, Pleanum Press. 6. S. Warren, Designing Organic Synthesis, Wiley.



CHEM 402 (B) – HETEROCYCLIC CHEMISTRY

Learning Outcomes: On successful completion of the course student will be able to- Interpret aromatic and non- aromatic heterocycles. Elaborate the synthesis of various types of heterocyclic compounds. Illustrate benzo fused five-membered and six-membered heterocycles.

Unit-I

1. Nomenclature of HeterocyclesReplacement and systematic nomenclature (Hantzsch-Widman system) for monocyclic, fused and bridged heterocycles.

2. Aromatic Heterocycles General chemical behavior of aromatic hetrocycles, classification (structural type), criteria of aromaticity (Bond lengths, ring current and chemical shifts in 1H NMR-spectra, empirical resonance energy, delocalization energy and Dewar resonance energy, dimagnetic susceptibility exaltations.) Heteroaromatic reactivity and tautomerism in aromatic heterocycles.

3. Non Aromatic Hetrocycles Strain-bond angle and torsional strains and their consequences in small ring heterocycles. Conformation of six-membered heterocycles with reference to molecular geometry, barrier to ring inversion, pyramidal inversion and 1,3-diaxial interaction. Stereo-electronic effects-anomeric and related effects. Attractive interactions-hydrogen bonding and intramolecular nucleophilic- electrophilic interactions.

Unit-II

1. Heterocyclic Synthesis Principles of heterocyclic synthesis involving cyclization reaction and cycloaddition reactions.

2. Small Ring Heterocycles Three - membered and four - membered heterocyles - synthesis and reactions of aziridines, oxiranes, azetidines, oxetanes.

3. Heterocyclic Systems containing P- Heterocyclic ring containing phosphorus: Introduction, nomenclature, synthesis and characteristics of 5-and 6 membered ring systems-phosphorinanes, phospholanes and phospholes.

4. Six Membered Heterocycles with one HeteroatomSynthesis and reaction of quinolizinium and benzopyrilium salts, coumarins and chromones.

Unit-III

1. Benzo Fused Five-membered Heterocyles Synthesis and reactions including medicinal applications of benzopyrroles, benzofurans and benzothiophenes. Meso-Ionic heterocycles.

2. Six-Membered heterocycles with Two or More Heteroatoms Synthesis and reactions of tetrazines and thiazines.

Reference Books:1. R.R. Gupta, M.K. Kumar and V. Gupta, Heterocyclic Chemistry Vol. 1-3, Springer Verlag.2. T. Eicher and S. Hauptmann, The Chemistry of Heterocycles, Thieme. 3. T.L. Gilchrist, Heterocyclic Chemistry, Longman Scientific Technical 4. J.A. Joule, K. Mills and G.F. Smith, Heterocyclic Chemistry, Chapman and Hall. 5. G.R. Newkome and W.W Paudler, Contemporary Heterocyclic Chemistry, wiley- Inter Science. 6. R.M. Acheson, An introduction to the heterocyclic Compounds, John Wiley. 7. A.R. Karizky and C.W. Reeds, Comprehensive Heterocyclic Chemistry, eds. Pergamon Press. 8. IL. Finar, Organic Chemistry, Vol. 2, ELBS.



CHEM 403 (B) – NATURAL PRODUCTS

Learning Outcomes: On successful completion of the course student will be able to- Explain the synthesis of various types of terpenoids, carotenoids and alkaloids. Illustrate the prostaglandins, pyrethroids, rotenones and steroids. Analyse plant pigments and porphyrins.

Unit-I

1. Terpenoids and Carotenoids Classification, nomenclature, occurrence, isolation, general methods of structure determination,

isoprene rule. Structure determination, stereochemistry, biosynthesis and synthesis of the following representative

molecules: Citral, Geraniol, α -Terpineol, Menthol, Farnesol, Santonin, Phytol, Abietic acid and β -Carotene.

2. Alkaloids Definition, nomenclature and physiological action, occurrence, isolation, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring, role of alkaloidsin plants. Structure, stereochemistry, synthesis and biosynthesis of the following: Ephedrine, Nicotine, Atropine, Quinine and Morphine

Unit-II 1. Prostaglandins Occurrence, Nomenclature, Classification, biogenesis and physiological effects. Synthesis of PGE2

and PGF2α

2. Pyrethroids and Rotenones Synthesis and reactions of Pyrethroids and Rotenones.

3. Steroids- Occurrence, nomenclature and basic skeleton, Diel's hydrocarbon and stereochemistry, isolation, structure determiantion and synthesis of Cholesterol, Bile acids, Androsterone, Testosterone, Estrone, Progesterone, Aldosterone. Biosynthesis of Steroids.

Unit-III 1. Plant Pigment

Occurrence, nomenclature and general methods of structure determination, isolation and synthesis ofQuercetin, Myricetin, Diadzein, Butein, Cyanidin, Hirsutidin. Biosynthesis of flavonoids; Acetate pathway and Shikimic acid pathway.

2. Porphyrins- Structure and synthesis of Haemoglobin and Chlorophyll.

Reference Books:

1. Mann, R.S. Davidson, J.B. Hobbs, D.V. Banthrope and J.B. Harbome, Natural Products: Chemistry and Biological Significance, J Longman, Essex.

2. IL. Finar, Organic Chemistry, Vol2. ELBS. 3. S. coffey, Rodd's Chemistry of Carbon Compounds, ED, Elsevier. 4. Kurt Hostettmann, M.P. Gupta and A. Marston harwood , Chemistry, Biological and

Pharmacological Properties of Medical Plants from the Americas, Ed. Academic Publishers. 5. B.A. Bohm, Introduction to Flavonoids, Harwood Academic Publishers. 6. Atta-ur-rahman and M.I. Choudhary, New Trends in Natural Products Chemistry, Harwood

Academic Publishers.


Max. Marks : 100(Ext:70, Int:30) Min. Marks: 40

CHEM – 404 (Group A,B)

Elective I- DISSERTATION

Data Collection and report writing : 70

Presentation and viva : 30


Max. Marks : 100(Ext:70, Int:30) Min. Marks: 40

CHEM – 404 (Group A,B)

Elective II- ANALYTICAL CHEMISTRY

Unit-I

1. Data analysis and statistics Types and sources of errors, Accuracy and precision, Significant figures; Mean ,Median and

Standard Deviation, Rejection of results, Q-Test, Tests of significance, Comparison of the means of two samples, Analysis of Variance, Replicate determinations, Correlation, Regression, Uses of Statistics.

2. Solvent Extraction Partition: The theory of Extraction, Mechanism of solvent extraction, Extraction involving ion

association complexes, Synergistic extraction, Solvent extraction by macromolecules, Techniques forsolvent extraction, Applications, Solid phase extraction (SPE), Solid phase micro extraction (SPME).

Unit-II

Thermal methods of analysis1. Thermogravimetric analysis –Introduction, instrumentation, TG –curves, factors affecting TGA,

application of TGA2. Differential thermal analysis- Differential scanning calorimetry, instrumentation, Factors affecting

DTA and DSC curves.3. Thermometric titrations Introduction, instrumentation, Application of thermometric titrations.

Unit-IIIChromatographic TechniquesIntroduction and classification of chromatographic techniques - Paper chromatography, Column Chromatography, Thin Layer Chromatography, Gas Chromatography- Introduction, instrumentation andapplications.

Reference Books:1. G.H. Jeffery, J.Bassett, J.Mendham, R.C. Denney, Vogel’s Textbook of Quantitative Chemical Analysis: John Wiley and Sons 2. H. Kaur, Methods for Instrumental Analysis: Pragati Prakashan 3. Gurdeep Chatwal, Sham Anand, Instrumental methods of Chemical Analysis: Himalaya Publishing House 4. S.M. Khopkar, Basic Concepts of Analytical Chemistry: Wiley Eastern Limited

SOPHIA GIRLS’ COLLEGE, AJMER · Sem Paper Code Nomenclature Contact Hours Credits Total Marks...

Documents

Transcript of SOPHIA GIRLS’ COLLEGE, AJMER · Sem Paper Code Nomenclature Contact Hours Credits Total Marks...