Smooth Muscle Physiology. Muscular System Functions Body movement (Locomotion) Maintenance of...
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Transcript of Smooth Muscle Physiology. Muscular System Functions Body movement (Locomotion) Maintenance of...
Muscular System Functions
• Body movement (Locomotion)• Maintenance of posture• Respiration
– Diaphragm and intercostal contractions
• Communication (Verbal and Facial)• Constriction of organs and vessels
– Peristalsis of intestinal tract– Vasoconstriction of b.v. and other structures (pupils)
• Heart beat • Production of body heat (Thermogenesis)
Properties of Muscle
• Excitability: capacity of muscle to respond to a stimulus
• Contractility: ability of a muscle to shorten and generate pulling force
• Extensibility: muscle can be stretched back to its original length
• Elasticity: ability of muscle to recoil to original resting length after stretched
Types of Muscle
• Skeletal– Attached to bones– Makes up 40% of body weight– Responsible for locomotion, facial expressions, posture, respiratory movements,
other types of body movement– Voluntary in action; controlled by somatic motor neurons
• Smooth– In the walls of hollow organs, blood vessels, eye, glands, uterus, skin– Some functions: propel urine, mix food in digestive tract, dilating/constricting
pupils, regulating blood flow, – In some locations, autorhythmic– Controlled involuntarily by endocrine and autonomic nervous systems
• Cardiac– Heart: major source of movement of blood– Autorhythmic– Controlled involuntarily by endocrine and autonomic nervous systems
Connective Tissue Sheaths
• Connective Tissue of a Muscle– Epimysium. Dense regular c.t. surrounding entire muscle
• Separates muscle from surrounding tissues and organs• Connected to the deep fascia
– Perimysium. Collagen and elastic fibers surrounding a group of muscle fibers called a fascicle
• Contains b.v and nerves
– Endomysium. Loose connective tissue that surrounds individual muscle fibers
• Also contains b.v., nerves, and satellite cells (embryonic stem cells function in repair of muscle tissue
• Collagen fibers of all 3 layers come together at each end of muscle to form a tendon or aponeurosis.
Nerve and Blood Vessel Supply
• Motor neurons– stimulate muscle fibers to contract
– Neuron axons branch so that each muscle fiber (muscle cell) is innervated
– Form a neuromuscular junction (= myoneural junction)
• Capillary beds surround muscle fibers
– Muscles require large amts of energy
– Extensive vascular network delivers necessary oxygen and nutrients and carries away metabolic waste produced by muscle fibers
Smooth Muscle
• Fusiform cells
• One nucleus per cell
• Nonstriated
• Involuntary
• Slow, wave-like contractions
Smooth Muscle
• Cells are not striated• Fibers smaller than those in skeletal
muscle• Spindle-shaped; single, central nucleus• More actin than myosin• No sarcomeres
– Not arranged as symmetrically as in skeletal muscle, thus NO striations.
• Caveolae: indentations in sarcolemma;– May act like T tubules
• Dense bodies instead of Z disks – Have noncontractile intermediate filaments
Smooth Muscle• Grouped into sheets in walls of hollow organs
• Longitudinal layer – muscle fibers run parallel to organ’s long axis• Circular layer – muscle fibers run around circumference of the organ
• Both layers participate in peristalsis
Smooth Muscle
• Is innervated by autonomic nervous system (ANS)• Visceral or unitary smooth muscle
– Only a few muscle fibers innervated in each group
– Impulse spreads through gap junctions
– Who sheet contracts as a unit
– Often autorhythmic
• Multiunit: – Cells or groups of cells act as independent units
– Arrector pili of skin and iris of eye
Properties of Single-Unit Smooth Muscle
– Gap junctions
– Pacemaker cells with spontaneous depolarizations
– Innervation to few cells
– Tone = level of contraction without stimulation
– Increases/decreases in tension
– Graded Contractions• No recruitment
• Vary intracellular calcium
– Stretch Reflex• Relaxation in
response to sudden or prolonged stretch