Spinning Fragments Into Lead Molecules: A New Impulse in Fragment-Based Drug DiscoverySpinning Fragments Into Lead Molecules: A New Impulse in Fragment-Based Drug Discovery

Gregg SiegalZoBio

ZoBio Corporate OverviewZoBio Corporate Overview

Founded as Dutch BV 11/2004

Full access to all lab facilities of UL including 600 & 850 MHz NMR spectrometers

Self funded (grants and commercial activities)

10 employees

Customers: 9 of 15 largest pharma, many medium pharma and biotech

Business model:

Primarily Fee-for-Service

Limited internal discovery via academic collaboration

Projects typically completed in 1-2 months

www.zobio.com

Role in ZoBio : CSO & Founder

Key responsibilities:• Scientific Vision• Strategic Planning• Business Development

Background:Ph.D. studentBiochemistry, University of Rochester, USA

Post-Doc1.ETH Zürich, Lab of Prof. Kurt Wüthrich2.Ludwig Institute for Cancer Research, London, Prof. Paul Driscoll

Current AcademicLeiden University, Docent Protein Chemistry group

Gregg Siegal

Ron WesterRon Wester

Role in ZoBio : Post-doctoral Scientist

Key responsibilities:• Cloning, expression and production of protein targets (Bacterial and Insect cell cultures)• Application of isotope labeling for NMR based studies of protein targets • NMR methods to investigate target-small molecule binding• Preparation of a project plan as a part of a quotation to a customer• Reporting research results to customers

Currently involved in:• As a Project Leader for one project• Specific activities in 6 different projects

Background:Ph.D. studentResearch title- Developing efficient NMR methods to investigate protein-small molecule interactionsCo-promoter – Dr. Gregg Siegal; Promoter- Prof.dr.Marcellus UbbinkLeiden Institute of Chemistry, Leiden University

M.Res (Master of Research in Biomedical Sciences)Expression and characterization of GPCRs suitable for biophysical studiesDr. Niall Fraser and Prof. dr. Graeme Milligan (University of Glasgow, U.K)

B.Pharm.Sci (Bachelor’s of Pharmaceutical Sciences)Institute of Chemical Technology, Mumbai, India

Dipen Shah

Ron WesterRon Wester