Smallpox

Eradication

Amanda Srsic

Smallpox is caused by a DNA virus called Variola

Virus

The virus spreads by replicating in the host’s cytoplasm and

bursting the cell

The virus is transmitted through air, indirect contact,

and direct contact

Smallpox causes characteristic skin lesions that gave the disease its name

Asymptomatic for 12 days, then…

1/3 patients die, and those that

survive can end with scarring or

blindness

Smallpox was a grave disease that infected people in almost all

countries

Inoculation was a successful, ancient technique to prevent

smallpox

Dr. Edward Jenner transformed the

burden of smallpox by developing the first

vaccine in 1796

The smallpox vaccine developed to be grown on cow skin or chicken

eggs and delivered through a bifurcated needle

Kretzschmar M, van den Hof S, Wallinga J, van Wijngaarden J. Ring vaccination and smallpox control. Emerg Infect Dis [serial on the Internet]. 2004 May [date cited]. Available from: http://wwwnc.cdc.gov/eid/article/10/5/03-0419.htm

The vaccine effectively prevents smallpox transmission

In 1967, the WHO worked toward eradication by mass vaccination

Ring vaccination was a new method that proved very effective

Ring Vaccination decreased smallpox in Africa

India was one of the last frontiers in the eradication campaign

In 1980, smallpox was the first disease eradicated!

The eradication was successful because of the type of disease and public health

methods

Works Cited• PowerPoint “Old Killers, New Killers,” Dr. Amanda Thompson, UNC Chapel

Hill• http://www.pbs.org/wgbh/rxforsurvival/series/video/index.html• http://en.wikipedia.org/wiki/Smallpox#Transmission• http://www.who.int/features/2010/smallpox/en/index.html• http://www.cgdev.org/section/initiatives/_archive/millionssaved/studies/

case_1• http://www.cgdev.org/doc/millions/MS_case_1.pdf• http://www.news-medical.net/health/Smallpox-Eradication.aspx• http://www.ted.com/talks/larry_brilliant_wants_to_stop_pandemics.html• http://choo.fis.utoronto.ca/fis/courses/lis2102/ko.who.case.html• http://aje.oxfordjournals.org/content/94/4/316.full.pdf• http://www.cbsnews.com/2300-204_162-10007793-3.html?tag=page;next• http://science.nationalgeographic.com/science/photos/smallpox/#/smallpox-

virus_1216_600x450.jpg• http://www.eduplace.com/science/hmsc/6/a/cricket/cktcontent_6a22.shtml• http://www.bt.cdc.gov/agent/smallpox/overview/disease-facts.asp• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC475879/pdf/jclinpath00145-

0001.pdf • http://www.fda.gov/BiologicsBloodVaccines/Vaccines/

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