Slides last updated: March 2015. 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C,...

Slides last updated: March 2015

1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International

Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 11/03/2015.

Lung cancer incidence and mortality

0

5

10

15

20

25

Bothsexes

Men Women

Mor

talit

y (%

of a

ll ca

ncer

type

s)

Lung

Stomach

Liver

Colorectal

Femalebreast

Lung cancer is one of the most common

cancers, with 1.8 million new cases in 2012

worldwide1

Lung cancer is the most common cause of death from cancer, responsible

for 19.4% of all cancer deaths in 20121

Rates of lung cancer incidence and mortality differ worldwide1

58% of new lung cancer cases occur in developing countries

Highest lung cancer rates are found in Northern AmericaLung cancer is the most common cancer in men and the third most common in women

Lowest lung cancer rates are found in Western AfricaLung cancer is the 8th most common cancer in this region

Northern America

Micronesia

Eastern Asia

More developed regions

Western Europe

Central and Eastern Europe

Southern Europe

Northern Europe

Australia/New Zealand

Polynesia

World

Western Asia

Less developed regions

South-Eastern Asia

Caribbean

Southern Africa

South America

Melanesia

Northern Africa

South-Central Asia

Central America

Eastern Africa

Middle Africa

Western Africa80 60 40 20 0 20 40 60 80

Male Female

IncidenceMortality

Estimated age-standardized rates (World) per 100,000



Lung

Prostate

Colorectum

Stomach

Liver

Bladder

Oesophagus

Non-Hodgkin lymphoma

Kidney

Leukaemia

Lip, oral cavity

Pancreas

Brain, nervous syst.

Larynx

Melanoma of skin

2000 1500 1000 500 0

ASR (W) rate per 100,000

Breast

Colorectum

Lung

Cervix uteri

Stomach

Corpus uteri

Ovary

Thyroid

Liver

Non-Hodgkin lymphoma

Pancreas

Leukaemia

Oesophagus

Kidney

Brain, nervous syst.

0 500 1000 1500 2000

ASR (W) rate per 100,000

Lung1,242,0001,099,000 Lung

583,000491,000

Rates of lung cancer incidence differ between men and women1

IncidenceMortality



1975

1980

1985

1990

1995

1999

2003

2007

0

10

20

30

40

50

60

70

80

90

100

Five-year survival trend

Breastcancer

Colo-rectal

cancer

Lungcancer

High unmet medical need

Survival rates for lung cancer are generally low1

Survival rates vary depending on stage at diagnosis. The later the stage of diagnosis the lower the survival rates tend to be.

PE

RC

EN

TAG

E (%

)

1. SEER. Fast Stats Online. 5 year survival by diagnosis. 1975-2012. All races. All ages. Male and Female. Available online: seer.cancer.gov/faststats/selections.php, accessed on 09/07/2015.

Prostatecancer

NSCLC (83.6% of lung cancer)

Lung Cancer (100%)

NSCLC makes up approximately 84% of lung cancer1

Other NSCLC(19.1% of lung cancer)

Large cell carcinoma(2.0% of lung cancer)

Squamous cell carcinoma(18.6% of lung cancer)

Adenocarcinoma(44.1% of lung cancer)

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER

web site, April 2014, accessed on 12/03/2015.

The distribution of NSCLC subtypes is changing1

Since the 1980’s, squamous cell carcinomas have become relatively less common

Meanwhile, adenocarcinomas have become relatively more common

1. Devasa S, Bray F, Vizcaino A, et al. Int. J. Cancer 2005: 117, 294–299

The reasons for these changes are unclear, but may be due to changes in the composition and filtering of cigarettes

Slides last updated: March 2015. 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C,...

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