Slide Source Kaplan-Meier Curve of Time to Primary End Point Proportion of Events (%) Pioglitazone...
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Slide Source www.lipidsonline.org 0 5 10 15 20 25 Kaplan-Meier Curve of Time to Kaplan-Meier Curve of Time to Primary End Point Primary End Point Proportion of Events (%) Pioglitazo ne Placebo PROactive investigators. Lancet 2005;366:1279-1289. 2488 2530 2302 2317 2218 2215 348 345 Pioglitazone (514 events) Placebo (572 events) 2146 2122 2373 2413 0 6 12 24 30 18 36 No. at Risk Time from Randomization (months) HR = 0.90 (95% CI 0.80- 1.02) p = 0.095
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Slide Source Baseline Change in Posterior-Wall Mean CIMT LS Mean Change from Baseline, mm No. of Observations Glimepiride Pioglitazone Week Glimepiride Pioglitazone Mazzone T et al. JAMA 2006;296:
Transcript of Slide Source Kaplan-Meier Curve of Time to Primary End Point Proportion of Events (%) Pioglitazone...
Slide Sourcewww.lipidsonline.org
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Kaplan-Meier Curve of Time to Kaplan-Meier Curve of Time to Primary End PointPrimary End Point
Prop
ortio
n of
Eve
nts (
%)
PioglitazonePlacebo
PROactive investigators. Lancet 2005;366:1279-1289.
24882530
23022317
22182215
348345
Pioglitazone (514 events)Placebo (572 events)
21462122
23732413
0 6 12 24 3018 36No. at Risk Time from Randomization (months)
HR = 0.90 (95% CI 0.80-1.02)p = 0.095
Slide Sourcewww.lipidsonline.org
0
5
10
15
20
25
Kaplan-Meier Curve of Time to Kaplan-Meier Curve of Time to Secondary End PointSecondary End Point
Prop
ortio
n of
Eve
nts (
%)
PioglitazonePlacebo
PROactive investigators. Lancet 2005;366:1279-1289.
25362566
24352442
23812371
396390
Pioglitazone (301 events)Placebo (358 events)
23362315
24872504
0 6 12 24 3018 36No. at Risk Time from Randomization (months)
HR = 0.84 (95% CI 0.72-0.98)p = 0.027
Slide Sourcewww.lipidsonline.org
724824Baseline
Change in Posterior-Wall Mean CIMTChange in Posterior-Wall Mean CIMTLS
Mea
n Ch
ange
from
Ba
selin
e, m
m
No. of ObservationsGlimepiridePioglitazone
-0.12
-0.08-0.04
0.00
0.04
0.080.12
0.16
Week
Glimepiride Pioglitazone
186175
170166
186175
186175
Mazzone T et al. JAMA 2006;296:2572-2581.
Slide Sourcewww.lipidsonline.org
724824Baseline
Change in Posterior-Wall Maximum CIMTChange in Posterior-Wall Maximum CIMTLS
Mea
n Ch
ange
from
Ba
selin
e, m
m
No. of ObservationsGlimepiridePioglitazone
-0.02
-0.01
0.00
0.01
0.02
0.03
0.04
Week
Glimepiride Pioglitazone
186175
170166
186175
186175
Mazzone T et al. JAMA 2006;296:2572-2581.
