SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter)...
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Transcript of SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter)...
![Page 1: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/1.jpg)
SL MD4
Enzyme inhibitors as medicines
![Page 2: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/2.jpg)
A bit like the antagonists!
• Noradrenaline (neurotransmitter)
• Fits into receptor site
• Electrical impulse sent to heart muscles
• Increases heart beat• Bad for heart
• Antagonist (propanolol) blocks receptor site
• Angiotensin I (substrate)
• Fits into active site of enzyme (ACE)
• Changes it to angiotensin II
• Increases blood pressure• Causes heart attacks and
strokes• ACE inhibitor (captopril)
blocks active site
![Page 3: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/3.jpg)
What causes the high blood pressure?
angiotensin I angiotensin II + dipeptide
ACE - Angiotensin Converting Enzyme
Inactive Active – causes high blood pressure
Need enzyme inhibitor
![Page 4: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/4.jpg)
Following the lead
Venom of Brazilian
Arrowhead Viper can
kill by lowering
blood pressure
It contained
several proteins
which were ACE
inhibitors
But proteins
are digested
in the stomach
![Page 5: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/5.jpg)
![Page 6: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/6.jpg)
Try Ass 9.
![Page 7: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/7.jpg)
Back to the lead compounds ..
Active proteins from snake venom had the amino acid proline at the COOH end of the
chain.
![Page 8: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/8.jpg)
![Page 9: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/9.jpg)
After synthesising hundreds of compounds with proline in …
Not a protein so can be taken
orally!
![Page 10: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/10.jpg)
![Page 11: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/11.jpg)
Try Ass 10.
![Page 12: SL MD4 Enzyme inhibitors as medicines. A bit like the antagonists! Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to.](https://reader030.fdocuments.in/reader030/viewer/2022032522/56649d635503460f94a46693/html5/thumbnails/12.jpg)
A bit like the antagonists!
• Noradrenaline (neurotransmitter)
• Fits into receptor site
• Electrical impulse sent to heart muscles
• Increases heart beat• Bad for heart
• Antagonist (propanolol) blocks receptor site
• Angiotensin I (substrate)
• Fits into active site of enzyme (ACE)
• Changes it to angiotensin II
• Increases blood pressure• Causes heart attacks and
strokes• ACE inhibitor (captopril)
blocks active site