Single nucleotide polymorphism
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Transcript of Single nucleotide polymorphism
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Presented by:
PARICHAY S.R
14KUSAG004
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INTRODUCTION…
• SINGLE NUCLEOTIDE POLYMORPHISM -HALOTYPES • Applying SNP Profiles in Drug choices • Summary • References
INTRODUCTION….
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• Frequently called SNP’s, are the most common type of genetic variation Among people • SNP represents a difference in a single DNA building block called nucleotide • SNP’s occur normally throughout a Persons DNA
• They occur once in every 300 nucleotides on average - which means they are 10 million SNP’s in human genome
Single Nucleotide Polymorphism….
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• They act as Biological markers • SNP’s help to predict an individual’s response to certain drugs • Also used to track the inheritance of disease genes within families.
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HALOTYPES
• SNP’s doesn’t tell much about a person, in order to find an association b/n SNP’s and medication - Scientists have to look at multiple SNP’s across the stretch of DNA.
T A A/
G G T A C
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T A A/
G G T A C C C
G/
T A C
T/
C G A
SNP SNP SNP
T A A G T A C C C T A C T G A
T A G G T A C C C G A C T G A
T A G G T A C C C T A C T G A
T A A G T A C C C G A C C G A
T A A G T A C C C T A C C G A
T A G G T A C C C G A C C G A
T A G G T A C C C T A C C G A
T A A G T A C C C G A C T G A • Three SNP’s can be arranged In 23 or eight different Combinations • Each combination of SNP’s -- Halotype
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T A A G T A C C C T A C T G A
T A G G T A C C C G A C T G A
T A G G T A C C C T A C T G A
T A A G T A C C C G A C C G A
T A A G T A C C C T A C C G A
T A G G T A C C C G A C C G A
T A G G T A C C C T A C C G A
T A A G T A C C C G A C T G A HAPLOTYPE 1
HAPLOTYPE 2
HAPLOTYPE 3
HAPLOTYPE 4
HAPLOTYPE 5
HAPLOTYPE 6
HAPLOTYPE 7
HAPLOTYPE 8
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Applying SNP Profiles in Drug Choices….
The Drug Albuterol is commonly prescribed to relieve the symptoms of Asthma
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Albuterol
Beta 2AR protein
Albuterol acts on the beta- 2 adrenergic receptor to relieve asthma attacks
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Albuterol
Beta 2AR protein
The beta2AR protein is encoded by ADRB2 Gene.
ADRB2 Gene
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ADRB2 Gene
C T G
SNP’s
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Summary….
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References......
• biocyclopedia.com/snips • http://learn.genetics.utah.edu/content/pharma/snips/ • Alberts- Molecular biology of cell.
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