Signaling via Ras See: .

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Signaling via Ras See: www.mpi-dortmund.mpg.de/imprs/Experiment3.pdf

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Transcript of Signaling via Ras See: .

Page 1: Signaling via Ras See: .

Signaling via Ras

See: www.mpi-dortmund.mpg.de/imprs/Experiment3.pdf

Page 2: Signaling via Ras See: .

Inhibitors of Farnesylation

From: Johnston, Lancet Oncol. 2001, 2, 18

Page 3: Signaling via Ras See: .

N-Glycosylation

Page 4: Signaling via Ras See: .

Glycosylation in the ER

From: http://glycores.ncifcrf.gov/

Page 5: Signaling via Ras See: .

Glycan Diversity Generated in Golgi

Page 6: Signaling via Ras See: .

Structure of N-Glycan

Imperiali, Curr. Opin. Chem. Biol. 1999, 3, 643

Page 7: Signaling via Ras See: .

Pharmacological Inhibitors of Glycosylation

Page 8: Signaling via Ras See: .

Glycosylation is Essential

D. S. Peal, unpublished results

Page 9: Signaling via Ras See: .

Glycosylation Involved in Quality Control of Protein Folding

Page 10: Signaling via Ras See: .

Notch Signaling Pathway

Blacklow, Curr. Opin. Chem. Biol. 2002, 6, 501

Page 11: Signaling via Ras See: .

Notch Regulation by Glycosylation

Haltiwanger, Curr. Opin. Struct. Biol. 2002, 12, 593

Notch – Ligand Preference Influenced by Glycosylation


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