Shultz CV 4.28.2021 - JAX

LeonardD.Shultz,Ph.D.TheJacksonLaboratory,BarHarbor,ME04609Phone:207-288-6405•Fax:207-288-6077

Email:[email protected]

CurriculumVitae

EDUCATION1967 B.A.,Biology,NortheasternUniversity,Boston,MA1971-1972 PredoctoralTrainee,USPublicHealthServices,UniversityofMassachusetts,Amherst,MA1972 Ph.D.,MedicalMicrobiology,UniversityofMassachusetts,Amherst,MA1972-1974 PostdoctoralFellow,TheJacksonLaboratory,BarHarbor,MERESEARCHPOSITIONS1967-1968 ResearchAssistant,TuftsUniversitySchoolofMedicine,Boston,MA1968-1970 GraduateTeachingAssistant,UniversityofMassachusetts,Amherst,MA1970-1971 Lecturer,UniversityofMassachusetts,AmherstMA1974-1976 ResearchAssociate,TheJacksonLaboratory,BarHarbor,ME1976-1979 AssistantProfessor,TheJacksonLaboratory,BarHarbor,ME1979-1991 AssociateProfessor,TheJacksonLaboratory,BarHarbor,ME1981 CooperatingProfessorinZoology,UniversityofMaine,Orono,ME1988-present GraduateFacultyMember,SchoolofBiomedicalSciencesandEngineering(GSBSE),

UniversityofMaine,Orono,ME1991-present Professor,TheJacksonLaboratory,BarHarbor,ME1995-2017 ResearchProfessor,DepartmentofMedicine,SchoolofMedicine,Universityof

MassachusettsMedicalSchool,Worcester,MA2017-present ProfessorofMedicine,DepartmentofMedicine,SchoolofMedicine,Universityof

MassachusettsMedicalSchool,Worcester,MA1998-present ResearchProfessor,GraduateSchoolofBiomedicalSciences,UniversityofMassachusetts

MedicalSchool,Worcester,MA2006-2007 AssistantClinicalProfessor,DepartmentofImmunology,UniversityofConnecticut,School

ofMedicine,Farmington,CT2008 AdjunctAssistantProfessor,DepartmentofImmunology,UniversityofConnecticut,School

ofMedicine,Farmington,CTRESEARCHINTERESTSDevelopmentandregulationoftheimmunesysteminnormalandpathologicstates:immunodeficiency;autoimmunity;tumorimmunology;infectiousdisease;diabetes;developmentofhumanizedmousemodelsasapreclinicalbridgefortranslationalinvestigations.PROFESSIONALACTIVITIESBoardMembership:1990-2015 InVivo2003-2008 ExperimentalBiologyandMedicine2004-2016 StemCell2008-2014 BetaCellBiologyConsortium(BCBC),PrincipalInvestigator2012-2017 StemCellCobreExternalAdvisoryCommittee,MaineMedicalResearchCenter

LeonardD.Shultz,Ph.D.

2

2018 ExternalAdvisoryCommittee,TargetedSphingolipidMetabolismforAML,UniversityofVirginiaMedicalCenter

GrantReviewPanels:1987 Member,SpecialNIHStudySection1992 Member,NIHAdhocStudySection1994 NIHStudySectionMechanismsofProstateCancer1996 Member,NIHSpecialStudySectiononProstateCarcinomaInvasionandMetastasisFactors1997 SpecialNIAIDReviewCommitteeonSCID-HIVAnimalModelsforEvaluatingHIV

Therapeutics1998 NationalCancerInstituteReviewCommitteeSiteVisittotheFoxChaseCancerInstitute1999 NationalCancerInstitute,ProgramProjectsinImmunologyReviewCommittee2001 Member,NIHStudySectionastheDeutofNovelAidstherapies2003 NIHSpecialReviewpanelonProstateCarcinomaProgramProjects2004 NIHStudySectionMechanismsofProstateCancer2005 NIH/NAIADAdhocStudySectionpaneltoreviewapplicationsforTissuebasedsmall

animalmodelsforHIVDrugDiscovery2005 Member,AdHocStudySectiontoreviewtheintramuralprogramoftheDermatology

branchoftheNationalCancerInstitute2005 AdHocReview,NIHKidneyBiologicalandHematologicalSubcommittee2006 NIH/NAIAD,AdhocStudySectionPaneltoreviewapplicationsfortissuebasedsmall

animalmodelsforHIVDrugDiscovery2010 JDRFGrantsReviewStudySection2011 MedicalResearchCouncilofCanada2011 TheArthritisFoundation2011 SwissNationalFundforScientificResearch2015 US-IsraelBi-NationalScienceFoundationAdhocManuscriptReviewsforPeerReviewedJournals:TheJournalofImmunology,ProceedingsoftheNationalAcademyofSciences,USA,TheAmericanJournalofPathology,TheJournalofGerontology,TheJournalofNutrition,Nature,Science,NatureGenetics,ExperimentalHematology,StemCellReports,TrendsinImmunology,PLoSONE,DrugDiscovery,TheJournalofAutoimmunity,StemCellsandDevelopmentInstitutionalCommittees:2004-present GeneticResourcesCommittee2004-present RAFAdvisoryCommittee2005-2015 HumanSubjectsIRB,Chair2005-present ResearchGrantsCommittee2006-2007 CancerCoreGrantCommittee2014-present Radiation&LabSafety,Co-Chair2017-present ScientificServicesPDXFacultyCommittee2018-present MentorforGaryRen


3

PROFESSIONALSOCIETIESAmericanAssociationofImmunologists,AmericanSocietyforMicrobiology,AmericanDiabetesAssociation,AmericanAssociationfortheAdvancementofScience,AmericanSocietyforHematology,InternationalAssociationforComparativeResearchonLeukemiaandRelatedDiseasesEXTRAMURALRESEARCHSUPPORTCurrent:2021-2026 Co-Investigator,U24CA263963-01,“PediatricOncologyInVivoTestingProgram

CoordinatingCenter,”NIH/NCI(8/25/2021-6/30/2026)2021-2026 Co-Investigator,1R01CA251433-01A1,“LungResidentMesenchymalCellsinthePre-

MetastaticNicheFormation,”NIH/NCI(4/1/2021-3/31/2026)2021-2024 ConsortiumPrincipalInvestigator,Contract#75N93021C00004(Yr1),“Characterizingand

ImprovingHumanizedImmuneSystemMouseModels,”NIH/NIAID(2/2/2021-2/1/2024)2020-2025 PrincipalInvestigator,JDRF-5-COE-2020-967-M-N-02,“ACureforType1Diabetes,”Juvenile

DiabetesResearchFoundationInt’l(10/1/2020-9/30/2025)2020-2025 Co-Investigator,1R37CA237307-02,“TheRoleofLungResidentMesenchymalStemCellsin

Post-ChemotherapyLungMetastasesofBreastCancer,”NIH/NCI(2/4/2020-1/31/2025)2020-2025 ProjectLead,2P30CA034196-35,“CancerCenterSupport(Core)Grant–CancerModels

DevelopmentSharedResource,”NIH/NCI(04/01/2020-3/31/2025)2020-2022 PrincipleInvestigator,JAX-DIF-FY20-LDS-Validation,“ValidationofanNSGHumanized

MouseModelforInvestigationsofHumanMatureNeutrophilDevelopmentandFunction,”TheJacksonLaboratoryDirector’sInnovationFund(2/1/2020-10/18/2022)

2020-2021 PrincipleInvestigator,JAX-DIF-LDS-CoVID-20,“DevelopmentofaHumanizedMouseModelforSARS-CoV-2Infection,”TheJacksonLaboratoryDirector’sInnovationFund(4/7/2020-11/7/2021)

2019-2023 ConsortiumPrincipalInvestigator,5R24OD026440-03,“ImmunogenicityofHumanStemCell-DerivedBetaCellsandMuscleCellsinHumanizedMice,”NIH/OD(08/15/2019-07/31/2023)

2019-2023 ConsortiumPrincipalInvestigator,5U01DK104218-04,“HumanizedMouseAvatarsforT1D,”NIH/NIDDK(09/20/2019/19-05/31/2023)

2018-2023 Co-Investigator,1U01CA224013-04,“CSHL-JAXPatient-DerivedModelsofPancreaticCancerasSystemsforInvestigatingTumorHeterogeneity,”NIH/NCI(03/06/2018-02/28/2023)

2017-2022 ConsortiumPrincipalInvestigator,5R01AI132963-05,“NovelHumanizedMouseModelDevelopedfromCordBloodCD34PositiveHSCandAutologousiPSCellDerivedThymus,”NIH/NIAID(05/01/2017-04/30/2022)

Completed:2020-2020 ConsortiumPrincipalInvestigator,OSP32191-00,“DevelopingHumanPluripotentStemCells

forInvestigationandTreatmentofHypoparathyroidism,”TrusteesoftheUniversityofPennsylvania(1/1/2020-12/31/2020)

2018-2020 PrincipalInvestigator,COLLAB-UMASS-LDS-2018,“Umass/JAXCollaborativeStudy:Tobeginthedevelopmentofamodelofdiet-inducedfattyliverdiseaseleadingtonon-alcoholicsteatohepatitis(NASH)inhumanizedmice,”UniversityofMassachusettsMedicalSchool(02/01/2018-01/31/2020)


4

2018-2020 PrincipalInvestigator,ShultzDIFNovelNSGMice-01,“DevelopmentofNovelStrainsofNSGMiceDemonstratingEnhancedStructureandFunctionofLymphoidOrgansandHeightenedHumanImmuneFunctionFollowingHumanHSCEngraftment,”TheJacksonLaboratoryDirector'sInnovationFund(01/09/2018-01/08/2020)

2017-2018 PrincipalInvestigator,JAX-DIF-FY17-SAM-MKV-LDS“ANovelComplementSufficientNSGMouseModeltoStudyComplement-MediatedModulationofImmuneResponsesAgainstHumanCancer,”TheJacksonLaboratoryDirector’sInnovationFund(11/01/2017-10/31/2018)

2017-2018 PrincipalInvestigator,JAX-DIF-FY17-LDS-JGK-MVW“DevelopmentofNSGMousetoFacilitatePharmacokineticEfficacyTesting,”TheJacksonLaboratoryDirector’sInnovationFund(09/15/2017-09/14/2018)

2017-2018 PrincipalInvestigator,JAX-DIF-FY17-LDS-novelcomplement“ANovelComplementSufficientNSGMouse-Model,”TheJacksonLaboratoryDirector’sInnovationFund(11/01/2017-12/31/2018)

2014-2019 ConsortiumPrincipalInvestigator,1UC4DK104218-01“HumanizedMouseAvatarsforT1D,”NIH/NIDDK(9/25/2014-6/30/2019)

2013-2019 PrincipalInvestigator,5R25CA174584-05“SummerResearchExperienceinCancerBiologyandGenomicsforUndergraduates,”NIH/NCI(4/1/2013-3/31/2019)

2013-2018 ConsortiumPrincipalInvestigator,5P01CA171983-05“TargetedSphingolipidMetabolismforTreatmentofAML,”NIH/NCI(9/10/2013-8/31/2018)

PATENTS&LICENSINGAGREEMENTSShultzLD,VermaMK,GreinerDL,BrehmMA.2020.Geneticallymodifiednon-humananimalsandmethods

relatingtocomplementdependentcytotoxicity.U.SPublicationNo.20200359609.JUSTIAPatents.ShultzLD,BrehmMA,GreinerDL.2020.Immunodeficientmiceexpressinghumaninterleukin15.U.S.

PublicationNo.20200236916.JUSTIAPatents.ShultzLD,VermaMK,GreinerDL,BrehmMA.2020.Geneticallymodifiednon-humananimalsandmethods

relatingtocomplementdependentcytotoxicity.U.S.PatientNo.10701911.JUSTIAPatents.BrehmMA,WilesMV,GreinerDL,ShultzLD.2020NSGmicelackingMHCClassIandClassII.U.S.

PublicationNo.20200060245.JUSTIAPatents.ShultzLD,KeckJG,GreinerDL,BrehmMA.2019.Humanizedmousemodelwithimprovedhumaninnate

immunecelldevelopment.U.S.PublicationNo.20190320633.JUSTIAPatents.ShultzLD.2019.Geneticallymodifiedmousemodelforhumanhepatocytexenotransplantation.U.S.

PublicationNo.20190274290.JUSTIAPatents.ShultzLD,WilesMV.2019.Methodsandcompositionsrelatingtoimprovedhumanredbloodcellsurvival

ingeneticallymodifiedimmunodeficientnon-humananimals.U.S.PublicationNo.20190183101.JUSTIAPatents.

WilesMV,HosurV,ShultzLD.2018.Compositionsandmethodsrelatingtotumoranalysis.U.S.PublicationNo.20180325085.JUSTIAPatents.

ShultzLD,GreinerDL,BrehmMA.2018.Geneticallymodifiednon-humananimalsandmethodsrelatingtoinnateimmunesystemresponsedetection.2018.U.S.PatentNo.10021861.JUSTIAPatents.

ShultzLD,VermaMK,GreinerDL,BrehmMA.2018.Geneticallymodifiednon-humananimalsandmethodsrelatingtocomplementdependentcytotoxicity.U.S.PublicationNo.20180184629.JUSTIAPatents.

HosurV,ShultzLD.2017.Methodsforidentifyingcompoundsthataltertheactivityofirhompolypeptidesandusethereof.U.S.PublicationNo.20170241986.JUSTIAPatents.


5

ShultzLD,GreinerDL,BrehmMA.2016.Geneticallymodifiednon-humananimalsandmethodsrelatingtoinnateimmunesystemresponsedetection.U.S.PublicationNo.20160345548.JUSTIAPatents.

ShultzLD,GreinerDL,BrehmMA.2016.Geneticallymodifiednon-humananimalsandmethodsrelatingtoinnateimmunesystemresponsedetection.2016.U.S.PatentNo.9414576.JUSTIAPatents.

IshikawaF,SaitoY,OharaO,ShultzLD.2015.Mousehavinghumanleukemicstemcellandleukemicnon-stemcellamplifiedtherein,andmethodsforproductionthereof.U.S.PatentNo.9125384.JUSTIAPatents.

ShultzLD,GreinerDL,BrehmMA.2015.Geneticallymodifiednon-humananimalsandmethodsrelatingtoinnateimmunesystemresponsedetection.U.S.PatentApplicationNo.20150105288.JUSTIAPatents.

IshikawaF,OharaO,SaitoY,KitamuraH,HijikataA,OzawaH,ShultzLD.2014.Leukemiastemcellmarkers.U.S.PublicationNo.20140274788.JUSTIAPatents.

ShultzLD,GreinerDL.2013.Transgenicnon-humananimalandmethodsforstemcellengraftment.U.S.PatentNo.8431767.JUSTIAPatents.

IshikawaF,SaitoY,ShultzLD.2012.Agentforpreventingrecurrenceofleukemia.U.S.PublicationNo.20120121535.JUSTIAPatents.

IshikawaF,OharaO,SaitoY,KitamuraH,HijikataA,OzawaH,ShultzLD.2012.Leukemiastemcellmarkers.U.S.PatentApplicationNo.20120070450.JUSTIAPatents.

IshikawaF,SaitoY,OharaO,ShultzLD.2011.Mousehavinghumanleukemicstemcellandleukemicnon-stemcellamplifiedtherein,andmethodforproductionthereof.U.S.PublicationNo.20110307964.JUSTIAPatents.

ShultzLD,GreinerDL.2011.Transgenicnon-humananimalandmethodsforstemcellengraftment.U.S.PublicationNo.20110113496.JUSTIAPatents.

INVITEDTALKS(2008–PRESENT)Presentation,EmergingModelsofHumanizedMiceforBiomedicalResearch,NationalCancerInstitute,

2021CIRPAnnualVirtualMeeting,June17,2021.InvitedSpeaker,DiscussionHumanizedMouseModelsforPDXEfforts,NCI/FNLCR,Virtualmeeting,June3,

2021InvitedSpeaker,Emerginghumanizedmousemodelsforcancerresearch,Hematology/OncologyGrand

Rounds,PennStateHersheyCancerCenter,Hershey,PA,February6,2020.InvitedSpeaker,Emerginghumanizedmousemodelsforcancerresearch,NationalCancerInstitute,NCI-

Immuno-OncologyModelsWorkshop(Virtual),July9-10,2020.InvitedSpeaker,ImmuneMechanismsWorkingGroupMeetingoftheNIHImmuno-OncologyTranslational

Network,September8,2020.InvitedSpeaker,NIHVirtualWorkshoponValidationofAnimalModelsandToolsforBiomedicalResearch,

December2020.InvitedSpeaker,Nextgenerationhumanizedmiceforcancerimmunotherapy,CancerImmune

ResponsivenessWorkshop,SanFrancisco,CA,May14,2018InvitedSpeaker,DesigningthePatient-DerivedModelPlatformoftheFuture,TheJacksonLaboratory-Beth

IsraelDeaconessMedicalCenter(JAX-BIDMC)Workshop,Farmington,CT,June12,2018NovartisPharmaceuticalCorp,Cambridge,MA,June27,2018InvitedSpeaker,Humanizedmousemodelsforcancerresearch:challengesandopportunities,The6th

AnnualDr.StanleyG.NathensonMemorialLecture,AlbertEinsteinCollegeofMedicine,Bronx,NY,November7,2018


6

Regeneron’sWorkshoponHumanizedImmuneSystemMice,RegeneronAuditorium,RegeneronPharmaceuticals,Tarrytown,NY,November28-29,2018

PlenarySpeaker,RecentAdvancesandOpportunitiesintheDevelopmentandUseofHumanizedImmuneSystemMouseModels,NationalInstitutesofHealth,Bethesda,MD,December18,2018

InvitedSpeaker,Humanizedmiceforcancerresearch,DepartmentofMedicine,DivisionofHematologyandOncology,SchoolofMedicine,UniversityofAlabama,Birmingham,AL,January31-February2,2017

InvitedSpeaker,Generationofimprovedhumanizedmousemodelsforhumaninfectiousdiseases,LesPensieres,FoundationMerieuxConferenceCenter,VeyrierduLac,France,April27,2017

InvitedSpeaker,HumanizedmiceinCancerResearch,2ndAnnualAdvancesinImmuno-OncologyCongress,OxfordGlobal,London,England,May15-16,2017

InvitedSpeaker,Nextgenerationhumanizedmousemodelsforcancerresearch,2017SummitforCancerImmunotherapy,BioCanRx,Gatineau,Quebec,Canada,June26,2017

InvitedSpeaker,Immuneinterventionsinoncology:Athinktankonmodelingopportunitiesusingmiceandhumanspecimens,NationalCancerInstitute(NCI)Workshopon“ModelingImmunotherapyinMouse,”Rockville,MD,September17-20,2017

InvitedSpeaker,Highlightsandperspectivesofhumanizedmice,Humanizedmiceinbiomedicalresearch,EMBOPracticalCourse,EMBL,Heidelberg,Germany,October15-20,2017

InvitedSpeaker,Nextgenerationhumanizedmiceinbiomedicalresearch,2017AmericanCollegeofVeterinaryPathologists(ACVP),Vancouver,BC,Canada,November3-6,2017

InstituteforNeurodegenerativeDiseases,WeilInstituteforNeurosciences,UniversityofCaliforniaSanFrancisco,November6,2017

5thInternationalWorkshoponHumanizedMice(IWHM5),UniversityofZurich,Switzerland,Jan28-30,2016

InvitedSpeaker,Humanizedmousemodelsfortranslationalbiomedicalresearch,Medimmune,TheJacksonLaboratory,BarHarbor,ME,February18,2016

JuvenileDiabetesResearchFoundation(JDRF)nPOD8thAnnualMeeting,Miami,FL,Feb21-24,2016NationalEmergingInfectiousDiseasesLaboratoriesMeeting(NEIDL),Boston,MA,April5-9,20162016NeuroendocrineTumorWorkshop,Cambridge,MA,May4-6,2016InvitedSpeaker,Humanizedmiceintranslationalimmunology,Immunology2016,AmericanAssociationof

ImmunologistsAnnualMeeting,WashingtonStateConventionCenter,Seattle,WA,May13,2016HumanIsletResearchNetworkMeeting,Bethesda,MD,May24-25,2016Janssen,PharmaceuticalCompaniesofJohnson&Johnson,Philadelphia,PA,August17-20,2016PreclinicalModelsforImmunotherapyDevelopmentScientificInputEngagement,SanFrancisco,CA,

September26-27,2016FacultyRetreat,PointLookoutConferenceCenter,TheJacksonLaboratory,Northport,ME,October13-14,

2016AMLP01ExternalAdvisoryBoardMeeting,PennStateHersheyMedicalCenter,Hershey,PA,October20-

21,2016TheJacksonLaboratoryFacultyRetreat,Portsmouth,NH,Oct24-26,20169thAnnualBethIsraelDeaconessMedicalCenter(BIDMC)CancerSymposium,JosephB.MartinCenter,

HarvardMedicalSchool,Boston,MA,November2,2016JanssenPharmaceuticalCompaniesofJohnson&Johnson,SpringHouse,PA,November6-7,2016TheJacksonLaboratoryCancerCenter2016WinterRetreat,Portland,ME,Dec7-9,2016JAXCancerCenterRetreat,Portland,ME,December10-11,2016


7

TheJacksonLaboratory-BethIsraelDeaconessMedicalCenter(JAX-BIDMC)ImmunologySymposium,Boston,MA,December15-17,2016

MyelodysPlasticSyndromeFundraisingMeeting,JerryHughes/MDSResearchFund-Raising,Bangor,ME,March7,2015

HumanizedMouseWorkshop,Boston,MA,March11-12,2015InvitedSpeaker,Ofhumanizedmiceandmen,StanfordUniversity,SanFrancisco,CA,March25-27,2015TheJacksonLaboratory-BethIsraelDeaconessMedicalCenter(JAX-BIDMC)ImmunologyWorkshop,JAX-

GM,Farmington,CT,March31-April2,2015HIRNDiabetesMeeting,Bethesda,MD,May13-15,2015.InvitedSpeaker,Ofnextgenerationhumanizedmiceandmen,AIDS/NIAID/NIH/DHHS-Improvementsand

LimitationsofHumanizedMouseModelsfor,Rockville,MD,May14-15,2015InvitedSpeaker,Closingthegapbetweenthemouseandhumanimmunesystems,American

GastroenterologicalAssociation(AGA)-DigestiveDiseaseWeek,Bethesda,MD,May15-17,2015IntegratedTranslationalScienceCenterWorkshop,TheBanburyCenter,ColdSpringHarborLaboratory,

LongIsland,NY,June18-20,2015AmericanSocietyofTropicalMedicine&Hygiene(ASTMH)64thAnnualMeeting,Philadelphia,PA,October

25-29,20152014AnnualnPODmeeting,AtlanticBeach,FL,February23-March1,2014InvitedSpeaker,Humanizedmiceforbiomedicalresearch,AmericanSocietyofGene&CellTherapy17th

AnnualMeeting,WashingtonD.C.,May23,2014BIDMC/JAXWorkshop,Boston,MA,October21,2014TheJacksonLaboratory,FacultyRetreat,Northport,ME,November3-5,2014InvitedSpeaker,HumanizedSCIDmousemodelsforbiomedicalresearch,StemCellInstituteSeminar

Series,UniversityofMinnesotaMedicalSchool,Minneapolis,MN,November12,2014InvitedSpeaker,HumanizedSCIDmousemodelsforbiomedicalresearch,StemCellInstitute,Universityof

Minneapolis,Minneapolis,MN,November11-13,2014EMMCCancerCareofMaine,Brewer,ME,January7,2013InvitedSpeaker,HumanizedSCIDmousemodelsforcancerresearch,HollingsCancerCenter2013Spring

ResearchSymposium,ModelsofHumanCancerforTranslationalResearch,MedicalUniversityofSouthCarolina,Charleston,SC,March15,2013

AstraZeneca,Waltham,MA,April28-30,2013MerckResearchLaboratories,Boston,MA,April28-30,20132013BCBCInvestigatorRetreat,BiologyoftheBetaCellSymposium,Reston,VA,May6-9,2013BristolMyersSquibb,Philadelphia,PA,August18-20,2013InvitedSpeaker,Humanizedmiceasmodelsforcancergrowthandtherapy,4thInternationalWorkshopon

HumanizedMice,“HumanizedMiceasModelsforCancerGrowthandTherapy,”Seoul-Incheon,Korea,October1,2013

InvitedSpeaker,Humanizedmousemodelsinbiomedicalresearch,46thAnnualMeetingoftheSocietyforLeukocyteBiology,HumanizedMouseModelsinBiomedicalResearch,Newport,RI,October20,2013

InvitedSpeaker,AnimalModelsandPersonalizedMedicine,NIHSymposium“AnimalModelsandPersonalizedMedicine,”Bethesda,MD,Oct28,2013

InvitedSpeaker,Humanizedmice:Abridgetotheclinic,UniversityofRochesterMedicalCenter,GrandRounds,UniversityofRochester,Rochester,NY,April5,2012

2012BCBCInvestigatorRetreat,NIDDK,Chantilly,VA,May1-4,2012


8

InvitedSpeaker,HumanizedMice:Stateoftheart,2012ACLAMForumforLife,StPetersburgBeach,FL,May9,2012

InvitedSpeaker,Miceinbiomedicalresearch:Abridgetotheclinic,IndianaUniversitySchoolofMedicine,DepartmentofMicrobiology/Immunology,Indianapolis,IN,May17,2012

NextGenerationAnimalModelsTargetingPersonalizedDiseasePhenotypes,NIH,Bethesda,MD,September6-7,2012

17thInternationalConferenceoftheInflammationResearchAssociation,BoltonLanding,NY,September9-12,2012

UniversityofFloridaCollegeofMedicine,DepartmentofPathology,ImmunologyandLaboratoryMedicine,Gainesville,FL,February15,2011

InvitedSpeaker,Humanizedmousemodel,HelmsleyProjectMeeting,Boston,MA,March24,2011InvitedSpeaker,Humanizedmiceinbiomedicalresearch,GeorgeMasonUniversity,NationalCenterfor

BiodefenseandInfectiousDiseases,Manassas,VA,April22,2011InvitedSpeaker,Humanizedmice:Abridgetotheclinic,BeckmanResearchInstitute,CityofHope,Duarte,

CA;May24,2011InvitedSpeaker,Bridgingthegapwithhumanizedmice,DARPA-USAMRIIDWorkshop,WashingtonDC,

FortDetrick,MD,July29,2011InvitedSpeaker,Overviewofhumanizedmice:Progress,limitationsandinfectiousdiseases,Joint

LaboratoryRetreat,TheJacksonLaboratory,VanderbiltUniversity,USAMRIID,TheUniversityofMassachusettsMedicalSchool,Harvard,September21,2011

InvitedSpeaker,Humanizedmiceintranslationalbiomedicalresearch,TheNewYorkAcademyofSciencesConference,AnimalModelsandTheirValueinPredictingEfficacyandToxicity,NewYork,NY,September16,2011

ThirdInternationalWorkshoponHumanizedMice,Pittsburgh,PA,October28-31,2011JDRFAutoimmunityCenterConsortiumRetreat,NewYork,NY,March1-3,2010StateUniversityofNewYork,Buffalo,NY,April14,2010InvitedSpeaker,Thehumanizedmousemodelintranslationalresearch,BiogenInc.,Cambridge,MA,May6-

7,2010InvitedSpeaker,Humanizedmiceintranslationalresearch,UnitedServicesUniversityofHealthSciences,

Washington,DC,May12,2010WorkshoponHumanizedMice,Hannover,Germany,June10,2010HumanizedMouseModelMeeting,WashingtonDC,June21,2010SanofiAventis,Bridgewater,NJ,June29,2010JuvenileDiabetesResearchFoundation,DiabeticMouseModels,NewYork,NYJuly14.PfizerInc,Boston,MAJuly20,2010AnimalModelsofDiabeticComplicationsConsortium(AMDCC)Meeting,Baltimore,MD,August4,2010InvitedSpeaker,Stateoftheartofhumanizedmice,8thAnnual"AdvancesinInflammationResearch"

Symposium,BrownUniversity,Providence,RI,September17,2010InvitedSpeaker,Humanizedmiceintranslationalresearch,NIH,Bethesda,MD,October11-12,2010Johnson&JohnsonPharmaceuticals,SpringHouse,PA,November9,2010Symposium,ExecutiveSummit:HumanizedMouseModelsandPreclinicalResearch,Philadelphia,PA,

November10,2010InvitedSpeaker,Humanizedmice:Stateoftheart,FrontierSpeakerSeries,Eisai,Inc,Andover/Boston,MA,

November19,2010


9

MaineMedicalResearchInstitute,Scarborough,ME,Dec.9,2010InvitedSpeaker,HumanizedSCIDmiceinbiomedicalresearch,VermontCancerCenterJuckettLecture,

UniversityofVermont,Burlington,VT,January6,2009SanofiAventisWebSeminar,Feb.3,2009InvitedSpeaker,Humanizedmousemodelsforbiomedicalresearch,TexasTechUniversityHealthSciences

Center,ElPaso,TX,March18,20092ndInternationalHumanizedMouseSymposium,Amsterdam,TheNetherlands,April4,2009Optimizationoftheimmunodeficientmouserecipient,StudyingType1DiabetesbyCombiningHumaniPS

andHumanizedMouseTechnologies,Boston,MA,April21,2009Humanizedmousemodels,TheJacksonLaboratory-West,Sacramento,CA,May5,2009Children’sHospital,Pittsburgh,PA,May18,2009BetaCellBiologyConsortium,InvestigatorRetreat,Washington,DC,May27,2009JuvenileDiabetesResearchFoundationMeeting,Worcester,MA,July14,2009MoundDesertIslandBiologicalLaboratoryStemCellSymposium,BarHarbor,ME,August8,2009CancerGeneticsMeeting,JacksonLaboratory,BarHarbor,ME,August23,2009NextGenerationBetaCellTransplantation,NIHCampus,Bethesda,MD,November9,2009InvitedSpeaker,HumanizedSCIDmiceinbiomedicalresearch,UniversityofAlabama,Birmingham,AL,

December9,2009InvitedSpeaker,HumanizedSCIDmiceintranslationalbiomedicalresearch,CharitéCampusVirchow-

Klinikum,UniversitatsmedizinBerlin,MolecularBasisofClinicalVariabilityinMendelianDisorders,MaxPlanckInstitutfürMolekulareGenetik,Berlin,Germany,February5,2008

InstituteofMedicalGenetics,CharitéBerlin,HumboldtUniversity,Leipzig,Germany,February6,2008InvitedSpeaker,HumanizedSCIDmice:Aroadwell-traveled,DepartmentofPathologyandLaboratory

Medicine,MedicalUniversityofSouthCarolina,Charleston,SC,March3,2008InvitedSpeaker,HumanizedSCIDmice:Aroadwell-traveled,2ndAnnualMeetingofHumanizedSCID

MouseModels:StemCells,Cancer&ViralPathogenesis,Geneva,NY,May14,2008InvitedSpeaker,Modelsfortheinvivofunctionalanalysisofmouseandhumanbetastemandprogenitor

cells,BCBCInvestigatorRetreat,WashingtonDC,May18,2008InvitedSpeaker,HumanizedSCIDmice:Aroadwell-traveled,DiscoveryStrategiesConference:Modeling

Human,AutoimmuneDiseasesintheLaboratoryRodent,TheJacksonLaboratory,BarHarbor,ME,May28,2008

JuvenileDiabetesResearchFoundation,SponsoredWorkshop,NewYork,NY,June17,2008InvitedSpeaker,Humanizedmousemodels,19thAnnualNASASpaceRadiationInvestigatorsWorkshop,

HyattRegencyHotel,Penn’sLanding,Philadelphia,PA,July1,2008InvitedSpeaker,Overviewofthedevelopmentofhumanizedmiceandtheirapplicationinbiomedical

research,JDRFandJacksonLaboratoryWorkshopon“BetaCellDevelopmentandFunctioninMiceEngraftedwithHumanImmuneSystems”BarHarbor,ME,August3,2008

NIAIDDengueVirusWorkshop,Washington,DC,Sept.19,2008HumanizedMouseModelMeeting,FortDetrick,MD,October8,2008InvitedSpeaker,Immunologyofhumanizedmice,TranslationalResearchinImmunology,The38thAnnual

MeetingoftheJapaneseSocietyforImmunology,Kyoto,Japan,Dec3,2008


10

TEACHINGEXPERIENCE1977-2004 AnnualShortCourseonMedicalandExperimentalMammalianGenetics,TheJackson

Laboratory,BarHarbor,ME1984 FacultyofBarHarborMedicalSymposium2005 DiscoveryStrategies:ImprovingthePredictiveValueofMouseModelsinDrugDiscovery

andDevelopment,TheJacksonLaboratory,BarHarbor,ME2006 DiscoveryStrategies:TheLaboratoryMouseinTranslationalCancerResearchand

Discovery,NewYork,NY2006-2007 AnnualShortCourseonExperimentalGeneticsoftheLaboratoryMouseinCancerResearch,

TheJacksonLaboratory,BarHarbor,ME2006-2008 MethodsinHumanEmbryonicStemCellResearch,TheJacksonLaboratory,BarHarbor,ME2007 DiscoveryStrategies:ModelingHumanMetabolicSyndromeandType2Diabetesin

Rodents,TheJacksonLaboratory,BarHarbor,ME2007 AnnualWorkshoponthePathologyofMouseModelsforHumanDisease,TheJackson

Laboratory,BarHarbor,ME2007-2020 AnnualShortCourseonExperimentalModelsofHumanCancer,TheJacksonLaboratory,

BarHarbor,ME2008 DiscoveryStrategies:ModelingHumanAutoimmuneDiseasesintheLaboratoryRodent,

TheJacksonLaboratory,BarHarbor,ME2009 SpecialSymposiumpresentation,GrandOpeningofTheJacksonLaboratory-West,

Sacramento,CA2010 WorkshoponAnimalModelsforHumanStemCellTherapy,TheJacksonLaboratory,Bar

Harbor,ME2015 WorkshoponTechniquesinModelingHumanCancerinMice,TheJacksonLaboratory,Bar

Harbor,ME2015 Organizer,HumanizedMiceinTranslationalResearch:Cancer,DiabetesandBeyond,The

JacksonLaboratory,BarHarbor,ME2015-2018 AnnualShortCourseonMedicalandExperimentalMammalianGenetics,TheJackson

Laboratory,BarHarbor,ME2017-2020 HumanandMammalianGeneticsandGenomics:TheMcKusickShortCoursePOST-DOCTORALFELLOWS1987-1989 PeterA.Schweitzer1989-1991 JaneE.Disney1991-1993 SandraM.Hayes1993-1996 StephenC.Pelsue1993-1996 SeanMcKenna1997-2000 SyujiUmeda1998-2001 MelissaRelyea1999-2002 BonnieLyons2004-2005 MotonobuUeno2005-2009 ThomasChase2007-2009 MelissaCox2010-2014 VishnuV.Hosur


11

2013-2016 MohitVermaGRADUATESTUDENTS/COLLEGESTUDENTS/SUMMERSTUDENTS1973 PeterJ.Horneffer,SummerStudent1974 SusanB.Tarnofsky,SummerStudent1975 CarolJ.Wright,SummerStudent1976 DebbieR.Cooper,SummerStudent1976 CynthiaL.Sammis,SummerStudent1977 MaryEllenMcCarthy1978 RobertQ.Terrill,SummerStudent1980 RoseL.Glynne,SummerStudent1980 RoseLouiseMorello,SummerStudent1981 CarolineM.Haas1982 KathleenA.Kaiser-Rogers,SummerStudent1983 KellyK.Petrison1984 TracyElizabethGiordano,SummerStudent1985 KatherineS.Ullman,SummerStudent1986 GlennParadis,SummerStudent1987 CherylA.Skinner,SummerStudent1988 DavidW.Sehy,SummerStudent1988 JenniferWinslow,SummerStudent1989 EmilyMiyashita,SummerStudent1989 DeborahC.Pichler,SummerStudent1990 AlisonL.Barth,SummerStudent1990 PhilipE.Schaner,SummerStudent1991 HollySherburne,SummerStudent1992 GracianaLapetina,SummerStudent1993 TracM.Duong1994 GillianL.Beamer1995 MeenakshiH.Rajan1996 RachelC.Kidman2001 JaneJih2004 GinaM.MacMannis2006 AlexanderS.Burn2008 JenniferM.Wagner2009 EricaBrown2010 WilliamCheng2011 DeidreMichaud,SummerStudent2012 NoahV.Lupica,SummerStudent2013 ChantalBarksdale,SummerStudent2014 OliviaA.Baranowski,SummerStudent2014 PaulC.Macklis,SummerStudent


12

2015 JuliaL.Clemens,SummerStudent2016 CedricLozano,SummerStudent2018 AnaCastaner,SummerStudentPUBLICATIONS1. ShultzLD,WilderMS.1971.CytotoxicityofrabbitbloodforListeriamonocytogenes.InfectImmun4:

703-708.PMCID:PMC416377.2. ShultzLD,WilderMS.1973.FateofListeriamonocytogenesinnormalrabbitserum.InfectImmun7:

289-297.PMCID:PMC422672.3. GreenMC,ShultzLD.1975.Motheaten,animmunodeficientmutantofthemouse.I.Geneticsand

pathology.JHered66:250-258.4. GreenMC,ShultzLD,NedziLA.1975.Abnormalnuclearmorphologyofleukocytesinthemouse

mutantichthyosis.Transplantation20:172-175.5. ShultzLD,BaileyDW.1975.Geneticcontrolofcontactsensitivityinmice:EffectofH-2andnon-H-2

loci.Immunogenetics1:570-583.6. ShultzLD,GreenMC.1976.Motheaten,animmunodeficientmutantofthemouse.II.Depressed

immunecompetenceandelevatedserumimmunoglobulins.JImmunol116:936-943.7. ShultzLD,HeinigerHJ,EicherEM.1978.Immunopathologyofstreakermice,aremutationtonude

intheAKR/Jstrain.In:ComparativeandDevelopmentalAspectsofImmunityandDisease,GershwinME,CooperEL(eds).NewYork,PergamonPress,pp.211-222.

8. ShultzLD,SidmanCL,UnanueER.1978.Immunologicdysfunctionin"motheaten"mice:Immunodeficiency,autoimmunityandhyperimmunoglobulinemiainashort-livedmutant.In:AnimalModelsofComparativeandDevelopmentalAspectsofImmunityandDisease,GershwinME,CooperEL(eds).NewYork,PergamonPress,pp.260-269.

9. ShultzLD,ZurierRB.1978."Motheaten":Asinglegenemodelforstemcelldysfunctionandearlyonsetautoimmunity.In:GeneticControlofAutoimmuneDisease,RoseNR,BigazziP,WarnerN(eds).NewYork,Elsevier,pp.229-240.

10. SidmanCL,ShultzLD,UnanueER.1978.Themousemutant"motheaten."II.Functionalstudiesoftheimmunesystem.JImmunol121:2399-2404.

11. SidmanCL,ShultzLD,UnanueER.1978.Themousemutant"motheaten".I.Developmentoflymphocytepopulations.JImmunol121:2392-2398.

12. BedigianHG,ShultzLD,MeierH.1979.ExpressionofendogenousmurineleukemiavirusesinAKR/Jstreakermice.Nature279:434-436.

13. ShultzLD.1979.Mutantmousegenesaffectingdevelopmentoftheimmunesystem.In:InbredandGeneticallyDefinedStrainsofLaboratoryAnimals,AltmanPL,KatzDD(eds).Baltimore,MD,FederationofAmericanSocietiesforExperimentalBiology,pp.67-70.

14. ClarkEA,ShultzLD,PollackSB.1981.Mutationsinmicethatinfluencenaturalkiller(NK)cellactivity.Immunogenetics12:601-613.

15. GrzannaR,ShultzLD.1982.Thecontributionofmastcellstothehistaminecontentofthecentralnervoussystem:aregionalanalysis.LifeSci30:1959-1964.

16. JohnsonDA,ShultzLD,BedigianHG.1982.ImmunodeficiencyandreticulumcellsarcomainmicesegregatingforHRS/JandSJL/Jgenes.LeukRes6:711-720.

17. ShultzLD,BedigianHG,HeinigerHJ,EicherEM.1982.Thecongenitallyathymicstreakermouse.In:ProceedingsoftheThirdInternationalWorkshoponNudeMice,ReedND(ed).NewYork,FischerVerlag,pp.33-39.


13

18. ShultzLD,SweetHO,DavissonMT,ComanDR.1982.'Wasted',anewmutantofthemousewithabnormalitiescharacteristictoataxiatelangiectasia.Nature297:402-404.

19. LeiterEH,BeamerWG,ShultzLD.1983.Theeffectofimmunosuppressiononstreptozotocin-induceddiabetesinC57BL/KsJmice.Diabetes32:148-155.

20. ShultzLD,BaileyCL,ComanDR.1983.Hematopoieticstemcellfunctioninmotheatenmice.ExpHematol11:667-680.

21. ShultzLD,BedigianHG,CarlsonGA,ComanDR.1983.Effectofcongenitalathymiaonexpressionofpreleukemiccells.In:LeukemiaReviewsInternational,AdvancesinComparativeLeukemiaResearch,YohnDS(ed).NewYork,MarcelDekker,pp.225-226.

22. NordeenSK,SchaeferVG,EdgellMH,HutchisonCA,3rd,ShultzLD,SwiftM.1984.EvaluationsofwastedmousefibroblastsandSV-40transformedhumanfibroblastsasmodelsofataxiatelangiectasiainvitro.MutatRes140:219-222.

23. ShultzLD,BaileyCL,CarlsonGA,ComanDR,EvansR,OutzenHC.1984.Potentialof"viablemotheaten"miceforthegrowthoftumorxenografts.In:Immune-DeficientAnimals,SordatB(ed).Basel,Karger,pp.224-229.

24. ShultzLD,ComanDR,BaileyCL,BeamerWG,SidmanCL.1984."Viablemotheaten,"anewalleleatthemotheatenlocus.I.Pathology.AmJPathol116:(2)179-192.PMC1900532.

25. SidmanCL,MarshallJD,MasielloNC,RothsJB,ShultzLD.1984.NovelB-cellmaturationfactorfromspontaneouslyautoimmuneviablemotheatenmice.ProcNatlAcadSciUSA81:7199-7202.PMC392105.

26. SidmanCL,MarshallJD,ShultzLD,GrayPW,JohnsonHM.1984.g-interferonisoneofseveraldirectBcell-maturinglymphokines.Nature309:801-804.

27. GershwinME,ShultzL.1985.Mechanismsofgeneticallydeterminedimmunedysfunction.ImmunolToday6:36-37.

28. OutzenHC,CorrowD,ShultzLD.1985.AttenuationofexogenousmurinemammarytumorvirusvirulenceintheC3H/HeJmousesubstrainbearingtheLpsmutation.JNatlCancerInst75:917-923.

29. SidmanCL,ShultzLD,EvansR.1985.Aserum-derivedmoleculefromautoimmuneviablemotheatenmicepotentiatestheactionofaBcellmaturationfactor.JImmunol135:870-872.

30. GreinerDL,GoldschneiderI,KomschliesKL,MedlockES,BollumFJ,ShultzLD.1986.Defectivelymphopoiesisinthebonemarrowof"motheaten"(me/me)and"viablemotheaten"(mev/vev)mutantmice.I.Analysisofthedevelopmentofprothymocytes,earlyBlineagecells,andterminaldeoxynucleotidyltransferase-positivecells.JExpMed164:1129-1144.

31. HagiyaM,DavisDD,ShultzLD,SakanoH.1986.Non-germ-lineelements(NGE)arepresentintheTcellreceptor b-chaingenesisolatedfromthemutantmouse,motheaten(me/me).JImmunol136:2697-2700.

32. InoueT,AikawaK,TezukaH,KadaT,ShultzLD.1986.EffectofDNA-damagingagentsonisolatedspleencellsandlungfibroblastsfromthemousemutant"wasted,"aputativeanimalmodelforataxia-telangiectasia.CancerRes46:3979-3982.

33. InoueT,TezukaH,KadaT,AikawaK,ShultzLD.1986.Themousemutant"wasted":ananimalmodelforataxia-telangiectasia.BasicLifeSci39:323-335.

34. LeiterEH,ProchazkaM,ColemanDL,SerrezeDV,ShultzLD.1986.Geneticfactorspredisposingtodiabetessusceptibilityinmice.In:ImmunologyinDiabetes,MollnarGD,JaworskiMA(eds).NewYork,Elsevier,pp.28-38.

35. SidmanCL,ShultzLD,HardyRR,HayakawaK,HerzenbergLA.1986.ProductionofimmunoglobulinisotypesbyLy-1+Bcellsinviablemotheatenandnormalmice.Science232:1423-1425.


14

36. TezukaH,InoueT,NogutiT,KadaT,ShultzLD.1986.Evaluationofthemousemutant"wasted"asananimalmodelforataxiatelangiectasia.I.Age-dependentandtissue-specificeffects.MutatRes161:83-90.

37. KomschliesKL,GreinerDL,ShultzL,GoldschneiderI.1987.Defectivelymphopoiesisinthebonemarrowofmotheaten(me/me)andviablemotheaten(mev/mev)mutantmice.III.Normalmousebonemarrowcellsenablemev/mevprothymocytestogeneratethymocytesafterintravenoustransfer.JExpMed166:1162-1167.

38. LeiterEH,BeamerWG,ShultzLD,BarkerJE,LanePW.1987.Mousemodelsofgeneticdiseases.BirthDefectsOrigArticSer23:221-257.

39. LeiterEH,ProchazkaM,ShultzLD.1987.Effectofimmunodeficiencyondiabetogenesisingeneticallydiabetic(db/db)mice.JImmunol138:3224-3229.

40. MedlockES,GoldschneiderI,GreinerDL,ShultzL.1987.Defectivelymphopoiesisinthebonemarrowofmotheaten(me/me)andviablemotheaten(mev/mev)mutantmice.II.Descriptionofamicroenvironmentaldefectforthegenerationofterminaldeoxynucleotidyltransferase-positivebonemarrowcellsinvitro.JImmunol138:3590-3597.

41. ShultzLD.1987.Pleiotropicmutationscausingabnormalitiesinthemurineimmunesystemandtheskin.CurrProblDermatol17:236-250.

42. ShultzLD,ComanDR,LyonsBL,SidmanCL,TaylorS.1987.DevelopmentofplasmacytoidcellswithRussellbodiesinautoimmune"viablemotheaten"mice.AmJPathol127:38-50.PMCID:PMC1899601.

43. ShultzLD,RothsJS.1987.Euthymicmurinemodelsforimmunologicdysfunction.In:ImmuneDeficientAnimalsforBiomedicalResearch,RygaardJ,BrunnerN,GraemN(eds).NewYork,Karger,pp.1-14.

44. ShultzLD,SidmanCL.1987.Geneticallydeterminedmurinemodelsofimmunodeficiency.AnnuRevImmunol5:367-403.

45. WillisEH,CarsonDA,ShultzLD.1987.Adenosinedeaminaseactivityinrecipientsofbonemarrowfromimmunodeficientmicehomozygousforthewastedmutation.BiochemBiophysResCommun145:581-585.

46. BeamerWG,TennentBJ,ShultzKL,NadeauJH,ShultzLD,SkowLC.1988.Geneforovariangranulosacelltumorsusceptibility,Gct,inSWXJrecombinantinbredstrainsofmicerevealedbydehydroepiandrosterone.CancerRes48:5092-5095.

47. EvansR,DuffyTM,ShultzLD.1988.Theimmunologicalmousemutantsnude(nu)andrhino(hrrh)generatecytotoxiceffectorcellsfollowingadoptiveimmunotherapybutfailtorejectatransplantedtumor.CancerImmunolImmunother26:35-42.

48. HayashiS,WittePL,ShultzLD,KincadePW.1988.Lymphohemopoiesisincultureispreventedbyinteractionwithadherentbonemarrowcellsfrommutantviablemotheatenmice.JImmunol140:2139-2147.

49. McCuneJM,NamikawaR,KaneshimaH,ShultzLD,LiebermanM,WeissmanIL.1988.TheSCID-humouse:murinemodelfortheanalysisofhumanhematolymphoiddifferentiationandfunction.Science241:1632-1639.

50. SchweitzerPA,ShultzLD.1988.CharacterizationofMottcellhybridomasfromautoimmune"viablemotheaten"mutantmice.CurrTopMicrobiolImmunol137:223-226.

51. SerrezeDV,LeiterEH,WorthenSM,ShultzLD.1988.NODmarrowstemcellsadoptivelytransferdiabetestoresistant(NODxNON)F1mice.Diabetes37:252-255.

52. ShultzLD.1988.Pleiotropiceffectsofdeleteriousallelesatthe"motheaten"locus.CurrTopMicrobiolImmunol137:216-222.


15

53. BosmaGC,DavissonMT,RuetschNR,SweetHO,ShultzLD,BosmaMJ.1989.Themousemutationseverecombinedimmunedeficiency(scid)isonchromosome16.Immunogenetics29:54-57.

54. HaarJL,PoppJD,ShultzLD.1989.Defectiveinvitromigratorycapacityofbonemarrowcellsfromviablemotheatenmiceinresponsetonormalthymusculturesupernatants.ExpHematol17:21-24.

55. QuimbyFW,BosmaMJ,GoodRA,HansenCT,MyersDD,RichterCB,RothsJB,WortisHH,BrilesDE,DavissonMT,FernandesG,GreenMC,GuberskiDL,HaddadaH,HedrichHJ,KyogokuM,LanePW,LaskyJL,LeiterEH,RoderickTH,ShultzLD,ThorbeckeGJ.1989.ImmunodeficientRodents:AGuidetotheirImmunology,Husbandry,andUse.NationalAcademyPress.

56. ReedND,Hall-StoodleyLH,ShultzLD.1989.Mastcellproductionbyscid/scidmice:invivoandinvitrostudies.In:6thInternationalWorkshoponImmuneDeficientAnimalsinBiomedicalResearch,WuB-Q,ZhengJ(eds).pp.63-67.

57. ShultzLD.1989.Singlegenemodelsofimmunodeficiencydiseases.In:6thInternationalWorkshoponImmuneDeficientAnimalsinBiomedicalResearch,WuB-Q,ZhengJ(eds).pp.19-26.

58. ShultzLD,SchweitzerPA,HallEJ,SundbergJP,TaylorS,WalzerPD.1989.Pneumocystiscariniipneumoniainscid/scidmice.CurrTopMicrobiolImmunol152:243-249.

59. SundbergJP,BurnsteinT,ShultzLD,BedigianH.1989.IdentificationofPneumocystiscariniiinimmunodeficientmice.LabAnimSci39:213-218.

60. TennentBJ,BeamerWG,ShultzLD,AdamsonED.1989.EpidermalgrowthfactorreceptorsinspontaneousovariangranulosacelltumorsofSWR-derivedmice.IntJCancer44:477-482.

61. VanZantG,ShultzL.1989.Hematologicabnormalitiesoftheimmunodeficientmousemutant,viablemotheaten(mev).ExpHematol17:81-87.

62. WalzerPD,KimCK,LinkeMJ,PogueCL,HuerkampMJ,ChrispCE,LerroAV,WixsonSK,HallE,ShultzLD.1989.OutbreaksofPneumocystiscariniipneumoniaincoloniesofimmunodeficientmice.InfectImmun57:62-70.PMCID:PMC313041.

63. WillisEH,CarsonDA,ShultzLD.1989.Adenosinedeaminaseactivityinrecipientsofbonemarrowfromimmunodeficientmicehomozygousforthewastedmutation.AdvExpMedBiol253B:209-212.

64. CroitoruK,SteadRH,BienenstockJ,FulopG,HarnishDG,ShultzLD,JefferyPK,ErnstPB.1990.Presenceofintestinalintraepitheliallymphocytesinmicewithseverecombinedimmunodeficiencydisease.EurJImmunol20:645-651.

65. SerrezeDV,LeiterEH,ShultzLD.1990.TransplantationanalysisofBcelldestructionin(NODxCBA)F1mousebonemarrowchimeras.Diabetologia33:84-92.

66. SprecherE,BeckerY,KraalG,HallE,HarrisonD,ShultzLD.1990.EffectofagingonepidermaldendriticcellpopulationsinC57BL/6Jmice.JInvestDermatol94:247-253.

67. SprecherE,BeckerY,KraalG,HallE,ShultzLD.1990.EffectofgeneticallydeterminedimmunodeficiencyonepidermaldendriticcellpopulationsinC57BL/6Jmice.ArchDermatolRes282:188-193.

68. SundbergJP,BeamerWG,ShultzLD,DunstanRW.1990.Inheritedmousemutationsasmodelsofhumanadnexal,cornification,andpapulosquamousdermatoses.JInvestDermatol95:62S-63S.

69. YoshidaH,HayashiS,KunisadaT,OgawaM,NishikawaS,OkamuraH,SudoT,ShultzLD,NishikawaS.1990.Themurinemutationosteopetrosisisinthecodingregionofthemacrophagecolonystimulatingfactorgene.Nature345:442-444.

70. ChakrabortyNG,OkinoT,StabachP,PadulaS,YamaseY,MorseE,ShaafiR,TwardzikDR,ShultzLD,MukherjiB.1991.AdoptivetransferofactivatedautologousmacrophagesresultsinregressionoftransplantedhumanmelanomacellsinSCIDmice.InVivo5:609-614.


16

71. CroitoruK,SteadRH,BienenstockJ,ShultzLD,ErnstPB.1991.Tcellreceptorexpressionisnotrequiredforthelocalizationanddifferentiationofintraepitheliallymphocytes.ImmunolRes10:293-295.

72. DaviesTF,KimuraH,FongP,KendlerD,ShultzLD,ThungS,MartinA.1991.TheSCID-humouseandthyroidautoimmunity:characterizationofhumanthyroidautoantibodysecretion.ClinImmunolImmunopathol60:319-330.

73. GreinerDL,ShultzLD,RossiniAA,MordesJP,HandlerES,RajanTV.1991.RecapitulationofnormalandabnormalBBratimmunesystemdevelopmentinscidmouse/ratlymphohemopoieticchimeras.JClinInvest88:717-719.PMCID:PMC295424.

74. KolberDL,ShultzLD,RothsteinTL.1991.PhorbolesterresponsivenessofmurineLy-1-lineageBcellsfromnormalandviablemotheatenmutantmice.EurJImmunol21:721-729.

75. KooGC,ManyakCL,DaschJ,EllingsworthL,ShultzLD.1991.Suppressiveeffectsofmonocyticcellsandtransforminggrowthfactor-bonnaturalkillercelldifferentiationinautoimmuneviablemotheatenmutantmice.JImmunol147:1194-1200.

76. McCuneJM,KaneshimaH,KrowkaJ,NamikawaR,OutzenH,PeaultB,RabinL,ShihC,YeeE,LiebermanM,WeissmanIL,ShultzLD.1991.TheSCID-humouse:AsmallanimalmodelforHIVinfectionandpathogenesis.AnnRevImmunol9:399-429.

77. NaitoM,HayashiS,YoshidaH,NishikawaS,ShultzLD,TakahashiK.1991.Abnormaldifferentiationoftissuemacrophagepopulationsin'osteopetrosis'(op)micedefectiveintheproductionofmacrophagecolony-stimulatingfactor.AmJPathol139:657-667.PMCID:PMC1886220.

78. NelsonFK,GreinerDL,ShultzLD,RajanTV.1991.Theimmunodeficientscidmouseasamodelforhumanlymphaticfilariasis.JExpMed173:659-663.

79. SchweitzerPA,TaylorSE,ShultzLD.1991.Synthesisofabnormalimmunoglobulinsbyhybridomasfromautoimmune"viablemotheaten"mutantmice.JCellBiol114:35-43.

80. ShultzLD.1991.Hematopoiesisandmodelsofimmunodeficiency.SeminImmunol3:397-408.81. ShultzLD.1991.Immunologicalmutantsofthemouse.AmJAnat191:303-311.82. ShultzLD,LanePW,ComanDR,TaylorS,HallE,LyonsB,WoodBG,SchlagerG.1991.Hairpatches,a

singlegenemutationcharacterizedbyprogressiverenaldiseaseandalopeciainthemouse.Apotentialmodelforanewlydescribedheritablehumandisorder.LabInvest65:588-600.

83. SprecherE,ShultzLD,BeckerY.1991.Epidermaldendriticcellsinimmunodeficientmice.In:SkinLangerhans(Dentritic)CellsinVirusInfectionsandAIDS,BeckerY(ed).KluwerAcademicPublishers,pp.59-75.

84. SprecherE,ShultzLD,BeckerY.1991.EpidermaldendriticcellsinagedC57BL/6Jmice.In:SkinLangerhans(Dendritic)CellsinVirusInfectionsandAIDS,BeckerY(ed).KluwerAcademicPublishers,pp.99-117.

85. SundbergJP,ShultzLD.1991.Inheritedmousemutations:Modelsforthestudyofalopecia.JInvestDermatol91:95S-96S.

86. DisneyJE,BarthAL,ShultzLD.1992.Defectiverepairofradiation-inducedchromosomaldamageinscid/scidmice.CytogenetCellGenet59:39-44.

87. GreinerDL,RajanTV,ShultzLD.1992.Animalmodelsforimmunodeficiencydiseases.ImmunolToday13:116-117.

88. HayesSM,ShultzLD,GreinerDL.1992.Thymicinvolutioninviablemotheaten(mev)miceisassociatedwithalossofintrathymicprecursoractivity.DevImmunol2:191-205.PMCID:PMC2275861


17

89. MartinA,KimuraH,ThungS,FongP,ShultzLD,DaviesTF.1992.Characteristicsoflong-termhumanthyroidperoxidaseautoantibodysecretioninscidmicetransplantedwithlymphocytesfrompatientswithautoimmunethyroiditis.IntArchAllergyImmunol98:317-323.

90. NaitoM,HondaY,UmedaS,ShultzLD,TakahashiK.1992.Glucan-inducedgranulomaformationintheliverofosteopetrosis(op)andnude(nu)mutantmice.ProceedingsoftheSixthInternationalSymposiumonCellsoftheHepaticSinusoid.

91. OharaA,AnklesariaP,ShultzL,GreenbergerJS.1992.Isolationofpermanentclonalbonemarrowstromalcelllinesderivedfrom"viablemoth-eaten"and"severecombinedimmunodeficiency"mutantmice.IntJCellCloning10:33-46.

92. ProchazkaM,GaskinsHR,ShultzLD,LeiterEH.1992.Thenonobesediabeticscidmouse:modelforspontaneousthymomagenesisassociatedwithimmunodeficiency.ProcNatlAcadSciUSA89:3290-3294.PMCID:PMC48852.

93. RajanTV,NelsonFK,CuppE,ShultzLD,GreinerDL.1992.SurvivalofOnchocercavolvulusinnodulesimplantedinimmunodeficientrodents.JParasitol78:160-163.

94. RajanTV,NelsonFK,ShultzLD,KollerBH,GreinerDL.1992.CD8+Tlymphocytesarenotrequiredformurineresistancetohumanfilarialparasites.JParasitol78:744-746.

95. RajanTV,ShultzLD,GreinerDL.1992.Lackofperipherallyinducedtolerancetoestablishedskinallograftsinimmunologicallyreconstitutedscidmice.DevImmunol3:45-50.PMCID:PMC2275903

96. TakahashiK,NaitoM,ShultzLD.1992.DifferentiationofepidermalLangerhanscellsinmacrophagecolony-stimulating-factor-deficientmicehomozygousfortheosteopetrosis(op)mutation.JInvestDermatol99:46S-47S.

97. TakahashiK,NaitoM,ShultzLD.1992.Glucan-inducedgranulomaformationintheliverofosteopetrosis(op)micelackingmacrophagecolony-stimulatingactivity.Sarcoidosis9:293-294.

98. BeamerWG,ShultzKL,TennentBJ,ShultzLD.1993.Granulosacelltumorigenesisingeneticallyhypogonadal-immunodeficientmicegraftedwithovariesfromtumor-susceptibledonors.CancerRes53:3741-3746.

99. ChristiansonSW,ShultzLD,LeiterEH.1993.AdoptivetransferofdiabetesintoimmunodeficientNOD-scid/scidmice.RelativecontributionsofCD4+andCD8+T-cellsfromdiabeticversusprediabeticNOD.NON-Thy-1adonors.Diabetes42:44-55.

100. KapasiZF,BurtonGF,ShultzLD,TewJG,SzakalAK.1993.Inductionoffunctionalfolliculardendriticcelldevelopmentinseverecombinedimmunodeficiencymice.InfluenceofBandTcells.JImmunol150:2648-2658.

101. KapasiZF,BurtonGF,ShultzLD,TewJG,SzakalAK.1993.CellularrequirementsforfunctionalreconstitutionoffolliculardendriticcellsinSCIDmice.AdvExpMedBiol329:383-386.

102. KatohS,BendigMM,KanaiY,ShultzLD,HitoshiY,TakatsuK,TominagaA.1993.MaintenanceofCD5+Bcellsatanearlydevelopmentalstagebyinterleukin-5:evidencefromimmunoglobulingeneusageininterleukin-5transgenicmice.DNACellBiol12:481-491.

103. KooGC,RosenH,SirotinaA,MaXD,ShultzLD.1993.Anti-CD11bantibodypreventsimmunopathologicchangesinviablemoth-eatenbonemarrowchimericmice.JImmunol151:6733-6741.

104. MartinA,ValentineM,UngerP,LichtensteinC,SchwartzAE,FriedmanEW,ShultzLD,DaviesTF.1993.Preservationoffunctioninghumanthyroidorganoidsinthescidmouse:1.Systemcharacterization.JClinEndocrinolMetab77:305-310.

105. MatsuokaN,MartinA,ConcepcionES,UngerP,ShultzLD,DaviesTF.1993.Preservationoffunctioninghumanthyroidorganoidsinthescidmouse:II.BiaseduseofintrathyroidalTcellreceptorVgenes.JClinEndocrinolMetab77:311-315.


18

106. ShultzLD.1993.Mousemodelsofimmunodeficiencydiseases.ImmunolNews.107. ShultzLD,SchweitzerPA,RajanTV,YiT,IhleJN,MatthewsRJ,ThomasML,BeierDR.1993.Mutations

atthemurinemotheatenlocusarewithinthehematopoieticcellprotein-tyrosinephosphatase(Hcph)gene.Cell73:1445-1454.

108. SundbergJP,BoggessD,SundbergBA,BeamerWG,ShultzLD.1993.Epidermaldendriticcellpopulationsintheflakyskinmutantmouse.ImmunolInvest22:389-401.

109. Sundberg,LP,ShultzLD.1993.Severecombinedimmunodeficiency.CompPatholBull25:3-4.110. TakahashiK,NaitoM,MoriokaY,ShultzLD.1993.Immunophenotypicandultrastructural

differentiationandmaturationofnonlymphoiddendriticcellsinosteopetrotic(op)micewiththetotalabsenceofmacrophagecolonystimulatingfactor.AdvExpMedBiol329:293-297.

111. TakahashiK,NaitoM,ShultzLD,HayashiS,NishikawaS.1993.Differentiationofdendriticcellpopulationsinmacrophagecolony-stimulatingfactor-deficientmicehomozygousfortheosteopetrosis(op)mutation.JLeukocBiol53:19-28.

112. YeomanH,GressRE,BareCV,LearyAG,BoyseEA,BardJ,ShultzLD,HarrisDT,DeLucaD.1993.HumanbonemarrowandumbilicalcordbloodcellsgenerateCD4+andCD8+single-positiveTcellsinmurinefetalthymusorganculture.ProcNatlAcadSciUSA90:10778-10782.PMCID:PMC47861

113. DeRiuS,MartinA,ValentineM,ConcepcionES,ShultzLD,DaviesTF.1994.Graves'diseasethyroidtissuetransplantsinscidmice:persistentselectivityinhTcRVagenefamilyuse.Autoimmunity19:271-277.

114. GerlingIC,FriedmanH,GreinerDL,ShultzLD,LeiterEH.1994.Multiplelow-dosestreptozocin-induceddiabetesinNOD-scid/scidmiceintheabsenceoffunctionallymphocytes.Diabetes43:433-440.

115. HayesSM,ShultzLD,GreinerDL.1994.Localizationofprothymocytesfromwild-typeandviablemotheatenmicefollowingintravenousinjectionintoirradiatedadoptiverecipients.CellImmunol153:344-355.

116. KapasiZF,Kosco-VilboisMH,ShultzLD,TewJG,SzakalAK.1994.Cellularoriginoffolliculardendriticcells.AdvExpMedBiol355:231-235.

117. MartinA,ValentineM,UngerP,YeungSW,ShultzLD,DaviesTF.1994.Engraftmentofhumanlymphocytesandthyroidtissueintoscidandrag2-deficientmice:absentprogressionoflymphocyticinfiltration.JClinEndocrinolMetab79:716-723.

118. RajanTV,BailisJM,YatesJA,ShultzLD,GreinerDL,NelsonFK.1994.MaternalinfluenceonsusceptibilityofoffspringtoBrugiamalayiinfectioninamurinemodeloffilariasis.ActaTrop58:283-289.

119. RajanTV,NelsonFK,KilleenN,ShultzLD,YatesJA,BailisJM,LittmanDR,GreinerDL.1994.CD4+T-lymphocytesarenotrequiredformurineresistancetothehumanfilarialparasite,Brugiamalayi.ExpParasitol78:352-360.

120. RajanTV,NelsonFK,ShultzLD,ShultzKL,BeamerWG,YatesJ,GreinerDL.1994.InfluenceofgonadalsteroidsonsusceptibilitytoBrugiamalayiinscidmice.ActaTrop56:307-314.

121. SmithsonG,BeamerWG,ShultzKL,ChristiansonSW,ShultzLD,KincadePW.1994.IncreasedBlymphopoiesisingeneticallysexsteroid-deficienthypogonadal(hpg)mice.JExpMed180:717-720.

122. Szomolanyi-TsudaE,DundonPL,JorisI,ShultzLD,WodaBA,WelshRM.1994.Acute,lethal,naturalkillercell-resistantmyeloproliferativediseaseinducedbypolyomavirusinseverecombinedimmunodeficientmice.AmJPathol144:359-371.PMCID:PMC1887132.

123. TakahashiK,NaitoM,UmedaS,ShultzLD.1994.Theroleofmacrophagecolony-stimulatingfactorinhepaticglucan-inducedgranulomaformationintheosteopetrosismutantmousedefectiveinthe


19

productionofmacrophagecolony-stimulatingfactor.AmJPathol144:1381-1392.PMCID:PMC1887478.

124. TakahashiK,UmedaS,ShultzLD,HayashiS,NishikawaS.1994.Effectsofmacrophagecolony-stimulatingfactor(M-CSF)onthedevelopment,differentiation,andmaturationofmarginalmetallophilicmacrophagesandmarginalzonemacrophagesinthespleenofosteopetrosis(op)mutantmicelackingfunctionalM-CSFactivity.JLeukocBiol55:581-588.

125. UsudaH,NaitoM,UmedaS,TakahashiK,ShultzLD.1994.Ultrastructureofmacrophagesanddendriticcellsinosteopetrosis(op)mutantmicelackingmacrophagecolony-stimulatingfactor(M-CSF/CSF-1)activity.JSubmicroscCytolPathol26:111-119.

126. ValentineM,MartinA,UngerP,KatzN,ShultzLD,DaviesTF.1994.Preservationoffunctioninghumanthyroid"organoids"intheseverecombinedimmunodeficientmouse.III.Thyrotropinindependenceofthyroidfollicleformation.Endocrinology134:1225-1230.

127. WelshRM,O'DonnellCL,ShultzLD.1994.AntiviralactivityofNK1.1+naturalkillercellsinC57BL/6scidmiceinfectedwithmurinecytomegalovirus.NatImmun13:239-245.

128. BeamerWG,PelsueSC,ShultzLD,SundbergJP,BarkerJE.1995.Theflakyskin(fsn)mutationinmice:maplocationanddescriptionoftheanemia.Blood86:3220-3226.

129. BlazarBR,BrennanCA,BroxmeyerHE,ShultzLD,ValleraDA.1995.Transgenicmiceexpressingeitherbovinegrowthhormone(bGH)orhumanGHreleasinghormone(hGRH)haveincreasedsplenicprogenitorcellcolonyformationandDNAsynthesisinvitroandinvivo.ExpHematol23:1397-1406.

130. BuhlmannJE,FoyTM,AruffoA,CrassiKM,LedbetterJA,GreenWR,XuJC,ShultzLD,RoopenianD,FlavellRA,etal.1995.IntheabsenceofaCD40signal,Bcellsaretolerogenic.Immunity2:645-653.

131. DeLucaD,BluestoneJA,ShultzLD,SharrowSO,TatsumiY.1995.Programmeddifferentiationofmurinethymocytesduringfetalthymusorganculture.JImmunolMethods178:13-29.

132. GreinerDL,ShultzLD,YatesJ,AppelMC,PerdrizetG,HesseltonRM,SchweitzerI,BeamerWG,ShultzKL,PelsueSC,etal.1995.ImprovedengraftmentofhumanspleencellsinNOD/LtSz-scid/scidmiceascomparedwithC.B-17-scid/scidmice.AmJPathol146:888-902.PMCID:PMC1869266.

133. HesseltonRM,GreinerDL,MordesJP,RajanTV,SullivanJL,ShultzLD.1995.Highlevelsofhumanperipheralbloodmononuclearcellengraftmentandenhancedsusceptibilitytohumanimmunodeficiencyvirustype1infectioninNOD/LtSz-scid/scidmice.JInfectDis172:974-982.

134. LarochelleA,VormoorJ,LapidotT,SherG,FurukawaT,LiQ,ShultzLD,OlivieriNF,StamatoyannopoulosG,DickJE.1995.Engraftmentofimmune-deficientmicewithprimitivehematopoieticcellsfrom b-thalassemiaandsicklecellanemiapatients:implicationsforevaluatinghumangenetherapyprotocols.HumMolGenet4:163-172.

135. LubaroffDM,ShultzLD,BeamerWG.1995.SurvivalofhumanprostatetissuesandIL-2activatedlymphocytesinscidmice.Prostate27:32-41.

136. MooreJM,KumarN,ShultzLD,RajanTV.1995.Maintenanceofthehumanmalarialparasite,Plasmodiumfalciparum,inscidmiceandtransmissionofgametocytestomosquitoes.JExpMed181:2265-2270.

137. PelsueSC,SchweitzerPA,BeamerWG,ShultzLD.1995.Mappingoftheflakyskin(fsn)mutationondistalmousechromosome17.MammGenome6:758.

138. RajanTV,ShultzLD,YatesJ,GreinerDL.1995.Blymphocytesarenotrequiredformurineresistancetothehumanfilarialparasite,Brugiamalayi.JParasitol81:490-493.

139. RohanePW,ShimadaA,KimDT,EdwardsCT,CharltonB,ShultzLD,FathmanCG.1995.Islet-infiltratinglymphocytesfromprediabeticNODmicerapidlytransferdiabetestoNOD-scid/scidmice.Diabetes44:550-554.


20

140. SerrezeDV,LeiterEH,HansonMS,ChristiansonSW,ShultzLD,HesseltonRM,GreinerDL.1995.Emv30nullNOD-scidmice.Animprovedhostforadoptivetransferofautoimmunediabetesandgrowthofhumanlymphohematopoieticcells.Diabetes44:1392-1398.

141. ShultzLD,SchweitzerPA,ChristiansonSW,GottB,SchweitzerIB,TennentB,McKennaS,MobraatenL,RajanTV,GreinerDL,etal.1995.MultipledefectsininnateandadaptiveimmunologicfunctioninNOD/LtSz-scidmice.JImmunol154:180-191.

142. TakeokaY,WhitmerKJ,ChenSY,AnsariAA,BoydRL,ShultzLD,SuehiroS,GershwinME.1995.Thymicepithelialcellabnormalitiesin(NZBxH-2u)F1mice.ClinImmunolImmunopathol76:297-307.

143. ArakiM,FukumatsuY,KatabuchiH,ShultzLD,TakahashiK,OkamuraH.1996.Folliculardevelopmentandovulationinmacrophagecolony-stimulatingfactor-deficientmicehomozygousfortheosteopetrosis(op)mutation.BiolReprod54:478-484.

144. ChristiansonSW,GreinerDL,SchweitzerIB,GottB,BeamerGL,SchweitzerPA,HesseltonRM,ShultzLD.1996.RoleofnaturalkillercellsonengraftmentofhumanlymphoidcellsandonmetastasisofhumanT-lymphoblastoidleukemiacellsinC57BL/6J-scidmiceandinC57BL/6J-scidbgmice.CellImmunol171:186-199.

145. GreinerDL,ShultzLD,DelucaD,LeifJH,ChristiansonSW,HesseltonRM.1996.HIV-1infectivityofhumanTcellsinahuman/murinechimericfetalthymicorganculturesystem.InVivo10:33-37.

146. HeineD,PassmoreHC,PatelV,ShultzLD,Ward-BaileyP,CookSA,DavissonMT.1996.Effectofthemousescidmutationonmeioticrecombination.MammGenome7:497-500.

147. KunisadaT,YoshidaH,OgawaM,ShultzLD,NishikawaS-1.1996.Characterizationandisolationofmelanocyteprogenitorsfrommouseembryos.DevGrowthDiffer38:87-97.

148. LowryPA,ShultzLD,GreinerDL,HesseltonRM,KittlerEL,TiarksCY,RaoSS,ReillyJ,LeifJH,RamshawH,StewartFM,QuesenberryPJ.1996.ImprovedengraftmentofhumancordbloodstemcellsinNOD/LtSz-scid/scidmiceafterirradiationormultiple-dayinjectionsintounirradiatedrecipients.BiolBloodMarrowTransplant2:15-23.

149. NaitoM,UmedaS,TakahashiK,TakatsukaH,UsudaH,ItoS,UmezuH,ShultzLD.1996.Osteopetrotic(op/op)mice:Ananimalmodelforinvestigatingthebiologyofcolonystimulatingfactor-1(CSF-1/M-CSF).ActaMedBiol44:1-11.

150. NaitoM,UmedaS,YamamotoT,MoriyamaH,UmezuH,HasegawaG,UsudaH,ShultzLD,TakahashiK.1996.Development,differentiation,andphenotypicheterogeneityofmurinetissuemacrophages.JLeukocBiol59:133-138.

151. Noben-TrauthN,SchweitzerPA,JohnsonKR,WolfSF,KnowlesBB,ShultzLD.1996.Theinterleukin-12betasubunit(p40)mapstomousechromosome11.MammGenome7:392.

152. PflumioF,IzacB,KatzA,ShultzLD,VainchenkerW,CoulombelL.1996.Phenotypeandfunctionofhumanhematopoieticcellsengraftingimmune-deficientCB17-severecombinedimmunodeficiencymiceandnonobesediabetic-severecombinedimmunodeficiencymiceaftertransplantationofhumancordbloodmononuclearcells.Blood88:3731-3740.

153. PhillipsJA,RomballCG,HobbsMV,ErnstDN,ShultzL,WeigleWO.1996.CD4+TcellactivationandtoleranceinductioninBcellknockoutmice.JExpMed183:1339-1344.

154. RajanTV,GreinerDL,YatesJA,ShultzLD.1996.GrowthofthehumanfilarialparasiteBrugiamalayiinmicelackingmajorhistocompatibilitycomplexclassIIantigenexpression.ActaTrop61:267-271.

155. RajanTV,MooreJM,ShultzLD.1996.Immunodeficientmiceashostsforhemoparasiticinfections.ParasitolToday12:479-485.

156. RajanTV,PorteP,YatesJA,KeeferL,ShultzLD.1996.Roleofnitricoxideinhostdefenseagainstanextracellular,metazoanparasite,Brugiamalayi.InfectImmun64:3351-3353.PMCID:PMC174228


21

157. SchweitzerPA,Noben-TrauthN,PelsueSC,JohnsonKR,WolfSF,ShultzLD.1996.GeneticmappingoftheIL-12alphachaingene(Il12a)onmousechromosome3.MammGenome7:394-395.

158. SerrezeDV,ChapmanHD,VarnumDS,HansonMS,ReifsnyderPC,RichardSD,FlemingSA,LeiterEH,ShultzLD.1996.BlymphocytesareessentialfortheinitiationofTcell-mediatedautoimmunediabetes:analysisofanew"speedcongenic"stockofNOD.Igµnullmice.JExpMed184:2049-2053.

159. ShultzLD.1996.Singlegenemodelsofimmunodeficiencyandautoimmunedisease.In:Weir'sHandbookofExperimentalImmunology,5thEd.BlackwellScienceInc.,4:1-150.

160. TakeokaY,ChenSY,YagoH,BoydR,SuehiroS,ShultzLD,AnsariAA,GershwinME.1996.Themurinethymicmicroenvironment:changeswithage.IntArchAllergyImmunol111:5-12.

161. UmedaS,TakahashiK,NaitoM,ShultzLD,TakagiK.1996.Neonatalchangesofosteoclastsinosteopetrosis(op/op)micedefectiveinproductionoffunctionalmacrophagecolony-stimulatingfactor(M-CSF)proteinandeffectsofM-CSFonosteoclastdevelopmentanddifferentiation.JSubmicroscCytolPathol28:13-26.

162. UmedaS,TakahashiK,ShultzLD,NaitoM,TakagiK.1996.Effectsofmacrophagecolony-stimulatingfactoronmacrophagesandtheirrelatedcellpopulationsintheosteopetrosismousedefectiveinproductionoffunctionalmacrophagecolony-stimulatingfactorprotein.AmJPathol149:559-574.PMCID:PMC1865316.

163. VellaAT,SchererMT,ShultzLD,KapplerJW,MarrackP.1996.BcellsarenotessentialforperipheralTcelltolerance.ProcNatlAcadSciUSA93:951-955.

164. YoshidaH,HayashiS,ShultzLD,YamamuraK,NishikawaS,NishikawaS,KunisadaT.1996.Neuralandskincell-specificexpressionpatternconferredbysteelfactorregulatorysequenceintransgenicmice.DevDyn207:222-232.

165. ZhongRK,DonnenbergAD,ShultzLD,SwerdlowSH,LeeE,RubinJ,KoziiR,ChenJ,GriffinDL,WilsonJ,BallED.1996.Evaluationofmonoclonalantibody-mediatedanti-acutemyeloidleukemiaimmunotherapyinaSCID/humodel.LeukRes20:581-589.

166. AllayJA,DennisJE,HaynesworthSE,MajumdarMK,ClappDW,ShultzLD,CaplanAI,GersonSL.1997.LacZandinterleukin-3expressionInVivoafterretroviraltransductionofmarrow-derivedhumanosteogenicmesenchymalprogenitors.HumGeneTher8:1417-1427.

167. CashmanJD,LapidotT,WangJC,DoedensM,ShultzLD,LansdorpP,DickJE,EavesCJ.1997.Kineticevidenceoftheregenerationofmultilineagehematopoiesisfromprimitivecellsinnormalhumanbonemarrowtransplantedintoimmunodeficientmice.Blood89:4307-4316.

168. ChristiansonSW,GreinerDL,HesseltonRA,LeifJH,WagarEJ,SchweitzerIB,RajanTV,GottB,RoopenianDC,ShultzLD.1997.EnhancedhumanCD4+Tcellengraftmentin b2-microglobulin-deficientNOD-scidmice.JImmunol158:3578-3586.

169. HoganCJ,ShpallEJ,McNultyO,McNieceI,DickJE,ShultzLD,KellerG.1997.EngraftmentanddevelopmentofhumanCD34+-enrichedcellsfromumbilicalcordbloodinNOD/LtSz-scid/scidmice.Blood90:85-96.

170. JiaoH,YangW,BerradaK,TabriziM,ShultzL,YiT.1997.MacrophagesfrommotheatenandviablemotheatenmutantmiceshowincreasedproliferativeresponsestoGM-CSF:detectionofpotentialHCPsubstratesinGM-CSFsignaltransduction.ExpHematol25:592-600.

171. KochPJ,MahoneyMG,IshikawaH,PulkkinenL,UittoJ,ShultzL,MurphyGF,Whitaker-MenezesD,StanleyJR.1997.Targeteddisruptionofthepemphigusvulgarisantigen(desmoglein3)geneinmicecauseslossofkeratinocytecelladhesionwithaphenotypesimilartopemphigusvulgaris.JCellBiol137:1091-1102.


22

172. MarkeesTG,PhillipsNE,NoelleRJ,ShultzLD,MordesJP,GreinerDL,RossiniAA.1997.ProlongedsurvivalofmouseskinallograftsinrecipientstreatedwithdonorsplenocytesandantibodytoCD40ligand.Transplantation64:329-335.

173. MartinA,MatsuokaN,ZhangJ,ZhouA,NakashimaM,UngerP,SchwartzAE,FriedmanEW,ShultzLD,DaviesTF.1997.Preservationoffunctioninghumanthyroid"organoids"inthescidmouse.IV.InVivoselectionofanintrathyroidalTcellreceptorrepertoire.Endocrinology138:4868-4875.

174. NaitoM,UmedaS,TakahashiK,ShultzLD.1997.Macrophagedifferentiationandgranulomatousinflammationinosteopetroticmice(op/op)defectiveintheproductionofCSF-1.MolReprodDev46:85-91.

175. NakamuraMC,NiemiEC,FisherMJ,ShultzLD,SeamanWE,RyanJC.1997.MouseLy-49AinterruptsearlysignalingeventsinnaturalkillercellcytotoxicityandfunctionallyassociateswiththeSHP-1tyrosinephosphatase.JExpMed185:673-684.PMCID:PMC2196152.

176. NakayamaK,TakahashiK,ShultzLD,MiyakawaK,TomitaK.1997.Abnormaldevelopmentanddifferentiationofmacrophagesanddendriticcellsinviablemotheatenmutantmicedeficientinhaematopoieticcellphosphatase.IntJExpPathol78:245-257.

177. Noben-TrauthN,ShultzLD,BrombacherF,UrbanJF,Jr.,GuH,PaulWE.1997.Aninterleukin4(IL-4)-independentpathwayforCD4+TcellIL-4productionisrevealedinIL-4receptor-deficientmice.ProcNatlAcadSciUSA94:10838-10843.PMCID:PMC23501.

178. SerrezeDV,ChapmanHD,VarnumDS,GerlingI,LeiterEH,ShultzLD.1997.InitiationofautoimmunediabetesinNOD/LtmiceisMHCclassI-dependent.JImmunol158:3978-3986.

179. ShultzLD,RajanTV,GreinerDL.1997.SeveredefectsinimmunityandhematopoiesiscausedbySHP-1protein-tyrosine-phosphatasedeficiency.TrendsBiotechnol15:302-307.

180. SundbergJP,FranceM,BoggessD,SundbergBA,JensonAB,BeamerWG,ShultzLD.1997.Developmentandprogressionofpsoriasiformdermatitisandsystemiclesionsintheflakyskin(fsn)mousemutant.Pathobiology65:271-286.

181. TakedaK,HamelmannE,JoethamA,ShultzLD,LarsenGL,IrvinCG,GelfandEW.1997.Developmentofeosinophilicairwayinflammationandairwayhyperresponsivenessinmastcell-deficientmice.JExpMed186:449-454.PMCID:PMC2198995.

182. TakeokaY,ChenSY,BoydRL,TsuneyamaK,TaguchiN,MoritaS,YagoH,SuehiroS,AnsariAA,ShultzLD,GershwinME.1997.Acomparativeanalysisofthemurinethymicmicroenvironmentinnormal,autoimmune,andimmunodeficiencystates.DevImmunol5:79-89.PMCID:PMC2275982.

183. TapleyP,ShevdeNK,SchweitzerPA,GallinaM,ChristiansonSW,LinIL,SteinRB,ShultzLD,RosenJ,LambP.1997.IncreasedG-CSFresponsivenessofbonemarrowcellsfromhematopoieticcellphosphatasedeficientviablemotheatenmice.ExpHematol25:122-131.

184. ThrallRS,VogelSN,EvansR,ShultzLD.1997.Roleoftumornecrosisfactor-alphainthespontaneousdevelopmentofpulmonaryfibrosisinviablemotheatenmutantmice.AmJPathol151:1303-1310.PMCID:PMC1858072.

185. WesthoffCM,WhittierA,KatholS,McHughJ,ZajicekC,ShultzLD,WylieDE.1997.DNA-bindingantibodiesfromviablemotheatenmutantmice:ImplicationsforBcelltolerance.JImmunol159:3024-3033.

186. ZhuH,NaitoM,UmezuH,MoriyamaH,TakatsukaH,TakahashiK,ShultzLD.1997.Macrophagedifferentiationandexpressionofmacrophagecolony-stimulatingfactorinmurinemilkyspotsandmomentumaftermacrophageelimination.JLeukocBiol61:436-444.

187. BabuS,PorteP,KleiTR,ShultzLD,RajanTV.1998.HostNKcellsarerequiredforthegrowthofthehumanfilarialparasiteBrugiamalayiinmice.JImmunol161:1428-1432.


23

188. BrownBAII,LiY,BrownJC,HardinCC,RobertsJF,PelsueSC,ShultzLD.1998.Isolationandcharacterizationofamonoclonalanti-quadruplexDNAantibodyfromautoimmune"viablemotheaten"mice.Biochemistry37:16325-16337.

189. EvansR,ShultzLD,DranoffG,FullerJA,KamdarSJ.1998.CSF-1regulationofIl6geneexpressionbymurinemacrophages:apivotalroleforGM-CSF.JLeukocBiol64:810-816.

190. FoyTM,McIlraithM,MastersSR,DunnJJ,RossiniAA,ShultzLD,HesseltonRA,WagarEJ,LipskyPE,NoelleRJ,GreinerDL.1998.BlockadeofCD40-CD154interfereswithhumanTcellengraftmentinscidmice.CellTransplant7:25-35.

191. GordonEJ,MarkeesTG,PhillipsNE,NoelleRJ,ShultzLD,MordesJP,RossiniAA,GreinerDL.1998.Prolongedsurvivalofratisletandskinxenograftsinmicetreatedwithdonorsplenocytesandanti-CD154monoclonalantibody.Diabetes47:1199-1206.

192. GreinerDL,HesseltonRA,ShultzLD.1998.SCIDmousemodelsofhumanstemcellengraftment.StemCells16:166-177.

193. GreinerDL,ShultzLD.1998.UseofNOD/LtSz-scid/scidmiceinbiomedicalresearch.In:NODMiceandRelatedStrains:ResearchApplicationsinDiabetes,AIDS,Cancer,andotherDiseases,LeiterEH,AtkinsonMA(eds).LandesPublishing,pp.173-203.

194. HerbstLH,SundbergJP,ShultzLD,GrayBA,KleinPA.1998.Tumorigenicityofgreenturtlefibropapilloma-derivedfibroblastlinesinimmunodeficientmice.LabAnimSci48:162-167.

195. KapasiZF,QinD,KerrWG,Kosco-VilboisMH,ShultzLD,TewJG,SzakalAK.1998.Folliculardendriticcell(FDC)precursorsinprimarylymphoidtissues.JImmunol160:1078-1084.

196. KunisadaT,YoshidaH,YamazakiH,MiyamotoA,HemmiH,NishimuraE,ShultzLD,NishikawaS,HayashiS.1998.Transgeneexpressionofsteelfactorinthebasallayerofepidermispromotessurvival,proliferation,differentiationandmigrationofmelanocyteprecursors.Development125:2915-2923.

197. MarkeesTG,PhillipsNE,GordonEJ,NoelleRJ,ShultzLD,MordesJP,GreinerDL,RossiniAA.1998.Long-termsurvivalofskinallograftsinducedbydonorsplenocytesandanti-CD154antibodyinthymectomizedmicerequiresCD4+Tcells,interferon-gamma,andCTLA4.JClinInvest101:2446-2455.PMCID:PMC508834.

198. MiyamotoA,KunisadaT,YamazakiH,MiyakeK,NishikawaSI,SudoT,ShultzLD,HayashiSI.1998.Establishmentandcharacterizationofpro-BcelllinesfrommotheatenmutantmousedefectiveinSHP-1proteintyrosinephosphatase.ImmunolLett63:75-82.

199. NguyenVT,LeeTX,NdoyeA,ShultzLD,PittelkowMR,DahlMV,LynchPL,GrandoSA.1998.Thepathophysiologicalsignificanceofnondesmogleintargetsofpemphigusautoimmunity.Developmentofantibodiesagainstkeratinocytecholinergicreceptorsinpatientswithpemphigusvulgarisandpemphigusfoliaceus.ArchDermatol134:971-980.

200. PelsueSC,SchweitzerPA,SchweitzerIB,ChristiansonSW,GottB,SundbergJP,BeamerWG,ShultzLD.1998.Lymphadenopathy,elevatedserumIgElevels,autoimmunity,andmastcellaccumulationinflakyskinmutantmice.EurJImmunol28:1379-1388.

201. RajanTV,ShultzLD,BabuS,DoukasJ,GreinerD,PorteP.1998.Diethylcarbamazine(DEC)doesnotinducenitricoxide(NO)synthesis.ExpParasitol88:217-222.

202. RamirezM,RottmanGA,ShultzLD,CivinCI.1998.Maturehumanhematopoieticcellsindonorbonemarrowcomplicateinterpretationofstem/progenitorcellassaysinxenogeneichematopoieticchimeras.ExpHematol26:332-344.

203. SundbergJP,ShultzLD,KingLE,MontagutelliX.1998.Mousemodelsforpemphigusvulgaris.CompPathBull30:3-4.


24

204. TakahashiK,MiyakawaK,WynnAA,NakayamaK,MyintYY,NaitoM,ShultzLD,TominagaA,TakatsuK.1998.Effectsofgranulocyte/macrophagecolony-stimulatingfactoronthedevelopmentanddifferentiationofCD5-positivemacrophagesandtheirpotentialderivationfromaCD5-positiveB-celllineageinmice.AmJPathol152:445-456.PMCID:PMC1857972.

205. TakatsukaH,UmezuH,HasegawaG,UsudaH,EbeY,NaitoM,ShultzLD.1998.Boneremodelingandmacrophagedifferentiationinosteopetrosis(op)mutantmicedefectiveintheproductionofmacrophagecolony-stimulatingfactor.JSubmicroscCytolPathol30:239-247.

206. VuTN,LeeTX,NdoyeA,ShultzLD,PittelkowMR,DahlMV,LynchPJ,GrandoSA.1998.Thepathophysiologicalsignificanceofnondesmogleintargetsofpemphigusautoimmunity.Developmentofantibodiesagainstkeratinocytecholinergicreceptorsinpatientswithpemphigusvulgarisandpemphigusfoliaceus.ArchDermatol134:971-980.

207. YamadaG,NakamuraS,HaraguchiR,SakaiM,SuzukiK,MiyadoK,HasuwaH,OginoY,MinamiT,TohnoY,BlumM,ShultzLD.1998.Aberrantregulationofbonetraceelementsinmotheatenandosteopetrosismutantmice.CellMolBiol(Noisy-le-grand)44:315-319.

208. YangW,McKennaSD,JiaoH,TabriziM,LynesMA,ShultzLD,YiT.1998.SHP-1deficiencyinB-lineagecellsisassociatedwithheightenedlynproteinexpressionandincreasedlynkinaseactivity.ExpHematol26:1126-1132.

209. ZhongR-K,ShultzLD,SwerdlowSH,LeeE,ChenJ,JiangB,ElderE,WhitesideTL,BallED.1998.Bi-specificantibodytherapyofhumanAMLinaSCIDmousemodel.CanResTherCon5:67-76.

210. BabuS,ShultzLD,KleiTR,RajanTV.1999.Immunityinexperimentalmurinefilariasis:rolesofTandBcellsrevisited.InfectImmun67:3166-3167.PMCID:PMC96639.

211. BabuS,ShultzLD,RajanTV.1999.TcellsfacilitateBrugiamalayidevelopmentinTCR anullmice.ExpParasitol93:55-57.

212. ItoS,NaitoM,KobayashiY,TakatsukaH,JiangS,UsudaH,UmezuH,HasegawaG,ArakawaM,ShultzLD,ElomaaO,TryggvasonK.1999.Rolesofamacrophagereceptorwithcollagenousstructure(MARCO)inhostdefenseandheterogeneityofsplenicmarginalzonemacrophages.ArchHistolCytol62:83-95.

213. KolletO,AviramR,ChebathJ,ben-HurH,NaglerA,ShultzL,RevelM,LapidotT.1999.Thesolubleinterleukin-6(IL-6)receptor/IL-6fusionproteinenhancesinvitromaintenanceandproliferationofhumanCD34+CD38-/lowcellscapableofrepopulatingseverecombinedimmunodeficiencymice.Blood94:923-931.

214. LynesMA,RichardsonCA,McCabeR,CrowthersKC,LeeJC,YounJ,SchweitzerIB,ShultzLD.1999.Metallothionein-mediatedalterationsinautoimmunediseaseprocesses.In:MetallothioneinIV,KlassenC(ed).BirkhausserVerlagBasel,pp.437-444.

215. MarkeesTG,SerrezeDV,PhillipsNE,SorliCH,GordonEJ,ShultzLD,NoelleRJ,WodaBA,GreinerDL,MordesJP,RossiniAA.1999.NODmicehaveageneralizeddefectintheirresponsetotransplantationtoleranceinduction.Diabetes48:967-974.

216. MyintYY,MiyakawaK,NaitoM,ShultzLD,OikeY,YamamuraK,TakahashiK.1999.Granulocyte/macrophagecolony-stimulatingfactorandinterleukin-3correctosteopetrosisinmicewithosteopetrosismutation.AmJPathol154:553-566.PMCID:PMC1850013.

217. PeledA,PetitI,KolletO,MagidM,PonomaryovT,BykT,NaglerA,Ben-HurH,ManyA,ShultzL,LiderO,AlonR,ZiporiD,LapidotT.1999.DependenceofhumanstemcellengraftmentandrepopulationofNOD/SCIDmiceonCXCR4.Science283:845-848.

218. SaitoH,ShultzLD,SinhaM,PapaconstantinouJ.1999.Inductionofthe a1-antichymotrypsingeneinthebrainassociatedwithTGF-b1deficiencyorsystemicadministrationofendotoxin.BiochemBiophysResCommun263:270-275.


25

219. SchwarzeJ,CieslewiczG,HamelmannE,JoethamA,ShultzLD,LamersMC,GelfandEW.1999.IL-5andeosinophilsareessentialforthedevelopmentofairwayhyperresponsivenessfollowingacuterespiratorysyncytialvirusinfection.JImmunol162:2997-3004.

220. TaguchiN,HashimotoY,NaikiM,FarrAG,BoydRL,AnsariAA,ShultzLD,KotzinBL,DorshkindK,IkeharaS,GershwinME.1999.Abnormalthymicexpressionofepithelialcelladhesionmolecule(EP-CAM)inNewZealandBlack(NZB)mice.JAutoimmun13:393-404.

221. TakeokaY,TaguchiN,KotzinBL,BennettS,VyseTJ,BoydRL,NaikiM,KonishiJ,AnsariAA,ShultzLD,GershwinME.1999.ThymicmicroenvironmentandNZBmice:theabnormalthymicmicroenvironmentofNewZealandmicecorrelateswithimmunopathology.ClinImmunol90:388-398.

222. TakeokaY,TaguchiN,ShultzL,BoydRL,NaikiM,AnsariAA,GershwinME.1999.Apoptosisandthethymicmicroenvironmentinmurinelupus.JAutoimmun13:325-334.

223. TurgeonNA,IwakoshiN,MeyersWC,ShultzL,GreinerDL,MordesJP,RossiniAA..1999.Analysisofhumanimmuneresponsestohumanallograftsinsmallanimalmodels.SurgForum50:393-395.

224. UmedaS,BeamerWG,TakagiK,NaitoM,HayashiS,YonemitsuH,YiT,ShultzLD.1999.DeficiencyofSHP-1protein-tyrosinephosphataseactivityresultsinheightenedosteoclastfunctionanddecreasedbonedensity.AmJPathol155:223-233.PMCID:PMC1866654.

225. BabuS,GanleyLM,KleiTR,ShultzLD,RajanTV.2000.Roleofgammainterferonandinterleukin-4inhostdefenseagainstthehumanfilarialparasiteBrugiamalayi.InfectImmun68:3034-3035.PMCID:PMC97525.

226. BallenK,BeckerPS,GreinerD,ValinskiH,ShearinD,BerriosV,DoonerG,HsiehCC,WuuJ,ShultzL,CernyJ,LeifJ,StewartFM,QuesenberryP.2000.EffectofexvivocytokinetreatmentonhumancordbloodengraftmentinNOD-scidmice.BrJHaematol108:629-640.

227. HamelmannE,TakedaK,HaczkuA,CieslewiczG,ShultzL,HamidQ,XingZ,GauldieJ,GelfandEW.2000.Interleukin(IL)-5butnotimmunoglobulinEreconstitutesairwayinflammationandairwayhyperresponsivenessinIL-4-deficientmice.AmJRespirCellMolBiol23:327-334.

228. HashimotoY,DorshkindK,Montecino-RodriguezE,TaguchiN,ShultzL,GershwinME.2000.NZBmiceexhibitaprimaryTcelldefectinfetalthymicorganculture.JImmunol164:1569-1575.

229. JiangS,NaitoM,KaizuC,KuwataK,HasegawaG,MukaidaN,ShultzLD.2000.Lipopolysaccharide-inducedcytokineandreceptorexpressionandneutrophilinfiltrationintheliverofosteopetrosis(op/op)mutantmice.Liver20:465-474.

230. KolletO,MooreJG,AviramR,Ben-HurH,LiuBL,NaglerA,ShultzL,FeldmanM,LapidotT.2000.TheplantlectinFRILsupportsprolongedinvitromaintenanceofquiescenthumancordbloodCD34+CD38-/low/SCIDrepopulatingstemcells.ExpHematol28:726-736.

231. KolletO,PeledA,BykT,Ben-HurH,GreinerD,ShultzL,LapidotT.2000. b2microglobulin-deficient(B2mnull)NOD/SCIDmiceareexcellentrecipientsforstudyinghumanstemcellfunction.Blood95:3102-3105.

232. NguyenVT,NdoyeA,ShultzLD,PittelkowMR,GrandoSA.2000.Antibodiesagainstkeratinocyteantigensotherthandesmogleins1and3caninducepemphigusvulgaris-likelesions.JClinInvest106:1467-1479.PMCID:PMC387253.

233. PaciorkowskiN,PorteP,ShultzLD,RajanTV.2000.B1Blymphocytesplayacriticalroleinhostprotectionagainstlymphaticfilarialparasites.JExpMed191:731-736.PMCID:PMC2195839.

234. SasakiA,YokooH,NaitoM,KaizuC,ShultzLD,NakazatoY.2000.Effectsofmacrophage-colony-stimulatingfactordeficiencyonthematurationofmicrogliaandbrainmacrophagesandontheirexpressionofscavengerreceptor.Neuropathology20:134-142.


26

235. SchwarzeJ,CieslewiczG,JoethamA,IkemuraT,MakelaMJ,DakhamaA,ShultzLD,LamersMC,GelfandEW.2000.Criticalrolesforinterleukin-4andinterleukin-5duringrespiratorysyncytialvirusinfectioninthedevelopmentofairwayhyperresponsivenessafterairwaysensitization.AmJRespirCritCareMed162:380-386.

236. Shimada-HiratsukaM,NaitoM,KaizuC,ShuyingJ,HasegawaG,ShultzLD.2000.Defectivemacrophagerecruitmentandclearanceofapoptoticcellsintheuterusofosteopetroticmutantmicelackingmacrophagecolony-stimulatingfactor(M-CSF).JSubmicroscCytolPathol32:297-307.

237. ShultzLD,LangPA,ChristiansonSW,GottB,LyonsB,UmedaS,LeiterE,HesseltonR,WagarEJ,LeifJH,KolletO,LapidotT,GreinerDL.2000.NOD/LtSz-Rag1nullmice:animmunodeficientandradioresistantmodelforengraftmentofhumanhematolymphoidcells,HIVinfection,andadoptivetransferofNODmousediabetogenicTcells.JImmunol164:2496-2507.

238. SundbergJP,BoggessD,BascomC,LimbergBJ,ShultzLD,SundbergBA,KingLE,Jr.,MontagutelliX.2000.Lanceolatehair-J(lahJ):amousemodelforhumanhairdisorders.ExpDermatol9:206-218.

239. SundbergJP,BoggessD,ShultzLD,FijnemanRJA,DemantP,HogeneschH,CoxGA.2000.Thechronicproliferativedermatitismousemutation(cpdm):mappingofthemutantgenelocus.JExpAnimSci41:101-108.

240. TagayaH,KunisadaT,YamazakiH,YamaneT,TokuhisaT,WagnerEF,SudoT,ShultzLD,HayashiSI.2000.IntramedullaryandextramedullaryBlymphopoiesisinosteopetroticmice.Blood95:3363-3370.

241. TurgeonNA,IwakoshiNN,MeyersWC,DahlDM,ShultzLD,GreinerDL,RossiniAA.2000.Humanskinallograftrejectioninasmallanimalmodel.SurgForum41:348-350.

242. WagarEJ,CromwellMA,ShultzLD,WodaBA,SullivanJL,HesseltonRM,GreinerDL.2000.RegulationofhumancellengraftmentanddevelopmentofEBV-relatedlymphoproliferativedisordersinHu-PBL-scidmice.JImmunol165:518-527.

243. BallenKK,ValinskiH,GreinerD,ShultzLD,BeckerPS,HsiehCC,StewartFM,QuesenberryPJ.2001.Variablestopredictengraftmentofumbilicalcordbloodintoimmunodeficientmice:usefulnessofthenon-obesediabetic--severecombinedimmunodeficientassay.BrJHaematol114:211-218.

244. BanuelosSJ,TurgeonN,ShultzLD,HarlandRC,LyonsB,RossiniAA,GreinerDL,AppelMC.2001.HumanlymphocytereconstitutedNOD-scidB2MnullmicerejecthumanDR4transgenicNOD-scidmouseskin.SurgForum52:325-327.

245. DuezC,TomkinsonA,ShultzLD,BrattonDL,GelfandEW.2001.Fasdeficiencydelaystheresolutionofairwayhyperresponsivenessafterallergensensitizationandchallenge.JAllergyClinImmunol108:547-556.

246. GlimmH,EistererW,LeeK,CashmanJ,HolyoakeTL,NicoliniF,ShultzLD,vonKalleC,EavesCJ.2001.Previouslyundetectedhumanhematopoieticcellpopulationswithshort-termrepopulatingactivityselectivelyengraftNOD/SCID- b2microglobulin-nullmice.JClinInvest107:199-206.PMCID:PMC199177.

247. GordonEJ,WodaBA,ShultzLD,RossiniAA,GreinerDL,MordesJP.2001.Ratxenograftsurvivalinmicetreatedwithdonor-specifictransfusionandanti-CD154antibodyisenhancedbyeliminationofhostCD4+cells.Transplantation71:319-327.

248. GrandoSA,PittelkowMR,ShultzLD,DmochowskiM,NguyenVT.2001.Pemphigus:anunfoldingstory.JInvestDermatol117:990-995.

249. HsuHC,ShultzLD,SuX,ShiJ,YangPA,RelyeaMJ,ZhangHG,MountzJD.2001.Mutationofthehematopoieticcellphosphatase(Hcph)geneisassociatedwithresistanceto g-irradiation-inducedapoptosisinSrchomologyproteintyrosinephosphatase(SHP)-1-deficient"motheaten"mutantmice.JImmunol166:772-780.


27

250. JoliatMJ,ShultzLD.2001.Themolecularbasesofspontaneousimmunologicalmutationsinthemouseandtheirhomologoushumandiseases.ClinImmunol101:113-129.

251. NguyenVT,NdoyeA,BasslerKD,ShultzLD,ShieldsMC,RubenBS,WebberRJ,PittelkowMR,LynchPJ,GrandoSA.2001.Classification,clinicalmanifestations,andimmunopathologicalmechanismsoftheepithelialvariantofparaneoplasticautoimmunemultiorgansyndrome:areappraisalofparaneoplasticpemphigus.ArchDermatol137:193-206.

252. NystuenA,LegareME,ShultzLD,FrankelWN.2001.Anullmutationininositolpolyphosphate4-phosphatasetypeIcausesselectiveneuronallossinweeblemutantmice.Neuron32:203-212.

253. RossiMI,MedinaKL,GarrettK,KolarG,CompPC,ShultzLD,CapraJD,WilsonP,SchipulA,KincadePW.2001.RelativelynormalhumanlymphopoiesisbutrapidturnoverofnewlyformedBcellsintransplantednonobesediabetic/SCIDmice.JImmunol167:3033-3042.

254. SpencerL,ShultzL,RajanTV.2001.Interleukin-4receptor-Stat6signalinginmurineinfectionswithatissue-dwellingnematodeparasite.InfectImmun69:7743-7752.

255. TaguchiN,AnsariA,HsuT,HashimotoY,DorshkindK,ShultzL,NaikiM,GershwinME.2001.IncreasedexpressionofmXBP-1(TREB-5)inthymicBcellsinNewZealandmice.JAutoimmun16:401-410.

256. TaguchiN,HashimotoY,HsuT,AnsariAA,ShultzL,DorshkindK,IkeharaS,NaikiM,GershwinME.2001.BcellsareselectivelyassociatedwiththymiccorticalbutnotmedullarypathologyinNZBmice.JAutoimmun16:393-400.

257. ZhongRK,vandeWinkelJGJ,ThepenT,ShultzLD,BallED.2001.Cytotoxicityofanti-CD64-ricin:AchainimmunotoxinagainsthumanacutemyeloidleukemiacellsinvitroandinSCIDmice.JHematotherStemCellRes10:95-105.

258. ChristiansonSW,GreinerDL,DelucaD,LeifJ,PhillipsNE,HayesSM,HayashiS,JoliatMJ,LyonsBL,ShultzLD.2002.Tcelldevelopmentaldefectsin'viablemotheaten'micedeficientinSHP-1protein-tyrosinephosphatase.Developmentaldefectsarecorrectedinvitrointhepresenceofnormalhematopoietic-originstromalcellsandinvivobyexogenousIL-7.JAutoimmun18:119-130.

259. Dell'AgnolaC,RabascioC,MancusoP,CapilloM,PruneriG,GobbiA,MinucciS,RonzoniS,VolorioS,CalabreseL,TradatiN,MartinelliG,ShultzL,BertoliniF.2002.Invitroandinvivohematopoieticpotentialofhumanstemcellsresidinginmuscletissue.ExpHematol30:905-914.

260. HoffmannK,DregerCK,OlinsAL,OlinsDE,ShultzLD,LuckeB,KarlH,KapsR,MullerD,VayaA,AznarJ,WareRE,SoteloCruzN,LindnerTH,HerrmannH,ReisA,SperlingK.2002.MutationsinthegeneencodingthelaminBreceptorproduceanalterednuclearmorphologyingranulocytes(Pelger-Huëtanomaly).NatGenet31:410-414.

261. JoliatMJ,LangPA,LyonsBL,BurzenskiL,LynesMA,YiT,SundbergJP,ShultzLD.2002.AbsenceofCD5dramaticallyreducesprogressionofpulmonaryinflammatorylesionsinSHP-1protein-tyrosinephosphatase-deficient'viablemotheaten'mice.JAutoimmun18:105-117.

262. JoliatMJ,UmedaS,LyonsBL,LynesMA,ShultzLD.2002.Establishmentandcharacterizationofanewosteogeniccellline(MOS-J)fromaspontaneousC57BL/6Jmouseosteosarcoma.InVivo16:223-228.

263. KhannaKV,WhaleyKJ,ZeitlinL,MoenchTR,MehrazarK,ConeRA,LiaoZ,HildrethJE,HoenTE,ShultzL,MarkhamRB.2002.Vaginaltransmissionofcell-associatedHIV-1inthemouseisblockedbyatopical,membrane-modifyingagent.JClinInvest109:205-211.

264. LianZX,KitaH,OkadaT,HsuT,ShultzLD,DorshkindK,AnsariAA,IkeharaS,NaikiM,GershwinME.2002.Increasedfrequencyofpre-proBcellsinthebonemarrowofNewZealandBlack(NZB)mice:implicationsforadevelopmentalblockinBcelldifferentiation.DevImmunol9:35-45.PMCID:PMC2276087.


28

265. LianZX,OkadaT,KitaH,HsuT,ShultzLD,DorshkindK,AnsariAA,NaikiM,IkeharaS,GershwinME.2002.Age-relatedalterationsinthelymphohematopoieticandB-lineageprecursorpopulationsinNZBmice.StemCells20:293-300.

266. RajanTV,GanleyL,PaciorkowskiN,SpencerL,KleiTR,ShultzLD.2002.Brugianinfectionsintheperitonealcavitiesoflaboratorymice:kineticsofinfectionandcellularresponses.ExpParasitol100:235-247.

267. SasakiM,LongSA,VanDeWaterJ,HeXS,ShultzL,CoppelRL,AnsariA,NakanumaY,GershwinME.2002.TheSJL/JmouseisnotamodelforPBC.Hepatology35:1284-1286.

268. CapilloM,MancusoP,GobbiA,MonestiroliS,PruneriG,Dell'AgnolaC,MartinelliG,ShultzL,BertoliniF.2003.Continuousinfusionofendostatininhibitsdifferentiation,mobilization,andclonogenicpotentialofendothelialcellprogenitors.ClinCancerRes9:377-382.

269. HayashiS,YamadaT,TsunetoM,YamaneT,TakahashiM,ShultzLD,YamazakiH.2003.DistinctosteoclastprecursorsinthebonemarrowandextramedullaryorganscharacterizedbyresponsivenesstoToll-likereceptorligandsandTNF-a.JImmunol171:5130-5139.

270. JohnsonKR,LanePW,CookSA,HarrisBS,Ward-BaileyPF,BronsonRT,LyonsBL,ShultzLD,DavissonMT.2003.Curlybare(cub),anewmousemutationonchromosome11causingskinandhairabnormalities,andamodifiergene(mcub)onchromosome5.Genomics81:6-14.

271. KikuchiK,LianZX,HeXS,AnsariAA,IshibashiM,MiyakawaH,ShultzLD,IkeharaS,GershwinME.2003.AppearanceofhumanplasmacellsfollowingdifferentiationofhumanBcellsinNOD/SCIDmousespleen.ClinDevImmunol10:197-202.PMCID:PMC2485411.

272. LyonsBL,LynesMA,BurzenskiL,JoliatMJ,HadjoutN,ShultzLD.2003.MechanismsofanemiainSHP-1proteintyrosinephosphatase-deficient"viablemotheaten"mice.ExpHematol31:234-243.

273. PaciorkowskiN,ShultzLD,RajanTV.2003.PrimedperitonealBlymphocytesaresufficienttotransferprotectionagainstBrugiapahangiinfectioninmice.InfectImmun71:1370-1378.PMCID:PMC148870.

274. PearsonT,MarkeesTG,SerrezeDV,PierceMA,MarronMP,WickerLS,PetersonLB,ShultzLD,MordesJP,RossiniAA,GreinerDL.2003.Geneticdisassociationofautoimmunityandresistancetocostimulationblockade-inducedtransplantationtoleranceinnonobesediabeticmice.JImmunol171:185-195.

275. PearsonT,MarkeesTG,SerrezeDV,PierceMA,WickerLS,PetersonLB,ShultzLD,MordesJP,RossiniAA,GreinerDL.2003.Isletcellautoimmunityandtransplantationtolerance:twodistinctmechanisms?AnnNYAcadSci1005:148-156.

276. PearsonT,MarkeesTG,SerrezeDV,PierceMA,WickerLS,PetersonLB,ShultzLD,MordesJP,RossiniAA,GreinerDL.2003.GeneticseparationofthetransplantationtoleranceandautoimmunephenotypesinNODmice.RevEndocrMetabDisord4:255-261.

277. ShultzLD,BanuelosS,LyonsB,SamuelsR,BurzenskiL,GottB,LangP,LeifJ,AppelM,RossiniA,GreinerDL.2003.NOD/LtSz-Rag1nullPfpnullmice:anewmodelsystemwithincreasedlevelsofhumanperipheralleukocyteandhematopoieticstem-cellengraftment.Transplantation76:1036-1042.

278. ShultzLD,BanuelosSJ,LeifJ,AppelMC,CunninghamM,BallenK,BurzenskiL,GreinerDL.2003.Regulationofhumanshort-termrepopulatingcell(STRC)engraftmentinNOD/SCIDmicebyhostCD122+cells.ExpHematol31:551-558.

279. ShultzLD,LyonsBL,BurzenskiLM,GottB,SamuelsR,SchweitzerPA,DregerC,HerrmannH,KalscheuerV,OlinsAL,OlinsDE,SperlingK,HoffmannK.2003.MutationsatthemouseichthyosislocusarewithinthelaminBreceptorgene:asinglegenemodelforhumanPelger-Huëtanomaly.HumMolGenet12:61-69.


29

280. SpencerL,ShultzL,RajanTV.2003.TcellsarerequiredforhostprotectionagainstBrugiamalayibutneednotproduceorrespondtointerleukin-4.InfectImmun71:3097-3106.

281. TurgeonNA,BanuelosSJ,ShultzLD,LyonsBL,IwakoshiN,GreinerDL,MordesJP,RossiniAA,AppelMC.2003.Alloimmuneinjuryandrejectionofhumanskingraftsonhumanperipheralbloodlymphocyte-reconstitutednon-obesediabeticseverecombinedimmunodeficientbeta2-microglobulin-nullmice.ExpBiolMed(Maywood)228:1096-1104.

282. ZhouJ,ChenJ,MokotoffM,ZhongR,ShultzLD,BallED.2003.Bombesin/gastrin-releasingpeptidereceptor:apotentialtargetforantibody-mediatedtherapyofsmallcelllungcancer.ClinCancerRes9:4953-4960.

283. AppelMC,BanuelosSJ,GreinerDL,ShultzLD,MordesJP,RossiniAA.2004.Prolongedsurvivalofneonatalporcineisletxenograftsinmicetreatedwithadonor-specifictransfusionandanti-CD154antibody.Transplantation77:1341-1349.

284. BanuelosSJ,MarkeesTG,PhillipsNE,AppelMC,CuthbertA,LeifJ,MordesJP,ShultzLD,RossiniAA,GreinerDL.2004.RegulationofskinandisletallograftsurvivalinmicetreatedwithcostimulationblockadeismediatedbydifferentCD4+cellsubsetsanddifferentmechanisms.Transplantation78:660-667.

285. BanuelosSJ,ShultzLD,GreinerDL,BurzenskiLM,GottB,LyonsBL,RossiniAA,AppelMC.2004.RejectionofhumanisletsandhumanHLA-A2.1transgenicmouseisletsbyalloreactivehumanlymphocytesinimmunodeficientNOD-scidandNOD-Rag1nullPrf1nullmice.ClinImmunol112:273-283.

286. HayashiS,TsunetoM,YamadaT,NoseM,YoshinoM,ShultzLD,YamazakiH.2004.Lipopolysaccharide-inducedosteoclastogenesisinSrchomology2-domainphosphatase-1-deficientviablemotheatenmice.Endocrinology145:2721-2729.

287. IshikawaF,YasukawaM,YoshidaS,NakamuraK,NagatoshiY,KanemaruT,ShimodaK,ShimodaS,MiyamotoT,OkamuraJ,ShultzLD,HaradaM.2004.Humancordblood-andbonemarrow-derivedCD34+cellsregenerategastrointestinalepithelialcells.FasebJ18:1958-1960.

288. Kuzin,II,UgineGD,BarthRK,ShultzLD,NahmMH,YoungFM,BottaroA.2004.Anewmurinemodelofhumoralimmuno-deficiencyspecificallyaffectsclassswitchingtoT-independentantigens.EurJImmunol34:1807-1816.

289. MakatsoriD,KourmouliN,PolioudakiH,ShultzLD,McLeanK,TheodoropoulosPA,SinghPB,GeorgatosSD.2004.TheinnernuclearmembraneproteinlaminBreceptorformsdistinctmicrodomainsandlinksepigeneticallymarkedchromatintothenuclearenvelope.JBiolChem279:25567-25573.

290. MarkeesTG,PearsonT,CuthbertA,PearsonAL,ShultzLD,LeifJ,PhillipsNE,MordesJP,GreinerDL,RossiniAA.2004.Evaluationofdonor-specifictransfusionsources:uniquefailureofbonemarrowcellstoinduceprolongedskinallograftsurvivalwithanti-CD154monoclonalantibody.Transplantation78:1601-1608.

291. ParkJW,TaubeC,JoethamA,TakedaK,KodamaT,DakhamaA,McConvilleG,AllenCB,SfyroeraG,ShultzLD,LambrisJD,GiclasPC,HolersVM,GelfandEW.2004.Complementactivationiscriticaltoairwayhyperresponsivenessafteracuteozoneexposure.AmJRespirCritCareMed169:726-732.

292. PearsonT,WeiserP,MarkeesTG,SerrezeDV,WickerLS,PetersonLB,CumiskyAM,ShultzLD,MordesJP,RossiniAA,GreinerDL.2004.IsletallograftsurvivalinducedbycostimulationblockadeinNODmiceiscontrolledbyallelicvariantsofIdd3.Diabetes53:1972-1978.

293. TaubeC,WeiX,SwaseyCH,JoethamA,ZariniS,LivelyT,TakedaK,LoaderJ,MiyaharaN,KodamaT,ShultzLD,DonaldsonDD,HamelmannEH,DakhamaA,GelfandEW.2004.Mastcells,FceRI,andIL-13arerequiredfordevelopmentofairwayhyperresponsivenessafteraerosolizedallergenexposureintheabsenceofadjuvant.JImmunol172:6398-6406.


30

294. GordonEJ,WickerLS,PetersonLB,SerrezeDV,MarkeesTG,ShultzLD,RossiniAA,GreinerDL,MordesJP.2005.AutoimmunediabetesandresistancetoxenografttransplantationtoleranceinNODmice.Diabetes54:107-115.

295. HelmsC,PelsueS,CaoL,LambE,LoffredoB,Taillon-MillerP,HerrinB,BurzenskiLM,GottB,LyonsBL,KepplerD,ShultzLD,BowcockAM.2005.TheTetratricopeptiderepeatdomain7geneismutatedinflakyskinmice:amodelforpsoriasis,autoimmunity,andanemia.ExpBiolMed(Maywood)230:659-667.

296. HuangZ,ColemanJM,SuY,MannM,RyanJ,ShultzLD,HuangH.2005.SHP-1regulatesSTAT6phosphorylationandIL-4-mediatedfunctioninacelltype-specificmanner.Cytokine29:118-124.

297. IshikawaF,YasukawaM,LyonsB,YoshidaS,MiyamotoT,YoshimotoG,WatanabeT,AkashiK,ShultzLD,HaradaM.2005.DevelopmentoffunctionalhumanbloodandimmunesystemsinNOD/SCID/IL2receptorgchainnullmice.Blood106:1565-1573.PMCID:PMC1895228.

298. JaeschkeA,RinconM,DoranB,ReillyJ,NeubergD,GreinerDL,ShultzLD,RossiniAA,FlavellRA,DavisRJ.2005.DisruptionoftheJnk2(Mapk9)genereducesdestructiveinsulitisanddiabetesinamousemodeloftypeIdiabetes.ProcNatlAcadSciUSA102:6931-6935.PMCID:PMC1100789.

299. KawanoN,IshikawaF,ShimodaK,YasukawaM,NagafujiK,MiyamotoT,BabaE,TanakaT,YamasakiS,GondoH,OtsukaT,OhshimaK,ShultzLD,AkashiK,HaradaM.2005.EfficientengraftmentofprimaryadultT-cellleukemiacellsinnewbornNOD/SCID/ b-microglobulinnullmice.Leukemia19:1384-1390.

300. MacchiariniF,ManzMG,PaluckaAK,ShultzLD.2005.Humanizedmice:arewethereyet?JExpMed202:1307-1311.PMCID:PMC2212979.

301. MinamiguchiH,WingardJR,LaverJH,MainaliES,ShultzLD,OgawaM.2005.Anassayforhumanhematopoieticstemcellsbasedontransplantationintononobesediabeticrecombinationactivatinggene-nullperforin-nullmice.BiolBloodMarrowTransplant11:487-494.

302. ParkIK,ShultzLD,LetterioJJ,GorhamJD.2005.TGF- b1inhibitsT-betinductionbyIFN-ginmurineCD4+TcellsthroughtheproteintyrosinephosphataseSrchomologyregion2domain-containingphosphatase-1.JImmunol175:5666-5674.

303. ShultzLD,LyonsBL,BurzenskiLM,GottB,ChenX,ChaleffS,KotbM,GilliesSD,KingM,MangadaJ,GreinerDL,HandgretingerR.2005.HumanlymphoidandmyeloidcelldevelopmentinNOD/LtSz-scidIL2Rgnullmiceengraftedwithmobilizedhumanhemopoieticstemcells.JImmunol174:6477-6489.

304. UenoM,LyonsBL,BurzenskiLM,GottB,ShafferDJ,RoopenianDC,ShultzLD.2005.Acceleratedwoundhealingofalkali-burnedcorneasinMRLmiceisassociatedwithareducedinflammatorysignature.InvestOphthalmolVisSci46:4097-4106.

305. YoshidaS,IshikawaF,KawanoN,ShimodaK,NagafuchiS,ShimodaS,YasukawaM,KanemaruT,IshibashiH,ShultzLD,HaradaM.2005.Humancordblood--derivedcellsgenerateinsulin-producingcellsinvivo.StemCells23:1409-1416.

306. AdachiY,OyaizuH,TaketaniS,MinaminoK,YamaguchiK,ShultzLD,IwasakiM,TomitaM,SuzukiY,NakanoK,KoikeY,YasumizuR,SataM,HiramaN,KubotaI,FukuharaS,IkeharaS.2006.TreatmentandtransferofemphysemabyanewbonemarrowtransplantationmethodfromnormalmicetoTskmiceandviceversa.StemCells24:2071-2077.

307. IshikawaF,ShimazuH,ShultzLD,FukataM,NakamuraR,LyonsB,ShimodaK,ShimodaS,KanemaruT,NakamuraK,ItoH,KajiY,PerryAC,HaradaM.2006.Purifiedhumanhematopoieticstemcellscontributetothegenerationofcardiomyocytesthroughcellfusion.FasebJ20:950-952.

308. LyonsBL,SmithRS,HurdRE,HawesNL,BurzenskiLM,NusinowitzS,HashamMG,ChangB,ShultzLD.2006.DeficiencyofSHP-1protein-tyrosinephosphatasein"viablemotheaten"miceresultsinretinaldegeneration.InvestOphthalmolVisSci47:1201-1209.


31

309. MasakiH,AppelMC,LeahyL,LeifJ,PaquinL,ShultzLD,MordesJP,GreinerDL,RossiniAA.2006.Anti-mouseCD154antibodytreatmentfacilitatesgenerationofmixedxenogeneicrathematopoieticchimerism,preventswastingdiseaseandprolongsxenograftsurvivalinmice.Xenotransplantation13:224-232.

310. MikaelianI,HovickM,SilvaKA,BurzenskiLM,ShultzLD,Ackert-BicknellCL,CoxGA,SundbergJP.2006.Expressionofterminaldifferentiationproteinsdefinesstagesofmousemammaryglanddevelopment.VetPathol43:36-49.

311. TaubeC,MiyaharaN,OttV,SwansonB,TakedaK,LoaderJ,ShultzLD,TagerAM,LusterAD,DakhamaA,GelfandEW.2006.TheleukotrieneB4receptor(BLT1)isrequiredforeffectorCD8+Tcell-mediated,mastcell-dependentairwayhyperresponsiveness.JImmunol176:3157-3164.

312. ThornleyTB,BrehmMA,MarkeesTG,ShultzLD,MordesJP,WelshRM,RossiniAA,GreinerDL.2006.TLRagonistsabrogatecostimulationblockade-inducedprolongationofskinallografts.JImmunol176:1561-1570.

313. YoshinoM,YamazakiH,ShultzLD,HayashiS.2006.Constantrateofsteady-stateself-antigentraffickingfromskintoregionallymphnodes.IntImmunol18:1541-1548.

314. ZhouJ,ChenJ,ZhongR,MokotoffM,ShultzLD,BallED.2006.Targetinggastrin-releasingpeptidereceptorsonsmallcelllungcancercellswithabispecificmoleculethatactivatespolyclonalTlymphocytes.ClinCancerRes12:2224-2231.

315. DashY,RameshM,GreinerD,ShultzLD,KleiTR,RajanTV.2007.Determinantsofmemoryinexperimentalfilarialinfectionsinmice.ParasiteImmunol29:567-574.

316. IshikawaF,NiiroH,IinoT,YoshidaS,SaitoN,OnoharaS,MiyamotoT,MinagawaH,FujiiS,ShultzLD,HaradaM,AkashiK.2007.Thedevelopmentalprogramofhumandendriticcellsisoperatedindependentlyofconventionalmyeloidandlymphoidpathways.Blood110:3591-3660.PMCID:PMC2077309.

317. IshikawaF,YoshidaS,SaitoY,HijikataA,KitamuraH,TanakaS,NakamuraR,TanakaT,TomiyamaH,SaitoN,FukataM,MiyamotoT,LyonsB,OhshimaK,UchidaN,TaniguchiS,OharaO,AkashiK,HaradaM,ShultzLD.2007.Chemotherapy-resistanthumanAMLstemcellshometoandengraftwithinthebone-marrowendostealregion.NatBiotechnol25:1315-1321.

318. KingM,PearsonT,ShultzLD,LeifJ,BottinoR,TruccoM,AtkinsonM,WasserfallC,HeroldK,MordesJP,RossiniAA,GreinerDL.2007.Developmentofnew-generationHU-PBMC-NOD/SCIDmicetostudyhumanisletalloreactivity.AnnNYAcadSci1103:90-93.

319. MeyerroseTE,DeUgarteDA,HoflingAA,HerrbrichPE,CordonnierTD,ShultzLD,EagonJC,WirthlinL,SandsMS,HedrickMA,NoltaJA.2007.Invivodistributionofhumanadipose-derivedmesenchymalstemcellsinnovelxenotransplantationmodels.StemCells25:220-227.

320. RameshM,PaciorkowskiN,DashY,ShultzL,RajanTV.2007.AcutebutnotchronicmacrophagerecruitmentinfilarialinfectionsinmiceisdependentonC-Cchemokineligand2.ParasiteImmunol29:395-404.

321. SeymourRE,HashamMG,CoxGA,ShultzLD,HogeneschH,RoopenianDC,SundbergJP.2007.SpontaneousmutationsinthemouseSharpingeneresultinmultiorganinflammation,immunesystemdysregulationanddermatitis.GenesImmun8:416-421.

322. ShultzLD,IshikawaF,GreinerDL.2007.Humanizedmiceintranslationalbiomedicalresearch.NatRevImmunol7:118-130.

323. ShultzLD,PearsonT,KingM,GiassiL,CarneyL,GottB,LyonsB,RossiniAA,GreinerDL.2007.HumanizedNOD/LtSz-scidIL2receptorcommongammachainknockoutmiceindiabetesresearch.AnnNYAcadSci1103:77-89.


32

324. ThornleyTB,PhillipsNE,Beaudette-ZlatanovaBC,MarkeesTG,BahlK,BrehmMA,ShultzLD,Kurt-JonesEA,MordesJP,WelshRM,RossiniAA,GreinerDL.2007.Type1IFNmediatescross-talkbetweeninnateandadaptiveimmunitythatabrogatestransplantationtolerance.JImmunol179:6620-6629.

325. YamazakiM,PearsonT,BrehmMA,MillerDM,MangadaJA,MarkeesTG,ShultzLD,MordesJP,RossiniAA,GreinerDL.2007.Differentmechanismscontrolperipheralandcentraltoleranceinhematopoieticchimericmice.AmJTransplant7:1710-1721.

326. IshikawaF,SaitoY,YoshidaS,HaradaM,ShultzLD.2008.Thedifferentiativeandregenerativepropertiesofhumanhematopoieticstem/progenitorcellsinNOD-SCID/IL2rg gnullmice.CurrTopMicrobiolImmunol324:87-94.

327. KingM,PearsonT,ShultzLD,LeifJ,BottinoR,TruccoM,AtkinsonMA,WasserfallC,HeroldKC,WoodlandRT,SchmidtMR,WodaBA,ThompsonMJ,RossiniAA,GreinerDL.2008.AnewHu-PBLmodelforthestudyofhumanisletalloreactivitybasedonNOD-scidmicebearingatargetedmutationintheIL-2receptorgammachaingene.ClinImmunol126:303-314.

328. KongY,YoshidaS,SaitoY,DoiT,NagatoshiY,FukataM,SaitoN,YangSM,IwamotoC,OkamuraJ,LiuKY,HuangXJ,LuDP,ShultzLD,HaradaM,IshikawaF.2008.CD34+CD38+CD19+aswellasCD34+CD38-CD19+cellsareleukemia-initiatingcellswithself-renewalcapacityinhumanB-precursorALL.Leukemia22:1207-1213.

329. PearsonT,GreinerDL,ShultzLD.2008.Creationof"humanized"micetostudyhumanimmunity.CurrProtocImmunolChapter15:Unit1521.

330. PearsonT,GreinerDL,ShultzLD.2008.HumanizedSCIDmousemodelsforbiomedicalresearch.CurrTopMicrobiolImmunol324:25-51.

331. Simpson-AbelsonMR,SonnenbergGF,TakitaH,YokotaSJ,ConwayTF,Jr.,KelleherRJ,Jr.,ShultzLD,BarcosM,BankertRB.2008.Long-termengraftmentandexpansionoftumor-derivedmemoryTcellsfollowingtheimplantationofnon-disruptedpiecesofhumanlungtumorintoNOD-scidIL2RgnullMice.JImmunol180:7009-7018.

332. YamamotoT,KaizuC,KawasakiT,HasegawaG,UmezuH,OhashiR,SakuradaJ,JiangS,ShultzL,NaitoM.2008.Macrophagecolony-stimulatingfactorisindispensableforrepopulationanddifferentiationofKupffercellsbutnotforsplenicredpulpmacrophagesinosteopetrotic(op/op)miceaftermacrophagedepletion.CellTissueRes332:245-256.

333. GainesP,TienCW,OlinsAL,OlinsDE,ShultzLD,CarneyL,BerlinerN.2008.MouseneutrophilslackinglaminB-receptorexpressionexhibitaberrantdevelopmentandlackcriticalfunctionalresponses.ExpHematol36:965-976.PMCID:PMC2543941.

334. leViseurC,HotfilderM,BomkenS,WilsonK,RottgersS,SchrauderA,RosemannA,IrvingJ,StamRW,ShultzLD,HarbottJ,JurgensH,SchrappeM,PietersR,VormoorJ.2008.Inchildhoodacutelymphoblasticleukemia,blastsatdifferentstagesofimmunophenotypicmaturationhavestemcellproperties.CancerCell14:47-58.PMCID:PMC2572185.

335. PearsonT,ShultzLD,LiefJ,BurzenskiL,GottB,ChaseT,ForemanO,RossiniAA,BottinoR,TruccoM,GreinerDL.2008.AnewimmunodeficienthyperglycaemicmousemodelbasedontheIns2Akitamutationforanalysesofhumanisletandbetastemandprogenitorcellfunction.Diabetologia51:1449-1456.PMCID:PMC2719841.

336. GiassiLJ,PearsonT,ShultzLD,LaningJ,BiberK,KrausM,WodaBA,SchmidtMR,WoodlandRT,RossiniAA,GreinerDL.2008.ExpandedCD34+humanumbilicalcordbloodcellsgeneratemultiplelymphohematopoieticlineagesinNOD-scidIL2r gnullmice.ExpBiolMed(Maywood)233:997-1012.PMCID:PMC2757278.

337. KingM,PearsonT,RossiniAA,ShultzLD,GreinerDL.2008.Humanizedmiceforthestudyoftype1diabetesandbetacellfunction.AnnNYAcadSci1150:46-53.PMCID:PMC2620029.


33

338. PearsonT,ShultzLD,MillerD,KingM,LaningJ,FodorW,CuthbertA,BurzenskiL,GottB,LyonsB,ForemanO,RossiniAA,GreinerDL.2008.Non-obesediabetic-recombinationactivatinggene-1(NOD-Rag1null)interleukin(IL)-2receptorcommongammachain(IL2rgnull)nullmice:aradioresistantmodelforhumanlymphohaematopoieticengraftment.ClinExpImmunol154:270-284.PMCID:PMC2612717.

339. AglianoA,Martin-PaduraI,MancusoP,MarighettiP,RabascioC,PruneriG,ShultzLD,BertoliniF.2008.HumanacuteleukemiacellsinjectedinNOD/LtSz-scid/IL-2RgnullmicegenerateafasterandmoreefficientdiseasecomparedtootherNOD/scid-relatedstrains.IntJCancer123:2222-2227.

340. KumarP,BanHS,KimSS,WuH,PearsonT,GreinerDL,LaouarA,YaoJ,HaridasV,HabiroK,YangYG,JeongJH,LeeKY,KimYH,KimSW,PeippM,FeyGH,ManjunathN,ShultzLD,LeeSK,ShankarP.2008.Tcell-specificsiRNAdeliverysuppressesHIV-1infectioninhumanizedmice.Cell134:577-586.PMCID:PMC2943428.

341. IshikawaF,SaitoY,ShultzLD.2008.Modelinghumanleukemiausingimmune-compromisedmice.In:MouseModelsofHumanBloodCancers.,Li,S.(Ed).SpringerPress,NewYork.

342. CrokerBA,LawsonBR,RutschmannS,BergerM,EidenschenkC,BlasiusAL,MorescoEM,SovathS,CengiaL,ShultzLD,TheofilopoulosAN,PetterssonS,BeutlerBA.2008.InflammationandautoimmunitycausedbyaSHP1mutationdependonIL-1,MyD88,andamicrobialtrigger.ProcNatlAcadSciUSA105:15028-15033.PMCID:PMC2567487.

343. HarrisMA,YangH,LowBE,MukherjeeJ,GuhaA,BronsonRT,ShultzLD,IsraelMA,YunK.2008.Cancerstemcellsareenrichedinthesidepopulationcellsinamousemodelofglioma.CancerRes68:10051-10059.PMCID:PMC2841432.

344. MoriK,BlanchardF,CharrierC,BattagliaS,AndoK,DuplombL,ShultzLD,RediniF,HeymannD.2008.ConditionedmediafrommouseosteosarcomacellspromoteMC3T3-E1cellproliferationusingJAKsandPI3-K/Aktsignalcrosstalk.CancerSci99:2170-2176.

345. MangadaJ,PearsonT,BrehmMA,WickerLS,PetersonLB,ShultzLD,SerrezeDV,RossiniAA,GreinerDL.2009.IddlocisynergizetoprolongisletallograftsurvivalinducedbycostimulationblockadeinNODmice.Diabetes58:165-173.PMCID:PMC2606867.

346. SchmidtMR,AppelMC,GiassiLJ,GreinerDL,ShultzLD,WoodlandRT.2008.HumanBLySfacilitatesengraftmentofhumanPBLderivedBcellsinimmunodeficientmice.PLoSOne3:e3192.PMCID:PMC2527131.

347. ChopraP,DijorioP,PinoSC,WilsonSB,PhillipsNE,MordesJP,RossiniAA,GreinerDL,ShultzLD,BortellR.2009.Failureof a-galactosylceramidetopreventdiabetesinvirus-induciblemodelsoftype1diabetesintherat.InVivo23:195-201.PMCID:PMC2718559.

348. KingMA,CovassinL,BrehmMA,RackiW,PearsonT,LeifJ,LaningJ,FodorW,ForemanO,BurzenskiL,ChaseTH,GottB,RossiniAA,BortellR,ShultzLD,GreinerDL.2009.Humanperipheralbloodleucocytenon-obesediabetic-severecombinedimmunodeficiencyinterleukin-2receptorgammachaingenemousemodelofxenogeneicgraft-versus-host-likediseaseandtheroleofhostmajorhistocompatibilitycomplex.ClinExpImmunol157:104-118.PMCID:PMC2710598.

349. MillerDM,ThornleyTB,PearsonT,KrugerAJ,YamazakiM,ShultzLD,WelshRM,BrehmMA,RossiniAA,GreinerDL.2009.TLRagonistspreventtheestablishmentofallogeneichematopoieticchimerisminmicetreatedwithcostimulationblockade.JImmunol182:5547-5559.PMCID:PMC2721273.

350. JaiswalS,PearsonT,FribergH,ShultzLD,GreinerDL,RothmanAL,MathewA.2009.Denguevirusinfectionandvirus-specificHLA-A2restrictedimmuneresponsesinhumanizedNOD-scidIL2rgnullmice.PLoSOne4:e7251.PMCID:PMC2749937.

351. UnsingerJ,McDonoughJS,ShultzLD,FergusonTA,HotchkissRS.2009.Sepsis-inducedhumanlymphocyteapoptosisandcytokineproductionin“humanized”mice.JLeukocBiol86:219-227.PMCID:PMC2726769.


34

352. AnderssonA,BroselS,KnosallaC,ShultzLD,EggerD,VolkHD,Schmitt-KnosallaI.2010.AnalysisofthelymphoidsysteminNOD/LtSz-scidIL2R gnullmiceengraftedwithpurifiedcordbloodderivedstemcells.Journalofstemcells&regenerativemedicine6(2):91-92.

353. Jimenez-DiazMB,MuletT,VieraS,GomezV,GarutiH,IbanezJ,Alvarez-DovalA,ShultzLD,MartinezA,Gargallo-ViolaD,Angulo-BarturenI.2009.Improvedmurinemodelofmalariausingplasmodiumfalciparumcompetentstrainsandnon-myelodepletedNOD-scidIL2Rgnullmiceengraftedwithhumanerythrocytes.AntimicrobAgentsChemother53:4533-4536.PMCID:PMC2764183.

354. TianX,HexumMK,PenchevVR,TaylorRJ,ShultzLD,KaufmanDS.2009.Bioluminescentimagingdemonstratesthattransplantedhumanembryonicstemcell-derivedCD34+cellspreferentiallydevelopintoendothelialcells.StemCells27:2675-2685.PMCID:PMC2857550.

355. ChaseTH,CoxGA,BurzenskiL,ForemanO,ShultzLD.2009.Dysferlindeficiencyandthedevelopmentofcardiomyopathyinamousemodeloflimb-girdlemusculardystrophy2B.AmJPathol175:2299-2308.PMCID:PMC2789639.

356. ChaseTH,LyonsBL,BronsonRT,ForemanO,DonahueLR,BurzenskiLM,GottB,LaneP,HarrisB,CeglarekU,ThieryJ,WittenburgH,ThonJN,ItalianoJE,Jr.,JohnsonKR,ShultzLD.2010.Themousemutation"thrombocytopeniaandcardiomyopathy"(trac)disruptsAbcg5:aspontaneoussinglegenemodelforhumanhereditaryphytosterolemia/sitosterolemia.Blood.115:1267-1276.PMCID:PMC2826237.

357. BernsteinJM,BrooksSP,LehmanHK,PopeL,SandsA,ShultzLD,BankertRB.2009.HumannasalpolypmicroenvironmentsmaintainedinaviableandfunctionalstateasxenograftsinNOD-scidIL2 gnullmice.AnnOtolRhinolLaryngol.118:866-875.PMCID:PMC3005296.

358. SubramanyaS,KimSS,AbrahamS,YaoJ,KumarM,KumarP,HaridasV,LeeSK,ShultzL,GreinerD,ShankarMN,ShankarP.2010.TargeteddeliveryofsiRNAtohumandendriticcellstosuppressDengueviralinfectionandassociatedproinflammatorycytokineproduction.JVirology.84:2490-2501.PMCID:PMC2820933.

359. GoriJL,TianX,SwansonD,GuntherR,ShultzLD,McIvorRS,KaufmanDS.2010.Invivoselectionofhumanembryonicstemcell-derivedcellsexpressingmethotrexate-resistantdihydrofolatereductase.GeneTher.17:238-249.PMCID:PMC2820606.

360. PinoS,BrehmMA,Covassin-BarberisL,ChaseT,WagnerJmBurzenskiL,ForemanO,GreinerDL,ShultzLD.2010.DevelopmentofnovelmajorhistocompatibilitycomplexclassIandclassII-deficientNOD-SCIDIL2gammachainknockoutmiceformodelinghumanxenogeneicgraft-versus-hostdisease.MethodsMolBiol.602:105-17.

361. BrehmM,CuthbertA,YangC,MillerDM,DilorioP,LaningJ,BurzenskiL,ForemanO,KavirayaniA,HerlihyM,RossiniAA,ShultzLD,GreinerDL.2010.Parametersforestablishinghumanizedmousemodelstostudyhumanimmunity:AnalysisofhumanhematopoieticstemcellengraftmentinthreeimmunodeficientstrainsofmicebearingtheIL2rgnullmutation.ClinImmunol.135:84-98.PMCID:PMC2835837.

362. RackiWJ,CovassinL,BrehmM,PinoS,IgnotzR,DunnR,LaningJ,GravesSK,RossiniAA,ShultzLD,GreinerDL.2010.NOD-scidIL2rgnullmousemodelofhumanskintransplantationandallograftrejection.Transplantation.89:527-536.PMCID:PMC2901915.

363. BrehmMA,ShultzLD,GreinerDL.2010.Humanizedmousemodelstostudyhumandiseases.CurrOpinEndocrinolDiabetes.17:120-125.PMCID:PMC2892284.

364. SaitoY,UchidaN,TanakaS,SuzukiN,Tomizawa-MurasawaM,SoneA,NajimaY,TakagiS,AokiY,WakeA,TaniguchiS,ShultzLD,IshikawaF.2010.InductionofcellcycleentryeliminateshumanleukemiastemcellsinamousemodelofAML.NatBiotechnol.28:275-280.


35

365. SaitoY,KitamuraH,HijkataA,Tomizawa-MurasawaM,TanakaS,TakagiS,UchidaN,SuzukiN,SoneA,NajimaY,OzawaH,WakeA,TaniguchiS,ShultzLD,OharaO,IshikawaF.2010.Identificationoftherapeutictargetsforquiescent,chemotherapy-resistanthumanleukemiastemcells.SciTranslMed.2:17ra9.PMCID:PMC3005290.

366. ZhangB,StraussA,ChuS,MinL,HoY,ShiangKD,SnyderDS,HuettnerCS,ShultzLD,HolyoakeT,BhatiaR.2010.Effectivetargetingofquiescentchronicmyelogenousleukemiastemcellsbyhistonedeacetylaseinhibitorsincombinationwithimatinibmesylate.CancerCell17:427-442.PMCID:PMC2873971.

367. ShultzLD,SaitoY,NajimaY,TanakaS,OchiT,TomizawaM,DoiT,SoneA,SuzukiN,FujiwaraH,YasukawaM,IshikawaF.2010.GenerationoffunctionalhumanT-cellsubsetswithHLA-restrictedimmuneresponsesinHLAclassIexpressingNOD/SCID/IL2rgnullhumanizedmice.ProcNatlAcadSciUSA107:13022-13027.PMCID:PMC2919921.

368. BrehmMA,BortellR,DiiorioP,LeifJ,LaningJ,CuthbertA,YangC,HerlihyM,BurzenskiL,GottB,ForemanO,PowersAC,GreinerDL,ShultzLD.2010.HumanimmunesystemdevelopmentandrejectionofhumanisletallograftsinspontaneouslydiabeticNOD-Rag1nullIL2rɣnullIns2Akitamice.Diabetes59:2265-2270.PMCID:PMC2927949.

369. MorisotS,WayneAS,Bohana-KashtanOB,KaplanIM,HildrethR,GockeCD,Stetler-StevensonM,MeltzerPS,WheelanSJ,BrownP,ShultzLD,CivinCI.2010.HighfrequenciesofleukemiastemcellsinpooroutcomechildhoodprecursorBacuteLymphoblasticleukemias.Leukemia24:1859-66.PMCID:PMC3035974.

370. LibbySJ,BrehmMA,GreinerDL,ShultzLD,McClellandM,SmithKD,CooksonBT,KarlinseyJE,KinkelTL,PorwollikS,CanalsR,CummingsLA,FangFC.2010.Humanizednonobesediabetic-scidIL2rɣnullmicearesusceptibletolethalSalmonellaTyphiinfection.ProcNatlAcadSciUSA107:15589-15594.PMCID:PMC2932584.

371. ForemanO,KavirayaniAM,GriffeySM,ReaderR,ShultzLD.2011.OpportunisticbacterialinfectionsinbreedingcoloniesoftheNSGmousestrain.VetPathol48:495-499.PMCID:PMC3101569.

372. DorrellC,GrompeMT,PanFC,ZhongY,CanadayPS,ShultzLD,GreinerDL,WrightCV,StreeterPR,GrompeM.2011.Isolationofmousepancreaticalpha,beta,ductandacinarpopulationswithcellsurfacemarkers.MolCellEndocrinol339:144-150.PMCID:PMC3112273.

373. RobinsonSN,SimmonsPJ,ThomasMW,BrouardN,JavniJA,TrilokS,ShimJS,YangH,SteinerD,DeckerWK,XingD,ShultzLD,SavoldoB,DottiG,BollardCM,MillerL,ChamplinRE,ShpallEJ,Zweidler-McKayPA.2012.ExvivofucosylationimproveshumancordbloodengraftmentinNOD-SCIDIL-2R gnullmice.ExpHematol40(6):445-456.PMCID:PMC3352960.

374. DiiorioP,JurczykA,YangC,RackiWJ,BrehmMA,AtkinsonMA,PowersAC,ShultzLD,GreinerDL,BortellR.2011.Hyperglycemia-InducedProliferationofAdultHumanBetaCellsEngraftedIntoSpontaneouslyDiabeticImmunodeficientNOD-Rag1nullIL2rgnullIns2AkitaMice.Pancreas40:1147-1149.PMCID:PMC3176417.

375. DashY,RameshM,KalyanasundaramR,MunirathinamG,ShultzLD,RajanTV.2011.GranulomaformationaroundFilarialLarvaetriggeredbyhostresponsestoanExcretory/Secretoryantigen.InfectImmun79:838-845.PMCID:PMC3028858.

376. MoriceauG,OryB,MitrofanL,RigantiC,BlanchardF,BrionR,CharrierC,BattagliaS,PiletP,DenisM,ShultzLD,MonkkonenJ,RediniF,HeymannD.2010.ZoledronicacidpotentiatesmTORinhibitionandabolishestheresistanceofosteosarcomacellstoRAD001(Everolimus):pivotalroleoftheprenylationprocess.CancerRes70:10329-10339.PMCID:PMC3097388.

377. CovassinL,LaningJ,AbdiR,LangevinDL,PhillipsNE,ShultzLD,andBrehmMA.2011.HumanperipheralbloodCD4Tcell-engraftedNOD-scidIL2rγnullAb1tm1GruTg(humanleucocyteantigenD-


36

related4)mice:Amousemodelofhumanallogeneicgraft-versus-hostdisease.ClinExpImmunol166:269-280.PMCID:PMC3219902.

378. LiuG,DouS,ChengD,LeifJ,RusckowskiM,StreeterPR,ShultzLD,HnatowichDJ,GreinerDL.2011.HumanisletcellMORF/cMORFpretargetinginaxenogeneicmurinetransplantmodel.MolPharm8:767-773.PMCID:PMC3109173.

379. Whitfield-LarryF,YoungEF,TalmageG,FudgeE,AzamA,PatelS,LargayJ,ByrdW,BuseJ,CalikogluAS,ShultzLD,FrelingerJA.2011.HLA-A2-matchedperipheralbloodmononuclearcellsfromType1Diabeticpatients,butnotnondiabeticdonors,transferinsulitistoNOD-scid/ɣcnull/HLA-A2transgenicmiceconcurrentwiththeexpansionofislet-specificCD8+Tcells.Diabetes60:1726-1733.PMCID:PMC3114397.

380. ZhaoL,SpassievaSD,JuciusTJ,ShultzLD,ShickHE,MacklinWB,HannunYA,ObeidLM,AckermanSL.2011.Adeficiencyofceramidebiosynthesiscausescerebellarpurkinjecellneurodegenerationandlipofuscinaccumulation.PLoSGenet7:e1002063.PMCID:PMC3098191.

381. BankertRB,Balu-IyerSV,OdunsiK,ShultzLD,KelleherRJ,Jr.,BarnasJL,Simpson-AbelsonM,ParsonsR,YokotaSJ.2011.Humanizedmousemodelofovariancancerrecapitulatespatientsolidtumorprogression,ascitesformation,andmetastasis.PLoSOne6:e24420.PMCID:PMC3174163.

382. SchleifmanEB,BindraR,LeifJ,DelCampoJ,RogersFA,UchilP,KutschO,ShultzLD,KumarP,GreinerDL,GlazerPM.2011.TargetedDisruptionoftheCCR5GeneinHumanHematopoieticStemCellsStimulatedbyPeptideNucleicAcids.ChemBiol18:1189-1198.PMCID:PMC3183429.

383. LiuG,DouS,AkalinA,RusckowskiM,StreeterPR,ShultzLD,GreinerDL.2012.Pretargetingvs.directtargetingofhumanbetalox5isletcellssubcutaneouslyimplantedinmiceusingananti-humanisletcellantibody.NuclMedBiol39:645-651.PMCID:PMC3361517.

384. ZhangB,LiM,McDonaldT,HolyoakeTL,MoonRT,CampanaD,ShultzL,BhatiaR.2013.MicroenvironmentalprotectionofCMLstemandprogenitorcellsfromtyrosinekinaseinhibitorsthroughN-cadherinandWnt-b-cateninsignaling.Blood121(10):1824-1838.PMCID:PMC3591802

385. ShultzLD,BrehmMA,BavariS,GreinerDL.2011.Humanizedmiceasapreclinicaltoolforinfectiousdiseaseandbiomedicalresearch.AnnNYAcadSci1245:50-54.

386. GreinerDL,BrehmMA,HosurV,HarlanDM,PowersAC,ShultzLD.2011.Humanizedmiceforthestudyoftype1andtype2diabetes.AnnNYAcadSci1245:55-58.PMCID:PMC3384500

387. JaiswalS,PazolesP,WodaM,ShultzLD,GreinerDL,BrehmMA,MathewA.2012.EnhancedhumoralandHLA-A2-restricteddenguevirus-specificTcellresponsesinhumanizedBLTNSGmice.Immunology136(3):334-343.PMCID:PMC3385033.

388. DuyneRV,NarayananA,Kehn-HallK,SaifuddinM,ShultzL,KashanchiF.2011.HumanizedmousemodelsofHIV-1latency.CurrHIVRes9:595-605.Review.

389. BrehmMA,RackiWJ,LeifJ,BurzenskiL,HosurV,WetmoreA,GottB,HerlihyM,IgnotzR,DunnR,ShultzLD,GreinerDL.2012.EngraftmentofhumanHSCinnon-irradiatednewbornNOD-scidIL2rɣnullmiceisenhancedbytransgenicexpressionofmembrane-boundhumanSCF.Blood119:2778-2788.PMCID:PMC3327456.

390. TakagiS,SaitoY,HijikataA,TanakaS,WatanabeT,HasegawaT,MochizukiS,KunisawaJ,KiyonoH,KosekiH,OharaO,SaitoT,TaniguchiS,ShultzLD,IshikawaF.2012.Membrane-boundhumanSCF/KLpromotesinvivohumanhematopoieticengraftmentandmyeloiddifferentiation.Blood119(12):2768-2777.PMCID:PMC3327455.

391. BrehmMA,ShultzLD.2012.Humanallograftrejectioninhumanizedmice:ahistoricalperspective.CellMolImmunol9(3):225-231.Review.


37

392. BrehmMA,PowersAC,ShultzLD,GreinerDL.2012.Advancinganimalmodelsofhumantype1diabetesbyengraftmentoffunctionalhumantissuesinimmunodeficientmice.ColdSpringHarbPerspectMed2(5):a007757.PMCID:PMC3331686.

393. LiM,ZhouM,GongM,MaJ,PeiF,BeamerWG,ShultzLD,HockJM,YuX.2012.Anovelanimalmodelforbonemetastasisinhumanlungcancer.OncologyLetters3(4):802-806.PMCID:PMC3362336.

394. RobinsonSN,SimmonsPJ,ThomasMW,BrouardN,JavniJA,TrilokS,ShimJS,YangH,SteinerD,DeckerWK,XingD,ShultzLD,SavoldoB,DottiG,BollardCM,MillerL,ChamplinRE,ShpallEJ,Zweidler-McKayPA.2012.ExvivofucosylationimproveshumancordbloodengraftmentinNOD-SCIDIL-2R gnullmice.ExpHematol.;40(6):445-56.PMCID:PMC3352960.

395. IppolitoGC,HoiKH,ReddyST,CarrollSM,GeX,RogoschT,ZemlinM,ShultzLD,EllingtonAD,VandenbergCL,GeorgiouG.2012.AntibodyrepertoiresinhumanizedNOD-scid-IL2RɣnullmiceandhumanBcellsrevealshuman-likediversificationandtolerancecheckpointsinthemouse.PLoSOne7:e35497.PMCID:PMC3338711.

396. TanakaS,SaitoY,KunisawaJ,KurashimaY,WakeT,SuzukiN,ShultzLD,KiyonoH,IshikawaF.2012.Developmentofmatureandfunctionalhumanmyeloidsubsetsinhematopoieticstemcell-engraftedNOD/SCID/IL2rɣKOmice.JImmunol188(12):6145-6155.PMCID:PMC3370073.

397. HosurV,KavirayaniA,RieflerJ,CarneyLMB,LyonsB,GottB,CoxGA,ShultzLD.2012.Dystrophinanddysferlindoublemutantmice:anovelmodelforrhabdomyosarcoma.CancerGenetics205(5):232-241.PMCID:PMC3372852.

398. BernsteinJM,LehmanH,LisM,SandsA,WildingGE,ShultzL,BankertR,BobekL.2012.HumanizedmousemodelusedtomonitorMUCgeneexpressioninnasalpolypsandtopreclinicallyevaluatetheefficacyofmontelukastinreducingmucusproduction.AnnOtolRhinolLaryngol121(5):307-316.PMCID:PMC3621975.

399. HosurV,CoxML,BurzenskiLM,RidingRL,AlleyL,LyonsBL,KavirayaniA,MartinKA,CoxGA,JohnsonKR,ShultzLD.2013.RetrotransposoninsertionintheT-cellacutelymphocyticleukemia1(Tal1)geneisassociatedwithsevererenaldiseaseandpatchyalopeciainhairpatches(Hpt)mice.PLoSOne8(1):e53426.PMCID:PMC3534690.

400. SaitoY,YukiH,KurataniM,HashizumeY,TakagiS,HonmaT,TanakaA,ShirouzuM,MikuniJ,HandaN,OgaharaI,SoneA,NajimaY,TomabechiY,WakiyamaM,UchidaN,Tomizawa-MurasawaM,KanekoA,TanakaS,SuzukiN,KajitaH,AokiY,OharaO,ShultzLD,FukamiT,GotoT,TaniguchiS,YokoyamaS,IshikawaF.2013.APyrrolo-PyrimidineDerivativeTargetsHumanPrimaryAMLStemCellsinVivo.SciTranslMed5(181):181ra152.

401. TanakaT,FujitaY,UenoM,ShultzLD,YamashitaT.2013.SuppressionofSHP-1promotescorticospinaltractsproutingandfunctionalrecoveryafterbraininjury.CellDeathDis4:e567.PMCID:PMC3641325.

402. UngerWW,PearsonT,AbreuJR,LabanS,vanderSlikAR,derKrachtSM,KesterMG,SerrezeDV,ShultzLD,GriffioenM,DrijfhoutJW,GreinerDL,RoepBO.2012.Islet-specificCTLclonedfromatype1diabetespatientcausebeta-celldestructionafterengraftmentintoHLA-A2transgenicNOD/SCID/IL2RGnullmice.PLoSOne7:(11)e49213.PMCID:PMC3498321.

403. GuendelI,IordanskiyS,VanDuyneR,Kehn-HallK,SaifuddinM,DasR,JaworskiE,SampeyGC,SeninaS,ShultzL,NarayananA,ChenH,LepeneB,ZengC,KashanchiF.2014.NovelNeuroprotectiveGSK-3bInhibitorRestrictsTat-MediatedHIV-1Replication.JVirol88(2):1189-1208.PMCID:PMC3911635.

404. ShultzLD,BrehmMA,Garcia-MartinezJV,GreinerDL.2012.Humanizedmiceforimmunesysteminvestigation:progress,promiseandchallenges.NatRevImmunol12(11):786-798.PMCID:PMC3749872.


38

405. Jimenez-DiazMB,VieraS,IbanezJ,MuletT,Magan-MarchalN,GarutiH,GomezV,Cortes-GilL,MartinezA,FerrerS,FraileMT,CalderonF,FernandezE,ShultzLD,LeroyD,WilsonDM,Garcia-BustosJF,GamoFJ,Angulo-BarturenI.2013.Anewinvivoscreeningparadigmtoaccelerateantimalarialdrugdiscovery.PLoSOne8(6):e66967.PMCID:PMC3692522.

406. WilsonDW,OslundKL,LyonsB,ForemanO,BurzenskiL,SvensonKL,ChaseTH,ShultzLD.2013.InflammatorydilatedcardiomyopathyinAbcg5-deficientmice.ToxicolPathol41(6):880-892.PMCID:PMC3905339.

407. GoelHL,PursellB,ChangC,ShawLM,MaoJ,SiminK,KumarP,VanderKooiCW,ShultzLD,GreinerDL,NorumJH,ToftgardR,KuperwasserC,MercurioAM.2013.GLI1regulatesanovelneuropilin-2/a6b1integrinbasedautocrinepathwaythatcontributestobreastcancerinitiation.EMBOMolMed5:488-508.PMCID:PMC3628099.

408. CovassinL,JangalweS,JouvetN,LaningJ,BurzenskiL,ShultzLD,BrehmMA.2013.Humanimmunesystemdevelopmentandsurvivalofnon-obesediabetic(NOD)-scidIL2rɣnull(NSG)engraftedwithhumanthymusandautologoushematopoieticstemcells.ClinExpImmunol174(3):372-388.PMCID:3826304.

409. YokotaSJ,FacciponteJG,KelleherRJ,Jr.,ShultzLD,LoyallJL,ParsonsRR,OdunsiK,FrelingerJG,LordEM,GerberSA,Balu-IyerSV,BankertRB.2013.Changesinovariantumorcellnumber,tumorvasculature,andTcellfunctionmonitoredinvivousinganovelxenograftmodel.CancerImmun13:11.PMCID:PMC3721261.

410. McNeerNA,SchleifmanEB,CuthbertA,BrehmM,JacksonA,ChengC,AnandalingamK,KumarP,ShultzLD,GreinerDL,MarkSaltzmanW,GlazerPM.2013.Systemicdeliveryoftriplex-formingPNAanddonorDNAbynanoparticlesmediatessite-specificgenomeeditingofhumanhematopoieticcellsinvivo.GeneTher20(6):658-669.PMCID:PMC3713483.

411. ShultzLD,GoodwinN,IshikawaF,HosurV,LyonsBL,GreinerDL.2014.Humancancergrowthandtherapyinimmunodeficientmousemodels.ColdSpringHarbProtoc2014(7):694-708.PMCID:PMC4411952.

412. ShultzLD,GoodwinN,IshikawaF,HosurV,LyonsBL,GreinerDL.2014.Subcapsulartransplantationoftissueinthekidney.In:MouseModelsofCancer:ALaboratoryManual,ShenC-A;PolitiK,ChodoshLA,OliveKP;(eds).ColdSpringHarbor,NY:ColdSpringHarborLaboratoryPress,p268-271.

413. SeymourR,ShirleyBJ,HogeneschH,ShultzLD,SundbergJP.2013.LossoffunctionofthemouseSharpingeneresultsinPeyer'spatchregression.PLoSOne8:(2)e55224.PMCID:PMC3570409.

414. BarthBM,KeaseyNR,WangX,ShanmugavelandySS,RampalR,HricikT,CabotMC,KesterM,WangH-G,ShultzLD,TallmanMS,LevineRL,LoughranTPJr,ClaxtonDF.2014.EngraftmentofhumanprimaryacutemyeloidleukemiadefinedbyintegratedgeneticprofilinginNOD/SCID/IL2rgnullmiceforpreclinicalceramide-basedtherapeuticevaluation.JLeuk2(3):146.

415. DouS,WangY,BartonB,ChenL,RusckowskiM,ShultzLD,GreinerDL,LiuG.2014.Comparisonbetweentwolabeledagentsinmiceusingacoinjection-ratioapproachincontrasttoaconventionalgroupapproach.NuclMedBiol41(1):127-131.PMCID:PMC3855254.

416. AokiY,WatanabeT,SaitoY,KurokiY,HijikataA,TakagiM,TomizawaD,EguchiM,Eguchi-IshimaeM,KanekoA,OnoR,SatoK,SuzukiN,FujikiS,KohK,IshiiE,ShultzLD,OharaO,MizutaniS,IshikawaF.2015.IdentificationofCD34+andCD34-leukemia-initiatingcellsinMLL-rearrangedhumanacutelymphoblasticleukemia.Blood125(6):967-980.PMCID:PMC4319237.

417. BrehmMA,JouvetN,GreinerDL,ShultzLD.2013.Humanizedmiceforthestudyofinfectiousdiseases.CurrOpinImmunol25(4):428-435.PMCID:PMC3775881.

418. HickeyRD,GalivoF,SchugJ,BrehmMA,HaftA,WangY,BenedettiE,GuG,MagnusonMA,ShultzLD,LagasseE,GreinerDL,KaestnerKH,GrompeM.2013.Generationofislet-likecellsfrommousegallbladderbydirectexvivoreprogramming.StemCellRes11(1):503-515.PMCID:PMC3940065.


39

419. PotterCS,WangZ,SilvaKA,KennedyVE,StearnsTM,BurzenskiL,ShultzLD,HogeneschH,SundbergJP.2014.ChronicProliferativeDermatitisinSharpinNullMice:DevelopmentofanAutoinflammatoryDiseaseintheAbsenceofBandTLymphocytesandIL4/IL13Signaling.PLoSOne9(1):e85666.PMCID:PMC3897490.

420. BrehmMA,ShultzLD,LubanJ,GreinerDL.2013.Overcomingcurrentlimitationsinhumanizedmouseresearch.JInfectDis208suppl2:S125-130.PMCID:PMC3807974.

421. JurczykA,DilorioP,BrostowinD,LeehyL,YangC,UranoF,HarlanDM,ShultzLD,GreinerDL,BortellR.2013.ImprovedfunctionandproliferationofadulthumanbetacellsengraftedindiabeticimmunodeficientNOD-scidIL2rgnullmicetreatedwithalogliptin.DiabetesMetabSyndrObes:TargetsandTherapy6:493-499.PMCID:PMC3864939.

422. SchleifmanEB,McNeerNA,JacksonA,YamtichJ,BrehmMA,ShultzLD,GreinerDL,KumarP,SaltzmanWM,GlazerPM.2013.Site-specificGenomeEditinginPBMCsWithPLGANanoparticle-deliveredPNAsConfersHIV-1ResistanceinHumanizedMice.MolTherNucleicAcids2:e135.PMCID:PMC3889188.

423. LeeJ,BrehmMA,GreinerD,ShultzLD,KornfeldH.2013.EngraftedhumancellsgenerateadaptiveimmuneresponsestoMycobacteriumbovisBCGinfectioninhumanizedmice.BMCImmunol14(1):53.PMCID:PMC3924189.

424. RoderickJE,TesellJ,ShultzLD,BrehmMA,GreinerDL,HarrisMH,SilvermanLB,SallanSE,GutierrezA,LookAT,QiJ,BradnerJE,KelliherMA.2014.c-MycinhibitionpreventsleukemiainitiationinmiceandimpairsthegrowthofrelapsedandinductionfailurepediatricT-ALLcells.Blood123(7):1040-1050.PMCID:PMC3924926.

425. KnoechelB,RoderickJE,WilliamsonKE,ZhuJ,LohrJG,CottonMJ,GillespieSM,FernandezD,KuM,WangH,PiccioniF,SilverSJ,JainM,PearsonD,KlukMJ,OttCJ,ShultzLD,BrehmMA,GreinerDL,GutierrezA,StegmaierK,KungAL,RootDE,BradnerJE,AsterJC,KelliherMA,BernsteinBE.2014.AnepigeneticmechanismofresistancetotargetedtherapyinTcellacutelymphoblasticleukemia.NatGenet46(4):364-370.PMCID:PMC4086945.

426. BrehmMA,WilesMV,GreinerDL,ShultzLD.2014.Generationofimprovedhumanizedmousemodelsforhumaninfectiousdiseases.JImmunolMethods410C:3-17.PMCID:PMC4155027.

427. HosurV,JohnsonKR,BurzenskiLM,StearnsTM,MaserRS,ShultzLD.2014.Rhbdf2mutationsincreaseitsproteinstabilityanddriveEGFRhyperactivationthroughenhancedsecretionofamphiregulin.ProcNatlAcadSciUSA111(21):E2200-2209.PMCID:PMC4040562.

428. MaykelJ,LiuJH,LiH,ShultzLD,GreinerDL,HoughtonJ.2014.NOD-scidIl2rgtm1WjlandNOD-Rag1nullIl2rgtm1Wjl:amodelforstromalcell-tumorcellinteractionforhumancoloncancer.Digestivediseasesandsciences59(6):1169-1179.PMCID:PMC4032472.

429. GoelHL,GritskoT,PursellB,ChangC,ShultzLD,GreinerDL,NorumJH,ToftgardR,ShawLM,MercurioAM.2014.Regulatedsplicingofthea6integrincytoplasmicdomaindeterminesthefateofbreastcancerstemcells.Cellreports7(3):747-761.PMCID:PMC4038359.

430. TrabuccoSE,GersteinRM,EvensAM,BradnerJE,ShultzLD,GreinerDL,ZhangH.2015.InhibitionofbromodomainproteinsforthetreatmentofhumandiffuselargeB-celllymphoma.ClinCancerRes21(1):113-122.PMCID:PMC4286476.

431. JaiswalS,SmithK,RamirezA,WodaM,PazolesP,ShultzLD,GreinerDL,BrehmMA,MathewA.2015.Denguevirusinfectioninducesbroadlycross-reactivehumanIgMantibodiesthatrecognizeintactvirionsinhumanizedBLT-NSGmice.Experimentalbiologyandmedicine240(1):67-78.PMCID:PMC4446989.

432. AryeeKE,ShultzLD,BrehmMA.2014.Immunodeficientmousemodelforhumanhematopoieticstemcellengraftmentandimmunesystemdevelopment.Methodsinmolecularbiology1185:267-278.


40

433. McCuneJM,ShultzLD.Humanizedmiceasmodelsforhumandisease.InLYPoluektova,JVGarcia,etal(Eds.),HumanizedMiceforHIVResearch.NewYork,NY:Springer;2015.p15-24.

434. GallagherGR,BrehmMA,FinbergRW,BartonBA,ShultzLD,GreinerDL,BortellR,WangJP.2015.Viralinfectionofengraftedhumanisletsleadstodiabetes.Diabetes64(4):1358-1369.PMCID:PMC4375078.

435. AbateF,TodaroM,vanderKrogtJA,BoiM,LandraI,MachiorlattiR,TabboF,MessanaK,AbeleC,BarrecaA,NoveroD,GaudianoM,AlibertiS,DiGiacomoF,TousseynT,LasorsaE,CrescenzoR,BessoneL,FicarraE,AcquavivaA,RinaldiA,PonzoniM,LongoDL,AimeS,ChengM,RuggeriB,PiccalugaPP,PileriS,TiacciE,FaliniB,Pera-GreselyB,CerchiettiL,IqbalJ,ChanWC,ShultzLD,KweeI,PivaR,WlodarskaI,RabadanR,BertoniF,InghiramiG,EuropeanTcLSG.2015.Anovelpatient-derivedtumorgraftmodelwithTRAF1-ALKanaplasticlarge-celllymphomatranslocation.Leukemia29(6):1390-1401.PMCID:PMC4864432.

436. ChangC,GoelHL,GaoH,PursellB,ShultzLD,GreinerDL,IngerpuuS,PatarroyoM,CaoS,LimE,MaoJ,McKeeKK,YurchencoPD,MercurioAM.2015.Alaminin511matrixisregulatedbyTAZandfunctionsastheligandforthea6Bb1integrintosustainbreastcancerstemcells.GenesDev29(1):1-6.PMCID:PMC4281560.

437. TangZ,DaiS,HeY,DotyRA,ShultzLD,SampsonSB,DaiC.2015.MEKguardsproteomestabilityandinhibitstumor-suppressiveamyloidogenesisviaHSF1.Cell160(4):729-744.PMCID:PMC4564124.

438. BabadJ,MukherjeeG,FollenziA,AliR,RoepBO,ShultzLD,SantamariaP,YangOO,GoldsteinH,GreinerDL,DiLorenzoTP.2015.Generationof bcell-specifichumancytotoxicTcellsbylentiviraltransductionandtheirsurvivalinimmunodeficienthumanleucocyteantigen-transgenicmice.Clinicalandexperimentalimmunology179(3):398-413.PMCID:PMC4337673.

439. SerrI,FurstRW,AchenbachP,SchermMG,GokmenF,HauptF,SedlmeierEM,KnopffA,ShultzL,WillisRA,ZieglerAG,DanielC.2016.Type1diabetesvaccinecandidatespromotehumanFoxp3+Treginductioninhumanizedmice.NatCommun7:10991.PMCID:PMC4796321.

440. CrescenzoR,AbateF,LasorsaE,TabboF,GaudianoM,ChiesaN,DiGiacomoF,SpaccarotellaE,BarbarossaL,ErcoleE,TodaroM,BoiM,AcquavivaA,FicarraE,NoveroD,RinaldiA,TousseynT,RosenwaldA,KennerL,CerroniL,TzankovA,PonzoniM,PaulliM,WeisenburgerD,ChanWC,IqbalJ,PirisMA,ZamoA,CiardulloC,RossiD,GaidanoG,PileriS,TiacciE,FaliniB,ShultzLD,MevellecL,VialardJE,PivaR,BertoniF,RabadanR,InghiramiG,etal.2015.ConvergentmutationsandkinasefusionsleadtooncogenicSTAT3activationinanaplasticlargecelllymphoma.Cancercell27(4):516-532.

441. SamantaS,SunH,GoelHL,PursellB,ChangC,KhanA,GreinerDL,CaoS,LimE,ShultzLD,MercurioAM.2016.IMP3promotesstem-likepropertiesintriple-negativebreastcancerbyregulatingSLUG.Oncogene35(9):1111-1121.

442. SewaldX,LadinskyMS,UchilPD,BeloorJ,PiR,HerrmannC,MotamediN,MurookaTT,BrehmMA,GreinerDL,ShultzLD,MempelTR,BjorkmanPJ,KumarP,MothesW.2015.RetrovirusesuseCD169-mediatedtrans-infectionofpermissivelymphocytestoestablishinfection.Science350(6260):563-567.PMCID:PMC4651917.

443. YangC,LoehnM,JurczykA,PrzewozniakN,LeehyL,HerreraPL,ShultzLD,GreinerDL,HarlanDM,BortellR.2015.Lixisenatideacceleratesrestorationofnormoglycemiaandimproveshumanbeta-cellfunctionandsurvivalindiabeticimmunodeficientNOD-scidIL-2rgnullRIP-DTRmiceengraftedwithhumanislets.Diabetes,metabolicsyndromeandobesity:targetsandtherapy8:387-398.PMCID:PMC4548726.

444. FriedlineRH,KoHJ,JungDY,LeeY,BortellR,DagdevirenS,PatelPR,HuX,InashimaK,KearnsC,TsitsilianosN,ShafiqU,ShultzLD,LeeKW,GreinerDL,KimJK.2016.Geneticablationoflymphocytesandcytokinesignalinginnonobesediabeticmicepreventsdiet-inducedobesityandinsulin


41

resistance.FASEBjournal:officialpublicationoftheFederationofAmericanSocietiesforExperimentalBiology30(3):1328-1338.PMCID:PMC4750424.

445. AkkinaR,AllamA,BalazsAB,BlanksonJN,BurnettJC,CasaresS,GarciaJV,HasenkrugKJ,KashanchiF,KitchenSG,KleinF,KumarP,LusterAD,PoluektovaLY,RaoM,Sanders-BeerBE,ShultzLD,ZackJA.2016.ImprovementsandLimitationsofHumanizedMouseModelsforHIVResearch:NIH/NIAID"MeettheExperts"2015WorkshopSummary.AIDSRexHumRetroviruses32(2):109-119.PMCID:PMC4761823.

446. ChengF,TwardowskiL,ReifenbergK,WinterK,CanisiusA,ProssE,FanJ,SchmittE,ShultzLD,LacknerKJ,TorzewskiM.2016.CombinedB,TandNKcelldeficiencyacceleratesatherosclerosisinBALB/cmice.PLosOne11(8):e0157311.PMCID:PMC5001715.

447. JurczykA,NowosielskaA,PrzewozniakN,AryeeKE,DiIorioP,BlodgettD,YangC,Campbell-ThompsonM,AtkinsonM,ShultzL,RittenhouseA,HarlanD,GreinerD,BortellR.2016.Beyondthebrain:disruptedinschizophrenia1regulatespancreatic b-cellfunctionviaglycogensynthasekinase-3b.FASEBjournal:officialpublicationoftheFederationofAmericanSocietiesforExperimentalBiology30(2):983-993.PMCID:PMC4714549.

448. DaiC,KaytonNS,ShostakA,PoffenbergerG,CyphertHA,AramandlaR,ThompsonC,PapagiannisIG,EmfingerC,ShiotaM,StaffordJM,GreinerDL,HerreraPL,ShultzLD,SteinR,PowersAC.2016.Stress-impairedtranscriptionfactorexpressionandinsulinsecretionintransplantedhumanislets.TheJournalofclinicalinvestigation126(5):1857-1870.PMCID:PMC4855919.

449. KenneyLL,ShultzLD,GreinerDL,BrehmMA.2016.HumanizedMouseModelsforTransplantImmunology.AmJTransplant16(2):389-397.PMCID:PMC5283075.

450. LiS,LingC,ZhongL,LiM,SuQ,HeR,TangQ,GreinerDL,ShultzLD,BrehmMA,FlotteTR,MuellerC,SrivastavaA,GaoG.2015.EfficientandTargetedTransductionofNonhumanPrimateLiverWithSystemicallyDeliveredOptimizedAAV3BVectors.MolTher23(12):1867-1876.PMCID:PMC4700112.

451. HasgurS,AryeeKE,ShultzLD,GreinerDL,BrehmMA.2016.GenerationofImmunodeficientMiceBearingHumanImmuneSystemsbytheEngraftmentofHematopoieticStemCells.MethodsMolBiol1438:67-78.PMCID:PMC5268072.

452. PresaM,ChenYG,GrierAE,LeiterEH,BrehmMA,GreinerDL,ShultzLD,SerrezeDV.2015.ThePresenceandPreferentialActivationofRegulatoryTCellsDiminishAdoptiveTransferofAutoimmuneDiabetesbyPolyclonalNonobeseDiabetic(NOD)TCellEffectorsintoNSGversusNOD-scidMice.Journalofimmunology195(7):3011-3019.PMCID:PMC4575869.

453. NajimaY,Tomizawa-MurasawaM,SaitoY,WatanabeT,OnoR,OchiT,SuzukiN,FujiwaraH,OharaO,ShultzLD,YasukawaM,IshikawaF.2016.InductionofWT1-specifichumanCD8+TcellsfromhumanHSCsinHLAclassITgNOD/SCID/IL2rgKOmice.Blood127(6):722-734.PMCID:PMC4751022.

454. AliR,BabadJ,FollenziA,GebeJA,BrehmMA,NepomGT,ShultzLD,GreinerDL,DiLorenzoTP.2016.GeneticallymodifiedhumanCD4+Tcellscanbeevaluatedinvivowithoutlethalgraft-versus-hostdisease.Immunology148(4):339-351.PMCID:PMC4948041.

455. GoelHL,PursellB,ShultzLD,GreinerDL,BrekkenRA,VanderKooiCW,MercurioAM.2016.P-Rex1promotesresistancetoVEGF/VEGFR-Targetedtherapyinprostatecancer.CellRep14(9):2193-2208.PMCID:PMC4791963.

456. LiuET,BultCJ,ShultzLD.2016.Patient-DerivedTumorXenografts:WhyNow?JAMAOncol2(5):567-8.

457. SamuelovL,LiQ,BochnerR,NajorNA,AlbrechtL,MalchinN,GoldsmithT,Grafi-CohenM,VodoD,FainbergG,MeilikB,GoldbergI,WarshauerE,RogersT,EdieS,Ishida-YamamotoA,BurzenskiL,ErezN,MurraySA,IrvineAD,ShultzL,GreenKJ,UittoJ,SprecherE,SarigO.2017.SVEP1playsacrucialroleinepidermaldifferentiation.ExpDermatol26(5):423-430.PMCID:PMC5543306.


42

458. WalshNC,KenneyLL,JangalweS,AryeeKE,GreinerDL,BrehmMA,ShultzLD.2017.Humanizedmousemodelsofclinicaldisease.AnnuRevPathol12:187-215.PMCID:PMC5280554.

459. HosurV,LowBE,ShultzLD,WilesMV.2017.Geneticdeletionofamphiregulinrestoresthenormalskinphenotypeinamousemodelofthehumanskindiseasetylosis.BiolOpen6(8):1174-1179.PMCID:PMC5576083.

460. BrycePJ,FalahatiR,KenneyLL,LeungJ,BebbingtonC,TomasevicN,KrierRA,HsuCL,ShultzLD,GreinerDL,BrehmMA.2016.Humanizedmousemodelofmastcell-mediatedpassivecutaneousanaphylaxisandpassivesystemicanaphylaxis.JAllergyClinImmunol138(3):769-779.PMCID:PMC5014665.

461. Mercado-LuboR,ZhangY,ZhaoL,RossiK,WuX,ZouY,CastilloA,LeonardJ,BortellR,GreinerDL,ShultzLD,HanG,McCormickBA.2016.ASalmonellananoparticlemimicovercomesmultidrugresistanceintumours.NatCommun7:12225.PMCID:PMC5512628

462. SaitoY,MochizukiY,OgaharaI,WatanabeT,HogdalL,TakagiS,SatoK,KanekoA,KajitaH,UchidaN,FukamiT,ShultzLD,TaniguchiS,OharaO,LetaiAG,IshikawaF.2017.Overcomingmutationalcomplexityinacutemyeloidleukemiabyinhibitionofcriticalpathways.SciTranslMed9:(413).PMCID:PMC5377281.

463. BoudreauJE,LiuXR,ZhaoZ,ZhangA,ShultzLD,GreinerDL,DupontB,HsuKC.2016.Cell-extrinsicMHCClassImoleculeengagementaugmentshumanNKcelleducationprogrammedbycell-intrinsicMHCClassI.Immunity45(2):280-291.PMCID:PMC5003427.

464. JangalweS,ShultzLD,MathewA,BrehmMA.2016.ImprovedBcelldevelopmentinhumanizedNOD-scidIL2Rgnullmicetransgenicallyexpressinghumanstemcellfactor,granulocyte-macrophagecolony-stimulatingfactorandinterleukin-3.ImmunInflammDis4:(4)427-440.PMCID:PMC5134721.

465. MoserJ,vanArkJ,vanDijkMC,GreinerDL,ShultzLD,vanGoorH,HillebrandsJL.2016.Distinctdifferencesonneointimaformationinimmunodeficientandhumanizedmiceaftercarotidorfemoralarterialinjury.SciRep6:35387.PMCID:PMC5069488.

466. MillerPH,RabuG,MacAldazM,KnappDJ,CheungAM,DhillonK,NakamichiN,BeerPA,ShultzLD,HumphriesRK,EavesCJ.2017.Analysisofparametersthataffecthumanhematopoieticcelloutputsinmutantc-kit-immunodeficientmice.ExpHematol48:41-49.PMCID:PMC5926796.

467. LiuET,Bolcun-FilasE,GrassDS,LutzC,MurrayS,ShultzL,RosenthalN.2017.OfmiceandCRISPR:Thepost-CRISPRfutureofthemouseasamodelsystemforthehumancondition.EMBORep18(2):187-193.PMCID:PMC5286389.

468. HosurV,BurzenskiLM,StearnsTM,FarleyML,SundbergJP,WilesMV,ShultzLD.2017.EarlyinductionofNRF2antioxidantpathwaybyRHBDF2mediatesrapidcutaneouswoundhealing.ExpMolPathol102(2):337-346.PMCID:PMC5436942.

469. LeeJ,DykstraB,SpencerJA,KenneyLL,GreinerDL,ShultzLD,BrehmMA,LinCP,SacksteinR,RossiDJ.2017.mRNA-mediatedglycoengineeringamelioratesdeficienthomingofhumanstemcell-derivedhematopoieticprogenitors.JClinInvest127(6):2433-2437.PMCID:PMC5451245.

470. HosurV,LowBE,AveryC,ShultzLD,WilesMV.2017.Developmentofhumanizedmiceintheageofgenomeediting.JCellBiochem118(10):3043-3048.PMCID:PMC5550330.

471. BrehmMA,BortellR,VermaM,ShultzLD,GreinerDL.2016.Humanizedmiceintranslationalimmunology.In:TranslationalImmunology,MechanismsandPharmacologicApproaches,TanS-L(ed).AcademicPress:Elsevier;p.285-326.

472. VermaMK,ClemensJ,BurzenskiL,SampsonSB,BrehmMA,GreinerDL,ShultzLD.2017.Anovelhemolyticcomplement-sufficientNSGmousemodelsupportsstudiesofcomplement-mediatedantitumoractivityinvivo.JImmunolMethods446:47-53.PMCID:PMC5480316.


43

473. DurostPA,AryeeKE,ManzoorF,TischRM,MuellerC,JurczykA,ShultzLD,BrehmMA.2018.Genetherapywithanadeno-associatedviralvectorexpressinghumaninterleukin-2altersimmunesystemhomeostasisinhumanizedmice.HumGeneTher29(3):352-365.PMC5865247.

474. SerrI,FurstRW,AchenbachP,SchermMG,GokmenF,HauptF,SedlmeierEM,KnopffA,ShultzL,WillisRA,ZieglerAG,DanielC.2016.Type1diabetesvaccinecandidatespromotehumanFoxp3+Treginductioninhumanizedmice.NatCommun7:10991.PMCID:PMC4796321.

475. KooremanNG,deAlmeidaPE,StackJP,NelakantiRV,DieckeS,ShaoNY,SwijnenburgRJ,Sanchez-FreireV,MatsaE,LiuC,ConnollyAJ,HammingJF,QuaxPHA,BrehmMA,GreinerDL,ShultzLD,WuJC.2017.Alloimmuneresponsesofhumanizedmicetohumanpluripotentstemcelltherapeutics.CellRep20(8):1978-1990.PMCID:PMC5573767.

476. BorelF,TangQ,GernouxG,GreerC,WangZ,BarzelA,KayMA,ShultzLD,GreinerDL,FlotteTR,BrehmMA,MuellerC.2017.Survivaladvantageofbothhumanhepatocytexenograftsandgenome-editedhepatocytesfortreatmentof a-1antitrypsindeficiency.MolTher25(11):2477-2489.PMCID:PMC5675605.

477. DaiC,HangY,ShostakA,PoffenbergerG,HartN,PrasadN,PhillipsN,LevySE,GreinerDL,ShultzLD,BottinoR,KimSK,PowersAC.2017.Age-dependenthuman bcellproliferationinducedbyglucagon-likepeptide1andcalcineurinsignaling.JClinInvest127(10):3835-3844.PMCID:PMC5617654.

478. HosurV,LyonsBL,BurzenskiLM,ShultzLD.2017.Tissue-specificroleofRHBDF2incutaneouswoundhealingandhyperproliferativeskindisease.BMCResNotes10(1):573.PMCID:PMC5678570.

479. WangM,YaoLC,ChengM,CaiD,MartinekJ,PanCX,ShiW,MaAH,DeVereWhiteRW,AirhartS,LiuET,BanchereauJ,BrehmMA,GreinerDL,ShultzLD,PaluckaK,KeckJG.2018.HumanizedmiceinstudyingefficacyandmechanismsofPD-1-targetedcancerimmunotherapy.FASEBJ32(3):1537-1549.PMCID:PMC5892726.

480. BahmaniB,UeharaM,OrdikhaniF,LiX,JiangL,BanouniN,IchimuraT,KasinathV,EskandariSK,AnnabiN,BrombergJS,ShultzLD,GreinerDL,AbdiR.2018.Ectopichighendothelialvenulesinpancreaticductaladenocarcinoma:Auniquesitefortargeteddelivery.EBioMedicine38:79-88.PMCID:PMC6306381.

481. BrissovaM,HaliyurR,SaundersD,ShresthaS,DaiC,BlodgettDM,BottinoR,Campbell-ThompsonM,AramandlaR,PoffenbergerG,LindnerJ,PanFC,vonHerrathMG,GreinerDL,ShultzLD,SanyouraM,PhilipsonLH,AtkinsonM,HarlanDM,LevySE,PrasadN,SteinR,PowersAC.2018. acellfunctionandgeneexpressionarecompromisedinType1Diabetes.CellRep22(10):2667-2676.PMCID:PMC6368357.

482. BurackWR,SpenceJM,SpenceJP,SpenceSA,RockPJ,ShenoyGN,ShultzLD,BankertRB,BernsteinSH.2017.Patient-derivedxenograftsoflow-gradeB-celllymphomasdemonstraterolesofthetumormicroenvironment.BloodAdv1(16):1263-1273.PMCID:PMC5728547.

483. HosurV,FarleyML,BurzenskiLM,ShultzLD,WilesMV.2018.ADAM17isessentialforectodomainsheddingoftheEGF-receptorligandamphiregulin.FEBSOpenBio8(4):702-710.PMCID:PMC5881543.

484. BrehmMA,KenneyLL,WilesMV,LowBE,TischRM,BurzenskiL,MuellerC,GreinerDL,ShultzLD.2019.Lackofacutexenogeneicgraft-versus-hostdisease,butretentionofT-cellfunctionfollowingengraftmentofhumanperipheralbloodmononuclearcellsinNSGmicedeficientinMHCclassIandIIexpression.FASEBJ33(3):3137-3151.PMCID:PMC6404556.

485. HuaL,ShiJ,ShultzLD,RenG.2018.Geneticmodelsofmacrophagedepletion.MethodsMolBiol1784:243-258.PMCID:PMC6333569.

486. HosurV,FarleyML,LowBE,BurzenskiLM,ShultzLD,WilesMV.2018.RHBDF2-regulatedgrowthfactorsignalinginararehumandisease,TylosisWithesophagealcancer:WhatcanwelearnFrommurinemodels?FrontGenet9:233.PMCID:PMC6039722.


44

487. YoungbloodBA,BrockEC,LeungJ,FalahatiR,BrycePJ,BrightJ,WilliamsJ,ShultzLD,GreinerDL,BrehmMA,BebbingtonC,TomasevicN.2019.AK002,aHumanizedSialicAcid-BindingImmunoglobulin-LikeLectin-8AntibodythatInducesAntibody-DependentCell-MediatedCytotoxicityagainstHumanEosinophilsandInhibitsMastCell-MediatedAnaphylaxisinMice.IntArchAllergyImmunol180(2):91-102.PMCID:PMC6878738.

488. SaundersDC,BrissovaM,PhillipsN,ShresthaS,WalkerJT,AramandlaR,PoffenbergerG,FlahertyDK,WellerKP,PelletierJ,CooperT,GoffMT,VirostkoJ,ShostakA,DeanED,GreinerDL,ShultzLD,PrasadN,LevySE,CarnahanRH,DaiC,SevignyJ,PowersAC.2019.Ectonucleosidetriphosphatediphosphohydrolase-3antibodytargetsadulthumanpancreatic bcellsforInVitroandInVivoanalysis.CellMetab29(3):745-754e4.PMCID:PMC6402969.

489. GawronMA,DuvalM,CarboneC,JaiswalS,WallaceA,MartinJC,3rd,DauphinA,BrehmMA,GreinerDL,ShultzLD,LubanJ,CavaciniLA.2019.Humananti-HIV-1gp120monoclonalantibodieswithneutralizingactivityclonedfromhumanizedmiceinfectedwithHIV-1.JImmunol202:(3)799-804.PMCID:PMC6344273.

490. OnoR,WatanabeT,KawakamiE,IwasakiM,Tomizawa-MurasawaM,MatsudaM,NajimaY,TakagiS,FujikiS,SatoR,MochizukiY,YoshidaH,SatoK,YabeH,KatoS,SaitoY,TaniguchiS,ShultzLD,OharaO,AmagaiM,KosekiH,IshikawaF.2019.Co-activationofmacrophagesandTcellscontributetochronicGVHDinhumanIL-6transgenichumanisedmousemodel.EBioMedicine41:584-596.PMCID:PMC6441951.

491. MatsudaM,OnoR,IyodaT,EndoT,IwasakiM,Tomizawa-MurasawaM,SaitoY,KanekoA,ShimizuK,YamadaD,OgonukiN,WatanabeT,NakayamaM,KosekiY,Kezuka-ShiotaniF,HasegawaT,YabeH,KatoS,OguraA,ShultzLD,OharaO,TaniguchiM,KosekiH,FujiiSI,IshikawaF.2019.HumanNKcelldevelopmentinhIL-7andhIL-15knockinNOD/SCID/IL2rgKOmice.LifeSciAlliance2(2):e201800195.PMCID:PMC6445396.

492. ShultzLD,KeckJ,BurzenskiL,JangalweS,VaidyaS,GreinerDL,BrehmMA.2019.Humanizedmousemodelsofimmunologicaldiseasesandprecisionmedicine.MammGenome30:(5-6)123-142.PMCID:PMC6610695.

493. LiP,GongZ,ShultzLD,RenG.2019.Mesenchymalstemcells:Fromregenerationtocancer.PharmacolTher200:42-54.PMCID:PMC6626571.

494. BedognettiD,CeccarelliM,GalluzziL,LuR,PaluckaK,SamayoaJ,SprangerS,WarrenS,WongKK,ZivE,ChowellD,CoussensLM,DeCarvalhoDD,DeNardoDG,GalonJ,KaufmanHL,KirchhoffT,LotzeMT,LukeJJ,MinnAJ,PolitiK,ShultzLD,SimonR,ThorssonV,WeidhaasJB,AsciertoML,AsciertoPA,BarnesJM,BarsanV,BommareddyPK,BotA,ChurchSE,CilibertoG,DeMariaA,DraganovD,HoWS,McGeeHM,MonetteA,MurphyJF,NisticoP,ParkW,PatelM,QuigleyM,RadvanyiL,RaftopoulosH,RudqvistNP,SnyderA,SweisRF,ValpioneS,ButterfieldLH,DisisML,FoxBA,CesanoA,MarincolaFM,SocietyforImmunotherapyofCancer(SITC)CancerImmuneResponsivenessTaskForceandWorkingGroup.2019.Towardacomprehensiveviewofcancerimmuneresponsiveness:asynopsisfromtheSITCworkshop.JImmunotherCancer7:(1)131.PMCID:PMC6529999.

495. KarlinseyJE,StepienTA,MayhoM,SingletaryLA,Bingham-RamosLK,BrehmMA,GreinerDL,ShultzLD,GallagherLA,BawnM,KingsleyRA,LibbySJ,FangFC.2019.Genome-wideAnalysisofSalmonellaentericaserovarTyphiinHumanizedMiceRevealsKeyVirulenceFeatures.CellHostMicrobe26(3):426-434e426.PMCID:PMC6742556.

496. deGrootAP,SaitoY,KawakamiE,HashimotoM,AokiY,OnoR,OgaharaI,FujikiS,KanekoA,SatoK,KajitaH,WatanabeT,TakagiM,TomizawaD,KohK,EguchiM,IshiiE,OharaO,ShultzLD,MizutaniS,IshikawaF.2021.Targetingcriticalkinasesandanti-apoptoticmoleculesovercomessteroidresistanceinMLL-rearrangedleukaemia.EBioMedicine64:103235.PMCID:PMC7878180.


45

497. BedognettiD,CeccarelliM,GalluzziL,LuR,PaluckaK,SamayoaJ,SprangerS,WarrenS,WongKK,ZivE,ChowellD,CoussensLM,DeCarvalhoDD,DeNardoDG,GalonJ,KaufmanHL,KirchhoffT,LotzeMT,LukeJJ,MinnAJ,PolitiK,ShultzLD,SimonR,ThorssonV,WeidhaasJB,AsciertoML,AsciertoPA,BarnesJM,BarsanV,BommareddyPK,BotA,ChurchSE,CilibertoG,DeMariaA,DraganovD,HoWS,McGeeHM,MonetteA,MurphyJF,NisticoP,ParkW,PatelM,QuigleyM,RadvanyiL,RaftopoulosH,RudqvistNP,SnyderA,SweisRF,ValpioneS,ZappasodiR,ButterfieldLH,DisisML,FoxBA,CesanoA,MarincolaFM,SocietyforImmunotherapyofCancer(SITC)CancerImmuneResponsivenessTaskForce,WorkingGroup.2019.Correctionto:Towardacomprehensiveviewofcancerimmuneresponsiveness:asynopsisfromtheSITCworkshop.JImmunotherCancer7:(1)167.PMCID:PMC6610889.

498. AllenTM,BrehmMA,BridgesS,FergusonS,KumarP,MirochnitchenkoO,PaluckaK,PelandaR,Sanders-BeerB,ShultzLD,SuL,PrabhuDasM.2019.Humanizedimmunesystemmousemodels:progress,challengesandopportunities.NatImmunol20:(7)770-774.PMC7265413.

499. WagenblastE,AzkanazM,SmithSA,ShakibL,McLeodJL,KrivdovaG,AraujoJ,ShultzLD,GanOI,DickJE,LechmanER.2019.FunctionalprofilingofsingleCRISPR/Cas9-editedhumanlong-termhematopoieticstemcells.NatCommun10:(1)4730.PMCID:PMC6802205.

500. RedickSD,LeehyL,RittenhouseAR,BlodgettDM,DerrAG,KucukuralA,GarberMG,ShultzLD,GreinerDL,WangJP,HarlanDM,BortellR,JurczykA.2020.Recoveryofviableendocrine-specificcellsandtranscriptomesfromhumanpancreaticislet-engraftedmice.FASEBJ34(1):1901-1911.PMCID:PMC6972551.

501. KierkelsGJJ,ScheperW,MeringaAD,JohannaI,BeringerDX,JanssenA,SchifflerM,Aarts-RiemensT,KramerL,StraetemansT,HeijhuursS,LeusenJHW,SanJoseE,FuchsK,GriffioenM,FalkenburgJH,BongiovanniL,deBruinA,Vargas-DiazD,AltelaarM,HeckAJR,ShultzLD,IshikawaF,NishimuraMI,SebestyenZ,KuballJ.2019.Identificationofatumor-specificallo-HLA-restricted gdTCR.BloodAdv3:(19)2870-2882.PMCID:PMC6784524.

502. SvobodaDS,BarrasaMI,ShuJ,RietjensR,ZhangS,MitalipovaM,BerubeP,FuD,ShultzLD,BellGW,JaenischR.2019.HumaniPSC-derivedmicrogliaassumeaprimarymicroglia-likestateaftertransplantationintotheneonatalmousebrain.ProcNatlAcadSciUSA116:(50)25293-25303.PMCID:PMC6911218.

503. DaiC,WalkerJT,ShostakA,PadgettA,SpearsE,WisniewskiS,PoffenbergerG,AramandlaR,DeanED,PrasadN,LevySE,GreinerDL,ShultzLD,BottinoR,PowersAC.2020.Tacrolimus-andsirolimus-inducedhumanbcelldysfunctionisreversibleandpreventable.JCIInsight5(1).PMCID:PMC7030815.

504. JohannaI,Hernandez-LopezP,HeijhuursS,BongiovanniL,deBruinA,BeringerD,vanDooremalenS,ShultzLD,IshikawaF,SebestyenZ,StraetemansT,KuballJ.2020.TEG011persistenceavertsextramedullarytumorgrowthwithoutexertingoff-targettoxicityagainsthealthytissuesinahumanizedHLA-A*24:02transgenicmice.JLeukocBiol107(6):1069-1079.PMCID:PMC7722393.

505. HashimotoM,SaitoY,NakagawaR,OgaharaI,TakagiS,TakataS,AmitaniH,EndoM,YukiH,RamilowskiJA,SeverinJ,ManabeR-i,WatanabeT,OzakiK,KanekoA,KajitaH,FujikiS,SatoK,HonmaT,UchidaN,FukamiT,OkazakiY,OharaO,ShultzLD,YamadaM,TaniguchiS,VyasP,deHoonM,MomozawaY,IshikawaF.2021.CombinedinhibitionofXIAPandBCL2drivesmaximaltherapeuticefficacyingeneticallydiverseaggressiveacutemyeloidleukemia.NatureCancer2(3):340-56.

506. SaitoY,ShultzLD,IshikawaF.2020.UnderstandingNormalandMalignantHumanHematopoiesisUsingNext-GenerationHumanizedMice.TrendsImmunol41(8):706-720.PMCID:PMC7395895.


46

507. HosurV,SkellyDA,FrancisC,LowBE,KoharV,BurzenskiLM,AmijiMM,ShultzLD,WilesMV.2020.Improvedmousemodelsandadvancedgeneticandgenomictechnologiesforthestudyofneutrophils.DrugDiscovToday.25(6):1013-25.PMCID:PMC7329609.

508. DaiC,WalkerJT,ShostakA,BouchiY,PoffenbergerG,HartNJ,JacobsonDA,CalcuttMW,BottinoR,GreinerDL,ShultzLD,McGuinnessOP,DeanED,PowersAC.2020.DapagliflozinDoesNotDirectlyAffectHuman aorbCells.Endocrinology161(8).PMCID:PMC7375801.

509. StripeckeR,MunzC,SchuringaJJ,BissigKD,SoperB,MeehamT,YaoLC,DiSantoJP,BrehmM,RodriguezE,WegeAK,BonnetD,GuionaudS,HowardKE,KitchenS,KleinF,Saeb-ParsyK,SamJ,SharmaAD,TrumppA,TrusolinoL,BultC,ShultzL.2020.Innovations,challenges,andminimalinformationforstandardizationofhumanizedmice.EMBOMolMed12(7):e8662.PMCID:PMC7338801.

510. HosurV,LowBE,LiD,StaffordGA,KoharV,ShultzLD,WilesMV.2020.Genesadapttooutsmartgene-targetingstrategiesinmutantmousestrainsbyskippingexonstoreinitiatetranscriptionandtranslation.GenomeBiol21(1):168.PMCID:PMC7350591.

511. YeC,YangH,ChengM,ShultzLD,GreinerDL,BrehmMA,KeckJG.2020.Arapid,sensitive,andreproducibleinvivoPBMChumanizedmurinemodelfordeterminingtherapeutic-relatedcytokinereleasesyndrome.FASEBJ34(9):12963-12975.PMCID:PMC7436391.

512. LiP,LuM,ShiJ,HuaL,GongZ,LiQ,ShultzLD,RenG.2020.DualrolesofneutrophilsinmetastaticcolonizationaregovernedbythehostNKcellstatus.NatCommun11(1):4387.PMCID:PMC7463263.

513. LiP,LuM,ShiJ,GongZ,HuaL,LiQ,LimB,ZhangXH,ChenX,LiS,ShultzLD,RenG.2020.Lungmesenchymalcellselicitlipidstorageinneutrophilsthatfuelbreastcancerlungmetastasis.NatImmunol21(11):1444-1455.PMCID:PMC7584447.

514. JiangL,WangYJ,ZhaoJ,UeharaM,HouQ,KasinathV,IchimuraT,BanouniN,DaiL,LiX,GreinerDL,ShultzLD,ZhangX,SunZJ,CurtinI,VangosNE,YeohZC,GeffkenEA,SeoHS,LiuZX,HeffronGJ,ShahK,Dhe-PaganonS,AbdiR.2020.DirectTumorKillingandImmunotherapythroughAnti-SerpinB9Therapy.Cell183(5):1219-1233e18.PMCID:PMC7927154.

515. ShenoyGN,GreeneCJ,BhattaM,BarojaML,LoyallJL,Balu-IyerSV,KelleherRJ,Jr.,CarrenoBM,LinetteGP,ShultzLD,BankertRB.2021.Preclinicalevaluationofcancerimmunetherapyusingpatient-derivedtumorantigen-specificTcellsinanovelxenograftplatform.ClinTranslImmunology10(2):e1246.PMCID:PMC7853904.

516. JiaB,ZhaoC,BayerlM,ShikeH,ClaxtonDF,EhmannWC,MineishiS,SchellTD,ZhengP,ZhangY,ShultzLD,PrabhuKS,PaulsonRF,ZhengH.2021.Anovelclinicallyrelevantgraft-versus-leukemiamodelinhumanizedmice.JLeukocBiol,onlineaheadofprint.

517. SuriK,BubierJA,WilesMV,ShultzLD,AmijiMM,HosurV.RoleofMicroRNAinInflammatoryBowelDisease:ClinicalEvidenceandtheDevelopmentofPreclinicalAnimalModels.Cells.2021;10(9).PMCID:PMC8468560.

518. BurzenskiLM,LowBE,KoharV,ShultzLD,WilesMV,HosurV.InactiverhomboidproteinsRHBDF1andRHBDF2(iRhoms):adecadeofresearchinmurinemodels.MammGenome.2021.Online ahead of print. PubMedPMID:34477920.

519. BhattaM,ShenoyGN,LoyallJL,GrayBD,BapardekarM,ConwayA,MindermanH,KelleherRJ,Jr.,CarrenoBM,LinetteG,ShultzLD,OdunsiK,Balu-IyerSV,PakKY,BankertRB.2021.Novelphosphatidylserine-bindingmoleculeenhancesantitumorT-cellresponsesbytargetingimmunosuppressiveexosomesinhumantumormicroenvironments.JImmunotherCancer9(10):e00314. PMCID:PMC8488709.

Shultz CV 4.28.2021 - JAX

Documents

Transcript of Shultz CV 4.28.2021 - JAX