SHAYAN SHARIF - University of GuelphShayan Sharif -Curriculum vitae. 2 December 2011 – to date,...

Shayan Sharif-Curriculum vitae

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SHAYAN SHARIF

Work Address: Department of Pathobiology, Ontario Veterinary College, University of

Guelph, Guelph, Ontario N1G 2W1, Canada

Tel: (519) 824-4120, ext. 54641

Fax: (519) 824-5930

Email: [email protected]

Citizenship: Canadian

Education:

Ph.D. (Immunology), Department of Pathobiology, Ontario Veterinary College, University of

Guelph 1993 - 1999

Doctor of Veterinary Medicine (DVM), February 1986 - October 1991, Faculty of Veterinary

Medicine, University of Tehran, Iran

Employment:

Professor, July 2011- to date, Department of Pathobiology, University of Guelph, Guelph,

Ontario, Canada

Associate Professor, July 2006-July 2011, Department of Pathobiology, University of

Guelph, Guelph, Ontario, Canada

Assistant Professor, July 2001-July 2006, Department of Pathobiology, University of

Guelph, Guelph, Ontario, Canada

Post-doctoral fellow, January 1999–June 2001, Autoimmunity and Diabetes Group, The

John P. Robarts Research Institute, London, Ontario, Canada

Veterinarian, 1991-1993, Saman Broiler Company, Iran

Academic and administrative Appointments:

July 2011- to date, Professor, Department of Pathobiology, Ontario Veterinary College,

University of Guelph

September 2015 – to date, Director, Emergency Management Program, University of Guelph

and Ontario Ministry of Agriculture, Food and Rural Affairs Partnership.


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December 2011 – to date, Leader, Poultry Health Research Network, University of Guelph

January 1, 2014- December 31, 2014, Acting Associate Dean, Research and Innovation,

Ontario Veterinary College

November 2008-September 2013, Vice-Chair, Department of Pathobiology, University of

Guelph

July 2006- July 2011, Associate Professor, Department of Pathobiology, Ontario Veterinary

College, University of Guelph

July 2001-July 2006, Assistant Professor, Department of Pathobiology, Ontario Veterinary

College, University of Guelph

September 1999–July 2001, Special Graduate Faculty, Department of Pathobiology,

Ontario Veterinary College, University of Guelph

Department/College/University Committee memberships:

January 2016- to date, Member, University of Guelph Advisory Committee for Strategic

Renewal Process. This committee is charged with the mandate of laying out the roadmap for

the University of Guelph.

March 2014- to date, Leader, Smart Animal Health Management Initiative. This initiative is

focused on advancing research to improve efficiency of livestock production while reducing

the environmental footprint of livestock agriculture. In phase I of this initiative, we have

submitted a $3.5 million grant for support of this line of research across campus.

December 2015- to date, Leader, Natural Sciences and Engineering Research Council of

Canada (NSERC) Strategic Network- Climate change effects on livestock production. This

initiative is aimed at creating a $5,000,000 national network to investigate the challenges

posed by climate change to livestock production and develop ways to mitigate these risks.

May 2015 – to date, Member, Canada’s First Research Excellence Funds Committee. The

committee is mandate to craft an application to receive close to $80 million in funding for

propelling research in the main area of agriculture and food at the University of Guelph

January 2014 – December 2014, Member, Dean’s Council

January 2014 – December 2014, Member, Dean’s Management Team

January 2014 – December 2014, Member, U of Guelph Research Services Council

January 2014 – December 2014, Member, U. of Guelph Graduate Studies Council


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January 2014 – December 2014, Ex Officio Member, Pet Trust Board

January 2014 – December 2014, Chair, College Research Advisory Committee

January 2014 – December 2014, Member, Advanced Analysis Center Advisory Committee

January 2014 – December 2014, Chair, Comparative Clinical Research Facility Advisory

Committee

June 2012 – March 2104, Member of the Avian Health and Disease Faculty Search

Committee

November 2009- March 2012, Member of the Strategic Research Plan Committee, University

of Guelph

March 2010–July 2011, Member of the Viral Immunology Faculty Search Committee

September 2008- September 2010, Member of the departmental Promotion and Tenure

Committee

Summer 2008, Member of the Pathobiology Chair selection Committee, Department of

Pathobiology, University of Guelph

July 2008-July 2011, Chair, Seminar Series Committee, Department of Pathobiology,


Summer 2007, Member of the Epidemiologist Search Committee, Department of Population

Medicine, University of Guelph

September 2006- 2008, Member of the Awards and Student Accessibility Committee of

Senate

October 2005- 2008, Member of the University of Guelph Senate

October 2004-to date, Departmental Research Committee member

September 2001–2008, Co-organizer of Department of Pathobiology seminar series

October 2001–2005, College Library Committee representative

June 2003–2005 University of Guelph Faculty Association Council member


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Training of Highly Qualified personnel

Name

Degree/Position

Short Project Title

Bahram Shojadoost PDF Vitamins/trace elements and immunity

Tamiru Alkie PDF Novel vaccine delivery

Khaled Abdelaziz PDF Vaccines against campylobacter

Wanderley Quinteiro Filho PDF Vitamins and immunity

Nadiya Alqazlan PhD Immunity to avian influenza

Jake Astill MBS Vaccine development against influenza

Shirene Singh PhD Adjuvants for avian flu vaccines

Rubee Bavananthasivam PhD Immunity to Marek’s disease

Neda Barjesteh PhD Innate immunity against flu virus

Adrianna Laursen MSc Immunity to Marek’s disease

Alexander Yitbarek PhD Microbiota and innate immunity

Ashley Harrison DVM Vaccines against Campylobacter

Nassim Haghighi BSc Vaccines against Campylobacter

Jennifer Brisbin PDF (completed) Probiotic development

Ashkan Firouzabadi MBS (completed) Neonatal immunology

Ayumi Matsuyama PDF (completed) Marek’s disease

Ian Villaneuva MSc (completed) Anti-influenza activities of NKT cells


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Douglas Hodgins

Research

associate

(completed) Immunity in chickens

Chandrika Sethilkumaran PDF (completed) Immunity in chickens

Evan Mallette

Project student

(completed) Immunity against influenza

Ala Roshdieh

Project student

(completed) Commensal bacteria and the immune system

Sarah Law

Project student

(completed) Immunity against influenza

Lysa Langevin

Project student

(completed) Immunity in chickens

Amin Ashkar

Project student

(completed) Antiviral responses in chickens

Michael Groff

Project students

(completed) Innate Immunity against flu virus

Lianne Davidge

Technician

(completed) Probiotic development

Michael St. Paul MSc (completed) Toll-like receptor ligands in chickens

Kamran Haq PhD (completed) Gene knockouts and immunity to Marek’s

Payvand Parvizi PhD (completed)

Characterization of immunity to Marek’s

disease

Neda Barjesteh

Visiting

Scholar

(completed) Immune response to Marek’s

Kourosh Adeli

Co-op student

(completed) Probiotics for chickens

Mahmoud Shams

Visiting scholar

(completed) Probiotics for chickens

Inas Elawadli MSc (completed)

Effect of bioactive peptides on immune

response

Amirul Islam Mallick

PDF

(completed) Avian influenza immunology


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Raveendra Kulkarni

PDF

(completed) Influenza immunology

Hamid Reza Haghighi Technician Avian influenza immunology

Leah Read Technician Avian influenza immunology

Ian Villanueva

Project student

(completed) Effect of TLR agonists on chicken cells

Shahriar Orouji

Technician

(completed) Marek’s disease immunology

Lianne Davidge

Project student

(completed) Innate responses to avian influenza virus

Sarah Paulochi

Project student

(completed) Innate immunity in chickens

Kiana Mahboubi

Project student

(completed)

Gut microflora and the immune system

Jennifer Brisbin PhD (completed)

Examination of the effects of antibiotics on

microflora and immune system

Jessica Esufali

Summer student


Sarah Oh

Project student

(completed) Innate receptors in chickens

Niroshan Thanthrige PhD (completed) Proteomics of Marek’s disease

Benjamin Schlegel

USRA student

(completed) Immunology of Marek’s disease

Hakimeh Mohammadi (co-

advisor) PhD (completed) Function of the N protein in nidoviruses

Mohamed Faizal Abdul-Careem PDF (completed) Immunity to Marek’s disease

Yanlong Pei

Technician


Claudia Ursprung

Summer student


Mohamed Faizal Abdul-Careem PhD (completed) Immunity to Marek’s disease

Aimie Sarson PhD (completed) Genomics of the chicken immune system


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Thomas Fear

Project student


Katelyn Andrzejewski

Project student


Raveendra Kulkarni (co-advisor) PhD (completed) Proteomics of Clostridium perfringens

Christopher Lusty

Project student

(completed) Effects of antibiotics on immune response

Sangitha Shunmuganathan

Coop and Project

student

(completed)

Avian influenza immunology and immunity

to MD

Julie-Helen Fairbrother

DVM rotation

(completed) Immunology of Marek’s disease

Dina Mayameei

Visiting scholar

(completed) Genetics of resistance to Marek’s disease

Mohammad Reza Akbari

Visiting scholar

(completed)

Gut microbiota interactions with immune

system

Melissa Lambourne

Project student

(completed) Genetics of chicken MHC

Melissa Lawson (co-advisor) MSc (graduated)

Development of probes for detection of

lactobacilli

Payvand Parvizi MSc (graduated) Identification of Marek’s disease epitopes

Mehran Haeri MSc (graduated)

Characterization of peptides associated with

chicken MHC-II

Justin Cumberbatch MSc (graduated)

Identification of Marek’s disease virus

epitopes

Patrycja Niemiec MSc (graduated) Development of chicken MHC tetramers

Subhashinie Karyawasam PDF (completed)

Expression of Marek’s disease virus

antigens

Huaijun Zhou PDF (completed)

Examination of the effects of antibiotics on

microflora and immune system

Sarah Wheaton

Co-op student

(completed) Genetics of TLR signaling in the chicken


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Dina Mayameei

Visiting scholar

(completed) Genetics of resistance to Marek’s disease

Hou Jibo

Visiting scholar

(completed) Chicken immunology

Norma Azpiroz

Visiting

veterinary student Development of chicken immune microarray

Haris Gisavi

Co-op student

(completed) Probiotics and immune system

Deirdre Callery

Summer student

(completed) Genetics of immune response genes

Rebecca Nazareth

Summer student

(completed) Genetics of immune response genes

Note: Over the last 15 years, I have mentored several trainees, one of whom is an associate

professor at Pennsylvania State University (Dr. Karyawasam) and the other is a tenured associate

professor at University of California-Davis (Dr. Zhou). In addition, one of my other former PhD

students, Dr. Abdul-Careem, is tenured associate professor of viral immunology at University of

Calgary. My former PDF, Dr. Mallick, is also an assistant professor in India. In addition, four of

the visiting scholars (Drs. Javaheri, Mayameei, Shams and Akbari) that I hosted in my lab are

now serving as faculty members at universities in Iran, one of whom was a Dean at the

University of Semnan. Dr. Jibo was also a visiting scholar in my lab. He is now Director of a

research institute in China. Many of my former students are now conducting their post-doctoral

research in Canada and the US or are in medical and veterinary schools. Two of my former PhD

students are now working in industry (Elanco and Ceva) as research scientists.


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Graduate advisory committees

MSc committees

Doctoral committees

Jake Astill (advisor)

Ashkan Firouzabadi (advisor)

Adrianna Laursen (advisor)

Neda Barjesteh (advisor)

Mehran Haeri (advisor)

Justin Cumberbatch (advisor)

Patrycja Niemiec (advisor)

Payvand Parvizi (advisor)

Inas Elawadli (advisor)

Michael St. Paul (advisor)

Melissa Lawson (co-advisor)

David Thompson (member)

Zhumei Kang (member)

Lorna Carrasco (member)

Joanna McPherson (member)

Zahra Alizadeh (member)

Sergey Duvanov (member)

Arusyak Abrahamyan (member)

Holly Pizzey (member)

Marcedes Vallance (member)

Lesley Berghuis (member)

Zafir Seyed (member)

Lynn Williams (member)

Nadiya Alqazlan (advisor)

Alexander Yitbarek (advisor)

Jegarubee Banavisthavam (advisor)

Neda barjesteh (advisor)

Shirene Singh (advisor)

Aimie Sarson (advisor)

Jennifer Brisbin (advisor)

Mohamd Faizal Abdul-Careem (advisor)

Kamran Haq (advisor)

Payvand Parvizi (advisor)

Niroshan Thantrige-Don (advisor)

Kamran Haq (advisor)

Hakimeh Mohammadi (co-advisor)

Raveendra Kulkarni (co-advisor)

Laura Bassell (Member)

Peyman Asadian (member)

Alexandra Floras (Member)

Li Deng (member)

Rasha Taiba (member)

Romina Zanabria (member)

Melanie Ammersbach (member)

Kuldeep Chatha (member)

Lois Valli (member)

Ivan Leyva (member)

Said El-Eshram (member)

Angela Tellez (member)

Maged Gomaa (member)

Shu-Hua Ma (member)

Deanna Russell (Member)

Chandrika Senthilkumaran (member)

Marlene Paibomesai (member)

Pegah Valizadeh (Member)

Saman Maleki

(University of Western Ontario, Member)

Shyamash Kumar

(Mississippi State University, member)

Afsaneh Najarian (member)

Niloufar Eslami (member)

Romina Zanabria (member)

Alexandra Floras (Member)

Monica Baquero (member)


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Thesis Examination Committee Membership


1. Shirene Singh (PhD), Immunity to avian influenza viruses (2016)

2. Bryan Griffin (PhD), Biology of fowl adenoviruses (2015)

3. Zafir Seyed (MSc) Studies of oncolytic viruses (2014)

4. Chandrika Centhilkumaran (PhD) The role of annexins in bovine pneumonia (2013)

5. Ian Villanueva (MSc) TLR-mediated responses of NKT cells (2013)

6. Michael St. Paul (MSc) Prophylactic use of TLR ligands for control of avian influenza

virus (2012)

7. Inas Elawadli (MSc) Stimulation of the immune system by lactobacilli (2012)

8. Kamran Haq (PhD) The role of cytokines in immunity against Marek’s disease (2012)

9. Payvand Parvizi (PhD) Immunity against Marek’s disease virus (2012)

10. Kathleen Thompson (PhD) Breeding for enhanced immune response in cattle (2012)

11. Hector Sosa Marin (PhD) Inhibition of DNA methyltransferase in bovine fibroblasts

(2011)

12. Jennifer Brisbin (PhD) Commensal bacteria interactions with the chicken immune system

(2011)

13. Icy D’Silva (PhD) Regulation of allergic responses to egg proteins, 2010

14. Niroshan Thanthrige-Don (PhD) Proteomics of host response to Marek’s disease virus,

2010

15. Kuldeep Chatha (PhD) Expression of membrane IgM, CD21 and CD32 on lymphocytes

in neonatal calves, 2010

16. Hakimeh Mohammadi (PhD) Molecular function of the N protein of arterivriuses, 2010

17. Elizabeth Hillyer (MSc) Distribution of antimicrobial resistance genes and class 1

integrons in Escherichia coli from Canadian beef cattle, 2009


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18. Behrouz Khashayar (MSc) Prevalence of antimicrobial resistance and of selected beta-

lactam resistance genes in E. coli isolates from canine urinary tract infections in Ontario

and Quebec, 2009

19. Korine Hamilton (MSc) Variation in immune response in neonatal pigs, 2008.

20. Joanna McPherson-Komorowski (MSc) Use of a probiotic formulation in control of

Eimeria tenella infection in broiler chickens, 2008.

21. Sergey Duvanov (MSc) Selection of oligonucleotides specific to chicken peripheral blood

mononuclear cells in whole blood ex vivo system, 2008.

22. Gordon Mitchell (PhD) Effect of stress on pulmonary host defences of cattle, 2008.

23. Mohamed Faizal Abdul-Careem (PhD) Characterization of host responses following

Marek’s disease virus infection or vaccination against Marek’s disease, 2008.

24. Payvand Parvizi (MSc) Cytokine gene expression in CD4+ and CD8+ T cell subsets of

chickens infected with Marek’s disease virus, 2008.

25. Arusyak Abrahamyan (MSc) Application of RNA interference methodology to inhibit

avian influenza virus replication in vitro, 2008.

26. Aimie Sarson (PhD) Genomics of host responses to Marek’s disease virus, 2007.

27. Nathalie Keirstead (PhD) The role of ficolins as anti-viral compounds, 2007.

28. Armando Heriazon (PhD) Phenotyping for immune response traits, 2007.

29. David Hobson (DVSc) Proteomic analysis of the type-1 allergic response to ovomucoid in

balb/c mice, 2007.

30. Shuhua Ma (2007) The effects of poly (A)-binding protein 1 (PABA1) over-expression on

mRNA metabolism and the regulation of PABP1 expression following recovery from heat

shock, 2007

31. Justin Cumberbatch (MSc) Analysis of self and viral peptides associated with chicken

major histocompatibility complex class II molecules, 2006.

32. Lorna Carrasco (MSc) Investigation of a leukotoxin containing immune stimulating

complex (iscom) vaccine and early immunization in dairy calves, 2006.

33. Candace Stewart (MSc) Presence of RNA interference (RNAi) in fetal porcine fibroblast

cells, 2006.


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34. Matthew Firth (MSc) Expression and characterization of recombinant bovine C3D fusion

proteins, 2006.

35. Patrycja Niemiec (MSc) Synthesis of chicken major histocompatibility class II oligomers,

2005.

36. Byram Bridle (PhD) Towards xenotolerance: Characterization and modulation of the rat

immune response to porcine cells, 2005.

37. Angela Borzychowski (PhD) Systemic inflammatory response in human pregnancy, 2005.

38. Felipe Reggeti (PhD) Host-virus interactions and molecular epidemiology of the feline

immunodeficiency virus, 2005

39. Helena Grgic (MSc) Pathogenicity and cross protection of infectious bronchitis virus field

isolates of Ontario, 2005.

40. Maureen Barry (DVSc) In vitro lymphocyte response from vaccinated dogs to canine

distemper virus vaccine, 2004.

41. Mehran Haeri (2004) Identification of Naturally presented peptides assoicated with

chicken major histocompatibility complex class II molecules, 2004.

42. Hamid Reza Hghighi (MSc) Assessment of vapA-DNA vaccination against Rhodococcus

equi in mice with naked DNA or a Salmonella vector, 2004.

43. Lori Whitcomb (MSc) Characterization of cytokine expression patterns in response to

infection with different strains of Eimeria maxima, 2004.

44. Haitham Ghunaim (MSc) Vaccines against Escherichia coli cellulitis and

respiratory/septicemic disease in broiler chickens, 2004.

45. David Thompson (MSc) Vaccine-based control of necrotic enteritis of broiler chickens,

2003.

46. Sarah Ledgwige (MSc) Associations between specific bovine leukocyte antigen DRB3

alleles and mastitis in Canadian Holsteins, 2003.

47. Aboubaker Sidahmad (MSc) Control of cytokine gene expression using antisense

oligodeoxynucleotide : blockage of interleukin-10 and interferon-gamma gene expression

in pig cells, 2002.

48. Armando Hernandez, Evaluation of delayed-type hypersensitivity for classification of

cows as high and low immune responders, 2002.


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Membership on Thesis Examination Committees as an External Examiner

1. Kristina Simon (PhD) Effect of early feeding on the chicken immune system

development, Wageningen University, The Netherlands

2. Sofie Ulrich-Lynge (PhD) Mannose binding receptor in chickens, Aarhus University,

Denmark

3. Mohammad Alizadeh (PhD) Chicken gut immunity, University of Manitoba, Canada

4. Kate Gosseens (PhD) Chicken antiviral genes, Daekin University, Australia.

5. Jayaum Booth (PhD) Effects of CpG ODN on development of immune response in the

ovine intestinal tract, University of Saskatchewan, Saskatoon, Canada

6. Kathleen Duffy (MSc) The effect of bovine lactoferrin and lactoferricin on influenza A

virus-specific CD8+ T cell responses in vivo. University of Western Ontario, London,

Ontario, Canada, August 2008.

7. Laura Starr (PhD) Robustness in chickens: Influence of genetic background, environment,

and early-life experiences, Wageningen University, The Netherlands, October 2008.

8. Amirul Islam Mallick (PhD) Fusogenic liposome based vaccines against some infectious

disease, Aligarh University, India, 2007.

PhD Qualifying Examination Committee Membership

1. Iman Mehdizadeh 2016

2. Alexander Yitbarek 2016

3. Laura Bassell 2016

4. Jegarubee Bavananthasivam 2015

5. Monica Baquero 2014

6. Neda Barjesteh 2014

7. Shirene Singh 2013

8. Ehab Misk 2013

9. Heather Chalmers 2012

10. Kayla Price 2012

11. Laurie Wagter-Lesperanse 2012

12. Yfke Pasman 2012

13. Chandrica Sentilkumaran 2011

14. Antonio Facciulo 2011


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15. Kathleen Thompson 2010

16. Melanie Ammersbach 2010

17. Julie Schmied 2010

18. Payvand Parvizi 2009

19. Hector Eduardo Sosa Marin 2009

20. Kamran Haq 2009

21. Jennifer Brisbin, 2007

22. Kuldeep Chatha, 2007

23. Matt Firth, 2007

24. Niroshan Thanthrige, 2007

25. Cheng Song, 2006

26. Angela Tellez, 2006

27. Heba Atalla, 2006

28. Gordon Mitchell, 2006

29. Said El-Eshram, 2006

30. Natalie Keirstead, 2005

31. Ravi Kulkarni, 2005

32. Byram Bridle, 2005

33. Chang-Hee Lee, 2005

34. Ivan Leyva, 2005

35. Mohamed Faizal Abdul-Careem, 2005

36. Armando Hernandez, 2005

37. Brandon Lillie, 2004

38. Aimie Sarson, 2004

39. Spencer Russell, 2004

40. Angela Crawley, 2002

External reviewer for Promotion and Tenure dossiers

Dr. Rami Dalloul, Promotion to Professor (Virginia Tech University)

Dr. Venu Nair, Promotion to Professor (Pirbright Institute, UK)

Dr. Karl Schmidt, Promotion to Professor (University of Delaware)

Dr. Frits van Ginkel, Promotion to Professor (Auburn University)

Dr. Byung-Whi Kong, Tenure and promotion to Associate Professor (University of Arkansas)

Dr. Mani Larijani, Tenure and promotion to Associate Professor (Memorial University)

Dr. Masahiro Niikura, Tenure and promotion to Associate Professor (Simon Fraser University)

Membership in Professional Associations:

American Association of Immunologists

Canadian Society for Immunology

American Society for Microbiology

American Association of Avian Pathologists

Poultry Science Association


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Awards and honors

DTL Smith Lectureship, Western College of Veterinary Medicine, University of Saskatchewan

(2015)

Pfizer Award for Research Excellence (2009)

Canadian Diabetes Association Postdoctoral Fellowship (1999-2001)

Immunology of Diabetes Association Travel Fellowship (2001)

Laforet Research Assistantship (1998)

Department of Veterinary Microbiology and Immunology Award for Graduate Student

Excellence (1996)

Ontario Veterinary College Graduate Student Recognition Award (1996)

International Society of Animal Genetics Scholarship (1996)

Ontario Veterinary College- Graduate Student Association Scholarship (1996)

D.G. Ingram Memorial Scholarship (1994 and 1996)

Ontario Veterinary College Alumni Scholarship (1996)

D.G. Ingram Graduate Travel Scholarship (1995)

Pfizer Food Animal scholarship (1995)

University of Guelph Graduate Scholarship (twice in 1994 and once in 1995).

Peer Review:

Journals: The Journal of Immunology, Virology, Proteomics, Biologia, Journal of Proteome

Research, Animal Genetics, Canadian Journal of Veterinary Research, Journal of Veterinary

Diagnostic Investigation, Vaccine, Canadian Journal of Microbiology, Avian Pathology, Viral

Immunology, Poultry Science, Veterinary Immunology and Immunopathology

Journal Editorial Board Membership

Co-Editor-in-Chief, Veterinary Immunology and Immunopathology

Associate Editor for Avian Pathology

Associate Editor for BMC Genomics

Associate Editor for Poultry Science

Editorial Board Member for Veterinary Immunology and Immunopathology

Granting agencies:

Evaluation Group Member, Genes, Cells and Molecules Evaluation Group, NSERC

Discovery, 3 year term, 2014-2017

Canadian Institutes of Health Research (CIHR)

Natural Sciences and Engineering Research Council of Canada (NSERC)-Discovery and


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Collaborative Research and Development grants

The Wellcome Trust (UK)

BBSRC (Biotechnology and Biological Sciences Research Council, UK)

National Science Foundation (NSF), USA

NIH grant review panel on immunity to influenza, USA

BARD (The USA-Israel Bi-national Agricultural Research & Development Fund)

Research Grants Competition

Danish Council of Science

Poultry Industry Council Research Board

Canadian Poultry Research Council Scientific Advisory Committee

Patents

Vaccines against Clostridium perfringens, US 8,501,190, issued: August 6, 2013

Co-inventors: John Prescott, Raveendra Kulkarni, Valeria Parreira, Shayan Sharif

Teaching experience

2007-to date Course coordinator and instructor, Graduate course in Immunology:

Immunobiology

2007-to date Course coordinator, Advanced graduate course in Immunology: Topics in

Immunology

2002- 2007 Instructor, Advanced graduate course in Immunology: Topics in Immunology

2002- 2007 Instructor, Graduate course in Immunology: Immunobiology

2003-to date Instructor, Graduate course: Mechanisms of Disease

2004-2006 Course coordinator, Undergraduate course: Genes and Immunity

Scholarly and professional activities


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Co-Editor-in-Chief, Veterinary Immunology and Immunopathology (July 15, 2015 – to

date)

Associate Editor, Avian Pathology (January 2009- 2015)

Associate Editor, BMC Genomics (March 2010- 2014)

Associate Editor, Poultry Science (July 2012- 2014)

Editorial Board Member, Veterinary Immunology and Immunopathology (March 2010-

July 15, 2015)

Veterinary Immune Reagent Network Advisory Board Member

Evaluation Group Member, Natural Sciences and Engineering Research Council of

Canada-Discovery Grants

Host and organizer, Avian Immunology Research Group, July 2014, Guelph, Ontario,

Canada

Member, Scientific Committee, Avian Immunology Research Group, 2016, Munich,

Germany

Member, Scientific Committee, Avian Herspesviruses Conference, 2016, Tours, France

Member, Organizing Committee, Smart Animal and Plant Management, September 2015,

Guelph, Canada

Member, scientific committee, The 5th

International Workshop on the Molecular

Pathogenesis of Marek's Disease Virus, Athens, Georgia, October 2010

Member, Scientific Advisory Committee, Canadian Poultry Research Council, 2009 &

2010.

Chair, Pathology Session, Annual Poultry Science Conference, Niagara Fall, July 2008

Organizer of the USDA-sponsored NE1016 (Genetic bases for immunity in avian species)

meeting, Guelph, Ontario, September 2007

Member of the Organizing Committee, 7th

International Veterinary Immunology

Symposium (IVIS), Quebec City, July 2004.

Co-organizer of the MHC Workshop, Chair of the Immune Response Genes, and Co-chair

of the Variation in Immune Response concurrent session of the 7th

International

Veterinary Immunology Symposium, Quebec City (IVIS), July 2004


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Chair (2004) and member (2003, 2006) of the Ontario Graduate Scholarship (OGS)

Review Panel. Members of each panel are responsible for reviewing approximately 80-

120 OGS applications.

Research Funding

Year Source Project title Co-recipient Amount

2016-

2019 OMAFRA Strategies for control of AIV transmission

Z.Poljak, R.

Dara and M.

Von Massow $141,000

2016-

2019

Saskatchewan

Chicken Industry Strategies for control of AIV transmission

Z.Poljak, R.

Dara and M.

Von Massow $45,000

2016-

2019

Egg Farmers of

Canada Strategies for control of AIV transmission

Z.Poljak, R.

Dara and M.

Von Massow $22,000

2015-

2018 OMAFRA Enhancing immunity to avian influenza

viruses E. Nagy $233,000

2015-

2018 OMAFRA In ovo delivery of immune stimulants N/A $64,500

2015-

2016

Alltech Selenium for enhancing immunity to avian

influenza N/A $48,000

2015-

2016

Ontario Centers

of Excellence Selenium for enhancing immunity to avian

influenza N/A $40,000

2013-

2017

AAFC and

CPRC Avian influenza control in chickens

S. Sharif (PI)

and two others $500,800

2014-

2017

NSERC-CRD,

PIC and CPRC Vaccines against Campylobacter N/A $170,000

2012-

2014

NSERC-CRD,

PIC and CPRC Probiotic development N/A $108,000


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2012-

2015 OMAFRA Novel adjuvants for chicken vaccines E. Nagy $190,000

2012-

2015 OMAFRA Prophylactic strategies against influenza

virus N/A $150,000

2011-

2016 NSERC Immunology of Marek’s disease N/A $240,000

2010-

2012 NSERC-CRD Lactobacilli will immune stimulatory

activities N/A $67,500

2010-

2013 CPRC-AAFC Biology and control of avian influenza

S. Sharif (PI) &

5 others $1,280,000

2010-

2013 OMAFRA Development of immune strategies for

control of viral diseases in chickens

É. Nagy (PI) &

S. Sharif $120,000

2010-

2013 OMAFRA Immunity against avian influenza virus

S. Sharif (PI) &

É. Nagy $230,000

2010-

2013 OMAFRA

Vaccination against Campylobacter in

chickens

S. Sharif (PI) &

Mario Monteiro $216,500

2009-

2011 PIC

Development of novel vaccine formulations

for enhanced immunogenicity and

protective efficacy of poultry vaccine N/A $40,000

2009-

2011 NSERC-CRD

Towards the development of novel vaccines

for control of Marek's disease and shedding

of Marek's disease virus from feathers Sarah Wootton $37,500

2009-

2011 PIC

Towards the development of novel vaccines

for control of Marek's disease and shedding

of Marek's disease virus from feathers $37,500

2009

NSERC-

Research Tools

& Equipment

High throughput real-time thermocycler for

studies of host-pathogen interactions

S. Sharif (PI)

with10 co-

applicants $86,000


20


2009-

2011 NSERC-CRD

Towards development of efficacious

vaccines against avian influenza virus N/A $84,000

2008

University-

Ministry of

Research

Innovation

Immunity to avian influenza (funds for a

PDF) N/A $100,000

2008

NSERC-

Research Tools

& Equipment Ultracentrifuge É. Nagy and 4

others $140,000

2007-

2009 PIC

Lactobacilli with superior immune

enhancing activities Joshua Gong $35,000

2007-

2009 PIC

Development of vaccines for avian

influenza $51,000

2007-

2010 SCIDF Avian influenza immunity N/A $30,000

2007-

2009 NSERC-CRD Enhancing immunity to Marek’s disease S. Golovan

A. Bendall $60,000

2006-

2010 OMAFRA Enhancing poultry health and welfare

É. Nagy and 11

others $3,288,500

2006-

2011

NSERC-

Discovery

Immunology of Marek’s disease infection

in chickens N/A $214,500

2006-

2008 NSERC-AAFC Immunity to avian influenza in chickens É. Nagy $240,000

2006-

2008

PIC

Immunology of avian influenza

K.A. Schat

E. Collisson

S. Behboudi

É. Nagy

$60,000

2006-

2008 CPRC

Immunology of avian influenza

K.A. Schat

E. Collisson

S. Behboudi $60,000


21


2005-

2007

NSERC-AAFC

Partnerships

Program

Examination of immunomodulatory effects

of gut microbiota manipulations in the

chicken N/A $48,000

2005-

2007 NSERC-CRD

Investigations into the effects of antibiotics

on chicken gut microflora and development

of immune response N/A $71,000

2005-

2007 NSERC-CRD

Resistance to Marek’s disease in

commercial lines Urs Kuhnlein $100,000

2005

NSERC-Reseach

Tools &

Equipment

Cytometry in animal health research

Dorothee

Bienzle and 6

others $144,182

2005-

2007 PIC


on chicken gut microflora composition and

development of immune response Joshua Gong $30,000

2004-

2006

Canadian Poultry

Research Council


on chicken gut microflora composition and

development of immune response Joshua Gong $45,000

2004-

2006 SCIDF

Gut microflora manipulations for control of

food-borne pathogens in chickens Jim Chambers $28,200

2004-

2006

Saskatchewan

Chicken Industry

Research and

Development

Funds (SCIDF)

The impact of in ovo vaccination on vaccine

efficacy and development of chicken

immune system Bruce Hunter $20,000

2004-

2006 PIC

An integrated genetic approach for control

of health and disease in poultry N/A $60,000

2003-

2005

NSERC/AAFC

Partnerships

Program

Towards an integrative genetic approach for

improved poultry health N/A $120,000


22


2003-

2005

OMAF-Food

Safety Research

Program

Antibiotic replacement therapy for control

of food-borne pathogens in poultry

Jim Chambers

Joshua Gong

Tony Hayes

Carlton Gyels

Babak Sanei $122,000

2003-

2005 PIC

Antibiotic replacement therapy for control

of food-borne pathogens in poultry

Jim Chambers

Joshua Gong

Tony Hayes

Babak Sanei $33,000

2003-

2006

OMAF-Poultry

Research

Program

Examination of pro- and prebiotics for

control of food-borne pathogens and

immune stimulation in poultry

Jim Chambers

Joshua Gong

Tony Hayes

Babak Sanei $42,000

2003-

2005 CFIA-MII

Application of quantitative PCR technology

to measure genetic and vaccination induced

resistance to Marek’s disease virus Lloyd Spencer $40,000

2003-

2005 PIC

Maintenance of genetically-defined

chickens in specific pathogen free

conditions N/A $40,000

2002-

2004

Food System

Biotechnology

Center

Dynamics of gene expression in genetically

defined chickens N/A $45,000

2002-

2003

Canada

Foundation for

Innovation

Infrastructure for studies of

immunogenetics of host resistance N/A $125,863

2002-

2003

Ontario

Innovation Trust

Infrastructure for studies of

immunogenetics of host resistance N/A $125,863

2002-

2004 PIC

Molecular genetics of disease resistance and

immune responsiveness in genetically

defined chickens N/A $59,200

2002-

2005 OMAF

Dynamics of the chicken immune system

gene expression in response to infections

with infectious bronchitis virus and Marek’s

disease virus N/A $30,000

2002-

2006 NSERC

Immunological aspects of infection with

Marek’s disease virus N/A $152,800


23


2001-

2002 PIC Enhancing immunity to Marek’s disease

virus N/A $25,000

In total, I have received over $10,00,000 in grants either as the PI or a co-applicant from

industry and government agencies.

Publications

Total H index = 31 (Google Scholar, Accessed May 2016)

Research and review articles:

1. N. Boodhoo, S. Sharif, S. Behboudi (2016) 1α,25(OH)2 Vitamin D3 Modulates Avian T

Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One

24;11(2):e0150134.

2. K. Taha-Abdelaziz, T.N. Alkie, H.C. Hodgins, B. Shojadoost, S. Sharif (2016)

Characterization of host responses induced by Toll-like receptor ligands in chicken cecal

tonsil cells. Veterinary Immunology and Immunopathology 174:19-25.

3. S.M. Singh, T.N. Alkie, K.T. Abdelaziz, D.C. Hodgins, A. Novy, É. Nagy, S. Sharif

(2016) Characterization of Immune Responses to an Inactivated Avian Influenza Virus

Vaccine Adjuvanted with Nanoparticles Containing CpG ODN. Viral Immunology

29(5):269-75.

4. W.M. Quinteiro-Filho, J.T. Brisbin, D.C. Hodgins, S. Sharif (2015) Lactobacillus and

Lactobacillus cell-free culture supernatants modulate chicken macrophage activities.

Research in Veterinary Science 103:170-5.

5. J. Guan, Q. Fu, S. Sharif (2015) Replication of an H9N2 Avian Influenza Virus and

Cytokine Gene Expression in Chickens Exposed by Aerosol or Intranasal Routes. Avian

Diseases 59(2):263-8.

6. P. Parvizi, J.T. Brisbin, L.R. Read, S. Sharif (2015) Cytokine Gene Expression in Lung

Mononuclear Cells of Chickens Vaccinated with Herpesvirus of Turkeys and Infected

with Marek's Disease Virus. Viral Immunology 28(9):538-43.

7. J.L. Hu, H. Yu, R.R. Kulkarni, S. Sharif, S.W. Cui, M.Y. Xie, S.P. Nie, J. Gong (2015)

Modulation of cytokine gene expression by selected Lactobacillus isolates in the ileum,

cecal tonsils, and spleen of Salmonella-challenged broilers. Avian Pathology 22:1-31.


24

8. N. Barjesteh, B. Shojadoost, J.T. Brisbin, M. Emam, D.C. Hodgins, É. Nagy, Sharif

(2015) Reduction of avian influenza virus shedding by administration of Toll-like

receptor ligands to chickens. Vaccine 33(38):4843-9.

9. L.B. Williams, J.B. Koenig, B. Black, T.W. Gibson, S. Sharif, T.G. Koch (2015) Equine

allogeneic umbilical-cord-blood mesenchymal stromal cells reduce synovial fluid

nucleated cell count and induce mild self-limiting inflammation when evaluated I a LPS

induced synovitis model. Equine Veterinary Journal 2015 Jun 26. doi:

10.1111/evj.12477.

10. S.M. Singh, T.N. Alkie, D.C. Hodgins, É. Nagy, B. Shojadoost, S. Sharif (2015) Systemic

immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using

class B CpG oligonucleotides in chickens. Vaccine 33(32):3947-52.

11. D.C. Hodgins, N. Barjesteh, M. St Paul, Z. Ma, M.A. Monteiro, S. Sharif S (2015)

Evaluation of a polysaccharide conjugate vaccine to reduce colonization by

Campylobacter jejuni in broiler chickens. BMC Research Notes 8:204.

12. N. Barjesteh, J.T. Brisbin, S. Behboudi, É. Nagy, S. Sharif (2015) Induction of antiviral

responses against avian influenza virus in embryonated chicken eggs with toll-like

receptor ligands. Viral Immunology 28(4):192-200.

13. S. Thapa, M.S. Cader, K. Murugananthan, É. Nagy, S. Sharif, M. Czub, M.F. Abdul-

Careem (2015) In ovo delivery of CpG DNA reduces avian infectious laryngotracheitis

virus induced mortality and morbidity. Viruses 7(4):1832-52.

14. J.T. Brisbin, L. Davidge, A. Roshdieh, S. Sharif (2015) Characterization of the effects of

three Lactobacillus species on the function of chicken macrophages. Research in

Veterinary Science 100:39-44.

15. B. Shojadoost, S. Behboudi, A.I. Villanueva, J.T. Brisbin, A.A. Ashkar, S. Sharif.

Vitamin D3 modulates the function of chicken macrophages. Research in Veterinary

Science 100:45-51.

16. K. Haq, S.K. Wootton, N. Barjesteh, S. Golovan, A.J. Bendall, S. Sharif (2015) Effects of

interferon-γ knockdown on vaccine-induced immunity against Marek's disease in

chickens. Canadian Journal of Veterinary Research 79(1):1-7.

17. A.M. Kameka, S. Haddadi, F.J. Jamaldeen, P. Moinul, X.T. He, F.H. Nawazdeen, S.

Bonfield, S. Sharif, N. van Rooijen, M.F. Abdul-Careem (2014) Clodronate treatment

significantly depletes macrophages in chickens. Canadian Journal of Veterinary

Research. 78(4):274-82.


25

18. A.N. Floras, M.K. Holowaychuk, D. Bienzle, A.M. Bersenas, S. Sharif, T. Harvey, S.K.

Nordone, G.A. Wood (2014) N-terminal pro-C-natriuretic peptide and cytokine kinetics

in dogs with endotoxemia. Journal of Veterinary Internal Medicine. 28(5):1447-53.

19. T.N. Alkie, M. St Paul, N. Barjesteh, J.T. Brisbin, S. Sharif (2015) Expression profiles of

antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands.

Veterinary Immunology & Immunopatholology. 163(3-4):157-63.

20. N. Barjesteh, S. Behboudi, J.T. Brisbin, A.I. Villanueva, E. Nagy, Sv Sharif(2014) TLR

ligands induce antiviral responses in chicken macrophages. PLoS One. Aug

28;9(8):e105713. doi: 10.1371/journal.pone.0105713. eCollection 2014.

21. A.I. Villanueva, S.M. Haeryfar, B.A. Mallard, R.R. Kulkarni, S. Sharif. Functions of

invariant NK T cells are modulated by TLR ligands and IFN-α. Innate Immunity 2014

Mar 28. pii: 1753425914527327. [Epub ahead of print] PubMed PMID: 24934453.

22. I. Elawadli, J.T. Brisbin, B.A. Mallard, M.W. Griffiths, M. Corredig, S. Sharif (2914)

Differential effects of lactobacilli on activation and maturation of mouse dendritic cells.

Beneficial Microbes 5(3):323-34.

23. X. Yang, J.T. Brisbin, H. Yu, Q. Wang, F. Yin, Y. Zhang, P. Sabour, S. Sharif, J. Gong

(2014) Selected lactic acid-producing bacterial isolates with the capacity to reduce

Salmonella translocation and virulence gene expression in chickens. PLoS One. 2014 Apr

11;9(4):e93022. doi: 10.1371/journal.pone.0093022. eCollection 2014.

24. M. St. Paul, J.T. Brisbin, N. Barjesteh, A.I. Villaneueva, P. Parvizi, L.R. Read, É. Nagy,

S. Sharif (2014) Avian influenza virus vaccines containing Toll-like receptor 2 and 5

ligand adjuvants promote protective immune responses in chickens. Viral Immunology.

27(4):160-6.

25. M. St. Paul, N. Barjesteh, J.T. Brisbin, A.I. Villaneueva, L.R. Read, D.C. Hodgins, É.

Nagy and S. Sharif (2014) Effects of Toll-like receptor 3, 4 and 21 ligands as adjuvants

on the immunogenicity of an avian influenza vaccine in chickens. Viral Immunology.

27(4):167-73.

26. M. Rytelewski, C.E. Meilleur, M. Atef Yekta, P.A. Szabo, N. Garg, T.D. Schell, A.M.

Jevnikar, S. Sharif, B. Singh, S.M. Haeryfar (2014) Suppression of immunodominant

antitumor and antiviral CD8(+) T cell responses by indoleamine 2,3-dioxygenase. PLoS

One. 2014 Feb 28;9(2):e90439. doi: 10.1371/journal.pone.0090439. eCollection 2014.

27. R. Zanabria, A.M. Tellez, M. Griffiths, S. Sharif, M. Corredig (2014) Modulation of

immune function by milk fat globule membrane isolates. Journal of Dairy Science.

97(4):2017-26.

28. P. Parvizi, M.F. Abdul-Careem, A.I. Mallick, K. Haq, H.R. Haghighi, S. Orouji, M.


26

Heidari, S. Behboudi, S. Sharif (2014) The effects of administration of ligands for Toll-

like receptor 4 and 21 against Marek's disease in chickens. Vaccine. 32(17):1932-8.

29. A.N. Floras, M.K. Holowaychuk, D.C. Hodgins, H.S. Marr, A. Birkenheuer, S. Sharif,

A.M. Bersenas, D. Bienzle (2014) Investigation of a Commercial ELISA for the

Detection of Canine Procalcitonin. Journal of Veterinary Internal Medicine. 28(2):599-

602.

30. H. Grgić, Z. Poljak, S. Sharif, E. Nagy (2013) Pathogenicity and cytokine gene expression

pattern of a serotype 4 fowl adenovirus isolate. PLoS One 18;8(10):e77601.

31. A.Yitbarek, J.C. Rodriguez-Lecompte, H.M. Echeverry, P. Munyaka, N. Barjesteh, S.

Sharif, G. Camelo-Jaimes (2013) Performance, histomorphology, and toll-like receptor,

chemokine, and cytokine profile locally and systemically in broiler chickens fed diets

supplemented with yeast-derived macromolecules. Poultry Science 92(9):2299-310.

32. M. St Paul, S. Paolucci, S. Sharif. (2013) Characterization of responses initiated by

different Toll-like receptor 2 ligands in chicken spleen cells. Research in Veterinary

Science. 95(3):919-23.

33. L. Deng, S. Sharif, E. Nagy (2013) Oral inoculation of chickens with a candidate fowl

adenovirus 9 vector. Clinical and Vaccine Immunology. 20(8):1189-96.

34. K. Haq, K.A. Schat, S. Sharif (2013) Immunity to Marek's disease: Where are we now?

Developmental & Comparative Immunology. 41(3):439-46.

35. N. Barjesteh, D.C. Hodgins, M. St. Paul, M.A. Monteiro, S. Sharif (2013) Induction of

chicken cytokine responses in vivo and in vitro by lipooligosaccharide of Campylobacter

jejuni HS:10, Veterinary Microbiology 164(1-2):122-30

36. K. Haq, S.K. Wootton, N. Barjesteh, M. St. Paul, S. Golovan, A.J. Bendall, S. Sharif

(2013) Small interfering RNA-mediated knockdown of chicken interferon-gamma

expression. Journal of Interferon and Cytokine Research, 33(6):319-27.

37. H. Grgic, S. Sharif, Z.Poljak, É Nagy (2013) Cytokine patterns associated with a serotype

8 fowl adenovirus infection. Viral Immunology 26(2):143-9.

38. M. St. Paul, S. Paolucci, N. Barjesteh, R.D. Wood, S. Sharif (2013) Chicken erythrocytes

respond to Toll-like receptor ligands by up-regulating cytokine transcripts. Research

Veterinary Science 95(1):87-91.

39. M. St Paul, J.T. Brisbin, M.F. Abdul-Careem, S. Sharif (2013) Immunostimulatory

properties of Toll-like receptor ligands in chickens. Veterinary Immunology

Immunopathology 152(3-4):191-9.


27

40. J.T. Brisbin, P. Parvizi, S. Sharif. Differential cytokine expression in T-cell subsets of

chicken caecal tonsils co-cultured with three species of Lactobacillus. Beneficial

Microbes. 2012 (3):205-10.

41. P.M. Munyaka, G. Tactacan, M. Jing, J.D. House, M. St Paul, S. Sharif, J.C. Rodriguez-

Lecompte. Response of older laying hens to an Escherichia coli lipopolysaccharide

challenge when fed diets with or without supplemental folic acid. Poultry Science. 2013

Jan;92(1):105-13.

42. M. St Paul, N. Barjesteh, S. Paolucci, Y. Pei, S. Sharif. Toll-like receptor ligands induce

the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC

Research Notes. 2012 Nov 1;5:616.

43. A. Yitbarek, H. Echeverry, J. Brady, J. Hernandez-Doria, G. Camelo-Jaimes, S. Sharif,

W. Guenter, J. D. House, and J. C. Rodriguez-Lecompte (2012) Innate immune response

to yeast derived carbohydrates in broiler chickens fed organic diets and challenged with

Clostridium perfringens. Poultry Science 91(5):1105-12.

44. J.C. Rodríguez-Lecompte, A. Yitbarek, J. Brady, S. Sharif, M.D. Cavanagh, G. Crow, W.

Guenter, J.D. House, G. Camelo-Jaimes (2012) The effect of microbial-nutrient

interaction on the immune system of young chicks following early probiotic and organic

acid administration. Journal of Animal Science 90(7):2246-54.

45. R.R. Kulkarni, A.I. Villanueva, I. Elawadli, P. Jayanth, L.R. Read, M. Haeryfar, Sharif S

(2012) Costimulatory activation of murine invariant natural killer T cells by toll-like

receptor agonists. Cellular Immunology. 277(1-2):33-43.

46. M. St. Paul, S. Paolucci, S. Sharif (2012) Treatment with ligands for Toll-like receptors 2

and 5 induce a mixed T-helper 1 and 2-like response in chicken splenocytes. Journal of

Interferon & Cytokine Research 32(12):592-8.

47. P. Parvizi, A.I. Mallick, K. Haq, B. Schlegel, S. Sharif (2012) A Toll-like receptor 3

agonist (polyI:C) elicits innate host responses in the spleen and lungs of chickens.

Canadian Journal of Veterinary Research 76(3):230-4.

48. K. Haq, T Fear, A. Ibraheem, M.F. Abdul-Careem, S. Sharif (2012) Influence of

vaccination with CVI988/Rispens on load and replication of a very virulent Marek’s

disease virus strain in feathers of chickens. Avian Pathology 41(1):69-75

49. A. I. Mallick, R.R. Kulkarni, M. St. Paul, P. Parvizi, É. Nagy, S. Behboudi,

S. Sharif

(2012) Vaccination with CpG-adjuvanted avian influenza virosomes promotes anti-viral

immune responses and reduces virus shedding in chickens. Viral Immunology 25(3):226-

31.

50. M. St. Paul, S. Paolucci, N. Barjesteh, R.D. Wood, K.A. Schat, S. Sharif (2012)


28

Characterization of chicken thrombocyte responses to Toll-like receptor ligands. PLoS

ONE (8):e43381

51. M. St Paul, A.I. Mallick, L.R. Read, A.I. Villanueva, P. Parvizi P, M.F. Abdul-Careem

MF, E. Nagy, S. Sharif S (2012). Prophylactic treatment with Toll-like receptor ligands

enhances host immunity to avian influenza virus in chickens. Vaccine 2012 Jun

22;30(30):4524-31.

52. M. St Paul, A.I. Mallick, K. Haq, S. Orouji, M.F. Abdul-Careem, S. Sharif (2011) In vivo

administration of ligands for chicken toll-like receptors 4 and 21 induces the expression

of immune system genes in the spleen. Veterinary Immunology and Immunopathology

144(3-4):228-37.

53. M. Xu, H. Zhang, L. Lee, H. Gao, S. Sharif, R.F. Silva, M. Heidari (2011) Gene

expression profiling in rMd5- and rMd5deltameq-infected chickens. Avian Diseases

55(3):358-67.

54. J.T. Brisbin, J. Gong, S. Orouji, J. Esufali, A.I. Mallick, P. Parvizi, P.E. Shewen, S. Sharif

(2011). Oral treatment of chickens with lactobacilli influences elicitation of immune

responses. Clinical and Vaccine Immunology 18(9):1447-55.

55. K. Haq, I. Elawadli, P. Parvizi, A.I. Mallick, S. Behboudi, S. Sharif (2011) Interferon-γ

influences immunity elicited by vaccines against very virulent Marek's disease virus.

Antiviral Research 90(3):218-26.

56. A.I. Mallick, K. Haq, J.T. Brisbin, M.F. Mian, R.R. Kulkarni, S. Sharif (2011)

Assessment of bioactivity of a recombinant chicken interferon-gamma expressed using a

baculovirus expression system. Journal of Interferon and Cytokine Research 31(6):493-

500.

57. A.I. Mallick, P. Parvizi, L.R. Read, E. Nagy, S. Behboudi, S. Sharif (2011) Enhancement

of immunogenicity of a virosome-based avian influenza vaccine in chickens by

incorporating CpG-ODN. Vaccine 29(8):1657-65.

58. L.A. Mannik, I. Chin-Yee, S. Sharif, L. Van Kaer, T.L. Delovitch, S.M. Haeryfar (2011)

Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced

mouse and human invariant natural killer T cell responses. Immunology 132(3):361-75.

59. Haq K, Brisbin JT, Thanthrige-Don N, Heidari M, Sharif S. Transcriptome and proteome

profiling of host responses to Marek's disease virus in chickens. Veterinary Immunology

& Immunopathology 15;138(4):292-302.

60. P. Parvizi, K. Andrzejewski, L.R Read, S. Behboudi, S. Sharif (2011) Expression

profiling of genes associated with regulatory functions of T-cell subsets in Marek's

disease virus-infected chickens. Avian Pathology 39(5):367-73


29

61. A.I. Villanueva, R.R. Kulkarni, S. Sharif (2011) Synthetic double-stranded RNA

oligonucleotides are immunostimulatory for chicken spleen cells. Developmental and

Comparative Immunology 35(1):28-34.

62. R.R. Kulkarni, S. Behboudi, S. Sharif (2011) Insights into the role of Toll-like receptors

in modulation of T cell responses. Cell and Tissue Research 343(1):141-52.

63. J.T. Brisbin, J. Gong, P. Parvizi, S. Sharif (2010) Effects of lactobacilli on cytokine

expression by chicken spleen and cecal tonsil cells. Clinical and Vaccine Immunology

17(9):1337-43.

64. K. Haq, M.F. Abdul-Careem, S. Shanmuganthan, N. Thanthrige-Don, L.R. Read, S.

Sharif (2010) Vaccine-induced host responses against very virulent Marek's disease virus

infection in the lungs of chickens. Vaccine 28(34):5565-72.

65. M. Heidari, A. Lopes, M. Huebner, S. Sharif, D. Kireev and H. Zhou (2010) Marek’s

disease virus-induced immunosuppression: array analysis of chicken immune response

genes expression profiling. Viral Immunology 23(3):309-19.

66. N. Thanthrige-Don, L.R. Read, M.F. Abdul-Careem, H. Mohammadi, A.I. Mallick, S.

Sharif (2010) Marek’s disease virus influences the expression of genes associated with

IFN- inducible MHC class II expression. Viral Immunology 23(2):227-32.

67. R.R. Kulkarni, S.M. Haeryfar, S. Sharif (2010) The invariant NKT cell subset in anti-viral

defenses: a dark horse in anti-influenza immunity? Journal of Leukocyte Biology.

88(4):635-43

68. K. Haq, J.T. Brisbin, N. Thanthrige, M. Heidari and S. Sharif (2010) Transcriptome and

Proteome Profiling of Host Responses to Marek’s Disease Virus in Chickens. Veterinary

Immunology and Immunopathology 138(4):292-302.

69. R. Kulkarni, S. Behboudi, S. Sharif (2010) Insights into the role of Toll-like receptors in

modulation of T cell responses. Cell and Tissue Research 343(1):141-52.

70. P. Parvizi, M.F. Abdul-Careem, K. Haq, N. Thanthrige-Don, K. A. Schat, S. Sharif

Immune responses against Marek’s disease virus (2010) Animal Health Research Reviews

11(2):123-34.

71. J.T. Brisbin, J. Gong, S. Sharif (2008) Interactions between commensal bacteria and the

gut-associated immune system of the chicken. Animal Health Research Reviews 9(1):101-

10.

72. N. Thanthrige-Don, P. Parvizi, A.J. Sarson, L.A. Shack, S.C. Burgess, S Sharif (2010)

Proteomic analysis of host responses to Marek's disease virus infection in spleens of


30

genetically resistant and susceptible chickens. Developmental and Comparative

Immunology 34(7):699-704.

73. H.R. Hghihghi, L.R. Read, H. Mohammadi, Y. Pei, C. Ursprung, E. Nagy, S. Behboudi, S.M.

Haeryfar, S. Sharif (2010) Characterization of host responses against a recombinant fowlpox

virus-vectored vaccine expressing the hemagglutinin antigen of an avian influenza virus.

Clinical and Vaccine Immunology 17(3):454-63.

74. H.R. Haghighi, L.R. Read, S.M. Haeryfar, S. Behboudi, S. Sharif (2009) Identification of

a dual-specific T cell epitope of the hemagglutinin antigen of an H5 avian influenza virus

in chickens. PLoS ONE 4(11):e7772.

75. N. Thanthrige-Don, M.F. Abdul-Careem, L.A. Shack, S.C. Burgess, S. Sharif (2009)

Analyses of the spleen proteome of chickens infected with Marek's disease virus.

Virology 390(2):356-67.

76. Y. Lu, A.J. Sarson, J. Gong, H. Zhou, W. Zhu, Z. Kang, H. Yu, S. Sharif, Y. Han (2009)

Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected

with Clostridium perfringens. Clinical and Vaccine Immunology 16(11):1639-47

77. M.F. Abdul-Careem, K. Haq, S. Shanmuganathan, L.R. Read, K.A. Schat, M. Heidari,

S. Sharif (2009). Induction of innate host responses in the lungs of chickens

following infection with a very virulent strain of Marek’s disease virus. Virology

393(2):250-7.

78. M.F. Abdul-Careem, A. Javaheri-Vayeghan, S. Shanmuganthan, H.R. Haghighi, L.R.

Read, K. Haq, K.A. Schat, M. Heidari, S. Sharif (2009) Establishment of an aerosol-based

Marek’s disease virus infection model. Avian Diseases 53(3):387-91.

79. P. Parvizi, L. Read, M.F. Abdul-Careem, A.J. Sarson, C. Lusty, M. Lambourne, N.

Thanthrige-Don, S.C. Burgess, S. Sharif (2009) Cytokine gene expression in splenic

CD4+ and CD8

+ T cell subsets of genetically-resistant and susceptible chickens infected

with Marek’s disease virus. Veterinary Immunology and Immunopathology 132(2-4):209-

17.

80. N. Thanthrige-Don, M.F. Abdul-Careem, L.A. Shack, S.C. Burgess, S. Sharif (2009)

Analyses of the spleen proteome of chickens infected with Marek's disease virus.

Virology 390(2):356-67.

81. J.L. Valli, A. Williamson, S. Sharif, J. Rice, P.E. Shewen (2009) In vitro cytokine responses of

peripheral blood mononuclear cells from healthy dogs to distemper virus, Malassezia and

Toxocara. Veterinary Immunology & Immunopathoogy 15;134(3-4):218-29.

82. H. Mohammadi, S. Sharif, R.R. Rowland, D. Yoo (2009) The lactate dehydrogenase-


31

elevating virus capsid protein is a nuclear-cytoplasmic protein. Archives of Virology

154(7):1071-80.

83. M.F. Abdul-Careem, L.R. Read, P. Parvizi P, N. Thanthrige-Don, S. Sharif (2009)

Marek’s disease virus-induced expression of cytokine genes in feathers of genetically-

defined chickens. Developmental and Comparative Immunology 33(4):618-23.

84. P. Parvizi, L.R. Read, M.F. Abdul-Careem, C. Lusty, S. Sharif (2009) Cytokine gene

expression in splenic CD4+ and CD8

+ T cell subsets of chickens infected with MDV.

Viral Immunology 22(1):31-8.

85. H. Zhou, J. Gong, J.T. Brisbin, H. Yu, A.J. Sarson, W. Si, S. Sharif, Y. Han (2009)

Transcriptional Profiling Analysis of Host response to Clostridium perfringens Infection

in Broilers. Poultry Science 88(5):1023-32.

86. Y. Pei, J. Swinton, D. Ojkic, S. Sharif (2009) Genetic characterization of two low

pathogenic avian influenza virus H5N1 isolates from Ontario, Canada. Virus Genes.

38:149-54.

87. M.R. Akbari, H.R. Haghighi, J.R. Chambers, J.T. Brisbin, L.R. Read, S. Sharif (2008)

Expression of antimicrobial peptides in cecal tonsils of chickens treated with probiotics

and infected with Salmonella. Clinical and Vaccine Immunology 15:1689-93.

88. M.F. Abdul-Careem, D.B. Hunter, S. Shanmuganathan, H.R. Haghighi, L. Read, M.

Heidari, S. Sharif (2008) Cellular and Cytokine Responses in Feathers of Chickens

Vaccinated against Marek’s Disease. Veterinary Immunology and Immunopathology

126(3-4):362-6.

89. M.F. Abdul-Careem, B.D. Hunter, L.F. Lee, J.H. Fairbrother, H.R. Haghighi, L. Read, P.

Parvizi, M. Heidari, S. Sharif (2008) Host responses in the bursa of Fabricius of chickens

infected with virulent Marek’s disease virus. Virology 379:256-65.

90. J. T. Brisbin, J. Gong, C. A. Lusty, P. Sabour, B. Sanei, Y. Han, P. E. Shewen, S. Sharif

(2008) Influence of In-Feed Virginiamycin on the Systemic and Mucosal Antibody

Response of Chickens. Poultry Science 87(10):1995-9.

91. G. N. Girgis, S. Sharif, J.R. Barta, H. J. Boermans, T. K. Smith (2008)

Immunomodulatory Effects of Feed-Borne Fusarium Mycotoxins in Chickens Infected

with Coccidia. Experimental Biology and Medicine, 233(11):1411-20.

92. R.R. Kulkarni, V.R. Parreira, S. Sharif, J.F. Prescott (2008) Oral immunization of broiler

chickens against necrotic enteritis with an attenuated Salmonella vaccine vector

expressing Clostridium perfringens antigens. Vaccine 26:4194-203.

93. M.F. Abdul-Careem, D.B. Hunter, M.D. Lambourne, L.R. Read, P. Parvizi, S. Sharif


32

(2008) Expression of cytokine genes following pre- and post-hatch immunization of

chickens with herpesvirus of turkeys. Vaccine 26:2369-77.

94. A.J. Sarson, M.F. Abdul-Careem, L.R. Read, J.T. Brisbin, S. Sharif (2008) Expression of

cytotoxicity-associated genes in Marek’s disease virus-infected chickens. Viral

Immunology 21:267-72.

95. M. Heidari, H.M. Zhang, S. Sharif (2008) Marek’s disease virus induces Th2 activities

during the cytolytic infection. Viral Immunology 21:203-14.

96. D. Praslickova, S. Sharif, A.J. Sarson, M.F. Abdul-Careem, D. Zadworny, A. Kulenkamp,

G. Ansah, U. Kuhnlein (2008) Association of a marker in the Vitamin D receptor gene

with Marek’s disease resistance in poultry. Poultry Science 87:1112-9.

97. A.J. Sarson, P. Parvizi, D. Lepp, M. Quinton, S. Sharif (2008) Transcriptional analysis of

host responses to Marek's disease virus infection in genetically resistant and susceptible

chickens. Animal Genetics 39:232-40.

98. A.F. Abdul-Careem, D.B. Hunter, N. Thanthrige-Don, H.R. Haghighi, M.D. Lambourne,

S. Sharif (2008) Cellular and cytokine responses associated with dinitrofluorobenzene-

induced contact hypersensitivity in the chicken. Veterinary Immunology and

Immunopathology. 122:275-84.

99. M.F. Abdul-Careem, B. D. Hunter, A. J. Sarson, P. Parvizi, H. R. Haghighi, L. Read, M.

Heidari, and S. Sharif (2008) Host responses are induced in feathers of chickens

infected with Marek's disease virus. Virology 370: 323-32.

100. H.R. Haghighi, M. F. Abdul-Careem, R. A. Dara, J. R. Chambers, and S. Sharif (2008)

Cytokine gene expression in chicken cecal tonsils following treatment with probiotics

and Salmonella infection. Veterinary Microbiology 126: 225-233.

101. J.T. Brisbin, J. T., H. Zhou, J. Gong, P. Sabour, M. R. Akbari, H. R. Haghighi, H. Yu,

A. Clarke, A. J. Sarson, and S. Sharif (2008) Gene expression profiling of chicken

lymphoid cells after treatment with Lactobacillus acidophilus cellular components.

Developmental and Comparative Immunology 32:563-74.

102. R.R. Kulkarni, V. R. Parreira, S. Sharif, and J. F. Prescott (2007) Immunization of

broiler chickens against Clostridium perfringens-induced necrotic enteritis. Clinical

and Vaccine Immunology 14: 1070-1077.

103. H. Zhou, J. Gong, J. T. Brisbin, H. Yu, B. Sanei, P. Sabour, and S. Sharif (2007)

Appropriate chicken sample size for identifying the composition of broiler intestinal

microbiota affected by dietary antibiotics, using the polymerase chain reaction-

denaturing gradient gel electrophoresis technique. Poultry Science 86: 2541-2549.


33

104. M.F. Abdul-Careem, D.B. Hunter, M.D. Lambourne, J. Barta, S. Sharif (2007)

Ontogeny of cytokine gene expression in the chicken spleen. Poultry Science,

86:1351-5.

105. A.J. Sarson, L.R. Read, H.R. Haghighi, M.D. Lambourne, H. Zhou and S. Sharif

(2007) Construction of a cDNA microarray for profiling gene expression in the

chicken immune system. Canadian Journal of Veterinary Research 71:108-18.

106. S. Wheaton, M.D. Lambourne, A.J. Sarson, J. Brisbin, A. Mayameei, S. Sharif (2007)

Molecular cloning and expression analysis of chicken MyD88 and TRIF genes. DNA

Sequence, 18: 478-484.

107. J. T. Brisbin, H.R. Haghighi, R. Kulkarni, S. Sharif (2007) Regulation of the Intestinal

Immune System by Commensal Microbiota in Avian and Ruminant Species.

Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources.

108. A.J. Sarson, M.F. Abdul-Careem, P. Parvizi, S. Sharif (2007) Host Resistance to

Infectious Disease: Immunogenetics of Marek’s Disease in Chickens. Perspectives in

Agriculture, Veterinary Science, Nutrition and Natural Resources.

109. M.F. Abdul-Careem, B.D. Hunter, P. Parvizi, H.R. Haghighi, N. Thanthrige-Don and

S. Sharif (2007) Cytokine gene expression patterns associated with immunization

against Marek’s disease in chickens. Vaccine 25:424-32.

110. A.J. Sarson, M.F. Abdul Careem, H. Zhou and S. Sharif (2006) Transcriptional

analysis of host response to Marek’s disease virus infection. Viral Immunology,

19:747-58.

111. R. R. Kulkarni, V. R. Parreira, S. Sharif, J. F Prescott (2006) Clostridium perfringens

antigens recognized by broiler chickens immune to necrotic enteritis. Clinical and

Vaccine Immunology 13:1358-62.

112. H.R. Haghighi, J. Gong, C.L. Gyles, M.A. Hayes, H. Zhou B. Sanei, J.R. Chambers

and S. Sharif (2006) Probiotics stimulate the production of natural antibodies in

chickens. Clinical & Vaccine Immunology 13:975-980.

113. M.F. Abdul-Careem, B.D. Hunter, A.J. Sarson, A. Mayameei, H. Zhou, and S. Sharif

(2006) Marek’s disease virus-induced transient paralysis is associated with cytokine

gene expression in the nervous system. Viral Immunology 19:167-76.

114. M.F. Abdul-Careem, B.D. Hunter, É. Nagy, L.R. Read, B. Sanei, J.L. Spencer and S.

Sharif (2006) Development of a real-time PCR assay using SYBR Green chemistry for

monitoring Marek’s Disease Virus genome load in feather tips. Journal of Virological

Methods 133:34-40


34

115. J.A. Cumberbatch, D. Brewer, I. Vidavsky, S. Sharif

(2006) Chicken major

histocompatibility complex class II molecules of B19

haplotype present self and foreign

peptides. Animal Genetics 37:393-396.

116. P. K. Niemiec, L.R. Read and S. Sharif (2006) Synthesis of chicken major

histocompatibility complex class II oligomers using a baculovirus expression system.

Protein Expression and Purification 46:390-400.

117. H.R. Haghighi, J. Gong, C.L. Gyles, M.A. Hayes, B. Sanei, P. Parvizi, H. Gisavi, J.R.

Chambers and S. Sharif (2005) Modulation of antibody-mediated immune response by

probiotics in chickens. Diagnostic and Clinical Laboratory Immunology 12:1387-

1392.

118. M. Lambourne, W. Si, P.K. Niemiec, L.R. Read, S. Kariyawasam and S. Sharif (2005)

Identification of novel polymorphisms in the B-LB locus of Gallus lafayettei. Animal

Genetics 36:445-448.

119. M. Haeri, L.R. Read, B.N. Wilkie and S. Sharif (2005) Identification of peptides

associated with chicken major histocompatibility complex class II molecules of B21

and B19 haplotypes. Immunogenetics 56:854-859.

120. L.R. Read, J.A. Cumberbatch, M.M. Buhr, A.J. Bendall and S. Sharif (2005) Cloning

and characterization of chicken stromal cell derived factor-1. Developmental and

Comparative Immunology 29:143-152.

121. S. Sharif, B.A. Mallard and B.N. Wilkie (2003) Characterization of naturally

processed and presented peptides associated with BoLA-DR molecules. Animal

Genetics 34:116-123.

122. S. Sharif, G.A. Arreaza, P. Zucker and T.L. Delovitch (2002) Regulatory NKT cells

protect against spontaneous and recurrent type I diabetes. Annals of the New York

Academy of Sciences 958:77-88.

123. S. Sharif. G.A. Arreaza, P. Zucker, Q-S., Mi and T.L. Delovitch (2002) Regulation of

autoimmune disease by NKT cells. Journal of Molecular Medicine 80, 290-300.

124. S. Sharif and T.L. Delovitch (2001) Regulation of immune responses by natural killer

T (NKT) cells. Archivum Immunolgiae et Therapiae Experimentalis, 49, Suppl. 1,

S23-31

125. S. Sharif, G.A. Arreaza, P. Zucker, Q.S. Mi, J. Sondhi, O.V. Naidenko, M.

Kronenberg, Y. Koezuka & T. L. Delovitch- J-M. Gombert, M. Leite-de-Moraes, C.

Gouarin, R. Zhu, A. Hameg, T. Nakayama, M. Taniguchi, F. Lepault,

A. Lehuen, J.F.

Bach & A. Herbelin (2001) Activation of NKT cells by alpha-galactosylceramide

treatment prevents the onset and recurrence of autoimmune type I diabetes. Nature


35

Medicine 7, 1057-1062.

126. M.J. Cameron, G.A. Arreaza, M. Grattan, C. Meagher, S. Sharif, M.D. Burdick, R.M.

Strieter, D.N. Cook, O. Smithies and T.L. Delovitch (2000) Differential expression of

CC chemokines and the CCR5 receptor is associated with the progression to type I

diabetes. The Journal of Immunology, 165, 1102-1110.

127. S. Sharif, B.A. Mallard and J.M. Sargeant (2000) Presence of Glutamine at position 74

of pocket 4 in the BoLA-DR antigen binding groove is associated with occurrence of

clinical mastitis caused by Staphylococcus species. Veterinary Immunology &

Immunopahtology, 76, 231-238.

128. S. Sharif, B.A. Mallard, B.N. Wilkie, J.M. Sargeant, H.M. Scott, J.C.M. Dekkers and

K.E. Leslie (1999) Bovine major histocompatibility complex BoLA-DRB3

associations with production traits. Animal Genetics 30, 157-160.

129. S. Sharif, B.A. Mallard, B.N. Wilkie, J.M. Sargeant, H.M. Scott, J.C.M. Dekkers and

K.E. Leslie (1998) Associations of the bovine major histocompatibility complex

DRB3 (BoLA-DRB3) alleles and occurrence of disease and somatic cell score in

Canadian dairy cattle. Animal Genetics 29, 185-193.

130. B.A. Mallard, J.C.M. Dekkers, M.J. Ireland, K.E. Leslie, S. Sharif, C. Lacey

VanKampen, L. Wagter and B.N. Wilkie (1997). Alterations in immune

responsiveness during the peripartum period and its ramification on dairy cow and calf

health. Journal of Dairy Science 81, 585-595.

Book Chapters

1. J.S. Weese, S. Sharif, and A. Rodriguez-Palacios (2007) Probiotics in Veterinary

Medicine. In: Therapeutic Microbiology: Probiotics and other strategies. James

Versalovic and Michael Wilson (Eds.) ASM Press.

2. C. Meagher, S. Sharif, S. Hussain, M.J. Cameron, G.A. Arreaza & T.L. Delovitch (2001)

Cytokines and chemokines in the pathogenesis of murine type I diabetes. In: Cyoktines

and chemokines in autoimmune disease. Pere Santamaria (Ed.), Landes Biosciences

Press.

3. G.A. Arreaza, S. Sharif, M. Cameron, W. Chen and T.L. Delovitch (2001) Role of

regulatory cells in the pathogenesis of type I diabetes. In: Molecular Pathology of Insulin-

Dependent Diabetes Mellitus. M. von Herrath and A. Theofilopoulos (Eds.), Current

Directions in Autoimmunity Series 4, 308-302.


36

Invited Speaker

1. S. Sharif (2016) Immunity to Marek’s disease, State-of-the-art lecture, presented at the

Avian Herpesviruses Conference, Tours, France

2. S. Sharif (2016) Chicken gut health. Presented at the Research Day, Poultry Industry

Council, Guelph

3. S. Sharif (2015) Immunity against avian influenza viruses. DTL Smith Lectureship.

Presented at the Western College of Veterinary Medicine, University of Saskatchewan

4. S. Sharif (2015) Protecting poultry against avian influenza: is it feasible? Presented as an

invited talk at the Poultry Industry Council Research Day.

5. S. Sharif (2015) Immune based strategies for control of avian influenza in chickens.

Presented as an invited talk at the American Society for Virology Annual Meeting,

London, Ontario, Canada, July 2015

6. S. Sharif (2015) Smart animal health management. Presented to a cross-sectoral group of

stakeholders, including academia, government and industry. The meeting was sponsored

by the Livestock Research and Innovation Corporation.

7. S. Sharif (2014) Immunity to Marek’s disease in chickens. Presented at the Vaccine and

Infectious Disease Organization, Saskatchewan, Canada.

8. S. Sharif (2013) Commensal bacterial interactions with the chicken immune system.

Presented at the Plant and Animal Genome Conference, San Diego, January 2013.

9. S. Sharif (2012) Immunity against Marek’s disease. Seminar at the Poultry Diagnostic

and Research Center, University of Georgia, Athens, October 2012.

10. S. Sharif (2012) Perspectives on immunity against Marek’s disease virus. State-of-the-art

lecture given at the Marek’s disease conference, Berlin, Germany, June 2012.

11. S. Sharif (2012) Immunity against avian influenza virus: implications for vaccine

development. Presented at the Pathobiology Seminar Series (March 2012)

12. S. Sharif (2012) Identification of lactobacilli with immune enhancing activities. Presented

at the Poultry Industry Council Research Day (May 2012)

13. S. Sharif (2012) Environmental influences on the chicken immune system. Presented at

the Science in the Pub even sponsored by the PIC (March 2012)

14. S. Sharif (2011) Immunology of avian influenza and implications for vaccine


37

development. Presented at the CPHAZ conference (June 2011).

15. S. Sharif (2011) Improving chicken immunity and health. Presented to the PIC Board and

producers (November 2011)

16. S. Sharif (2010) Immunology of avian herpesvirus infections. Presented at the Bortree

Lecture Series, Pennsylvania State University (October 2010).

17. S. Sharif. Probiotics and enhancement of chicken immune system. PIC Research Day,

Niagara Falls, November 2009.

18. S. Sharif. Probiotics and immune response: myths and facts. Department of Pathobiology,

University of Guelph, February 2009.

19. S. Sharif. Immunology of Marek’s disease virus in chickens. Invited speaker at

Wageningen University, The Netherlands, October 2008.

20. S. Sharif. Dissecting host responses to Marek’s disease virus. Invited speaker at the 8th

Marek’s Disease Symposium, Townsville, Australia, July 2008.

21. S. Sharif. Interactions between host and herpesviruses. Presented at Department of

Pathology and Molecular Medicine, McMaster University, May 2007.

22. S. Sharif Genetic bases for disease resistance in avian species. PIC Research Day,

Guelph, May 2007.

23. S. Sharif. Probiotics for enhancement of immune responses. SCIDF Research Day,

Videoconference, April 2007.

24. S. Sharif. Genetic factors associated with host resistance. The 78th

Northeastern

Conference on Avian Disease, Guelph, Ontario, June 2006 (keynote speech).

25. S. Sharif. Chicken Immunology and Immunogenetics Research; A Research Update.

Presented at the Poultry Industry Council Research Day, May 2005.

26. S. Sharif. The chicken Immune System. Presented at the Ontario Association of Poultry

Practitioners. Guelph, May 2004.

27. S. Sharif. The chicken immunology lab: A Research update. Presented to the members of

the Poultry Research Group, January 2004.

28. S. Sharif. Lipid processing and presentation in the immune system. Presented at the

Department of Human Health and Nutritional Sciences, University of Guelph, November

2004.


38

29. S. Sharif. Control of type I diabetes by regulation of NKT responses. Invited speaker at

the USDA-ADOL institute. January 2002

30. S. Sharif. Genetics of disease resistance in domestic animals. Invited speaker at the CGIL

Group, Animal & Poultry Science, April 1998.

Presentations and Abstracts:

My students and post-doctoral researchers have made over 120 poster or oral

presentations in the last 15 years. Below is a sample of these presentations during 2014

1. N. Barjesteh, T. Alkie, J.T. Brisbin, E. Nagy, S. Sharif. (2014) Control of avian influenza

virus in chickens. OMAFRA Emergency Management Research Expo. Guelph, Canada.

2. N. Barjesteh, B. Shojadoost., J.T. Brisbin, E. Nagy, S. Sharif (2014) Reduction of avian

influenza virus shedding by administration of Toll-like receptor ligands in chickens.

Graduate Student Research Symposium. Guelph, Canada.

3. N. Barjesteh, S. Sharif (2014) Targeting Avian Influenza virus: Extend our knowledge to

improve alternative strategies. Poultry health Research Network (PHRN). Guelph

Canada.

4. N. Barjesteh, J.T. Brisbin, S. Behboudi, M. Emam, M. St. Paul, E. Mallette, E. Nagy, S.

Sharif (2014) Induction of antiviral responses against avian influenza virus in

embryonated chicken eggs with TLR ligands. Avian Immunology Research Group

(AIRG). Guelph Canada.

5. N. Barjesteh, T. Alkie, J.T. Brisbin, E. Nagy, S. Sharif (2014) Local innate immune

responses to TLR ligands in chicken trachea. Avian Immunology Research Group


6. T. Alkie, M. St. Paul, N. Barjesteh, J.T. Brisbin, S. Sharif (2014, July) Chicken B cells:

beyond their roles in modulating adaptive immunity. Avian Immunology Research Group


7. D.C. Hodgins, N. Barjesteh, M. St. Paul, W.M. Quinteiro-Filho, C. DePass, M. Monteiro,

S. Sharif (2014) Capsular polysaccharide – diphtheria toxoid conjugate vaccine to reduce

cecal colonization by Campylobacter jejuni in broiler chickens. Avian Immunology

Research Group (AIRG). Guelph Canada.

8. N. Barjesteh, B. Shojadoost, S. Behboudi, J.T. Brisbin, E. Nagy, S. Sharif (2014) Poultry

Industry Council Research Day. Characterizing TLR ligands as antiviral components in

chickens against influenza virus. Guelph Canada.


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SHAYAN SHARIF - University of GuelphShayan Sharif -Curriculum vitae. 2 December 2011 – to date,...

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