Setting Specific Proposed Levels for bioactive compounds: … · Dietary Allowances Dietary...
Transcript of Setting Specific Proposed Levels for bioactive compounds: … · Dietary Allowances Dietary...
Setting
Specific Proposed Levels
for bioactive compounds
Recent experiences in China
Prof Yang Yuexin
China CDC
Chinese Nutrition society
yxyangcnsocorg
Key information
bull Developing SPL for phytochemicals
bull Defining the process of SPL
bull Key elements amp results
bull Limitations amp Challenges
History of RDA in China
as the Minimum Nutrient
Requirement for Chinese
people including 6 nutrients
protein carbohydrate and
vitamins
1938 1955 1976 1988 2000 2013
First MNR
RDA
DRIs
6 8 20 3215
the Recommended
Dietary Allowances Dietary Reference Intake
RDA
DRIs PI
gt36
bull Goals of the DRI Expert Committee
1) Revised and Setting Recommended Intake Values ndash RNI
and AI
-Both RNI and AI are intended to be used as goals in
planning nutritious diets
2) Facilitating Nutrition Research and Policy ndash EAR
-EAR values for the scientific basis upon which the RNI
values are set
3) Establishing Safety Guidelines ndash UL
-Identify potentially hazardous levels of nutrient intake
-Indispensable to consumers who take supplements or
consume foods or beverages to which vitamins or
minerals have been added
4)
4) Preventing Chronic Diseases
The DRI committee takes into account chronic disease
prevention wherever appropriate
-PI ( preventing intake -NCD)
the committee set lifelong intake goals for Na K VitC
at levels believed in the later years
-- Acceptable macronutrient Distribution Ranges (AMDR)
AMDR for FAT CHO and Protein
- Specific Proposed Level( SPL) a diet that provides
adequate Non - Nutrients Substance while reducing the
risk of chronic diseases
The DRI committee has made separate
recommendations for specific sets of people (specific
age ranges)
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Key information
bull Developing SPL for phytochemicals
bull Defining the process of SPL
bull Key elements amp results
bull Limitations amp Challenges
History of RDA in China
as the Minimum Nutrient
Requirement for Chinese
people including 6 nutrients
protein carbohydrate and
vitamins
1938 1955 1976 1988 2000 2013
First MNR
RDA
DRIs
6 8 20 3215
the Recommended
Dietary Allowances Dietary Reference Intake
RDA
DRIs PI
gt36
bull Goals of the DRI Expert Committee
1) Revised and Setting Recommended Intake Values ndash RNI
and AI
-Both RNI and AI are intended to be used as goals in
planning nutritious diets
2) Facilitating Nutrition Research and Policy ndash EAR
-EAR values for the scientific basis upon which the RNI
values are set
3) Establishing Safety Guidelines ndash UL
-Identify potentially hazardous levels of nutrient intake
-Indispensable to consumers who take supplements or
consume foods or beverages to which vitamins or
minerals have been added
4)
4) Preventing Chronic Diseases
The DRI committee takes into account chronic disease
prevention wherever appropriate
-PI ( preventing intake -NCD)
the committee set lifelong intake goals for Na K VitC
at levels believed in the later years
-- Acceptable macronutrient Distribution Ranges (AMDR)
AMDR for FAT CHO and Protein
- Specific Proposed Level( SPL) a diet that provides
adequate Non - Nutrients Substance while reducing the
risk of chronic diseases
The DRI committee has made separate
recommendations for specific sets of people (specific
age ranges)
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
History of RDA in China
as the Minimum Nutrient
Requirement for Chinese
people including 6 nutrients
protein carbohydrate and
vitamins
1938 1955 1976 1988 2000 2013
First MNR
RDA
DRIs
6 8 20 3215
the Recommended
Dietary Allowances Dietary Reference Intake
RDA
DRIs PI
gt36
bull Goals of the DRI Expert Committee
1) Revised and Setting Recommended Intake Values ndash RNI
and AI
-Both RNI and AI are intended to be used as goals in
planning nutritious diets
2) Facilitating Nutrition Research and Policy ndash EAR
-EAR values for the scientific basis upon which the RNI
values are set
3) Establishing Safety Guidelines ndash UL
-Identify potentially hazardous levels of nutrient intake
-Indispensable to consumers who take supplements or
consume foods or beverages to which vitamins or
minerals have been added
4)
4) Preventing Chronic Diseases
The DRI committee takes into account chronic disease
prevention wherever appropriate
-PI ( preventing intake -NCD)
the committee set lifelong intake goals for Na K VitC
at levels believed in the later years
-- Acceptable macronutrient Distribution Ranges (AMDR)
AMDR for FAT CHO and Protein
- Specific Proposed Level( SPL) a diet that provides
adequate Non - Nutrients Substance while reducing the
risk of chronic diseases
The DRI committee has made separate
recommendations for specific sets of people (specific
age ranges)
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
bull Goals of the DRI Expert Committee
1) Revised and Setting Recommended Intake Values ndash RNI
and AI
-Both RNI and AI are intended to be used as goals in
planning nutritious diets
2) Facilitating Nutrition Research and Policy ndash EAR
-EAR values for the scientific basis upon which the RNI
values are set
3) Establishing Safety Guidelines ndash UL
-Identify potentially hazardous levels of nutrient intake
-Indispensable to consumers who take supplements or
consume foods or beverages to which vitamins or
minerals have been added
4)
4) Preventing Chronic Diseases
The DRI committee takes into account chronic disease
prevention wherever appropriate
-PI ( preventing intake -NCD)
the committee set lifelong intake goals for Na K VitC
at levels believed in the later years
-- Acceptable macronutrient Distribution Ranges (AMDR)
AMDR for FAT CHO and Protein
- Specific Proposed Level( SPL) a diet that provides
adequate Non - Nutrients Substance while reducing the
risk of chronic diseases
The DRI committee has made separate
recommendations for specific sets of people (specific
age ranges)
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
4) Preventing Chronic Diseases
The DRI committee takes into account chronic disease
prevention wherever appropriate
-PI ( preventing intake -NCD)
the committee set lifelong intake goals for Na K VitC
at levels believed in the later years
-- Acceptable macronutrient Distribution Ranges (AMDR)
AMDR for FAT CHO and Protein
- Specific Proposed Level( SPL) a diet that provides
adequate Non - Nutrients Substance while reducing the
risk of chronic diseases
The DRI committee has made separate
recommendations for specific sets of people (specific
age ranges)
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Expert Review Panels 87 experts in 7 groups
bull E CHO Fat and fat acids DHA EPA n-3
bull ProteinMacronutrient
bull Vit A Vit E
bull Vit D Vit K
fat-soluble vitamins 4
bull VitB1 B2 B6 B12 Folic acid
bull Vit C NiacinCholine Biotin Pantothenic acid
water -soluble vitamins 10
bull Zinc Iron I se cobalt
bull Cu Mn Mo Cr FTrace Elements 10
bull Ca P Mg K Na
bull chlorideMacro-elements 6
bull Water Fiber
bull 18 Phytochemicals Non-nutrient 21
Introduction Definition methods formula application
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
DRI component Description
Estimated Average
Requirement (EAR)
Reflects the estimated median requirement and is
particularly appropriate for applications related to
planning and assessing intakes for groups of
people
Recommended Nutrient
Intake (RNI)
Derived from the EAR and intended to cover the
requirements for 97ndash98 percent of the population
Adequate Intake (AI) Used when an EARRNI cannot be developed
average intake level based on observed or
experimental intakes
Tolerable Upper Intake
Level (UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
Estimated Energy
Requirement (EER)
Average dietary energy intake predicted to maintain
energy balance in a healthy adult of defined age
gender weight height and level of physical activity
that is consistent with good health
Components of the Dietary Reference Intakes
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Component Description
Acceptable Macronutrient
Distribution Range (AMDR)
An intake range for an energy source
associated with reduced risk of chronic
disease
Fat fat acid CHO Ca
Proposed intake (PI) Dietary Goal for Preventing
Non-communicable Chronic Disease
Na K
Specific proposed level (SPL)
---non nutrients components
(phytochemicals)
Dietary level for Preventing Specific chronic
Disease
SPL predicted to maintain health in a healthy
adult
New Concepts Developed
Tolerable Upper Intake Level
(UL)
Tolerable Upper Intake Level (UL) Highest
average intake that is likely to pose no risk
most from NOAEL or LOAEL or ADI
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
What is SPLs
SPLs Specific Proposed
Level (abbreviations SPLs)
bull SPL and UL are a
comprehensive set of
phytochemical
values for healthy
populations that can
be used for a guide
for the diet
Principles The
SPLs reflect the
current state of
scientific knowledge
with respect to non-
nutrient guide and
are published as a
series of reports by
the CNS
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
WHY Setting SPL and UL for Non ndashnutrients components
Foods consist of thousands of different chemicals
- each has the potential of being beneficial neutral or
harmful to the body
-some may be beneficial in some ways and harmful in other
-some chemical may exert different effects on different
people or when taken at differing doses or at different
life stages
When considering concentrated supplements of
phytochemicals
-Be aware that any normally beneficial substance even
water can be toxic when taken in too high a dose
-Though most naturally occurring substances are safe for
most healthy people when consumed in foods
--adequate and safe dosages been established by
research evidence
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Why use novel concept SPL
Difference with nutrient and non nutrient
bull Definition Essential nutrient for body with the lack
of symptoms And non-nutrient are not maybe just
lifespan essential
bull Substantial scientific database
science required for DRI value
digestion absorption metabolism interactionhellip
bull Established process
EAR -----X---- RNI or RDA
Intake ----X---- AI lack FC database
Age group ---X limitation for infants children
woman
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
DRIs working Structure
DRIs
2013
ScientificAdvisory
Committee
DRI Scientific Board Committee
The Secretary
GroupExpert Review
ampworking
Panels
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
from literature
Non-nutrient substances
bull Non-nutrient bioactive substances
非营养素生物活性物质
bull bioactive substances 生物活性物质
bull Dietary ingredient 膳食成分
bull Photochemical 植物化合物
bull Botanical 植物药 deriving from plants
bull Botanical ingredient 植物有效成分
bull Extract 提取物
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Screening conditions for Non-nutrients components
bull Research data accumulated the abundant firsthand
materials
bull in natural foodstuffs
bull The use of large amounts of food industry
bull Others
After setting the definition for non-nutrients
components and SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
non-nutrients substances list
水 water
膳食纤维Dietary fiber
低聚果糖 FOS
花色甙anthhoyanin
白藜芦醇 Resveratrol
儿茶酚(儿茶素Catechol
榭皮素(角黄素)Quercetin
姜黄素 Curcumin
绿原酸 Chlorogenic acid
叶黄素Lutin
Zeaxanthin
番茄红素 Lycopene
原花青素 Proanthocyanidins
大豆异黄酮 Isoflavones
植物固醇 Phytosterol
异硫氰酸盐 Isothiocyanates
大蒜素 Allicin Gallic
氨基葡萄糖 Glucosamine
r ndash氨基丁酸 GABA
a-硫辛酸 alpha-Lipoic Acid (LA)
L-肉碱 L-carnitine
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Types of study used as a basis for Specific Proposed Level
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Hierarchy of evidence
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Approach of Expert Review Panels
The expert panels are responsible for
1 reviewing the scientific literature concerning specific food
component under study for each life-stage especially adult
2 considering the roles of nutrients in decreasing the risk of chronic
diseases and health conditions
3 evaluating possible criteria or indicators of adequacy and providing
a rationale for the choice of each criterion
4 estimating the average requirement(s) for each nutrient reviewed
for each life-stage
5 interpreting the current data on nutrient intakes of population
groups
6 reviewing the food resource for each nutrient or component
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
bull NOEL(no observed effect level)
bull LOEL(lowest observed effect level)
bull OSL(the observed safe level)
bull HOI(the highest observed intake)
UL approaches
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
How to document an effect
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
物质作用的不同阶段
毒性
治疗
稳态
营养
临界
Phytochimecals Specific Proposed Level
SPL obtained by observation or experiment
non-nutrient dietary ingredients that have
beneficial effect in the prevention of chronic
diseases for healthy adults
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Based Substantial Evidence and detary Intakes (if )
Meta-analyses
(Cochrane Collaboration)
(Health Assessment)
(Cohort studies)
(RCT)
Scientific data
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
summary on Curcumin RCT -meta analysis
Author and
yearCountr
y Subjects N (TC)
durati
on
Dose amp
methods
Biomarker
Results
Pungcharoenkul K
2009
泰国 healthy
adults
24
T1 8
T28
C 8
7d T1 姜黄素500mgdT2姜黄素1gd
C 维生素E200IUd
血清氧自由基清除能力uarr血清总胆固醇darr甘油三酯darr
Khajehdehi P
2011伊朗
糖尿病病人
T 20
C 20
2 m T 姜黄素500mgd
C 0mgd
与对照组相比血清TGF-βdarrIL-8darr
尿蛋白排出darr
Usharani P
2008
印度糖尿病病人
T 36
C 36
2 m T 姜黄素300mgd
C 0mgd
与对照组相比血清IL-6TNF-a等
炎症因子darr
Sahebkar A
2013
Meta分析
不同人群 T 133
C 90
2m T 姜黄素45mg-6gd
C 阿托伐他汀维生素E或安慰剂
血清总胆固醇LDL-C甘油三酯和HDL-C水平改变无统计学意义
Hanai H
2006
日本 静止期肠炎病人
T 45
C 44
6m T 姜黄素2gd
C 0mgd
肠炎活动指数内镜检查指数改善
Example
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
carotenoids and reduce risk of breast cancer
Author Long term
study Subjects
N duratio
n (y)
uplower intake
(microgd)
End point relative risk(RR95CI)
Larsson
2010
Sweden
prospective
Postmenopau
sal women1008 94 ge3160 vs lt1422 活检确诊
095
(078-116)
Cui2008 UKprospective 绝经后妇女 2879 76 ge2281 vs lt1000 临床确诊093
(080-107)
Cho2003 美国前瞻性 绝经前妇女 714 80 5939 vs 1006 临床确诊096
(075-122)
Terry2002 加拿大前瞻性 绝经前妇女1452病例
5239对照95 6838 vs1219 临床确诊
117
(090-153)
Horn-
Ross2002美国前瞻性
绝经前和
绝经后妇女711 20 ge1782 vs lt576 临床确诊
12
(090-160)
Zhang
1999美国前瞻性
绝经前和
绝经后妇女2697 140
绝经前8796
vs1376绝经后
8796vs 1376
临床确诊
079
(063-099)
095
(082-110)
表3 叶黄素与乳腺癌发生风险研究
retrospective or prospective cohort
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Evidences evaluation
Cardiovascular
protective
effects
Anti-
inflammatory
activity
Anti -
Cancer
diabetes
Evidence
grading
M L L L
白藜芦醇生物学功能证据等级
Resveratrol SPL not specific recommended
bull Examples Not approved due to lack of substantiation
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
UL recommended for adults (draft )
Group ANot necessary
Group BUL 值的建议
Group C 5资料限制Information
insufficient
Water
Catchiness
r-GABA
Anthocyanin
Lutein 60 mgd
Lycopene 50mgd
curcumin 180 mgd
Resveratrol 25gd
Proanthocyanin 800mg
phytosterol l 24g-39g
Fruit -oligosaccharide 15d
Soy lsoflavone 80mg
L- carnitine 2000mgd
Allicin
Glucosamine
DF
Isothiocyanates
Quercetin
Lipoic acid
Chlorogenic acid
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Specific Proposed Level ( SPL) for adults only draft
Group A
AI
Group B
SPL
Group C
Information
insufficient
Water 15-17L
Fiber 25-30 g
Soy lsoflavone
Lutein
Lycopene
phytosterol
Glucosamine
Anthocyanin
Proanthocyanin
50mg
6 mg
18 mgd
08gd 13gd()
1gd 15g
50mgd
200mgd
L-carnitine
Resveratrol
R -GABA
curcumin
Allicin
Chlorogenic acid
LA
Catechins
Iso thiocyanates
FOS
Quercetin
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
A model to understand for DRIs
PI --Preventing Lifestyle-related
Diseases SPL for phytochemicals
PI
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Scientific significance
1)First time to evaluate data of phytochemicals
2)Further understanding of the absorptiond metabolism
function
3)Establish the procedure method puts forward the
guiding value first suggested a new concepts
Temporary Guidence Levels
Social amp practical significance
1)To avoid overeating
2)To prevent lifestyle-related diseases
3)To increase the natural life-span of healthy humans
Evidence based PL
The importance of SPLs and UL of Phytochemicals
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Limitations and Challenges
1 Limited human data regarding Phyto-chmicals in global
2 Limited data concerning genetic variations to affect Phyto-nutrients requirements or hellip
such as Soy lsoflavone
3 Limited data on the surrogate biomarker to reflect status of marginal (sub clinical) ldquo deficiencyrdquo as well as progression of chronic diseases And in specific vulnerable population groups
4 Limited data on food composition database
food composition are not sufficiently available for assessment of some phyto-nutrients intake
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
For lifespan
to quantify a healthy diet should be not only including
essential nutrients but also others
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Acknowledgements
ProfChenyx prof Zhaify profYangxg
SPL expert penal 16 experts
Scientific Committee 15 experts
All experts in working panel 80 more
2010mdash2013
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
bull Thanks for your attention
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Primary Uses of DRIs
The four primary uses of the DRIs are
bull To assess the intakes of individuals
bull To assess the intakes of population groups
bull To plan diets for individuals
bull To plan diets for groups
Some of the dietary planning activities that are most
relevant to DRI use include dietary guidance institutional
food planning military food and nutrition planning
planning for food-assistance programs food labeling
food fortification developing new or modified food
products and food-safety assurance
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
SPLs put on evaluating scientific evidence for the role
played by hellip that could contribute to the prevention of the
major diet-related chronic diseases
Oo perspective has been accounted for in setting the
recommendation
The primary uses of the SPLs and UL are
bull In the prevention of major diet-related chronic diseases
bull To assess the intakes of individuals
bull For food-safety assurance during new or functional food
product development
Primary Uses of SPL and UL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL
Purpose
bull To maintain and promote health
bull To prevent lifestyle-related diseases and
illnesses due to insufficient and excessive
consumption of energy and nutrients
Target population Healthy individuals and groupsIncl those who have some mild ailments but do not
need dietary restrictions or prescribed diets
eg hypertension hyperlipidemia
DRIs
amp SPL