Serum Lactate Post-Antibiotic
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Serum Lactate Post- Antibiotic p r e - a n t i b i o t i c 3 h p o s t - 6 h p o s t - serum lactate (m m ol/L) 0 2 4 6 8 1 0 1 2 6 h r p o s t - s e p s i s a n t i b i o t i c 1 2 h r p o s t - s e p s i s a n t i b i o t i c 1 8 h r p o s t - s e p s i s a n t i b i o t i c antibiot ic antibiot ic † † ＊ ＊ Kumar et al. J Infect Dis 2006; 193: 251-258
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Serum Lactate Post-Antibiotic. †. ＊. ＊. †. antibiotic. antibiotic. Kumar et al. J Infect Dis 2006; 193: 251-258. Plasma TNF Post-Antibiotic. ＊. ＊. †. †. antibiotic. antibiotic. Kumar et al. J Infect Dis 2006; 193: 251-258. Plasma IL-6 Post-Antibiotic. †. †. †. †. - PowerPoint PPT Presentation
Transcript of Serum Lactate Post-Antibiotic
Serum Lactate Post-Antibiotic
p r e - a n t i b i o t i c 3 h p o s t - 6 h p o s t -
seru
m l
acta
te (
mm
ol/
L)
0
2
4
6
8
1 0
1 2
6 h r p o s t - s e p s i s a n t i b i o t i c1 2 h r p o s t - s e p s i s a n t i b i o t i c1 8 h r p o s t - s e p s i s a n t i b i o t i c
antibiotic antibiotic
†
†
＊
＊
Kumar et al. J Infect Dis 2006; 193: 251-258
Plasma TNF Post-Antibiotic
p r e - a n t i b i o t i c 3 h p o s t - 6 h p o s t -
se
rum
TN
F
(p
g/m
L)
0
1 0 0
2 0 0
3 0 0
4 0 0
5 0 0
6 0 0
7 0 06 h r p o s t - s e p s i s a n t i b i o t i c1 2 h r p o s t - s e p s i s a n t i b i o t i c1 8 h r p o s t - s e p s i s a n t i b i o t i c
antibiotic antibiotic
†
＊
†
＊
Kumar et al. J Infect Dis 2006; 193: 251-258
Plasma IL-6 Post-Antibiotic
p r e - a n t i b i o t i c 3 h p o s t - 6 h p o s t -
seru
m I
L-6
(p
g/m
L)
0
2 0 0 0
4 0 0 0
6 0 0 0
8 0 0 06 h r p o s t - s e p s i s a n t i b i o t i c1 2 h r p o s t - s e p s i s a n t i b i o t i c1 8 h r p o s t - s e p s i s a n t i b i o t i c
†
†
antibiotic antibiotic
†
††
†
Kumar et al. J Infect Dis 2006; 193: 251-258
Serum Lactate: Septic vs Sham
time post-sepsis induction (hrs)
pre-sepsis 6 h 12h 18 h 24 h
seru
m la
ctat
e (m
mo
l/L
)
0
2
4
6
8
10
12
14
sterile implantseptic implant
†
†
Kumar et al. J Infect Dis 2006; 193: 251-258
Plasma TNF: Septic vs Sham
time post-sepsis induction (hrs)
pre-sepsis 6 h 12h 18 h 24 h
seru
m T
NF
(pg
/mL
)
0
100
200
300
400
500
sterile implantseptic implant
††
†
†
Kumar et al. J Infect Dis 2006; 193: 251-258
Plasma IL-6: Septic vs Sham
time post-sepsis induction (hrs)
pre-sepsis 6 h 12h 18 h 24 h
seru
m I
L-6
(m
mo
l/L
)
0
1000
2000
3000
4000
5000
6000
7000sterile implantseptic implant
††
††
Kumar et al. J Infect Dis 2006; 193: 251-258
Serum Endotoxin: Effect of Antibiotics
AbRx 18h post implant (n=8)
pre-implant pre-antibiotic 3h post- 6h post-
0.01
0.1
1
10
100
1000
seru
m L
PS
co
ncen
tra
tio
n (
pg
/mL
)
AbRx 12h post-implant (n=8)AbRx 6h post-implant (n=8)sham (sterile) implant (n=8)
antibiotic antibioticKumar et al. J Infect Dis 2006; 193: 251-258
Heart Rate in Murine Septic Shock
Time (hr)
0 12 24 36 48 60 72 84 96
HR
(b
eats
/min
)
100
200
300
400
500
＊＊＊＊＊＊
p=0.0364
Kumar et al. J Infect Dis 2006; 193: 251-258
Stroke Volume in Murine Septic Shock
Time (hr)
0 12 24 36 48 60 72 84 96
SV
(u
L)
10
20
30
40
50
60
70
＊†
††
†
p<0.0001
Kumar et al. J Infect Dis 2006; 193: 251-258
Cardiac Output in Murine Septic Shock
Time (hr)
0 12 24 36 48 60 72 84 96
CO
(m
L/m
in)
0
5
10
15
20
25
＊†
†
† p<0.0001
Kumar et al. J Infect Dis 2006; 193: 251-258
Mean Arterial Pressure in Murine Septic Shock
Time (hr)
0 12 24 36 48 60 72 84 96
MA
P (
mm
Hg
)
20
40
60
80
100
120
＊
††
†††
†p<0.0001
Kumar et al. J Infect Dis 2006; 193: 251-258
Survival in Murine Septic Shock
Survival Duration (hrs post-implant)
0 12 24 36 48 60 72 84 96
Cu
mu
lati
ve S
urv
ival
(%
)
0
20
40
60
80
100
shamseptic no RxAbRx 0hAbRx 6hAbRx 12hAbRx 15hAbRx 18h
p<0.0001
Kumar et al. J Infect Dis 2006; 193: 251-258
