Sequence Services Phase 2--Hewlett-Packard
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© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.
HP Sequence ServicesPistoia Alliance Annual Conference
24th April 2012
Etzard Stolte, PhD, Hewlett-PackardRalph Schlapbach, PhD, ETH Zurich
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Technical / Scientific SupportTechnical & scientific QCProfessional life cycle management of bioinformatics tools and scientific quality control of analysis results
HP Cloud / Data Center Secure & scalable infrastructureHP’s consolidated IT infrastructure provides a flexible storage and compute both as services as well as public service
HP Sequence ServicesHigh scientific quality with maximal IT flexibility
Functional Platform
Mature functional platformComplete coverage of NGS workflows within proven data management and analysis system
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. 3
HP is the world's largest provider of IT infrastructure, software, services, and solutions to individuals and organizations of all sizes.• Fortune 11 – U.S.
• Fortune 28 – Global
• Doing business in approximately170 countries
• Over 320,000 employees
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Life science data management, analysis, and integrationFunctional Genomics Center Zurich
•Joint Swiss research and technology center of University Zurich & ETH
Zurich21 Nobel Laureates since beginning last century, 215 spin-offs since late nineties
•Comprehensive coverage of systems-oriented life science research
areasGenomics, Transcriptomics, Proteomics, Metabolomics
•Full project support in User Lab conceptScientific consulting, project consulting, researcher training, project collaboration, data
analysis QC
•10 Years of operational experience> 2000 Users, > 1000 Projects, > 240 Institutes, > 30 Companies
•Full coverage of state-of-the-art analytical technologies> 30 platforms, e.g. PacBio RS, Illumina HiSeq2000, LifeTech SOLiD5500xl, IonTorrent PGM, Roche/454 GS
FLX+
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© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Functionality overviewHP Sequence Services
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• Easy-to-use
• Cost-effective
• Increased scientific quality
• Comprehensive administration
• Powerful HP Cloud
• Industry leading security
• Open standards based
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
World-class, open standards based, secure cloud infrastructure
HP Converged Infrastructure – Private or Public
• Adapt to changing needs
• Scale up dynamically
• Access your data globally
• Pay only what you use
• No lock-in through open standards
• Hybrid approach (private/public)
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Sequencing in personalized medicine and resulting challenges
HP Sequence Services
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Diseasemechanism
Therapy DiseaseHealthy
Diseasecause
Therapeuticmeasure
Understandingof disease mechanism
Developmentof therapy
Diagnosticcharacterization
of disease
Characterizationof disease agent
Personalizedapplication of
therapeutic agent
Geneticcharacterization
of indvidual
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Technical & scientific supportHP Sequence Services
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• NGS analysis challenges at all levels• Experimental (specimen, molecular biology)
• Data management (terabytes per experiment)
• Data processing (large memory needs, large computational needs)
• Data processing and interpretation (algorithms, statistics, visualization)
• Technical and administrative support• Project setup and management, application support, scalability, special hardware requirement
• Scientific support• Essential at all levels of a successful project (beginning with experimental design)
• Feedback loops between bioinformatics and lab necessary to assess and enhance quality of
output
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.
Sequenceread the genetic code
Mapplace the reads on reference genome
Identifyfind SNPs, Indels and structural variations
Associatelink genetic changes to diseases
Validatevisualize results in Genome Browser
(c) Nature & ETH/UNI
HP Sequence Services
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Functional platform offering complete coverage of NGS workflows
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Data analysis from single experiments to data integrationHP Sequence Services
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Read processing• De-multiplexing• Trimming• Quality control
Read mapping• Alignment• Combination• Statistics
Functional association• Element identification• Element association
Validation• Result
visualization• Scientific
validation
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Data analysis from single experiments to data integrationHP Sequence Services
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Illumina, SOLiD, 454, IonTorrent, PacBio
Data combination• Long / short reads• Bias / error rates
Data integration• Other molecular
levels• Other technologies
Proteomics, Metabolomics
Hypothesisgeneration / validation
Data and knowledge export and linking
Collaboration• Technical
discussion• Scientific exchange
Communication, member management
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Roadmap
HP Sequence Services
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April July Dec
Pilot
• Transform platform• In-house data center• Minimal app set• Develop Web GUI• User acceptance
tests• Demo data (35 GB)
Release
• Extend platform
• HP Cloud 10th May
• LCM core apps
• Email based admin workflows
• Service ramp-up
Production
• Commercialize platform• Region specific data
center• Integrate extended app
set• Billing, pay-as-you-go• Technical & scientific
support• Concept-based search• Partner program
commercialdevelopment2012 2013
today
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
Three models starting 2013 – HP Cloud, in-house, or bothHP Sequence Services
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HP Cloud Subscription• Project setup• System training• Public data
sources
In-house HP data center• Run functional platform in-
house• HP platform support• Burst-out to HP Cloud (opt.)
Pay-by-use/project• Storage/Compute• Consultancy• Custom
applications
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted
High scientific quality with maximal IT flexibilityHP Sequence Services
• Complete administration• Automated administration tasks• Simplified IT admin, scientists,
secretarial work
• Increased scientific quality• Reproducibility of research results• Application life-cycle-
management• Scientific quality control & support• Meaning based search
• Open standards based• Community application approach• Easily extensible with new
applications• No vendor lock-in with OpenStack
• Easy-to-use• Easy & fast web-based data
access• Standard & ad-hoc analysis
workflows
• Industry leading security• Role-based user authorization• Regular security and quality
reviews
• Cost-effective• Transparent subscription & pay-
by-use• Public data life-cycle-management
• Powerful Search & HP Cloud• Dynamic storage & compute
power on the HP Cloud• Hybrid Cloud models
• John Wise• Michael
Braxenthaler• Nick Lynch• Ashley George• Deborah Ausman• -------
A true catalyst for the Pharma- and IT industries
© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.
THANK YOU