• Senna leaves• Medical plant names.• Plant description and origin .• Biochemical constituents & pharmacological effe

cts.• Uses.• Folk remedies.• Contraindications• Side effects and adverse reactions.• Pharmacokinetics.• Interactions with Senna medical preparations.• Drugs.• Senna fruits.

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Dr. Nidal Jaradat

Description

Legume

Leaflet

Fruit

Yellow flower

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Dr. Nidal Jaradat

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Dr. Nidal Jaradat

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Senna leaves :Senna leaflets:Folia Sennae-------------------------------------------

Cassia acutifolia –Alexandrian Senna

(Egyption)

Cassia angustifolia —Indian Senna

Family: Leguminosae

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Perennial small shrubs (trees) about 1m high with yellow flowers ,fruits form legume (pods) .

The leaves greenish blue but during drying turned yellow .

C. acutifolia :the leaves have acute apex C. angustifolia: the plant has narrow leavesOdor: slight or odorless.Taste: unpleasant .Origin : Mecca then cultivated in Egypt and

India . Main slide

Biochemical constituentsGlycosides; anthraquinone derivatives

(dianthrone): Sennoside A,B and traces from Sennoside C and D .

Pharmacological effects1.Stimulant laxative (contact) which

increases intestinal motility causes abdominal cramps (spasm) .

2. It soften the feces by increasing the flow of water and electrolytes into the large intestine.

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uses Strong laxative (purgative) used in

the case of acute or chronic constipation or when required soft stool (abdominal operations , anal-rectal operation ,hemorrhoids , x-ray for intestines).

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Folk remedies:

• Inflammatory skin conditions :the leaves were sometimes made into a paste and applied to various skin diseases. Ringworm and acne were both treated in this way.

• It is also used in hypertension and obesity.

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• Contraindications:

Senna should not be used during :

1. Pregnancy.

2. Lactation

3. Should not be given to children younger than 12 years of age.

Senna should not be used by persons with

1. intestinal obstruction.

2. ulcerative colitis.

3. C.H.F.

4. Gastrointestinal bleeding and inflammations b/c of irritations.  Main slide

Side effects/ Adverse Reactions• GIT: Nausea, Vomiting, Anorexia,

Cramping, Diarrhea, Flatulence.

It can be corrected by adding 1/4 amount of stomachic carminative herbs, like Ginger rhizomes or Fennel fruits, with its dosage.

• UT: Pink, red, brown or black urine.

• Metabolic: Hypocalcemia, alkalosis, hypokalemia , tetany.

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• This herb should not be used for longer than 1-2 weeks ( habit forming medication).

• Pharmacokinetics

Onset of action 6 to 24 hours\metabolized by liver ; excreted in feces.

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Interactions with Senna medical preparations: • Cardiac Glycosides( Digoxin and

others)

Chronic use of Senna leaves may potentiate cardiac glycosides.

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DrugsLax-Ray ® Jepharm Liquid

Florilax ® Caps

Jungborn ® :Taro Tea bags, granules

Lido ® ; Trima Tea bags

Midro® :Midro Tea bags

Pursennid®; Novortis Tab

X-prep® : Rafa Liquid

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• Eucarbon®; Trenka : Tablets

Carbo ligni pulvaris + Extract Rhei +Fol. Sennae.

Indications:

1. Mild laxative.

2. Adsorb gases.

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• Granulax® : Taro: Granules (chewed or swallowed with water)

• Sennoside A,B

• Relief of chronic and acute constipation.

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Also Senna fruits (pods) contain Sennoside BDrugs

Bekunis ® Dragees

Laxikal forte® : Teva TAB

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