Seminar Mima Template 2

7/24/2019 Seminar Mima Template 2

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KINETIKAINHIBISIENZIMSECARA IN

VTRO OLEHEKSTRAK DAUNAquilaria malac EBAGAI ANTIHIPERGLIKEMIK

-GLUKOSIDASE

MIMA AQMARINAG44100112

Pembimbi!"

D# He$ P%#&'i!(i)* MSiD# Hi+m' A,'i


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PENDAHULUAN


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DIABETES1.1 /UTA O#'!DIABETES

TAHUN 2000

/UTA ORANGMENINGKAT

TAHUN 200

(Wild et al. 2004)

DIABTIP

Te#b'$'

90

'#i '(%( i'b

(Goldstein dan M

DIABETES TIPE 2''+') (i#m $'! i(eb'b' 'ib'3 e%#'!' i(%+i'3'% ''$' #e(i(3e(i 3e#)''5 i(%+i 5'' 3i!'3 (e+ $'!me!'ib'3' m%6%+$' )i5e#!+iemi' ' !+i(%#i'7(Satyanaryana dan Chakrapani 2006)


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IM -GLUKOSIDASE#!#,#.+

Km5e3i3i8

Um5e3i3i8

N m5e3i3i8

C'm5%#'

1

(Goldstein dan Mller-Wieland 2008)

*+*M.+ '#!MICHAELIS-M

Lie&e'9e#-E'ie-H8(H'e(-:

INHIBITOR -GLUKOSIDASED'%Aquilaria malaccensisme!'%! (e'#m'3i6* e(3#' me3'+$' me!'%!('5i* '+'+i* 8e+i7;K)'+i+ et al. 201ian aktiitas inhi7isiEN"IM $ -GLUKOSIDASE

ra in vitro odiE kasi SanDheti et al ; 2009

ar/tanSAMPEL


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A !a20;2 M

071 mL S'm5e+

1 mL b%8e# 8(8'3;5H .70a =

+eaksi 7er

40 !m

*7so r7ans i ,*

5/>ian aktiitas inhi7isiEN"IM $ -GLUKOSIDASE


ar/tan ,lankoSAMPEL

!"#M


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A !a20;2 M

071 mL E3'+PA @

07 mL b%8e# 8(8'3;5H .70a =

+eaksi 7er

40 !m

*7so r7ans i ko



ar/tanKONTROL


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A !a20;2 M

071 mL E3'+PA @

1 mL b%8e# 8(8'3;5H .70a =

+eaksi 7er

40 !m

*7so r7ans i 7 la



ar/tan ,lanko

KONTROL!"#M


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Inhibisi (%) =

NGHAMBATAN AKTIITAS ENZIM

( )%100

Ac

AbAsAc


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A !a2C

0;2 M071 mL ('m5e+

07 mL b%8e# 8(8'3;5H .70$e.

>hen FF sse R;. 2004. In/es/in$ bsr#/in inhibi/rs fr /?#e 2 'ibe/es "e$$i/!s #reAen/in n' /re/"en

"hera$euticStrateies. 1(2)20120+.

sh ?n/ ,P Prsnn PP. 2008. Ph?/he"i$ n' n/i"irbi$ sreenin f ex/r/s f Aquilaria aallo

7(20)3531-3534.

e:i?n/i I &!is G e:/i ri F. 2012. he n/i'ibe/i /iAi/? f r bebe $eAesJ (,$nhe #inn/ fr" Ari!s res.J "ro$ Life Science. 2(2)37-39.

;$'s/ein !$$er-Cei$n' . 2008.Diabetes# Princi$les and Practice Second%dition. 6e: Fr (E@) Infr"

,/!n ; s/ers @ reAr . 2009.Basic and Clinical Pharmacoloy. &' e-11. 6e: Fr (E@) ;r:-i$

,h$i$ @ Rhi" h ,, b'$$h ,. 2013. >hr/eri/in f "e/hn$i ex/r/s f r:' $eAes.

88.

,!"r P@ @ @!'h. 2012. &A$!/in f $#h-"?$se n' $#h-$!si'se inhibi/r? #r#er/ies f se$e/e' se:

Int &es J Pharm. 3(8)129-130.

i F> >hen >, si @G ee @@. 2012. ri/er#enes s '-$!si'se inhibi/rs fr"(aus hayatae. Phytochemistr


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?!r @nhe/i @ @ @hr!/i @e @F. 2010. n/ixi'n/ n' '-$!si'se inhibi/r? #r##er/ies f Car$es

Med Plant&es. 4(15)1547-1553.

einr I. 2015. ,ine/i inhibisi eni" K-$!si'se ser in !itro$eh es/r '!n Aquilaria filaria seb

[sri#si*. r (I) Ins/i/!/ Per/nin r.

i/r R hn D r$e? @. 2007. e'iin$ #$n/s f $?si.APBN.11(2)105-110.

!ss 6 et al.. 2007. &ffe/s f r$ '"inis/r/in f orina oleifera" n $!se /$erne in /-

Clin Biochem Nutr. 40229-233.

!nJi" ,/rin ih:/i n'rini ,G h"!'h shi/. 2013. @reenin f K-$!si'se inhib

In'nesin "e'iin$ #$n/s.J Med Arom Plants. 2(2)144-150.

6r ""n's P @!//n R shrf/ @. 1989. he h?#er$?e"i n' ins!$in/r#i /iAi/? f ins#

h!"n n' r/ is$e/s n' I-15 e$$s.Diabetoloia. 32354-359.

P/e$ ishr @. 2012. nf$rine fr" "inos$ora cordiofolas/e" inhibi/s '-$?si'se n' is n/i$?

foods. 479-8+.

@nhe/i @ @n'esh @ @!n F@. 2009. >hen"e$es sinensis #/en/ K-n' L-$!si'se inhibi/r.Am J Phar@!i:/i @ @e/isih @ fifh &. 2009. n/ih?#er$?e"i /iAi/? f "h/ 'e: (Phaleria macrocar$a

ex/r/s s n $#h-$!si'se inhibi/r.Ma*ara *esehatan.13(2)74-78.

Menb$e @ shenbrenner @. 2005.Dru "hera$y in Nursin. ers/:n i##in// Ci$$i"s N Ci$ins.

Cn ! F @n >. 2010. $#h-$?si'se n' '-"?$se inhibi/r? /iAi/ies f !A $eAes.(ood Ch

Ci$' @ R$i ; ;reen @iree R ,in . 2004. ;$b$ #reA$ene f 'ibe/es es/i"/es fr /he ?er 20

2030.Diabetes Care.271047-1053

RIMA KASIH TERIMA KASIH TERIMA KASIH TERIMA KASIH


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TERIMA KASTERIMA KASTERIMA KAS

Seminar Mima Template 2

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