Self-­‐assembly  from  atoms  to  life  

October  3  to  5,  2016.  Tuxtla  Gutiérrez,  Chiapas,  México.  

Organizers:        Prof.  Charles  M.  Knobler  /  University  of  California  Los  Angeles  (USA)        Prof.  Alexander  J.  Levine  /  University  of  California  Los  Angeles  (USA)    

Prof.  Jaime  Ruiz  García  /  Universidad  Autónoma  de  San  Luis  Potosí  (México)        Dr.  Elías  Castellano  Alcantara  /  Mesoamerican  Centre  for  Theoretical  Physics  (MCTP)    Sponsor:  UCLA  Center  for  Biological  Physics,  UCLA  College  of  Letters  and  Sciences,  

UCLA  ICAM  branch,  ICAM,  12  ICAM  (http://icam-­‐i2cam.org/),  ICTP,    MCTP,  UNACH  and  CONACYT.  

 The   three-­‐day   October   2016   workshop   in   Mexico   will   honor   of  Professor  William  Gelbart’s  70th  birthday.    The  "Self-­‐assembly  from  atoms  to  life"  workshop  will  bring  together  both   young   and   senior   scientists   from   around   the   world   and   it  covers  research  areas  that  match  UCLA  physical  chemistry  professor  Gelbart's   broad   range   of   interests   that   he   has   pursued   over  a  45-­‐year  career  in  research.  It  will  take  place  October  3-­‐5,  2016,  at  the  Mesoamerican   Centre   for   Theoretical   Physics   in   Tuxtla   Gutiérrez,  Chiapas,   Mexico.     To   facilitate   travel   to   and   from   the   event,   the  Marriott  Tuxtla  Gutiérrez  Hotel  has  reserved  a  block  a  rooms  at  the  special  conference  rate  for  October  2  through  October  6.      The  workshop  organizers  are  Profs.  Alex  Levine  and  Chuck  Knobler  from   the   UCLA   Department   of   Chemistry   and   Biochemistry   and  Prof.  Jaime  Ruiz-­‐Garcia,  of  the  Physics  Institute  of  the  University  of  San  Luis  Potosi,  in  Mexico.      

One  archetypal  example  of  emergent  phenomena  in  nature  is  found  in   the   self-­‐assembly   of   complex   spatio-­‐temporal   structures,   either  in   the   relaxation   of   many-­‐body   systems   toward   their   thermal  equilibrium   or   in   non-­‐equilibrium   steady   states   characterized   by  continuous   energy   throughput.   Examples   of   the   former   include  crystallization   and   the   formation   of   higher   symmetry   liquid  crystalline   mesophases   (e.g.,   nematic,   columnar,   and   semetic  phases  of  thermotropic  liquid  crystals),  the  spontaneous  formation  of   lipids   (and   multi-­‐block   copolymers)   into   lamellar   and  bicontinuous   phases,   in   addition   to   cylindrical   and   spherical  micelles,   and   the   condensation   of   charged   biopolymers   into  disordered   and   ordered   (e.g.   chiral   hexatic)   bundles.   Recognizing  the   commonality   of   these   diverse   emergent   phenomena,    researchers   in   the   1970s   began   to   refer   to   this   set   of   self-­‐organization  as  “self-­‐assembly”  in  order  to  describe  the  phenomena  of   molecular   and   colloidal   organization   that   result   from   the  equilibrium  assembly  of  many  copies  of  one  or  a   small  number  of  constituents   via   weak   (non-­‐covalent)   interactions.   Fundamental  questions   have   been   explored   involving   the   prediction   of   the  complex   equilibrium   states   of   these   systems   and   their   low-­‐energy  excitations   and   linear   response   properties.   In   addition,   much  thought   has   gone   into   considerations   of   assembly   kinetics   and,   in  particular,  the  role  of  kinetic  traps  or  glassy  dynamics  inhibiting  the  formation  of  a   thermodynamic  ground   state  of   the   system.  Today,  researchers   have   shown   that   one   may   design   complex   pattern  formers  using  nanofabrication  techniques  so  that  one  may  encode  interesting   or   otherwise   desirable   complex   equilibrium   states   into  the  interactions  and  shapes  of  the  nanoparticles.  Examples  include  DNA  origami  and  pattern  formation  in  colloids  of  complex  shapes  or  with  precisely  controlled  binding  sites.   In  non-­‐equilibrium  systems,  such   examples   of   complex   spatio-­‐temporal   patterns   abound,   from  patterns   formed   in   convection   to   contractile   waves   in   active  contractile   gels   and   liquid-­‐crystal   elastomers.   Of   course,   the  

quintessential  examples  of  non-­‐equilibrium  structure  formation  are  found   in   biology:   viral   self-­‐assembly,   protein   folding   (and  misfolding),  and  the  dynamic  organization  of  cytoskeletal  networks  provide  frontier  problems  in  statistical  and  biological  physics  today.                                                                      

Schedule  of  the  workshop:  Arrival  will  be  on  the  evening/night  Oct.  2,  2016.  Activities  will  start  on  Oct.  3,  2016.    I.    October  3:  Self-­‐assembly  of  complex  structures:  Design  principles  for  complex  equilibrium  structures    9:00  -­‐10:00    Daan   Frankel   (Cambridge   Univ.)   “Self-­‐assembly   and   addressable  

complexity”    10:00-­‐11:00     Arthur  Evans  (University of Wisconsin)  “Ancient  art  and  modern  

mechanics:  Using  origami  and  elasticity  to  design  novel  structures”    11:00-­‐11:30   Coffee    11:30-­‐  12:30    Andrej  Kosmrlj  (Princeton)  Complex  pattern  formation  in  solid  

structures  induced  by  buckling    12:30-­‐1:00   Discussion  Session  I    Discussion  Leader:  R.  Granek  (Ben-­‐Gurion  Univ.)    1:00-­‐1:40   Inaugural  Ceremony      2:30-­‐3:30     Gabriel   Espinosa   (University   of   Michoaćan)   “Shear   and   compression  

rheology  of  Langmuir  monolayers”    3:30-­‐4:30   Rolando   Castillo   (UNAM)   “Disorder   induced   by   capillary   interactions  

between  colloidal  particles  at  the  air/water  interface”    4:30-­‐5:30   Discussion   Section   II   Discussion   Leader:     Eric   Raspaud   (Université  

Paris-­‐Sud)    6:30-­‐7:30     Laura  Palomares  (Inst.  Of  Biotechnology-­‐UNAM  Cuernavaca)  “Designing  

new  delivery  materials  based  on  viral  proteins”    7:30-­‐  8:30     Robijn   Bruinsma   (UCLA)   "Lev   Landau,   Chirality,   and   the   Assembly   of  

Capsids."                        

II.  October  4:  Self-­‐assembly  in  the  approach  to  equilibrium    9-­‐10        William  Jacobs  (Harvard)      10-­‐11   Noel  Clark  (U  Colorado,  Boulder)  “Features  of  an  ancient   liquid  crystal  

world”    11-­‐11:30   Coffee        11:30-­‐12:30   Discussion  Session  III  Discussion  Leader:  Dan.  Ou-­‐Yang  (Lehigh  Univ.)      12:30-­‐  1:30     Roya  Zandi  (U  California,  Riverside)  “The  assembly  of  small  symmetric  

nano-­‐shells”    2:30-­‐3:30   Mauricio  Comas-­‐Garcia  (NIH)"Understanding  HIV-­‐1  packaging  signal  by  

single-­‐molecule  spectroscopy"    3:30-­‐4:30   Ruben   Cadena-­‐Nava   (CnyN-­‐UNAM   Ensenada)   “CCMV   capsids   as  

nanovehicles  for  antimicrobial  peptides”    4:30-­‐  5:30     Irina   Tsvetkova   (Indiana)   “Virus   protein   shell   assembly   beyond  

triangulation  numbers:  thermodynamics  and  structure”    5:30-­‐6:30   Discussion  Section  IV:  Discussion  Leader:  R.  Garmann  (Harvard)      7:00-­‐  8:00   Poster  Session    8:00-­‐10:00   Dinner  and  Evening  Keynote  address:  Avinoam  Ben-­‐Shaul  (Hebrew  

University)  “Bill  Gelbart  and  the  assembly  of  a  scientific  career”                                

III  October  5:  Emergent  Structures  and  dynamical  assembly  in  living  systems    9:00  -­‐10:00   Joel  Stavans  (Weizmann  Inst.)  “One  day  in  the  lifetime  and  development  

of  a  one-­‐dimensional  organism”      10:00-­‐11:00     Rinat  Goren  (Weizmann  Inst.)  “In  vivo  visualization  of  target  location  by  

DNA  bacteriophage  lambda”      11-­‐11:30   Coffee        11:30-­‐12:30   Andrea   Liu   (University   of   Pennsylvania)   “Far-­‐from-­‐equilibrium   self-­‐

assembly  in  biological  systems”    12:30-­‐  1:30     Discussion  V  Discussion  Leader:    M.  Deserno  (Carnegie  Mellon  Univ.)    1:30  –  2:30  LUNCH      2:30-­‐3:30   Eric  Dykeman  (York    Univ.)  “RNA  folding  models  for  viral  assembly”    3:30-­‐4:30   Anton   Souslov   (Georgia   Tech.)     “Emergent   collective   properties   of  

many-­‐motor  systems  in  one  dimension”    4:30-­‐5:30   Eugenia   Corvera   (UNAM)   “Pulsatile   flows:   From   microfluidics   to   the  

arterial  network”        5:30-­‐6:30   Discussion  VI  Discussion  Leader:    OPEN  SLOT      6:30-­‐7:30     Bill  Gelbart  “Summing  up”      7:30  –  9pm     Dinner            Last  Changed  on:  9/26/16  11:25  AM