Self-Assembly of Surfactant-like Peptides
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Transcript of Self-Assembly of Surfactant-like Peptides
Self-Assembly of Surfactant-like Peptides
Steve S. Santoso, Sylvain Vauthey & Shuguang Zhang
Center for Biomedical EngineeringMassachusetts Institute of Technology
Nanostructures• Structures ranging from 1 to 100 nm• Sub-micrometer science and engineering that combine
multiple disciplines:• Chemistry• Biology• Physics• Material science• Engineering
• How to build / design nanostructures?• Want the atomic selectivity of synthetic chemistry yet the
expandability of engineering
• Molecular self-assembly may be useful
Self-assembly processes common in biological systems:• Cell membrane• Multi-component cellular machinery: ribosome• Protein folding
Self-assembly involves non-covalent bonding• van der Waals• hydrogen bonds• dipolar forces
dynamic process
[Ac]-VVVVVVDSix hydrophobic valines (tail)One polar aspartic acid (head)
2 nm
Surfactant-like peptides
Preliminary experiments and results• Some condition screening
• Use: dynamic light scattering (DLS), TEM
• Found larger structures for some conditions:
Cryo-TEM:
300 nm
Nanotubes are not the structure with energetic global minimum:
RF
• Controlled delivery of small chemicals• Use nanovesicle to study replication of biological materials in an enclosed environment
Nanovesicle
550 nm
150 nm
Summary• Peptide surfactants are promising substrates for advanced material and its application.
• Cost-effective• Certain structures will form under certain environmental and chemical conditions
• Tunable
• Biological origin may be advantageous for medical application• A good system to study self-assembly.