Selected Publications

Glentis S, Dimopoulos AC, Rouskas K, Ntritsos G, Evangelou E, Narod SA, Mes-Masson AM, Foulkes WD, Rivera B, Tonin PN, Ragoussis J, Dimas AS. Exome Sequencing in BRCA1- and BRCA2-Negative Greek Families Identifies MDM1 and NBEAL1 as Candidate Risk Genes for Hereditary Breast Cancer. Front Genet. 2019 Oct 18;10:1005.

Delivoria DC, Chia S, Habchi J, Perni M, Matis I, Papaevgeniou N, Reczko M, Chondrogianni N, Dobson CM, Vendruscolo M, Skretas G. Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation. Science Advances, 2019 Oct 16;5(10):eaax5108.

Koliaraki V, Chalkidi N, Henriques A, Tzaferis Ch, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. Cell Rep. 2019 Jan 15; 26(3): 536-545,e4.

Sakkou M, Chouvardas P, Ntari L, Prados A, Moreth K, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Denis MC, Karagianni N, Kollias G. Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valvestenosis. JCI Insight, 2018; 3(7).

Ntari L , Sakkou M, Chouvardas P, Mourouzis I, Prados A, Denis MC, Karagianni N, Pantos C, Kollias G. Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis. Ann Rheum Dis, 2018 Jun; 77(6):926-934.

Matis I, Delivoria DC, Mavroidi B, Papaevgeniou N, Panoutsou S, Bellou S, Papavasileiou KD, Linardaki ZI, Stavropoulou AV, Vekrellis K, Boukos N, Kolisis FN, Gonos ES, Margarity M, Papadopoulos MG, Efthimiopoulos S, Pelecanou M, Chondrogianni N & Skretas G. An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding. Nature Biomedical Engineering, 2017 Oct 10; 1:838–852.

Nikolaou CK, Moulos P, Harokopos V, Chalepakis G, Talianidis I. Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep. 2017 Jul 25; 20(4):909-922

Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A & Stathopoulos GT. Mutant KRAS promotes malignant pleural effusion formation. Nature Communications, 2017 May 16; 8: No

15205.

Sarris EM, Moulos P, Haroniti A, Giakountis A, Talianidis I. Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development. Cancer cell, 2016; 29: 354-366.

Giakountis A, Moulos P, Zarkou V, Oikonomou C, Harokopos V, Hatzigeorgiou GA, Reczko M, Hatzis P. A positive regulatory loop between a Wnt-regulated non-coding RNA and ASCL2 controls intestinal stem cell fate. Cell Rep. 2016 Jun 15;12: 2588–2596

Skliris A, Papadaki O, Kafasla P, Karakasiliotis I, Hazapis O, Reczko M, Grammenoudi S, Bauer J, Kontoyiannis LD. Neuroprotection requires the functions of the RNA-binding protein HuR. Cell death and differentiation, 2015; 22: 703-718.

Nikolaou CK, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. The EMBO journal, 2015; 34: 430-447.

Giannou AD, Marazioti A, Spella M, Kanellakis IN, Apostolopoulou H, Psallidas I, Prijovich ZM, Vreka M, Zazara DE, Lilis I, Papaleonidopoulos V, Kairi CA, Patmanidi AL, Giopanou I, Spiropoulou N, Harokopos V, Aidinis V, Spyratos D, Teliousi S, Papadaki H, Taraviras S, Snyder LA, Eickelberg O, Kardamakis D, Iwakura Y, Feyerabend TB, Rodewald HR, Kalomenidis I, Blackwell TS, Agalioti T, Stathopoulos GT. Mast cells mediate malignant pleural effusion formation. The Journal of clinical investigation, 2015; 125: 2317-2334.

Roulis M, Nikolaou C, Kotsaki E, Kaffe E, Karagianni N, Koliaraki V, Salpea K, Ragoussis J, Aidinis V, Martini E, Becker C, Herschman HR, Vetrano S, Danese S, Kollias G. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 2014; 111: E4658-4667.

Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis DL. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. The Journal of clinical investigation, 2012; 122: 48-61.

Nikolaou K, Tsagaratou A, Eftychi C, Kollias G, Mosialos G, Talianidis I. Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer cell, 2012; 21: 738-750.

Pandis I, Ospelt C, Karagianni N, Denis CM, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G. Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Annals of the rheumatic diseases, 2012; 71: 1716-1723.

Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, Harokopos V, Aidinis V, Hemberger M, Kontoyiannis DL. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Molecular and cellular biology, 2009; 29: 2762-2776.

Additional Publications

Konstantinou E, Zagoriti Z, Pyriochou A, Poulas K. Microcurrent Stimulation Triggers

MAPK Signaling and TGF-β1 Release in Fibroblast and Osteoblast-Like Cell Lines. Cells [MDPI], 2020 Aug 19; 9(9), 1924.

Karagianni N, Kranidioti K, Fikas N, Tsochatzidou M, Chouvardas P, Denis CM, Kollias G, Nikolaou Ch. An integrative transcriptome analysis framework for drug efficacy and similarity reveals drug-specific signatures of anti-TNF treatment in a mouse model of inflammatory polyarthritis. PLOS Computational Biology, 2019 May 9; 15(5): e1006933.

Desgrange A, Heliot C, Skovorodkin I, Akram SU, Heikkilä J, Ronkainen VP, Miinalainen I, DVainio SJ, Cereghini S. HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Development, 2017; 144(24): 4704-4719.

Burda P, Vargova J, Curik N, Salek C, Papadopoulos GL, Strouboulis J, Stopka T. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia. PloS one, 2016; 11: e0152234.

Filippou P, Antoniou C, Obata T, Van Der Kelen K, Harokopos V, Kanetis L, Aidinis V, Van Breusegem F, Fernie AR, Fotopoulos V. Kresoxim-methyl primes Medicago truncatula plants against abiotic stress factors via altered reactive oxygen and nitrogen species signaling leading to downstream transcriptional and metabolic readjustment. Journal of experimental botany, 2016; 67: 1259-1274.

Sagri E, Reczko M, Tsoumani KT, Gregoriou ME, Harokopos V, Mavridou AM, Tastsoglou S, Athanasiadis K, Ragoussis J, Mathiopoulos KD. The molecular biology of the olive fly comes of age. BMC genetics, 2014; 15 Suppl 2: S8.

Sagri E, Reczko M, Gregoriou ME, Tsoumani KT, Zygouridis NE, Salpea KD, Zalom FG, Ragoussis J, Mathiopoulos KD. Olive fly transcriptomics analysis implicates energy metabolism genes in spinosad resistance. BMC genomics, 2014; 15: 714.

Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V. ATX expression and LPA signalling are vital for the development of the nervous system. Developmental biology, 2010; 339: 451-464.

Chatzigeorgiou A, Harokopos V, Mylona-Karagianni C, Tsouvalas E, Aidinis V, Kamper EF. The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time. Annals of medicine, 2010; 42: 426-438.