Sediaan Tablet Teofillin

8/19/2019 Sediaan Tablet Teofillin

1/19

MAKALAH

PRAKTIKUM TEKNOLOGIFORMULASI

GRUP A

“TABLET N OFIL”ɛ

KELOMPOK V :

INDAH PERTIWI 1243050066

NURKHASANAH 1243050069

RISKA ARGUAR SYAH 1243050073

Fakulta Fa!"a#

U$#%&!#ta 17 A'utu 1945 (aka!ta

2015


2/19

TABLET N OFILɛ

(Tablet Teofilli !e"a Meto#e G$a%la&i Ba&a'

I) PEN!AHULUAN

Ta)l&t a*ala+ Ta)l&t a*ala+ &*#aa$ ,a*at k-",ak. *#)uat &/a!a k&",a/&tak.

*ala" )&$tuk ta)u$' ,#,#+ atau #!kul&!. k&*ua ,&!"ukaa$$a !ata atau /&")u$'.

"&$'a$*u$' atu &$# -)at atau l&)#+ *&$'a$ atau ta$,a at ta")a+a$ at ta")a+a$

a$' *#'u$aka$ *a,at )&!u$'# &)a'a# at ,&$'##. at ,&$'&")a$'. at ,&$'#kat. at

,&")aa+ atau at la#$ a$' /-/-k U$tuk "&")uat ta)l&t *#,&!luka$ at ta")a+a$

)&!u,a D&,k&. 1995 8

a at ,&$'## *#lu&$t u$tuk "&",&!)&a! %-lu"& ta)l&t -$t-+$a 8

a//+a!u" la/t#. a"lu" "a$#+-t

) at ,&$'#kat )#$*&! a'a! ta)l&t t#*ak ,&/a+ atau !&tak. *a,at "&!&kat

-$t-+$a 8 "u#la'- 'u""# a!a)#/# 10:20;

/ at ,&$'+a$/u! *##$t&'!a$t

*#"aukka$ a'a! ta)l&t *a,at +a$/u! *ala" ,&!ut -$t-+$a 8 a"lu" "a$#+-t k&!#$'. '&lat#$u"

* at ,&l#/a$ lu)!#/a$t *#"aukka$ a'a! ta)l&t t#*ak l&kat ,a*a /&taka$

"at! -$t-+$a 8 tal/u" 5 ;. "a'$&## t&a!ata

P&$''-l-$'a$ ta)l&t 8

a Ta)l&t k&",a atau ta)l&t k&",a ta$*a!

) Ta)l&t k&",a 'a$*a

/ Ta)l&t ak# *#,&!la"a atau ta)l&t alut &$t&!#/

* Ta)l&t alut 'ula

& Ta)l&t )&!alut la,#a$ t#,#

Ta)l&t ku$a+

' Ta)l&t )ukal *a$ u)l#$'ual


3/19

+ Ta)l&t t!-/+& *a$ l-&$'&

# Ta)l&t %a'#$al

Ta)l&t &&!%&/&$t

A) Meto#e Pe*b%ata Tablet


4/19

,a#&$ a"a *a$ ,&$ak#t ,a!u -)t!ukt# a$' k!-$#k. $a"u$ t#*ak &&kt# u$tuk

!&ak# akut ,a*a ,&$ak#t ,a!u -)t!ukt# k!-$#k

Alaa$ ,&"#l#+a$ t&k$#k '!a$ula# )aa+ ka!&$a t+&-#ll#$ "&"#l#k# #at ta+a$

,&"a$aa$ *a$ ta)#l t&!+a*a, l&")a) S&la#$ #tu. *&$'a$ "&$''u$aka$ "&t-*&

'!a$ula# )aa+ aka$ "&$'+a#lka$ ta)l&t l&)#+ )a#k *a$ *a,at *##",a$ l&)#+ la"a

*#)a$*#$' *&$'a$ "&t-*& '!a$ula# k&!#$'

II) PREFORMULASI

A) -at A.tif

T'eofili (FI E# IV Hal : /012/03

S#$-$#" 8 T+&-,+ll#$u"

T+&-#l#$ "&$'a$*u$' atu "-l&kul a#! +#*!at > a$+#*!at =&$'a$*u$' t#*ak

ku!a$' *a!# 970; *a$ t#*ak l&)#+ *a!# 1020; 2H? N4@2. *#+#tu$' t&!+a*a, at

a$' t&la+ *#k&!#$'ka$

Ru"u "-l&kul 8 2H? N4@2


5/19

Sta)#l#ta 8 Da,at *##",a$ ,a*a u+u ka"a!. *#)aa+ /a+aa l-!-&$#

t&!u "&$&!u &la"a &ku!a$':ku!a$'$a 1?0 +a!# ta$,a

,&!u)a+a$ k-$&$t!a# a$' #'$##ka$ *ala" )&$tuk la!uta$

&)a#k$a *#l#$*u$'# /a+aa. ta)#l *# u*a!a

Fu$'# 8 at akt# S,a"-l#t#ku" )!-$k#al

K-$&$t!a# 8 =ak#"u" &kal# 500 "'. &+a!# 1 '!a" *ala" &*#aa$

ta)l&t 250 "'

I$k-",at#)#l#ta 8 D&$'a$ &$aa ta$#$

P&$#",a$a$ 8 Dala" a*a+ t&!tutu, )a#k

B) E.&i,ie

a) A*il%* Mai'ot 4 Pati Si".o" (FI E# IV Hal : 56/2560

S#$-$#" 8 A"lu" =a$#+-t

=&!u,aka$ ,at# a$' *#,&!-l&+ *a!# u")# aka! Manihot utilissima P-++

Ru"u "-l&kul 8 6H10@5$

P&"&!#a$ 8 S&!)uk a$'at +alu. ,ut#+

K&la!uta$ 8 P!akt# t#*ak la!ut *ala" a#! *#$'#$ *a$ *ala" &ta$-l

Sta)#l#ta 8 K&!#$'. #ka *# ,a$aka$ aka$ ta)#l *a$ t&!l#$*u$'

*a!# ka,a$' Pat# *#a$''a, #$&!t *ala" k-$*##

,&$#",a$a$ a$' $-!"al Na"u$. ,&"a$aa$ ,ata

&/a!a ##k t#*ak ta)#l *a$ "u*a+ *#&!a$' -l&+

"#k!--!'a$#"&

Fu$'# 8 D##$t&'!a$ P&$'a+$/u!


6/19

K-$&$t!a# 8 10 ;

P&$#",a$a$ 8 Dala" a*a+ t&!tutu, !a,at

b) Tal. (Ha#boo. of P'a$*a+e%ti+al E7+i,iet E# V Hal : /8/2/89

S#$-$#" 8 Tal/u"

A*ala+ "a'$&#u" #l#kat +#*!at ala". ka*a$':ka*a$' "&$'a$*u$' &*#k#t

alu"#$#u" #l#kat

Ru"u "-l&kul 8 ='6S#2@54@H4

P&"&!#a$ 8 S&!)uk +a)lu! a$'at +alu. ,ut#+ atau ,ut#+ k&la)u


7/19

K&la!uta$ 8 Ca!ut +a",#! &",u!$a *ala" a#!. t&ta,# a$'at

la")at P!akt# t#*ak la!ut *ala" &ta$-l *a$ *ala" &t&!

Sta)#l#ta 8 C&)#+ "u*a+ t&!u!a# *&$'a$ a*a$a u*a!a *a!# lua!.

"u*a+ t&!u!a# -l&+ )akt&!# *a$ !&ak# &$#"at#k. *a$

"u*a+ t&!-k#*a#

Fu$'# 8 P&$'#kat

K-$&$t!a# 8 10 ;

I$k-",at#)#l#ta 8 D&$'a$ a"#*-,!#$. a,-"-!#$. a&!--l. &ta$-l 95 ;.

'a!a" &!!#. "-!#$. ta$#$. t#"-l. )a$ak ka$*u$'a$

'a!a" a$' *a,at "&$u!u$ %#k-#ta$a


#) Ma"e&i%* Stea$at

(Ha#boo. of P'a$*a+e%ti+al E7+i,iet E# V Hal : 316

S#$-$#" 8 =a'$&## St&a!a

=a'$&#u" t&a!at "&!u,aka$ &$aa "a'$&#au" *&$'a$ /a",u!a$ aa":

aa" -!'a$#k ,a*at a$' *#,&!-l&+ *a!# l&"ak. t&!uta"a t&!*#!# *a!#

"a'$&#u" t&a!at *a$ "a'$&#u" ,al"#tat *ala" )&!)a'a# ,&!)a$*#$'a$

=&$'a$*u$' &ta!a *&$'a$ t#*ak ku!a$' *a!# 6?; *a$ t#*ak l&)#+ *a!# ?3;

Ru"u "-l&kul 8 16H70='@4

P&"&!#a$ 8 S&!)uk +alu. ,ut#+. *a$ %-l#"#$u. )au l&"a+ k+a.

"&l&kat ,a*a kul#t. )&)a *a!# )ut#!:)ut#!a$

K&la!uta$ 8 T#*ak la!ut *ala" a#!. *ala" &ta$-l. *a$ *ala" &t&!

Sta)#l#ta 8 Sta)#l *#t&",at k&!#$'

Fu$'# 8 A$t# a*+&!&$


8/19

K-$&$t!a# 8 1;

I$k-",at#)#l#ta 8 D&$'a$ aa" kuat. )aa. *a$ 'a!a" )&# H#$*a!#

,&$/a",u!a$ *&$'a$ )a+a$ -k#*at-! kuat


e) Sa+'a$$%* La+ti& 4 La.to&a

(Ha#boo. of P'a$*a+e%ti+al E7+i,iet E# V Hal : 10;2100

S#$-$#" 8 Ca/t-u"

A*ala+ 'ula a$' *#,&!-l&+ *a!# uu *ala" )&$tuk a$+#*!at atau "&$'a$*u$'atu "-l&kul a#! +#*!at

Ru"u "-l&kul 8 12H22@11

"aa +a)lu!. k&!a. ,ut#+ atau ,ut#+ k!&"

T#*ak )&!)au *a$ !aa &*#k#t "a$# Sta)#l *#u*a!a

ta,# "u*a+ "&$&!a, )au

K&la!uta$ 8 =u*a+ *a$ ,&la$:,&la$ la!ut *ala" a#! *a$ l&)#+

"u*a+ la!ut *ala" a#! "&$*#*#+. a$'at uka! la!ut

*ala" &ta$-l. t#*ak la!ut *ala" kl-!--!" *a$ &t&!

Sta)#l#ta 8 Pa*a k-$*## l&")a) RH?0; *a,at t&!a*#

,&!tu")u+a$ ka,a$' S&la"a *##",a$. lakt-a *a,at

)&!u)a+ a!$a "&$a*# k&/-klata$ R&ak# #$#

*#,&!/&,at -l&+ ,a$a *a$ k-$*## l&")a) Ha!u

*##",a$ *ala" a*a+ t&!tutu, )a#k ,a*a t&",at

&uk *a$ k&!#$'


9/19

Fu$'# 8 P&$'##

K-$&$t!a# 8 H#$''a 100;

I$k-",at#)#l#ta 8 Cakt-a *a,at )&!u)a+ a!$a "&$a*# /-klat #ka

)&!&ak# *&$'a$ &$aa a$' "&$'a$*u$' 'u'u

a"#$ ,!#"&! !&ka# "a#lla!* I$k-",at#)#l#ta aa"

a"#$-. a"#$-#l#$. a"&ta"#$. l##$-,!#l


III) URAIAN FORMULA

R > T+&-#l#$ 250 "'

A"#lu" =a$#+-t 10 ;

Talk 5 ;

PGA 10 ;

=a'$&#u" St&a!at 1 ;

Sa//+a!u" Ca/t# a* 100 ;

Ba'a Ko&et$a&

i

Ke"%aa

T+&-#l#$ 250 "' S,a"-l#t#ku" )!-$k#al at akt#

A"#lu" =a$#+-t 10 ; D##$t&'!a$Talk 5 ; Gl#*a$

PGA 10 ; P&$'#kat

=a'$&#u" St&a!at 1 ; A$t# a*+&!&$

Sa//+a!u" Ca/t# a* 100; P&$'##

Aua *&t S&/uku,$a P&la!ut "u/#la'-

IV) ALAT < BAHAN A) Alat


10/19

• Cu",a$' *a$ alu

•


11/19

V) PERHITUNGAN !AN PENIMBANGAN

A) Fa& Dala" 92;

1 T+&-#ll#$ 250 "' 250 "' 30 7500 "' 7.5 '!a"

2 A"lu" =a$#+-t 10; 10 > 100 500 "' 30 1500 "' 1.5 '!a"

3 PGA 10; 10 > 100 500 "' 30 1500 "' 1.5 '!a"

4 Cakt-a 92 > 100 500 "' 30 13?00 "' 13. ? '!a"

13.? 7.5 1.5 1.5 3.3 '!a"

G!a$ul a& *ala" a$' *#,&!-l&+ &)a$ak 13 '!a" *&$'a$ ka*a! a#! 2;. "aka

u$tuk ka*a! a#! 0; a#tu 8


12/19

4


13/19

1) Ko*,$e&ibilita&

massan

=

ρ 50 xV

M

b

b = ρ

=&!u,aka$ ,&$u!u$a$

&u"la+ %-lu"& '!a$ul ak#)at +&$taka$ *a$ '&ta!a$ D#"a$a &"ak#$

k&/#l #$*&k ,&$'&ta,a$. "aka "ak#$ )a#k #at al#!$a U# ,&$'&ta,a$

*#lakuka$ *&$'a$ alat %-lu"&$-"&t&!. *&$'a$ $#la# #$*&k J 20;

;100 xC

nb

b

ρ ρ

ρ

−

=

3) Ke&e$a"a*a U.%$a

Pa!a"&t&! a$' )&!'u$a u$tuk "&$'&ta+u# ,&$&)a!a$ uku!a$ '!a$ul a$'

*#,&!-l&+. *&$'a$ "&$''u$aka$ aaka$ )&!t#$'kat Hal #$# ka!&$a. ,a*a

u"u"$a '!a$ul t#*ak aka$ "&"#l#k# uku!a$ a$' )&!%a!#a#


14/19

( ) ( )

( )∑∑

= ΧtGranul JumlahBobo

daAyakan DiameterPa x yakan BobotPadaA

5 Po$o&ita&

P-!-#ta atau k&a*aa$ )&!-$''a:!-$''a *a,at *#'u$aka$ u$tuk

"&$&laka$ t#$'kat k-$-l#*a# uatu &!)uk N#la# ,-!-#ta "&!u,aka$

,&!)a$*#$'a$ $#la# %-lu"& a$ta!a ,a!t#k&l *&$'a$ %-lu"& t-tal =ak#$

)&a! $#la# ,-!-#ta$a aka$ "&$&)a)ka$ tu!u$$a u"la+ -)at ,&!ta)l&t.

&+#$''a t&!a*# ,&$u!u$a$ "utu

6 Ka#a$ Ai$

K&l&)a,a$ *#*ala" at ,a*at *#$ataka$ )&!*aa!ka$ )&!at )aa+ atau )&!at

k&!#$'


15/19

B) U>i Eal%a&i Tablet

S&*#aa$ ta)l&t *#kataka$ )a#k a,a)#la t&la+ "&"&$u+# )&)&!a,a a!at a$'

t&la+ *#t&ta,ka$ U$tuk "&$'&ta+u# ka!akt&!#t#k uatu &*#aa$ ta)l&t "aka

*#,&!luka$ &!a$'ka#a$ &%alua# atau ,&$'u#a$ t&!+a*a, &*#aa$ t&!&)ut

S&+#$''a *a,at *#t&$tuka$ a,aka+ ta)l&t a$' *#+a#lka$ t&la+ "&"&$u+# a!at

atau t#*ak

1 K&&!a'a"a$


16/19

?) Ko*,$e&ibilita&

•


17/19

( ) ( ) ( ) ( ) ( ) ( ) ( )

m

x x x x x x x

µ 07740

7412

0057204105??10595009520?30?562125002131560536016705?70

= Χ

++++++= Χ

IC) HASIL PEMBAHASAN

E%alua# '!a$ul "&!u,aka$ uatu ,&$'u#a$ a$' )&!tuua$ u$tuk "&$'&ta+u#

a,aka+ '!a$ul u*a+ "&"&$u+# a!at u$tuk *#)uat ta)l&t atau t#*ak Dala" ,!akt#ku"

#$#. &%alua# '!a$ul a$' *#lakuka$ a*ala+ ,&$'u#a$ aktu al#! *a$ u*ut *#a". u#

k-",!&#)#l#ta. *a$ u# k&&!a'a"a$ uku!a$ '!a$ul U# aktu al#! *a$ u*ut *#a"

*#lakuka$ *&$'a$ "&$''u$aka$ alat )&!u,a /-!-$' alu"u$#u" Da!# +a#l a$'

*#lakuka$ aktu al#! *a!# a$' *#*a,at a#tu 9 *&t#k. &*a$'ka$ u*ut *#a" a$'

*#*a,at a#tu 260?B Hal #$# )&!a!t# &ua# ,&!a!ata$ a$' "&ataka$ katu al#! '!a$ul

a$' )a#k a*ala+ ku!a$' *a!# 10 *&t#k. *a$ u*ut *#a" a$' )a#k a$ta!a 25B:45B

U$tuk u# k-",!&#)#l#ta +a#l a$' *#*a,atka$ a#tu 1699;. a$' )&!a!t#

&ua# a!at a#tu *#)aa+ 20; G!a$ul *a,at *#$ataka$ ta+a$ t&!+a*a, '-$/a$'a$

"&ka$#k S&la$ut$a. u# k&&!a'a"a$ uku!a$ '!a$ul "&$*a,atka$ +a- 00774 M"

=aka. u$tuk u# &%alua# '!a$ul *a,at *#,at#ka$ )a+a '!a$ul t&-#l#$ a$' *#)uat

t&la+ "&"&$u+# ,&!a!ata$ Fa!"ak-,& I$*-$&#a

C) KESIMPULAN

CI) BROSUR !AN KEMASAN

A


18/19


19/19

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