score: Sum of three nuclear features (each 0 or · Nuclear score: Sum of three nuclear features...

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Nuclear features: Nuclear score: Sum of three nuclear features (each 0 or 1) Thus, total score will vary between 0 and 3 Absent/insufficiently expressed (0) Present/Sufficient (1) Slight changes not sufficient to call “present” 1) Size and Shape Enlargement Elongation Overlapping 2) Membrane Irregularities Irregular contours Grooves Intranuclear cytoplasmic inclusions 3) Chromatin Features Chromatin clearing Margination to nuclear membrane Glassy nuclei Criteria and examples for scoring nuclear features

Transcript of score: Sum of three nuclear features (each 0 or · Nuclear score: Sum of three nuclear features...

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Nuclear features:

Nuclear score: Sum of three nuclear features (each 0 or 1)Thus, total score will vary between 0 and 3

Absent/insufficiently expressed (0)                     Present/Sufficient (1)

Slight changes not sufficient to call “present”

1) Size and Shape• Enlargement• Elongation• Overlapping

2) Membrane Irregularities• Irregular contours• Grooves• Intranuclear cytoplasmic

inclusions

3) Chromatin Features• Chromatin clearing• Margination to nuclear

membrane• Glassy nuclei

Criteria and examples for scoring nuclear features

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Case A8

Uninvolved reference from case

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Uninvolved reference from case

Case A26

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Case A27

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Uninvolved reference from case

Case A29

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Case A35

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Case A36

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Case A37

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Uninvolved reference from case

Case A38

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Case A41

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Case A43

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Case A46

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Case A47

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Uninvolved reference from case

Case A52

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Case A56

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Case A58

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Case A59

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Uninvolved reference from case

Case A60

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Case A62

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Case A73

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Case A79

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Uninvolved reference from case

Case A80

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Case A102

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Case A111

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Case A120

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Case A121

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Case A126

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Case A127

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Case A128

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Case A134

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Uninvolved reference from case

Case A136