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scientificProgram

8th InternatIonal SympoSIum on neuroprotectIon and neurorepaIr 2014

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8th InternatIonal SympoSIum on neuroprotectIon and neurorepaIr 2014general InformatIon

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content

Welcome _______________________________________________________________________ 7

General information _____________________________________________________________ 8–9

Program overview ____________________________________________________________ 10–11

Program April 9, 2014 __________________________________________________________ 12–13

Program April 10, 2014 _________________________________________________________ 14–16

Program April 11, 2014 _________________________________________________________ 18–20

Program April 12, 2014 _________________________________________________________ 22–23

Poster exhibition______________________________________________________________ 24–36

Social events ___________________________________________________________________ 38

Exhibition/Sponsors ___________________________________________________________ 40–41

About Magdeburg _______________________________________________________________ 42

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dear colleagues and friends,

Welcome to Magdeburg at the 8th International Symposium on Neuroprotection and Neurorepair!

After visiting other very beautiful places in Germany, Rostock and Potsdam, this years the Neuroprotection and Neurorepair Symposium returns back to Magdeburg – the city where we have started the conference series in 1998. We were successful to establish an international platform for Neuroprotection and Neurorepair, focusing on basic, preclinical and clinical research in the fields of cerebral ischemia, stroke, dementia and stem cell repair.

From 2010 the rejuvenation of the generations started, when we invited Johannes Boltze and his team from Leipzig to join us. In addition we hired “eventlab” as our professional congress organizer. Meanwhile Johannes’ Fraunhofer team is the leading one in the organization of the conference. We, Klaus and Georg, promise that we will continue to actively support the subsequent meetings from 2016 onwards.

Over the years the “Magdeburg meeting” was growing to over 350 delegates coming from every corner of the globe. We are proud that our meeting stands for lively interactions, fruitful discussions and exchange of ideas between young researchers and senior experts. Please enjoy our 8th ISN&N in the 1200 years old city of Magdeburg with its scientific and touristic attractions.

Your “local heroes“ and senior ISN&N organizers!

Sincerely yours,

Klaus Reymann Georg Reiser

dear colleagues and friends,

Thanks to the continuous contribution of our experienced organizers from Magdeburg, this year’s meeting again became the largest one in the series with highest numbers of submitted abstracts and participants ever. We are convinced that all following meetings, starting with the 2016 Symposium in Leipzig, sustain the tradition assembled by our friends and colleagues from Magdeburg. We are looking forward to four days of scientific discussions and the exchange of novel ideas together with you!

Sincerely yours,

Johannes Boltze Alexander Kranz

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conference coordinatorsFraunhofer Institute for Cell Therapy and ImmunologyJohannes Boltze, Alexander KranzPerlickstr. 1, 04103 Leipzig

Otto-von-Guericke-Universität MagdeburgMedizinische Fakultät, Institut für NeurobiochemieGeorg ReiserLeipziger Str. 44, 39120 Magdeburg

Leibniz Institute for NeurobiologyKlaus ReymannBrenneckestr. 6, 39118 Magdeburg

CONFereNCe OFFICeevent lab. GmbH on siteDufourstr. 15, 04107 Leipzig Phone: +49 (0)172 77 88 656

conference dates | oPening hours registration deskWednesday, April 9, 2014 11:00 am – 8:00 pmThursday, April 10, 2014 8:00 am – 7:30 pmFriday, April 11, 2014 8:00 am – 7:30 pmSaturday, April 12, 2014 8:00 am – 1:00 pm

sPeaker´s PreviewThe speaker´s preview room (KÖLN), will be open at all times during the conference. Please come to the speaker´s preview room as soon as possible and no later than 2 hours before your session starts. Presentations will be delivered to the lecture hall.

languageThe official language of the symposium is English. There will be no translations.

ParticiPation | name tagsOfficial conference name tags will be required for admission to all conference functions, scientific sessions and exhibition areas. Participants who lose their name tags will have to pay a fee of 25.00 EUR to obtain a replacement tag.

certificationThe Medical Association of SaxonyAnhalt certificates the meeting with 21 continuing education points. Certificates will be issued at the registration desk.

internetTickets for WiFi can be purchased at the registration desk – 6.50 EUR for 24 hours.

exhibition informationThe exhibition will be located in the hall “Maritim 1” and open as follows:

Wednesday, April 9, 2014 12:00 pm – 10:00 pmThursday, April 10, 2014 8:00 am – 5:00 pmFriday, April 11, 2014 8:00 am – 5:00 pm

Poster sessionsGuided Poster Tour I–1, I–2, I–3, I–4 Thursday, April 10, 2014 1:00 pm – 3:00 pmGuided Poster Tour II–1, II–2, II–3, II–4 Friday, April 11, 2014 1:00 pm – 3:00 pm

The poster exhibition will be located in the hall “Maritim 1”. Poster presenters are requested to be present at their posters at least during the respective guided poster session. You will have about 1.5 to 2 minutes to present your poster to all participants.

Mounting and dismounting of posters The poster boards will be marked with numbers referring to those in the program. Materials for poster mounting will be provided. Make sure to remove all posters no later than Friday, 6:00 pm. Otherwise, posters will be removed by staff. We cannot accept responsibility for lost material.

Poster awardsThree best ISN&N posters will be awarded with following prizes:– 1st prize: 1.000 Euro– 2nd prize: 500 Euro– 3rd prize: 250 EuroPoster prizes will be awarded during the closing ceremony.

Poster PriZe nominationYou will receive a sticker during the registration process. Sticking it to your favorite poster nominates it for the best poster award. Your vote is worth 1 point. The meeting organizers will count all points (stickers on posters) at Friday evening to select the three best posters. If attending with colleagues, please do not conduct “group voting” to posters from your own institutions or group to provide all participants with a fair chance for being elected. Poster session chairs will denominate their favorite poster at the end of the respective poster session. Nomination will count five points.

young scientist awardWe are proud to announce that ALS Automated Lab Solutions will support a young scientist. The winner will be announced at the “Get together” at the ALS booth in the exhibition area.

Photo contestGilson and the International Symposium on Neuroprotection und Neurorepair organize the “Protection and Repair Photo Contest 2014“. The prize will be presented to the winner during the “Get together” on Wednesday night.


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Program overview

wednesday, aPril 9 thursday, aPril 10

main lecture hall maritim ii

exhibition area maritim i



8:00 am

8:30 am Selected from submitted abstracts

9:00 am Neurobiochemistry: molecular targets for neuroprotection

9:30 am

10:00 am

10:30 am Coffee break

11:00 am 11:15 Selected from submitted

abstracts11:30 am

12:00 pm

12:30 pm Opening Ceremony Lunch break

1:00 pm Presidential opening lecture Guided poster tour I

1:30 pm Hot news part I

2:00 pm

2:30 pm

3:00 pm Coffee break Glial cells, the blood brain barrier and the neurovascular unit

3:30 pm 3:40 pm Neuroregeneration and

neuroplasticity I4:00 pm

4:30 pm Coffee break

5:00 pm 4:50 pm Selected from submitted

abstracts

Imaging and novel diagnostics

5:30 pm


6:30 pm Hot news part II Break

7:00 pm Meet the chief editor: How to publish in high ranking

journals?7:30 pm

8:00 pm Get together in the exhibition area 8:30 pm Concert for organ and horn

friday, aPril 11 saturday, aPril 12





8:00 am

8:30 am Selected from submitted abstracts

Selected from submitted abstracts

9:00 am Neural network pathology in alzheimer dementiia

Focus on clinical translation: Novel thrombolytics and

innovative treatment concepts9:30 am

10:00 am

10:30 am Coffee break Coffee break

11:00 am The future of preclinical research for stroke and neuroprotection:

‚phase III‘ preclinical trials?

10:45 amThe ageing brain in health

and disease11:30 am

12:00 pm 12:05 pmPresidential closing lecture

12:30 pm Lunch break Closing ceremony including award presentation, farewell

1:00 pm Guided poster tour II

1:30 pm

2:00 pm

2:30 pm

3:00 pm Vascular regulation, vascular changes and the pathophysiology

of stroke and dementia3:30 pm

4:00 pm


5:00 pm Neuroregeneration and neuroplasticity II

5:30 pm

6:00 pm Understanding and controlling neuroinflammation

6:30 pm

7:00 pm

7:30 pm

8:00 pm Gala dinner


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scientific Program

wednesday, aPril 9, 2014

main lecture hall / maritim ii

12:30 – 1:00 Pm oPening ceremony

12:30 – 12:45 pm Boltze J., Reiser G., Reymann K. Welcome address

12:45 – 1:00 pm Düzel E. (Magdeburg, Germany) INVITED

Welcome note

1:00 – 1:30 Pm Presidential oPening lecture

Chairs: Carmichael T., Boltze J. Lo E. (Boston, USA) INVITED

Challenges and opportunities for translational stroke science

1:30 – 3:00 Pm hot news Part i

Chairs: Carmichael T., Boltze J.

1:30 – 1:50 pm Bix G. (Lexington, USA) INVITED

endothelial cell specific integrin knockdown prevents ischemic stroke injury

1:50 – 2:10 pm Hoehn M. (Cologne, Germany) INVITED

Novel in vivo fate mapping of intracerebral stem cell grafts shows localization, vitality, and neuronal differentiation

2:10 – 2:30 pm Savitz S.I. (Houston, USA) INVITED

Imaging brain repair in stroke patients treated with bone marrow mononuclear cells

2:30 – 2:50 pm Mays R. (Cleveland, USA) INVITED KINDly supporTED by

Mechanistic and clinical update on the use of multiStem in the treatment of acute ischemic stroke

3:00 – 3:40 pm Coffee break in the exhibition area

3:40 – 4:50 Pm neuroregeneration and neuroPlasticity i

Chairs: Wieloch T., Lauritzen M.

3:40 – 4:10 pm Carmichael T. (Los Angeles, USA) INVITED

Cellular environments for tissue regeneration in stroke

4:10 – 4:30 pm Flöel A. (Berlin, Germany) INVITED

Noninvasive brain stimulation to enhance neuroplasticity in health and disease

4:30 – 4:50 pm Kreutz M. (Magdeburg, Germany) INVITED

When synaptic proteins meet the genome – Transcriptional regulation in cell death and plasticity by synapto-nuclear messenger

4:50 – 6:05 Pm selected from submitted abstracts

Chairs: Clarkson A., Schäfer U.

4:50 – 5:05 pm Culmsee C. (Marburg, Germany) “PHOeNIX rISING”: Neural progenitor cell death is required to provide

neuroprotective effects in vitro and in vivo

5:05 – 5:20 pm Dressel A. (Greifswald, Germany) Human stroke impairs Treg function but depletion of Foxp3+ Treg does not alter

brain lesion volume in experimental stroke.

5:20 – 5:35 pm Radu B. (Verona, Italy) Brain microvascular endothelial cells are bricks in the wall of epileptogenesis

5:35 – 5:50 pm Parada E. (Madrid, Spain) Neuroprotective effect of melatonin against ischemia is partially mediated

by α-7 nicotinic receptor modulation and HO-1 overexpression

5:50 – 6:05 pm Joshi A. (Gießen, Germany) Novel role for factor VII activating protease (FSAP) in ischemic stroke


6:30 – 8:00 Pm hot news Part ii Chairs: Bulte J., Savitz S. I.

6:30 – 6:50 pm Abe K. (Okayama, Japan) INVITED

Neuroprotection and neuroregeneration for ischemic stroke

6:50 – 7:10 pm Walczak P. (Baltimore, USA) INVITED

Guiding cell delivery to the central nervous system with non-invasive imaging

7:10 – 7:30 pm Steinberg G. (Stanford, USA) INVITED

A novel phase 1/2A study of intraparenchymal transplantation of human modified bone marrow derived cells in patients with stable ischemic stroke

7:30 – 7:50 pm Dichgans M. (Munich, Germany) INVITED

Stroke genetics

7:50 – 8:00 pm Clarkson A. (Dunedin, New Zealand) Combined ampakine and BDNF treatments are required for post-stroke functional

recovery in aged mice

8:00 – 10:00 Pm get together in the exhibition area (see Page 38)


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scientific Program

thursday, aPril 10, 2014


8:30 – 9:00 am selected from submitted abstracts

Chairs: Reiser G., Vemuganti R.

8:30 – 8:45 am Wang Y. (Baltimore, USA) The role of a novel AIF-associated nuclease PAAN1 in ischemic neuronal injury

8:45 – 9:00 am Gellerich F. (Magdeburg, Germany) Different energization of mitochondria in neurons and astrocytes by the mito-

chondrial gas pedal: Pathophysiological consequences for neurodegeneration

9:00 – 10:45 am neurobiochemistry: molecular targets for neuroProtection

Chairs: Reiser G., Vemuganti R.

9:00 – 9:30 am Vemuganti R. (Madison, USA) INVITED

Secondary brain damage and non-coding rNAs

9:30 – 9:50 am Reiser G. (Magdeburg, Germany) INVITED

PPAr – a nuclear receptor family – and mitochondria as neuroprotectants

9:50 – 10:10 am Lechleiter J. (San Antonio, USA) INVITED

Purinergic signaling – astrocytes and mitochondrial metabolism in neuroprotection

10:10 – 10:30 am Landreth G. (Cleveland, USA) INVITED

Nuclear receptors as therapeutic targets in CNS disorders

10:30 – 10:45 am Schäfer U. (Graz, Austria) Brain injury associated mir-451 regulates maturation processes during in vivo

neurogenesis

10:45 – 11:15 am Coffee break in the exhibition area

11:15 am – selected from submitted abstracts

12:30 Pm

Chairs: Hoehn M., Bulte J.

11:15 – 11:30 am Turner R. (Adelaide, Australia) NK1 tachykinin receptor antagonist treatment reduces intracranial pressure fol-

lowing ovine middle cerebral artery occlusion

11:30 – 11:45 am Mohapatra D. (Iowa City, USA) The somatodendritic K+ channel Kv2.1 is a critical regulator of neuronal resilience

and death in multiple neuropathologies

11:45 – 12:00 am Zinnhardt B. (Münster, Germany) Imaging microglial activation and matrix-metalloproteinases (MMP) after stroke.

12:00 – 12:15 pm Schroeter M. (Cologne, Germany) In-vivo analysis of brain-resident and blood-derived parts of neuroinflammation

after cerebral ischemia

12:15 – 12:30 pm Stöber F. (Magdeburg, Germany) 201Thalliumdiethyldithiocarbamate-SPeCT for in-vivo imaging of early induced

alterations in cerebral potassium metabolism in focal cerebral ischemia

12:30 – 1:30 pm Lunch break in the exhibition area

exhibition area / maritim i

1:00 – 3:00 Pm Poster sessions i–1, i–2, i–3, i–4

I–1: Neurobiochemistry: Molecular targets for neuroprotection

I–2: Vascular changes and the pathophysiology of stroke and dementia

I–3: Future research directions in basic and clinical neuroscience clinical translation

I–4: Neurodegeneration in stroke, Alzheimer dementia and Parkinson’s disease


3:00 – 4:30 Pm glial cells, the blood brain barrier and the neurovascular unit

Chairs: Ayata C., Reiser G.

3:00 – 3:30 pm Bechmann I. (Leipzig, Germany) INVITED

Immune privilege and blood-brain barrier: Concepts and misconceptions

3:30 – 3:50 pm Engelhardt B. (Bern, Switzerland) INVITED

The neurovascular unit strictly controls immune cell trafficking into the CNS.

3:50 – 4:10 pm Pinteaux E. (Manchester, UK) INVITED

Mechanisms of inflammation and repair of the blood-brain barrier after stroke

4:10 – 4:30 pm Petzold G. (Bonn, Germany) INVITED

Mechanisms of astrocytic dysfunction in Alzheimer’s disease



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thursday, aPril 10, 2014


5:00 – 6:50 Pm imaging and novel diagnostics

Chairs: Dijkhuizen R., Kranz A.

5:00 – 5:30 pm Heiss W. (Cologne, Germany) INVITED

Perspectives of PeT for assessment of pathophysiology, differential diagnosis and potential for recovery in neurological diseases

5:30 – 5:50 pm Dijkhuizen R. (Utrecht, Netherlands) INVITED

MrI-based detection of cerebrovascular inflammation and remodeling after experimental stroke

5:50 – 6:10 pm Schaffer C. (Ithaca, USA) INVITED

In vivo imaging of brain cell dynamics in disease: visualizing the cause of brain blood flow disruption in Alzheimer‘s and the impact of microhemorrhages on neural health and function

6:10 – 6:30 pm Bulte J. (Baltimore, USA) INVITED

engineering and imaging of stem cells

6:30 – 6:50 pm Lauritzen M. (Glostrup, Denmark) INVITED

Cerebral blood flow and oxygen use in relation to Ca2+ dynamics during rises in activity and multicellular Ca2+ waves

7:00 – 8:00 Pm meet the chief editor: how to Publish in high ranking journals?

Fisher M. (Worcester, USA) INVITED

Dirnagl U. (Berlin, Germany) INVITED

8:30 Pm concert for organ and horn (see Page 38)

Cathedral St. Sebastian

scientific Program

world conference on regenerative medicine [Germany | Leipzig | October 21–23, 2015]

WWW.WCRM-LEIPZIG.COM

WE REGENERATION

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SAVE THE DATE

Follow us on Twitter! @FraunhoferIZIwww.facebook.com/WorldConferenceOnRegenerativeMedicine


18 | | 19

friday, aPril 11, 2014



Chairs: Vielhaber S., Reymann K.

8:30 – 8:45 am Karve I. (Melbourne, Australia) Ablation of type-1 interferon signalling engenders neuroprotection in a mouse

model of traumatic brain injury

8:45 – 9:00 am Brait V. (Barcelona, Spain) CD69 – A marker of lymphocyte activation, plays a beneficial role in ischemic stroke

9:00 – 10:30 am neural network Pathology in alZheimer dementia

Chairs: Vielhaber S., Reymann K.

9:00 – 9:30 am Palop J. (San Francisco, USA) INVITED

Mechanisms of network synchronization and cognitive decline in mouse models of Alzheimer’s disease

9:30 – 9:50 am Reymann K. (Magdeburg, Germany) INVITED

Disrupted cross-laminar cortical processing in β-amyloid pathology precedes cell death

9:50 – 10:10 am Barthel H. (Leipzig, Germany) INVITED

PeT Imaging – the key to early Alzheimer diagnosis

10:10 – 10:30 am Nestor P. (Magdeburg, Germany) INVITED

Alzheimer‘s disease: A true network degeneration

10:30 – 11:00 am Coffee break in the exhibition area

11:00 AM – the future of Preclinical research for stroke and neuroProtection:

12:30 PM ‚Phase iii‘ Preclinical trials?

Chairs: Fisher M., Boltze J.

11:00 – 11:20 am Dirnagl U. (Berlin, Germany) INVITED

The design of preclinical phase III multicenter trials

11:20 – 11:40 am Sena E. (Edinburgh, UK) INVITED

The rational of preclinical phase III multicenter trials 11:40 am – 12:30 pm Interactive plenum discussion

12:30 – 1:30 pm Lunch break in the exhibition area

scientific Program

exhibition area / maritim i

1:00 – 3:00 Pm Poster sessions ii–1, ii–2, ii–3, ii–4

II–1: Neuroregeneration, plasticity and rehabilitation

II–2: Glial cells, the blood brain barrier and the neurovascular unit

II–3: Understanding and controlling neuroinflammation

II–4: Imaging and novel diagnostics


3:00 – 4:20 Pm vascular regulation, vascular changes and the PathoPhysiology

of stroke and dementia

Chairs: Lauritzen M., Schmidt R.

3:00 – 3:20 pm Rosenberg G. (Albuquerque, USA) INVITED

White matter injury in spontaneously hypertensive rats: relationship to Binwanger‘s disease

3:20 – 3:40 pm Schmidt R. (Graz, Austria) INVITED

Vasular cognitive impairment

3:40 – 4:00 pm Ayata C. (Boston, USA) INVITED

Cerebral excitability in CADASIL

4:00 – 4:20 pm Plesnila N. (Munich, Germany) INVITED

Paradigm shift in research on subarachnoid hemorrhage: From macro to micro


5:00 – 6:00 Pm neuroregeneration and neuroPlasticity ii

Chairs: Kleinschnitz C., Barthel H.

5:00 – 5:20 pm Jolkkonen J. (Kuopio, Finland) INVITED

Novel mechanisms underlying the efficacy of CIMT in stroke animals

5:20 – 5:40 pm Wieloch T. (Lund, Sweden) INVITED

Promotion of brain plasticity after experimental stroke

5:40 – 6:00 pm Saur D. (Leipzig, Germany) INVITED

reorganisation of language networks after stroke


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scientific Program

friday, aPril 11, 2014


6:00 – 7:30 Pm understanding and controlling neuroinflammation

Chairs: Kleinschnitz C., Reiser G.

6:00 – 6:30 pm Iadecola C. (New York, USA) INVITED

Innate immunity receptors in stroke and neurodegeneration: New therapeutic targets?

6:30 – 6:50 pm Veltkamp R. (Heidelberg, Germany) INVITED

role of adaptive immune responses to stroke

6:50 – 7:10 pm Kleinschnitz C. (Würzburg, Germany) INVITED

Thrombo-Inflammation in acute ischemic stroke: Novel pathophysiological concept and future therapeutic option?

7:10 – 7:30 pm Becker K. (Washington, USA) INVITED

CNS Autoimmunity: A potential link between post-stroke infection and poor outcome

8:00 Pm gala dinner (see Page 38)

Kulturhistorisches Museum Mageburg

neurorepair-2016.de

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PLanned ToPics:

Translational stories: from bench to beside – and back

Improving stroke care: imaging and novel diagnostics

A point of view: current controversies in research and clinics

Post-stroke immunity: Has the time come for clinical trials?

New connections: neurorehabilitation and human brain plasticity

Along the supply chain: the neurovasculature in stroke and dementia

… and many more

feaTuringnew formaTs:

Minisymposia Plenary discussions

The Science Slam

unique meeting location:LeiPZig Zoo


22 | | 23

scientific Program

saturday, aPril 12, 2014



Chairs: Demuth H.-U., Aronowski J.

8:30 – 8:45 am Schmidt H. (Maastricht, Netherlands) The NO-cGMP and NOX-rOS balance in post-stroke blood brain barrier stability

and innovative therapeutic applications

8:45 – 9:00 am Michalski D. (Leipzig, Germany) Vascular and astrocytic alterations caused by focal cerebral ischaemia depend on

age and brain region in mice exhibiting an Alzheimer-like pathology

9:00 – 10:30 am focus on clinical translation: novel thrombolytics

and innovative treatment concePts

Chairs: Demuth H.-U., Aronowski J.

9:00 – 9:30 am Fisher M. (Boston, USA) INVITED

The need for and approaches to new pharmacological therapies for ischemic stroke

9:30 – 09:50 am Aronowski J. (Houston, USA) INVITED

rXr/PPArγ in microglia as target for the treatment of ICH

09:50 – 10:10 am Vivien D. (Caen, France) INVITED

The “Yin-Yang” of tissue-type plasminogen activator at the neuromuscular unit

10:10 – 10:30 am Borsody M. (Orinda, USA) INVITED KINDly supporTED by

The VitalFlow Stimulator: A treatment for undifferentiated stroke

10:30 – 10:45 am Coffee break

10:45 am – the ageing brain in health and disease

12:05 Pm

Chairs: Plesnila N., Boltze J.

10:45 – 11:05 am Demuth H. (Halle, Germany) INVITED

N-terminal modified β-amyloid peptides induce neurotoxic soluble oligomers in a prion-like manner – their augmentation leads to novel therapeutic strategies in AD

11:05 – 11:25 am Cynis H. (Halle, Germany) Generation of N-terminally truncated β-amyloid peptides by alternative

β-secretase processing

11:25 – 11:45 am Nicoletti F. (Rome, Italy) INVITED

Monomers of β-amyloid are neuroprotective and stimulate glucose uptake in neurons by interacting with type-I insulin-like growth factor receptors

11:45 am – 12:05 pm Kokaia Z. (Lund, Sweden) INVITED

Stem cells and the ageing brain

12:05 – 12:30 Pm Presidential closing lecture

Chair: Reymann K.

12:05 – 12:30 pm Sorokin L. (Münster, Germany) INVITED

The role of the extracellular matrix on in leukocyte migration into the brain

12:30 – 1:00 Pm closing ceremony including award Presentation, farewell


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Poster exhibition / maritim i

Poster sessions

The poster sessions PP I (PP I–1; PP I–2; PP I–3; PP I–4) will be on Thursday and the poster sessions PP II (PP II–1; PP II–2; PP II–3; PP II–4) on Friday.

Thursday, April 10, 2014

PP I – 1 (32 posters)Neurobiochemistry: Molecular targets for neurorotectionChairs: Reiser G., Vemuganti R.

PP I – 2 (24 posters)Vascular changes and the pathophysiology of stroke and dementiaChair: Ayata C.

PP I – 3 (17 posters)Future research directions in basic and clinical neuroscience /Clinical translation: Novel thrombolytics and innovative treatment conceptsChairs: Weise G., Janowski M.

PP I – 4 (23 posters)Neurodegeneration in stroke, Alzheimer dementia and Parkinson’s disease /Neural network pathology in Alzheimer dementiaChair: Kranz A.

Friday, April 11, 2014

PP II – 1 (43 posters)Neuroregeneration, plasticity and rehabilitationChair: Carmichael T.

PP II – 2 (20 posters)Glial cells, the blood brain barrier and the neurovascular unitChairs: Michalski D., Petzold G.

PP II – 3 (17 posters)Understanding and controlling neuroinflammationChair: Wagner D.C.

PP II – 4 (10 posters)Imaging and novel diagnosticsChair: Dijkhuizen R.

Neurobiochemistry: Molecular targets for neurorotectionChairs: Reiser G., Vemuganti R.

PP I – 1-1 The influence of Afobazole on lipofuscin level in rat brain under the conditions of new model of local ischemia alikhanyan K., meliksetyan V., stepanyan a., Hakobyan a.

PP I – 1-2 Inhibtion of JNK pathway improve the long-term outcome with early blood-brain barrier improvement after juvenile traumatic brain ajao D., sorensen D., Kamper J., Fukuda a., Hartman r., obenaus a., ashwal s., badaut J.

PP I – 1-4 Apoptosis signal-regulating kinase-1 aggravates rOS-mediated striatal degeneration in 3-nitropropionic acid-infused mice Cho K.

PP I – 1-5 Influence of hormones on neural precursor cells from rat mesencephalic tissue Huebner s., lahmann a., poehlke C., Heckmann m., Dressel a.

PP I – 1-7 Considering dual neuro- and bone protection in older adults: potential role (benefits or harms) of adipocytokines, vitamins D, B12, folic acid and iron supplements Fisher a.

PP I – 1-8 Mutated SOD1 causes impairments of OXPHOS and mitochondrial Ca2+ uptake with region specific differences in isolated CNS mitochondria of SOD1G93A mice as well as mitochon-drial dysfunction and impaired Ca homeostasis in fibroblasts from fALS patients Debska-Vielhaber G., Gizatullina Z., Gainutdinov T., schwalenstöcker b., ludolph a. C., Kunz W., Herrmann a., Zuschratter W., Vielhaber s., Gellerich F.-N.

PP I – 1-9 A role for the endoplasmic reticulum stress response in neuroprotection conferred by hamartin Hadley G., papadakis m., buchan a.

PP I – 1-10 Investigation of the neuroprotective impact of nimodipine on neuro2a cells by the means of a surgery-like stress model Herzfeld E., simmermacher s., strauss C., scheller C.

PP I – 1-11 Implications for a novel therapeutic compound, TAT-N-dimer, in stroke therapy Kristensen l. K., Clausen b. H., Hansen p. b. l., andersen m. G., bach a., strømgaard K., lambertsen K. l., Johansen F. F.

PP I – 1-12 Neuroprotective role of a novel lipophilic PPAr δ agonist in ischemic brain injury in Mice Knauss s., Hindinger C., Endres m., blaschke F., Kunz a.

PP I – 1-13 Cytoprotective functions of amyloid precursor protein family members in stress signal-ing and aging Kundu a., Zymny a., Chang s., röhner N., Kögel D.

PP I – 1-14 The immunoproteasome in focal cerebral ischemia – friend or foe? säring p., landgraf p., Gorny X., seifert u., Dieterich D. C.

PP I – 1-16 The degradation of collagen XV by recombinant tissue plasminogen activator may be protective after stroke Dhungana H., Huuskonen m., pihlajaniemi T., Heljasvaara r., parcq J., pomeshchik y., Korhonen p., Kanninen K., pruvost m., Vivien D., Koistinaho J., lemarchant s.


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PP I – 1-17 evaluation of the neuroprotective property of low molecular weight fraction of the venom of Bothrops jararaca in cultured hippocampal cells machado Querobino s., C. Carrettiero D., alberto-silva C.

PP I – 1-18 Mechanisms of N-Arachydonoyl dopamine neuroprotective and antihypoxic effects in acute normobaric hypoxia in vitro: role of CB1, CB2 and TrPV1 receptors mitroshina E., Vedunova m., sakharnova T., bobrov m., Khaspeckov l., mukhina I.

PP I – 1-19 Neuroprotective activity of ethyl-2-(2-(1-methylguanidino)acetylamino)acetate fumarate on the model of focal cerebral ischemia in rats Veselkina o. s., Nilov D. I., morozov V. a., borovitov m. E., Isaeva a. V.

PP I – 1-20 Integrating bioenergetics into neurodegeneration - PGC-1α as the connecting element and therapeutic target Noe N., Hofer a., Tischner C., lellek V., Kladt N., schauß a., Diaz F., Hida a., moraes C. T., Wenz T.

PP I – 1-22 The interaction of bid with VDAC1 is essential for neuronal cell death in vitro and in vivo oppermann s., mertins b., Elsässer K., Krasel C., meissner l., psakis G., reiß p., Dolga a., plesnila N., bünemann m., Essen l.- o., Culmsee C.

PP I – 1-23 Potential role of brain injury associated mir-451 in neurogenic processes in vitro patz s., Trattnig C., steinberger a., Grünbacher G., Fasching u., Klymiuk I., rinner b., absenger m., schäfer u.

PP I – 1-24 Glyoxalase 1 dynamics and inhibition in the aftermath of acute cerebral lesions pieroh p., Koch m., Wagner D.- C., boltze J., Ehrlich a., Ghadban C., Hobusch C., birkenmeier G., Dehghani F.

PP I – 1-25 Part 1 – time courses of neuroinflammation, corpus callosum demyelination, sensorimo-tor deficits, edema and lesion after traumatic brain injury by controlled cortical impact in mice Cho a., Taib T., leconte C., Deou E., palmier b., plotkine m., marchand-leroux C., besson V.

PP I – 1-26 realization of neuroprotective and antihypoxic properties of brain-derived neurotrophic factor (BDNF) through trkB signaling mechanisms during acute normobaric hypoxia in vitro sakharnova T., Vedunova m., mitroshina E., mukhina I.

PP I – 1-27 The tumor suppressor protein ‘merlin’ is required for axon structure maintenance schulz a., morrison H.

PP I – 1-28 MicrorNA profiling as a novel strategy to identify IGF-1-mediated neuroprotective mechanisms in aging bake s., selvamani a., sohrabji F.

PP I – 1-29 reduced content of acyl-carnitines protects mitochondria against anoxia-reoxygenation svalbe b., Zvejniece l., makrecka m., Volska K., Dambrova m., liepinsh E.

PP I – 1-30 extracellular mononucleosomal DNA as an indicator of the pathological process during the acute period of cerebrovascular accident Voznjouk I., Vasilyeva I.

PP I – 1-31 Neuroplastins induces filopodia formation via TrAF6 interaction Vemula s., Herrera-molina r., Gundelfinger E., seidenbecher C., Naumann m.

PP I – 1-32 Spatiotemporal SUMO expression in brain cells after in vivo and in vitro ischemia Wielsch b., Deten a., bosse I., Jaklin m., Wagner D.- C., boltze J., peters m.

Vascular changes and the pathophysiology of stroke and dementiaChair: Ayata C.

PP I – 2-1 SICFAIL – Stroke induced cardiac failure in mice and men bieber m., Kraft p., Frantz s., Heuschmann p., Kleinschnitz C.

PP I – 2-2 Molecular mechanisms involved in neutrophil trapping within the neurovascular unit after ischemic stroke Enzmann G., pavlidou s., mysiorek C., Cheng y.- J., Ghavampour s., Hannocks m.- J., prinz V., Dirnagl u., Endres m., prinz m., beschoner r., Harter p., mittelbronn m., sorokin l., Engelhardt b.

PP I – 2-3 The influence of age-related blood-brain barrier modifications on the outcome of ex-perimental stroke in elderly mice Gallizioli m., bacigaluppi m., russo G. l., Comi G., martino G.

PP I – 2-5 Age- and region-dependent changes in basement membrane proteins in the cerebrovas-culature of a rat model of chronic hypertension Held F., Hawkes C., Garz C., Heinze H.- J., schreiber s., Carare r.

PP I – 2-6 Folic acid defiency increases plasma homocysteine and results in learning defecits in a mouse model of chronic hypoperfusion Jadavji N. m., Farr T. D., lips J., Khalil a., boehm-sturm p., Harms C., Foddis m., Füchtemeier m., Dirnagl u.

PP I – 2-7 role of thyroid hormone in ischemic brain injury Kramer F., Heuer H.

PP I – 2-8 endothelial damage leads to BBB breakdown after transient and permanent experimen-tal stroke while tight junctions remain ultrastructurally unaffected Krueger m., bechmann I., reichenbach a., Härtig W., michalski D.

PP I – 2-9 Blood-brain barrier changes in obese mice may mediate enhanced responses to experimental stroke Haley m., lawrence C.

PP I – 2-10 role of the liver-brain axis on ischemic stroke and thrombolysis lemarchand E., Gauberti m., martinez de lizarrondo s., Villain H., repessé y., montagne a., Vivien D., ali C., rubio m.

PP I – 2-11 Combination of the potent PArP inhibitor PJ34 and tissue plasminogen activator in a thrombo-embolic model of cerebral ischemia in mice: a multi-faceted protective strategy El amki m., lerouet D., palmier b., Teng F., plotkine m., marchand-leroux C., margaill I.

PP I – 2-12 Hypertension results in changes in the perivascular drainage channels in the brain. Implications for the pathogenesis of Alzheimer’s disease morris a., Hawkes C., schreiber s., Heinze H.- J., Carare r.

PP I – 2-13 Systemic inflammation impairs cerebrovascular function through endothelin-dependent mechanisms in cerebral ischaemia murray K., Girard s., Holmes W., parkes l., Williams s., parry-Jones a., allan s.

PP I – 2-14 Intracranial pressure – cerebral oedema dissociation following stroke: An MrI study in experimental stroke with hypothermia murtha l., mcleod D., mcCabe C., Holmes W., logan C., spratt N., macrae I. m.

PP I – 2-15 Cerebrovascular dysfunction in the contralateral hemisphere following transient focal ischaemia Neuhaus a., broskova Z., sutherland b., buchan a.


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PP I – 2-16 Intravital imaging in spontaneously hypertensive stroke-prone rats – a pilot study Niklass s., Garz C., stoyanov s., bueche C., mencl s., reymann K., Heinze H.- J., Kleinschnitz C., schreiber s.

PP I – 2-17 Clinical and pathological improvement in stroke-prone spontaneously hypertensive rats associated with pleiotropic effect of cilostazol omote y., Deguchi K., Kurata T., yamashita T., Ikeda y., abe K.

PP I – 2-18 Diabetic Microangiopathy: implication for stroke severity and delayed angiogenesis after permanent cerebral occlusion in mice. poittevin m., bonnin p., rivière l., Charriaut-marlangue C., pimpie C., sébrié C., Dohan a.,

pocard m., Kubis N.

PP I – 2-19 Intracranial pressure elevation 24 hours after minor stroke is not caused by oedema and is triggered by factor(s) in the cerebrospinal fluid mcleod D. D., murtha l. a., Hood r., logan C. l., beard D., pepperall D. J., spratt N. J.

PP I – 2-20 APP and spontaneous parenchymal Aβ deposits in an experimental model of CSVD and BBB breakdown stanaszek l., Garz C., bueche C. Z., reymann K., Heinze H.- J., Carare r. o., schreiber s., Drukarch b., Wilhelmus m. m. m.

PP I – 2-21 Pericytes are susceptible to cell death following cerebral ischaemia sutherland b., reynell C., Hall C., buchan a., attwell D.

PP I – 2-22 effect of antihypertensive treatment on cerebral blood flow in a mouse model for Alzheimer’s disease Wiesmann m., Capone C., Zerbi V., mellendijk l., Heerschap a., Kiliaan a. J., Claassen J.

PP I – 2-23 Arterial diameter progressively increases mutant AD mice – a comparative study to human AD cases Wronski r., Havas D., Temmel m., attems J., Hutter H., Hutter-paier b.

PP I – 2-24 Neuropsychological correlates of polyunsaturated fatty acids in elderly patients with Alzheimer’s disease yamazaki T., Nagata K., Takano D., saitoh m., shinoda T., muraoka r., satoh y., Fujimaki y., maeda T.

Future research directions in basic and clinical neuroscience / Clinical translation: Novel thrombolytics and innovative treatment conceptsChairs: Weise G., Janowski M.

PP I – 3-1 Tissue plasminogen activator thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age in Japan Kono s., Deguchi K., yamashita T., Hishikawa N., manabe y., Takao y., Kashihara K., Inoue s., Kiriyama H., abe K.

PP I – 3-2 Therapeutic modulation of intracranial collateral flow improves outcome in experimental ischemic stroke Carone D., beretta s., Cuccione E., Versace a., riva m., padovano G., Dell’Era V., Cai r.,

presotto l., paternò G., pappadà G. b., Giussani C., sganzerla E. p., Ferrarese C.

PP I – 3-3 Potential for intravenous perfluorocarbon-based oxygen carriers combined with normobaric hyperoxia to support penumbra & improve stroke outcome. macrae m., Deuchar G. a., brennan D., mcCabe C., Holmes W., lopez-Gonzalez m. r., santosh C., muir K.

PP I – 3-4 Superselective intra-arterial administration of verapamil is profoundly neuroprotective in experimental ischemic stroke maniskas m., roberts J., bix G.

PP I – 3-6 Intracranial collateral flow defines the boundaries of molecular penumbra in experimental ischemic stroke beretta s., Cuccione E., Versace a., Carone D., riva m., padovano G., Dell’Era V., Cai r., presotto l., rousseau D., Chaveau F., paternò G., pappadà G. b., Giussani C., sganzerla E., Ferrarese C.

PP I – 3-7 Topographical and morphological patterns of post-reperfusion molecular penumbra Cuccione E., beretta s., padovano G., Versace a., Cai r., Dell’Era V., rodriguez-menendez V.,

riva m., Carone D., Ferrarese C.

PP I – 3-8 Intracerebral haemorrhage in a large animal model Ferrara F., Nitzsche b., pietsch s., Jakubke N., Harzendorf I., boltze J., Dreyer a.

PP I – 3-9 energy metabolism of mitochondria after ischemia and recovery times during aging and peripheral energy dysfunction in stroke patients: Focus on lymphocytes Villa r. F., Geroldi D., Devecchi E., Ferrari F., pero G., Gorini a.

PP I – 3-10 Selective inhibition of plasma Kallikrein protects brain from ischemia-induced neurodegeneration in mice Göb E., reymann s., langhauser F., Kleinschnitz C.

PP I – 3-11 effect of the sphingosine-1-phosphate receptor modulator FTY720 on the outcome in a mouse model of focal cortical cryolesion Hennig N., albert-Weissenberger C., Kleinschnitz C., siren a.- l.

PP I – 3-12 C1-inhibitor protects from traumatic brain injury by reducing blood-brain-barrier leakage and thrombus formation in mice Hopp s., albert-Weissenberger C., salur I., sirén a.- l., Nolte m., Kleinschnitz C.

PP I – 3-13 Blocking of alpha 4 Integrin does not protect from acute ischemic stroke in mice langhauser F., Kraft p., schuhmann m., Göb E., Kleinschnitz C.

PP I – 3-14 Diet-induced obesity is associated with worse stroke outcome and increased susceptibility to post storke infection maysami s., lawrence C.

PP I – 3-15 A comparison of three independent inhibitors of the NMDA receptor-PSD 95-nNOS axis as neuroprotective agents after tMCAO in mice mencl s., Kleikers p., schmidt H. H. H., Kleinschnitz C.

PP I – 3-16 Part 2 – late neurobehavioral disorders after traumatic brain injury by controlled cortical impact in mice leconte C., benedetto C., Cho a., mongeau r., plotkine m., marchand-leroux C., besson V.

PP I – 3-17 The apoptosis/necrosis ratio of H2O2-induced death of lymphocytes as a possible biomarker for early detection of Alzheimer’s disease. rogers N., behrens m., salech F., ponce D., mauricio H.


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Neurodegeneration in stroke, Alzheimer dementia and Parkinson’s disease /Neural network pathology in Alzheimer dementiaChair: Kranz A.

PP I – 4-1 Amyloid-beta induced changes in motional properties of BDNF-containing vesicles in hippocampal neurons seifert b., rönicke r., leschik J., lutz b., reymann K., lessmann V., brigadski T.

PP I – 4-2 Peripherally administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia Clausen b. H., Couch y., martin N. a., Karimi l., ormhøj m., bergholdt-scmidt m. l., Gredahl H., Gardiner C., sargent I. I. l., szymkowski D. E., Finsen b., petit G., Deierborg T., anthony D. C., lambertsen K. l.

PP I – 4-3 Type-1 Interferon signalling plays a deleterious role in the outcome after stroke. Crack p., Downes C., Wong C., minter m., Zhang m., mansell a., Hertzog p., Taylor J.

PP I – 4-5 Neuronal and glial regeneration after focal cerebral ischemia in rat, an electron microscopical and immunohistochemical study Dief a., Jirikowski G.

PP I – 4-6 Interaction between amyloid-β peptide and BDNF signaling in hippocampal neurogenesis Dobrota D., leßmann V., brigadski T.

PP I – 4-8 Neuroprotective effects of citicoline in cerebral ischemia Grigoryan T., papyan a., balasanyan m.

PP I – 4-9 Jacob – a messenger of amyloid beta induced CreB shut-off baer J., Grochowska K., Kaushik r., Kreutz m.

PP I – 4-10 Activation of endogenous stem cells by erythropoietin as potential rescue for neurodegenerative diseases Khairallah m., Kassem l., Zeckri m.

PP I – 4-13 Does endogenous tPA protect hippocampal neurons? lemarchand E., Gauberti m., Haelewyn b., maubert E., rubio m., Vivien D.

PP I – 4-14 The effect of α-synuclein oligomers on parkin expression in PC12 cells. relevance to Parkinson’s disease lenkiewicz a. m., Wilkaniec a., adamczyk a.

PP I – 4-15 Neuropsychological deficits and structural brain changes in the chronic phase after recurrent concussion list J., ott s., bukowski m., lindenberg r., Flöel a.

PP I – 4-16 exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice patrone C., Darsalia V., larsson m., Hua s., Johansson m., Nathanson D., Nyström T., sjöholm î, mallard C.

PP I – 4-18 Cellular markers of neuroinflammation after ischemic brain injury in the long-term survival rat model radenovic l., stamenkovic V., pluta r., andjus p.

PP I – 4-19 N-Terminal pyroglutamate formation of Aβ38 and Aβ40 increase potency to disrupt hippocampal long-term potentiation rönicke r., schlenzig D., schilling s., Demuth H.- u., reymann K. G.

PP I – 4-20 Over activation of amyloid beta-exposed microglia after parenchymal injury. stoyanov s., Goertler m., reymann K., Heinze H.- J., Neumman J.

PP I – 4-21 Ca2+ signaling is impaired in astrocytes from a mouse model of the inherited neurodegenerative disease INAD (human infantile neuroaxonal dystrophy) strokin m., reiser G.

PP I – 4-22 r-phenibut treatment improves functional recovery following ischemic strokes in rats Zvejniece l., Vavers E., svalbe b., Dambrova m.

PP I – 4-23 Human dopaminergic neurons as a model system for Parkinson’s disease Ganjam, G. K.; Dolga, a. m.; de andrade, a.; Neitemeier, s.; Örtel, W.; Höglinger, G. u.; Culmsee, C.

Neuroregeneration, plasticity and rehabilitationChair: Carmichael T.

PP II – 1-3 Modulation of neuronal differentiation by carbon monoxide and oxygen levels almeida a. s., Vieira m., alves p. m., Vieira H. l. a.

PP II – 1-4 Stroke-induced neuroinflammation and neurogenesis in the long-term survival rat model andjus p., stamenkovic V., stamenkovic s., bataveljic D., pluta r., radenovic l.

PP II – 1-5 Transorbital alternating current stimulation – a new tool for vision restoration? brösel D., sabel b. a., Franke G. H., Gall C.

PP II – 1-6 expression of eph/ephrin in periinfarct area and corticospinal tract after stroke Choi D. H., Kim J.- H., seo J.- H., lee K.- H., lee J.

PP II – 1-11 Tracking of autologous VSOP-labeled mesenchymal stem cells in the sheep brain using 3T MrI Dreyer a., Nitzsche b., pösel C., Zeisig V., lobsien D., Hoffmann K.- T., boltze J.

PP II – 1-12 Non-invasive alternating current stimulation to improve visual impairment after post-chiasmatic lesions Gall C., rossini p. m., Tatlisumak T., Waleszczyk W., brösel D., sabel b. a.

PP II – 1-13 Vestibular compensation and unilateral labyrinthectomy Hambardzumyan l.

PP II – 1-14 Non-invasive brain stimulation via the eye – effects along the physiological signal transduction pathway Henrich-Noack p., sergeeva E., Gorkin a., Wagner s., lazik s., Voigt N., bola m., sabel b.

PP II – 1-15 Immunosupression in transplantation of progenitor cells in an ovine model Hetz s., Dreyer a., Diehl r., peske K., Jakubke N., Harzendorf I., Knörr a., boltze J.

PP II – 1-16 The influence of histone deacetylase inhibitors on hippocampal neurogenesis after neonatal hypoxic ischemia. Jaworska J., Ziemka-Nalecz m., Zalewska T.

PP II – 1-18 Functional recovery mediated by enriched environment after middle cerebral artery occlusion in rats Justicia C., solà C., martinez E., Camón l., planas a. m.

PP II – 1-19 effect of action observation to imitate in corticospinal excitability: during vs after observation poonyarit s., Kitisomprayoonkul W.


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PP II – 1-20 Neurogenesis in Alzheimer’s disease and aging in enriched environment Komleva y., salmina a., Chernyh a., shestakova l., malinovskaya N., Kuvacheva N., morgun a.

PP II – 1-21 Wharton’s Jelly aggregates and mesenchymal stem cells isolated from the umbilical cord have neuroprotective properties and ability to neural differentiation Koniusz s., sypecka J., Jablonska a., siedlecka p., strojek l., Wielgos m., sarnowska a.

PP II – 1-23 Neonatal neural stem/progenitor cells and the canonical Wnt signaling pathway – the differentiation potential in vitro Kriska J., Honsa p., Dzamba D., butenko o., Tumova l., Korinek V., anderova m.

PP II – 1-24 The effects of Cerebrolysin on motor neuron-like cell-line NSC34 lucas b., steiner m., Fansa H., Keilhoff G.

PP II – 1-25 Delayed administration of perlecan Domain V signficantly increases neurogenesis and functional recovery after experimental ischemic stroke marcelo a., Kahle m., de Hoog l., bix G.

PP II – 1-26 Glandular stem cells for regeneration of peripheral nerve lesions mehnert J. m., brandenburger m.

PP II – 1-27 Preliminary results of the application of a combined bone marrow nucleated cells and mesenchymal stem cells therapy for the brain hypoxia derived encephalopathy in the group of four children milczarek o., Jarocha D., Kwiatkowski s., majka m., starowicz a., Wędrychowicz a.

PP II – 1-28 enhancing GABA mediated tonic inhibition to promote functional recovery after stroke Nagaraja r. y., Clarkson a. N.

PP II – 1-29 effects of weight loss and negative energy balance on memory performance and hippocampus volume in obese older women prehn K., Jumpertz r., mai K., Kerti l., Zeitz u., Witte a. V., Hampel D., szela a.- m., Fabian s., spranger J., Flöel a.

PP II – 1-30 tPA and ADAMTS-4 in the central nervous system pruvost m., Vivien D.

PP II – 1-31 enriched housing promotes reorganization of the extracellular matrix in the surviving regions of the neocortex after experimental stroke Quattromani m. J., Guerreiro C., madinier a., sjölund C., Jaworski T., Kaczmarek l., ruscher K., Wieloch T.

PP II – 1-32 enriched housing down-regulates the Toll-like receptor 2 response in the mouse brain after experimental stroke Quattromani m. J., Cordeau p., ruscher K., Kriz J., Wieloch T.

PP II – 1-33 The role of cart-petide in protective and compensatory mechanisms of the brain romanova I., mikhrina a., paskarenko N.

PP II – 1-34 Neural stem cell transplantation shapes post-ischemic neuronal plasticity by regulating glutamate homeostasis russo G. l., bacigaluppi m., peruzzotti-Jametti l., sandrone s., Gallizioli m., De Ceglia r., Colombo E., muzio l., Comi G., Invernizzi r. W., Hermann D. m., martino G.

PP II – 1-35 recovery of typical deficits of Alzheimer’s disease in the 5xFAD mouse model schneider F., baldauf K., Günther-Kern a., Wetzel W., reymann K. G.

PP II – 1-36 A novel in vitro model for neurogenesis studies schröder u., Garz C., Zavala r., reymann K. G.

PP II – 1-37 Neovascular potential of mesenchymal stem cells derived from Wharton jelly in brain ischemia siedlecka p., sarnowska a., strojek l., Drela K., Domanska-Janik K.

PP II – 1-38 Ovariectomy-induced neurodegeneration simonyan K.

PP II – 1-39 The role of tenascin C in adult neurogenesis induced by enriched environment stimulation stamenkovic V., stamenkovic s., radenovic l., andjus p.

PP II – 1-40 effect of neuroglobin on neural stem cell growth and survival. Van leuven W., Dewilde1 s., ponsaerts p.

PP II – 1-41 role of autophagy in motoneuron degeneration in SMA. Vercelli a., piras a., schiaffino l., boido m., Valsecchi V., Guglielmotto m., De amicis E., Tamagno E.

PP II – 1-42 Dinaciclib, a potent cyclin-dependent kinase inhibitor, and its novel function in neuronal development Wronski r., Taub N., Havas D., Hutter-paier b.

PP II – 1-43 Thrombin-activated PAr-1 triggers the PI3K/Akt/HIF-1α and rOS/MAPK/HIF-1α to promote proliferation of astrocytes Zhu Z., reiser G.

Glial cells, the blood brain barrier and the neurovascular unitChairs: Michalski D., Petzold G.

PP II – 2-1 reduction of cerebral hemorrhage by dabigatran via neurovascular protection after recanalization with tPA in ischemic stroke of rat Kono s., Deguchi K., omote y., yunoki T., yamashita T., Kurata T., Hishikawa N., abe K.

PP II – 2-3 Neural precursor cells of the subventricular zone maintain the periventricular blood brain barrier bacigaluppi m., amatruda m., russo G., Gallizioli m., butti E., Comi G., martino G.

PP II – 2-4 Perlecan domain V reduces the levels of tissue plasminogen activator in astrocyte-neuron co-culture berretta a., bix G. J., Clarkson a. N.

PP II – 2-5 Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor, BML-111, in a rat model of ischemic stroke Hawkins K., Demars K., singh J., yang C., Cho H., Frankowski J., Dore s., Candelario-Jalil E.

PP II – 2-6 Glutamate receptors in GFAP-positive glial cells in the mouse cortex following ischemic injury – focus on NMDA receptors Dzamba D., Valny m., Honsa p., rusnakova V., Kubista m., anderova m.

PP II – 2-7 Vascular alterations and leukocyte recruitment in epileptogenesis Fabene p., Constantin G.


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PP II – 2-8 Purinergic receptor P2X7 expression in brain microvessels and its role in blood-brain barrier tightness during the course of eAe. Grygorowicz T., rafałowska J., lenkiewicz a., strużyńska l.

PP II – 2-9 effect of liraglutide, a long-acting GLP-1 analogue, on cerebral edema and sensorimotor function after experimental traumatic brain injury. Hakon J., ruscher K., romner b., Tomasevic G.

PP II – 2-10 Visualisation of blood-brain barrier passage of drug carrier in vivo Henrich-Noack p., Voigt N., Kockentiedt s., Hintz W., Tomas J., sabel b.

PP II – 2-11 Polydendrocyte differentiation after focal cerebral ischemia is regulated by Sonic hedgehog Honsa p., Kriska J., Harantova l., anderova m.

PP II – 2-12 Augmentation of astrocyte release of VeGF and neuronal recovery after oxygen-glucose deprivation by inhibitors of soluble epoxide hydrolase Koehler r., Zhang y., Hammock b., sapirstein a.

PP II – 2-13 Maintenance of mitochondrial membrane potential following extended oxygen and glucose deprivation of mouse astrocytes in culture Korenic a., boltze J., Deten a., peters m., andjus p., radenovic l.

PP II – 2-14 LitAr Material and the cerebral cortex atrophy litvinov s., markov I.

PP II – 2-15 Homocysteine affects the survival of cultured human glial cells murín r., Škovierová H., mahmood s., blahovcová E., lehotský J.

PP II – 2-17 Pericytes acquire microglia phenotype after stroke ozen I., Deierborg T., padel T., Genove G., paul G.

PP II – 2-18 Depletion of glutathione in brain endothelial cells, but not in astrocytes, increases cell death following oxygen-glucose deprivation rabie T., sutherland b. a., buchan a. m.

PP II – 2-19 The TNF receptor 2 at interneurons is important for the inhibition of cortical spreading depolarization (CSD) by the proinflammatory cytokine TNFα in adult rat richter F., lütz W., leuchtweis J., Eitner a., lehmenkühler a., schaible H.- G.

PP II – 2-20 In vivo imaging of calcium dynamics, blood flow and cellular edema during peri-infarct depolarizations ulbrich C., petzold G. C.

Understanding and controlling neuroinflammationChair: Wagner D.C.

PP II – 3-1 IL-4 expression after stroke and alternative microglia/macrophage activation bonfill E., perez-de-puig I., salas-perdomo a., miro F., planas a.

PP II – 3-2 Intrathecal transplantation of neural precursor cells interferes with CNS-restricted inflammation of experimental autoimmune encephalomyelitis De Feo D., merlini a., brambilla E., laterza C., ruffini F., Comi G., martino G.

PP II – 3-3 role of GALeCTIN-3 in α-SYNUCLeIN model of microglial activation boza serrano a. J., reyes J. F., brundin p., Deierborg T.

PP II – 3-4 Minocycline suppresses M1 microglia activation while enhancing phagocytosis of Aβ fibrils El-shimy I. a., Heikal o., Hamdi N.

PP II – 3-5 Defining the myeloid subsets infiltrating the brain after ischemic stroke Habbita N., Enzmann G., ransohoff r. m., Charo I. F., Deutsch u., Engelhardt b.

PP II – 3-6 The effect of TNF depletion on catecholamine and serotonin synthesis after focal cerebral ischemia in mice lambertsen K. l., Kristensen l. K., Clausen b. H., Couch y., Fogtmann T., Ditzel N., anthony D. C., meyer m., Gramsbergen J. b., Finsen b.

PP II – 3-8 Viability and distribution of neural stem cells transplanted intrathecally in the presence of neuroinflammation merlini a., De Feo D., ruffini F., laterza C., brambilla E., Comi G., martino G.

PP II – 3-9 response of monocytes to brain ischemia in mice miro F., pérez de puig I., salas-pérdomo a., planas a.

PP II – 3-10 evaluation of brain inflammation in mice genetically deficient in the angiotensin-(1-7) receptor Mas during experimental endotoxemia

oliveira lima o., Duchene J., Cunha Xavier pinto m., Qadri F., alenina N., bader m., souza dos santos r. a., Carvalho Tavares J.

PP II – 3-11 Neutrophils & stroke riek-burchardt m., Neumann J., Herz J., Doeppner T. r., König r., Hütten H., Fischer T., Görtler m. W., Heinze H.- J., Hermann D., reymann K. G., Gunzer m.

PP II – 3-12 CXCr4/CXCr7 antagonism attenuates the microglial response and improves functional outcome after experimental stroke Walter H. l., van der maten G., Wieloch T., ruscher K.

PP II – 3-13 Adoptive transfer of preconditioned B cells alters post-stroke inflammation and reduces injury in recipient mice ortega s., Kong X., Chen D., meeuwissen a., stowe a.

PP II – 3-14 IFNAr1-/- mice are neuroprotected in the MPTP mouse model of parkinsons disease main b., Crack p., ayton s., brody K., Finkelstein D., Taylor J.

PP II – 3-15 relevance of chemokine receptor CXCr4 antagonism on the expression of fractalkine in mice Lacking the CX3C chemokine receptor 1 van der maten G., Walter H. l., Henck V., Wieloch T., ruscher K.

PP II – 3-16 Temporal differentiation in leukocyte infiltration Vindegaard Grønberg N., lykke lambertsen K., Degn Vinther m., Hjelm Clausen b., Hasseldam H., Fryd Johansen F.

PP II – 3-17 effects of late CD4 depletion on vascular remodeling and functional recovery in mice with experimental stroke Zhang T., Engel o., Winek K., meisel C., Dirnagl u., meisel a.


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Imaging and novel diagnosticsChair: Dijkhuizen R.

PP II – 4-1 Alteration in the retinotopic maps of early visual areas after repetitive transorbital alternating current stimulation: A single case with 7Tesla fMrI abd Hamid a. I., Gall C., brösel D., sabel b., speck o.

PP II – 4-2 In vivo optical imaging in post-stroke murine model treated by intravenous bone mar-row stromal cells or free radical scavengers yamashita T., Tian F., Deguchi K., omote y., abe K.

PP II – 4-3 Characterization of the neurogenic response to stroke in different age groups adamczak J. m., aswendt m., Couillard-Despres s., aigner l., Hoehn m.

PP II – 4-4 Mouse model of transient ischemic attack Quenault a., orset C., Etard o., Touzé E., Vivien D., ali C.

PP II – 4-5 Phenotypical and functional consequences of labeling human bone marrow mesenchymal cells with different vital stains prior to their transplantation andrzejewska a., Jablonska a., Nowakowski a., Janowski m., lukomska b.

PP II – 4-6 raman spectroscopy as tool for label-free identification of microglial activation schütze K., Gangnus r., Klein b., aigner l.

PP II – 4-7 DWI and complex brain networks analysis predict vascular cognitive impairment in Spontaneous Hypertensive rats undergoing executive function tests lópez-Gil X., amat-roldán I., Tudela r., prats-Galino a., planas a. m., Farr T. D., soria G.

PP II – 4-8 Towards monitoring the recruitment of bone marrow-derived neutrophils to infarcted area in a mouse model of transient cerebral ischemia Vaas m., licha K., périnat T., Enzmann G., rudin m., Engelhardt b., Klohs J.

PP II – 4-9 Thermosensitive biodegradable hydrogels for sustained delivery of therapeutic pro-teins: MrI-based monitoring of in vivo protein release yanev p., van Tilborg G. a. F., boere K. W. m., Vermonden T., van der Toorn a., Hennink W. E., Dijkhuizen r. m.

PP II – 4-10 [18F]FDG-labeling of ovine mesenchymal stem cells for PeT/Mr imaging Zeisig V., Großmann u., Dreyer a., patt m., schildan a., boltze J., sabri o., barthel H.

www.fs-leipzig.com

abstract deadline:

July 7th 2014

Main tOPics:

ProductionExtraction | Reprogramming

ManufacturingExpansion | Engineering | Differentiation

applicationTherapy | Drug Discovery | Toxicity Testing

FraunhoferLife Science SymposiumLeipzig2014

Organizing institutiOn:

Partner:

https://twitter.com/FraunhoferIZIfollow us on twitter:


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social events

get togetherwednesday, aPril 9, 2014 | 8:00 PmDo not miss this chance to mingle and mix with highly renowned researchers from every corner of the globe as well as industrial leaders of in Neuroprotection and Neurorepair. Be our guest at the get together in the exhibition area (Maritim I) with free drinks and a delicious buffet.Admission: free

concert for organ and hornthursday, aPril 10, 2014 | 8:30 PmMusic from baroque to modernProgram: Georg Philipp Telemann (1681–1767), Johann Sebastian Bach (1685–1750), Johann Georg Knechtel (1710–1773), Camille SaintSaens (1835–1921), Louis Vierne (1870–1937), and othersAdmission: freeAddress: Cathedral St. Sebastian (500m walking distance from the Congress venue) MaxJosefMetzgerStr. 1, 39104 Magdeburg

social dinnerfriday, aPril 11, 2014 | 8:00 PmWe are delighted to welcome you to our social dinner on Friday, April 11, 2014 in the KaiserOttoSaal of the Kulturhistorisches Museum Magdeburg. The museum was established in 1906 and is famous for cultural history presentations and archaeological findings. Otto I (23 November 912 – 7 May 973), also known as Otto the Great, was the founder of the Holy Roman Empire, reigning as German king from 936 until his death in 973. From 962 he was RomanGerman Kaiser (Emperor). His burial site can be visited in Magdeburger Dom, the most ancient Gothic cathedral in Germany. In the KaiserOttoSaal you can marvel at the original statue of the “Magdeburger Reiter“, and the gigantic mural painting of Arthur Kampf depicting the life of Otto I. Enjoy the unique historicalcultural atmosphere and spend an evening with your colleagues and friends.

Admission: closedAddress: Kulturhistorisches Museum Magdeburg; OttovonGuericke Straße 68 – 73, 39104 Magdeburg


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exhibition / sPonsors

Premium Partner

sPonsors / exhibitors

gold sPonsor silver sPonsors

No. Companyabcam plc

8 acris antibodies GmbH21 als automated lab solutions GmbH7 analysio GmbH26 arTImmuN aNalyTIK GmbH

athersys, Inc.biomedical Instruments - Dr. Joachim GündelbIoTrEND Chemikalien GmbH

18 bitplane aG Carl roth GmbH + Co. KG

12 CellTool GmbH

Center for behavioral brain sciences (Cbbs), funded by the federal state of saxony-anhalt

13 CorNING lIFE sCIENCEs6 Data sciences International (DsI)7 DmT Demminer maschinenbau Technik GmbH7 Dr. popa - bedarf medizinischer Forschung24 Eicom Europe

Fine science Tools GmbHFraunhofer Group for life sciencesGilson InternationalHEKa Elektronik Dr. schulze GmbH

10 Hiss Diagnostics GmbHHocomaIos press bV

No. Companyleica microsystems

4 loNZamicrobrightField Europe e.K.mobiTec GmbH

9 moor Instruments ltd.Nervive Inc.

25 Neuralynx Europe20 Novartis pharma GmbH15 Novus biologicals3 peproTech GmbH5 perimed Instruments GmbH11 phenocell sas14 Qps austria GmbH

raytest Isotopenmessgeräte GmbHsanofi-aventis Deutschland GmbH

2 sarstedt aG & Co.17 sErVa Electrophorensis GmbH23 stoelting Europe

sysTaT software GmbH 22 Thorlabs GmbH

1 Translational Centre for regenerative medicine (Trm) leipzig

16 TsE systems GmbH 19 Xceltis GmbH

innovation in microvascular assessment

Europe

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main lecture hall

poster Exhibition

poster Exhibition

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According to the guidelines of the FSA Code of Conduct, we disclose the financial support of the FSA members:

Novartis Pharma GmbHSanofi-Aventis Deutschland GmbH: Support of congress bags € 2.342,55


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Neuroprotection & Neurorepair_AD_TSE Systems 2014.indd 1 14.02.2014 09:11:43

about magdeburg

Located on the Elbe River, Magdeburg is one of Germany’s oldest cities and was founded by Charlemagne around 800 AD. In the 10th century, Magdeburg was home to Otto the Great, founder and first emperor of the Holy Roman Empire. You can expierence more than 1200 years of history including the relics of the former imperial residence, a baroque town, and the impressive Prussian fortresses. Among the most renowned historic sites are sacred buildings, such as Germany’s oldest gothic cathedral, the “Cathedral of Saints Catherine and Maurice” and the Romanesque Monastery “Unser Lieben Frauen”. A contemporary attraction in Magdeburg is the “Green Citadel”, the largest and final project of the famous Austrian architect Friedensreich Hundertwasser. The city also has a long history in the arts and sciences. For instance, the famous scientist and inventor, Otto von Guericke, known for the invention of vacuum technology and a father of experimentation in electrostatics, was a native of the city. He also was serving as Mayor during the 30years War in the 17th century. Moreover, the renowned baroque composer Georg Philipp Telemann was born and worked here. Our American friends can visit here the statue of Friedrich von Steuben, who was born in 1730 in Magdeburg. He later served as Major General of the Continental Army during the American War of Independence, and nowadays, he is celebrated at the yearly Steuben parade in New York. In the 1830s, Richard Wagner was conductor at the opera house in Magdeburg.

In modern times, Magdeburg has become a leading academic center in Germany, particularly in the field of Neurosciences.

1 main station2 maritim Hotel magdeburg3 bralo House4 Kaiser-otto-saal in

”Kulturhistorisches museum”

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5 Cathedral of magdeburg6 The Green Citadel of magdeburg

(”Hunderwasser-Haus”)7 Cathedral st. sebastian

(organ concert)

CITY MAP

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