Schematic diagram

-initial infection happens.

2-4 days after initial infection Primary viral replication occurs

4-6 days post-infection Second viral Infection

14-16 days post-infection

Susceptible Person

*Immunocompromised

*No known history of Varicella Zoster infection

*non-immunized by any form of Varicella Vaccine

Varicella Zoster Virus

Mucosae of the upper Respiratory tract

Sneezing

Coughing

Contact with blisters

Conjunctivae

Regional Lymph nodes

(Viral proliferation occurs)

Liver, spleen and other organs.

Invasion of the capillary endothelial cells, exit into the capillaries and spread into the dermis and epidermis

INFECTED PERSON

Centripetal Vesicular Rash

Low-grade fever, Myalgia, Body malaise, nausea ,anorexia,

headache