SCF

161

description

v. SCF. Inactive. Ras. GDP. nucleus. SCF. Inactive. Ras. GDP. nucleus. v. SCF. Inactive. Ras. GDP. nucleus. v. SCF. Inactive. Ras. GDP. nucleus. v. SCF. Inactive. Ras. GDP. nucleus. v. SCF. Inactive. Ras. GDP. nucleus. v. SCF. Inactive. Ras. GDP. nucleus. v. - PowerPoint PPT Presentation

Transcript of SCF

Page 1: SCF
Page 2: SCF

v

SCF

Ras

GDP

Inactive

nucleus

Page 3: SCF

SCF

Ras

GDP

Inactive

nucleus

Page 4: SCF

v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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v

SCF

Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

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Ras

GDP

Inactive

nucleus

P

P

P

P

Page 50: SCF

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

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P

PP

P

Ras

GDP

Inactive

Active!

nucleus

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P

PP

P

Ras

GDP

Inactive

Active!

nucleus

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

Src

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 108: SCF

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 110: SCF

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 129: SCF

GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

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GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 131: SCF

Ras

GDPGTPP

PP

P

RasInactive

nucleus

SrcPShcP

Grb2 Sos

Page 132: SCF

Ras

GDPGTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Page 133: SCF

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

Page 134: SCF

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

InactiveRaf-1

Page 135: SCF

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos Active!

Raf-1

Page 136: SCF

MEK

Inactive

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Page 137: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

Page 138: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

P

Page 139: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Page 140: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Page 141: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Page 142: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Page 143: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 144: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 145: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 146: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

PP

Page 147: SCF

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Active!

PP

Page 148: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 149: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 150: SCF

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 151: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 152: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 153: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 154: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 155: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 156: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 157: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription!

Page 158: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 159: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 160: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 161: SCF

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth