SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss...
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Transcript of SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss...
![Page 1: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/1.jpg)
SC430 Molecular Cell Biology
• Welcome to Unit 5 Seminar with Dr Hall-Pogar
• Tonight we will discuss metabolism and the cells energy▫Arguments for and against forensic DNA analysis
▫I will be available at AIM:KaplanHallPogar before and throughout the seminar if you have any questions or issues.
• We will begin promptly at 8:00pmEST
![Page 2: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/2.jpg)
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Unit Review• DB• Quiz• Project
▫ Real scientists that impacted molecular and cell biology James Watson, Gregor Mendel, and Frances Crick are applying
for a job with the research hospital in your community Include information to explain how his achievements could help
the hospital research disease treatment Cover letter should be 2-3 pages long and include important
information on his work or publications
![Page 3: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/3.jpg)
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Forensic DNA analysis
![Page 4: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/4.jpg)
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DNA Collection & Comparison
•Overview:▫Investigators gather samples from the crime
scene and from suspects and then analyze it for a set of specific DNA regions or markers.
▫A match of one marker is not usually unique, but if a sample matches four or five markers, there is a very good chance it is a match.
![Page 5: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/5.jpg)
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DNA Collection & Comparison• DNA is collected at crime scenes in a
variety of ways using tools such as:▫ Smear slides, scalpels, tweezers, scissors,
sterile cloth squares, UV light, luminol and/or blood collection kits (for sample collection of suspects or living victims)
• DNA samples can be from:▫ Saliva, blood, hair strands, skin, finger or
toe nails, and/or a tooth with root material
![Page 6: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/6.jpg)
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DNA Collection & Comparison• What happens after the samples are collected?
▫ A DNA profile is created….how?? Markers are found by designing small pieces of DNA
(probes) that will seek out and bind to complementary DNA sequences. This creates a distinct pattern. Again, one marker is not usually unique, but with four or five regions the match is likely
▫ The DNA profiles are compared with samples from suspects to find possible matches.
▫ If there are no suspects, a national database called CODIS may be used to find potential suspects.
![Page 7: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/7.jpg)
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Sources of DNA at Crime Scenes
•Cool table at:▫http://www.dna.gov/basics/evidence_collecti
on/identifying
![Page 8: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/8.jpg)
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How can DNA evidence be planted??•Sneezing or coughing over evidence•Person touches their mouth, nose or other
part of the face and then touches the area that may contain the DNA to be tested.
•Scene personnel can deposit hairs, fibers, or trace material from their clothing
•Wind can carry in contaminants
![Page 9: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/9.jpg)
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Ethical Issues• In the USA, police are unable to force suspects to give samples due to
the 4th amendment Once a person’s DNA is sequenced, it is kept on record
• Most states do not require that the DNA is destroyed after it is looked at, so the sample may be available at later times for evidence.
• Stored samples increase the possibility that someone could get a hold another human being genome.
• Use of this information for genetic discrimination = not allowing people to obtain loans, work, or get health insurance
![Page 10: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/10.jpg)
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Applications of the DNA
• Information stored on the DNA molecule is conveyed to RNA molecules through the process of transcription.
• The information contained in the RNA molecule is then used to produce proteins in the process of translation.
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Translation
QuickTime™ and a decompressor
are needed to see this picture.
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Transcription Field Trip
• Watch this simplified animation:
• http://www.stolaf.edu/people/giannini/flashanimat/molgenetics/transcription.swf
![Page 13: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/13.jpg)
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Translation
• Watch this simplified animation:• http://www.stolaf.
edu/people/giannini/flashanimat/molgenetics/translation.swf
![Page 14: SC430 Molecular Cell Biology Welcome to Unit 5 Seminar with Dr Hall-Pogar Tonight we will discuss metabolism and the cells energy ▫ Arguments for and against.](https://reader035.fdocuments.in/reader035/viewer/2022070411/56649f4f5503460f94c714eb/html5/thumbnails/14.jpg)
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