Sara Magdalena Reyna, Ph.D. GENERAL INFORMATION … · 2020-06-01 · 3 CV Reyna, Sara M. Details:...

1 CV Reyna, Sara M.

Sara Magdalena Reyna, Ph.D.

GENERAL INFORMATION PERSONAL DATA:

Address:

University of Texas Rio Grande Valley School of Medicine Department of Biomedical Sciences Edinburg Research Education Building 1214 W. Schunior St. Edinburg, TX 78541

Phone Number: (956) 665-6432 Fax Number: (956) 665-6402 Email Address: [email protected] EDUCATION: Year Degree Discipline Institution/Location

2002 Ph.D. Microbiology/Immunology University of Texas Health Science Center at San Antonio, San Antonio, TX

1991 B.S. Microbiology Texas A&M University, College Station, TX TRAINING: Postdoctoral Fellowship Year Discipline Institution/Location 2005-

2009 Pro-inflammatory Signaling Cascades in T2DM

Texas Diabetes Institute, San Antonio, TX 2002-

2005 Insulin Resistance in Skeletal Muscle

University of Texas Health Science Center at San Antonio, San Antonio, TX

2005-2005

Vascular Angiogenesis University of Texas Health Science Center at San Antonio, San Antonio, TX

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ADMINISTRATIVE APPOINTMENTS: 09/2015 – 08/2016 Interim Director of Physiology University of Texas Rio Grande Valley, School of Medicine, Department of Biomedical Sciences, Edinburg, Harlingen, Brownsville, TX ACADEMIC APPOINTMENTS:

09/2015 - Present Assistant Professor

University of Texas Rio Grande Valley, School of Medicine, Department of Biomedical Sciences, Edinburg, Harlingen, Brownsville, TX

Details: My research studies the molecular signaling pathways that regulate conditions involving insulin resistance, such as type 2 diabetes mellitus (T2DM), obesity, and atherosclerotic vascular disease. One focus of our research is to elucidate the role of extracellular signal-regulated kinase (ERK) in regulating Toll like receptor 4 (TLR4)-mediated inflammatory responses, and how this contributes to insulin resistance. A second focus of our research is to evaluate the molecular mechanisms by which phytonutrients can improve insulin sensitivity and to identify phytonutrients that can protect the skeletal muscle from inflammation in insulin resistance and T2DM.

09/2013 – 08/2015 Assistant Professor/Research

University of Texas Health Science Center at San Antonio, Department of Medicine/Division of Diabetes; Medical Research Division/Regional Academic Health Center, Department of Medical Research Division, Edinburg, TX

Details: My research studies the molecular signaling pathways that regulate conditions involving insulin resistance, such as type 2 diabetes mellitus (T2DM), obesity, and atherosclerotic vascular disease. One focus of our research is to elucidate the role of extracellular signal-regulated kinase (ERK) in regulating Toll like receptor 4 (TLR4)-mediated inflammatory responses, and how this contributes to insulin resistance. A second focus of our research is to evaluate the molecular mechanisms by which phytonutrients can improve insulin sensitivity and to identify phytonutrients that can protect the skeletal muscle from inflammation in insulin resistance and T2DM.

01/2010 - 08/2013 Instructor/Research

University of Texas Health Science Center at San Antonio, Department of Medicine/Division of Diabetes; Medical Research Division/Regional Academic Health Center, Edinburg, TX

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Details: My research interests focused on elucidating the role of ERK and TLR4 in inflammatory cells of insulin resistant individuals and whether exercise decreased the high levels of ERK and TLR4 expression in these cells. This study was supported by a NIH/NHLBI Individual NRSA.

NON-ACADEMIC APPOINTMENTS: 08/2005 - 12/2009 Postdoctoral Research

Fellow

Texas Diabetes Institute, San Antonio, TX

Details: My research projects, under the supervision of Dr. Nicolas Musi, involved mechanistic investigations in type 2 diabetes mellitus (T2DM) in humans (i.e. translational research). This laboratory afforded an ideal environment in which to acquire both basic and clinical research training in this field. My project focused on examining the aberrant expression and function of Toll-like receptor 4 (TLR4) in muscle of obese and T2DM subjects. Our published results demonstrated that insulin resistant individuals have elevated TLR4 expression in the skeletal muscle, and this is accompanied by an increase in nuclear factor kappa B (NF kappa B) signaling. My second project revealed that the inflammatory cells of insulin resistant subjects have increased extracellular signal-regulated kinase (ERK) signaling and TLR4 protein content. These events can contribute to the accelerating development of atherosclerosis in T2DM patients. These studies were supported by NIH/LRP Health Disparities Award and NIH/NHLBI Individual NRSA.

01/2005 - 07/2005 Postdoctoral Research

Fellow

University of Texas Health Science Center at San Antonio, Department of Surgery/Division of Vascular Surgery, San Antonio, TX

Details: The goal of my research, under the supervision of Dr. Paul Shireman, was to elucidate the role of monocyte chemotactic protein-1 (MCP-1) in skeletal muscle regeneration and angiogenesis after ischemia. Our published results demonstrated that ischemia robustly increased MCP-1 levels in muscle, and this increase was maximal at 3 days after ischemic injury. Moreover, MCP-1 was expressed in endothelial cells and infiltrating macrophages in the areas of ischemic injury during the early inflammatory response. Our data were in keeping with an important role for MCP-1 in the restoration of vascular perfusion and skeletal muscle recovery following ischemic injury. This study was supported by a NIH/NHLBI Institutional NRSA.

04/2002 - 01/2005 Postdoctoral Research

Fellow

University of Texas Health Science Center at San Antonio, Department of Medicine/Division of Diabetes, San Antonio, TX

Details: My research project, under the supervision of Dr. Lawrence Mandarino, focused on identifying novel serine and threonine phosphorylation sites of the protein, insulin receptor substrate-1 (IRS-1) and the possible role of these sites in insulin resistance in the skeletal

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muscle. In type 2 diabetes, insulin resistance in skeletal muscle cells develops, due to a specific interaction between IRS-1 and the protein tyrosine phosphatase SHP-2 molecules. Our published work demonstrated that the insulin IRS-1 molecule increases net insulin signaling by blocking this interaction, via phosphorylation of the IRS-1 Ser1223 residue. In addition, we reported that tumor necrosis factor (TNF)- alpha increases IRS-1 Thr446 phosphorylation, suggesting that this cytokine may inhibit insulin action by way of this activity as well. These studies were supported by NIH/NIDDK Minority Supplement and NIH/LRP Health Disparities Award.

HONORS AND AWARDS: 01/2016 UTRGV/Univ of Pennsylvania Supporting Student Resilience Program 01/2015 NSF ADVANCE Leadership Institute Program, Fellow, University of Texas Pan American (UTPA)

09/2007 NIH Health Disparities Loan Repayment Program Award 12/2006 Individual National Research Service Award: F32 01/2005 Institutional National Research Service Award: T32 09/2002 NIH Health Disparities Loan Repayment Program Award 05/2002 Graduate Student Leadership Award Women's Faculty Association, UTHSCSA 08/1999 NIH Predoctoral Minority Supplement Award

10/1998 Society for the Advancement of Chicanos and Native Americans in Science: Travel Award

10/1997 Society for the Advancement of Chicanos and Native Americans in Science: Travel Award

08/1997 Howard Hughes Medical Institute Enrichment Award

08/1994 NIH Predoctoral Training Award: Molecular Mechanisms of Microbial Pathogenesis, T32

TEACHING COURSE BASED TEACHING: Date Course Name Level Role

08/2016 – 09/2016

Molecules to Medicine

Graduate

Facilitator

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Preparation Hrs: 32, Student Contact Hrs:140 Guide and teach first year UTRGV medical students in problem based learning modules; attend facilitator meetings once a week for preparation of the next medical case; one-on-one student assessments 04/2017 – 05/2017 Preparation Hrs: 32, Student Contact Hrs:140 Guide and teach first year UTRGV medical students in problem based learning modules; attend facilitator meetings once a week for preparation of the next medical case; one-on-one student assessments 02/2017-Pres Preparation Hrs: 1/wk, Student Contact Hrs:2/wk Tutor UTRGV medical students in immunology and cell biology. 01/1998 - 05/1998

School of Medicine Renal and Male Genitourinary School of Medicine MICR5001 Micro for Sci Teachers

Graduate Graduate Graduate

Facilitator Faculty Tutor Lecturer

Preparation Hrs: 4, Student Contact Hrs: 2 ; Presented a lecture on basic immunology to elementary, middle school, and high school teachers in the Master‘s Program in the Department of Microbiology and Immunology at UTHSCSA.

08/1997 - 12/2002 MICR5027 Immunology

Graduate Teaching Assistant

Preparation Hrs: 15 hours, Student Contact Hrs: 30 ; During the span of 1997 through 2002, I taught immunology laboratory to first and second year medical students at UTHSCSA during the Fall semesters. I presented clinical cases, wet labs, and discuss the clinical cases with the students.

08/1997 - 12/1997 MICR5040 Basic Virology

Graduate Lecturer

Preparation Hrs: 5, Student Contact Hrs: 2 ; Presented a lecture on basic virology to elementary, middle school, and high school teachers in the Master‘s Program in the Department of Microbiology and Immunology at UTHSCSA.

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01/1993 - 01/1995 MICR5010 Basic

Medical Microbiology


Preparation Hrs: 15, Student Contact Hrs: 30 ; During the Spring Semesters, I taught medical microbiology laboratory to first and second year medical students at UTHSCSA. I presented clinical cases, wet labs, and discussed the clinical cases with the students.

01/1993 - 05/1993 MICR5012

Dental Microbiology


Preparation Hrs: 15, Student Contact Hrs: 30 ; I presented dental cases, wet labs, and discussed the cases with first and second year dental students at UTHSCSA.

OTHER TEACHING: High School/ Junior High School Student Supervision

Date Description Institution # Students

07/2015 – 08/2015 Supervised the education of laboratory skills of high school student volunteer, Chun-Kai Wei, from Science Academy, Mercedes, TX. 05/1997 - 08/1997

Science Academy

Howard Hughes Medical Institute Program

Medical Research Division, Regional Academic Health Center, University of Texas Health Science Center at San Antonio University of Texas Health Science Center at San Antonio

1 1

Mentored the education of laboratory skills/techniques (RT-PCR, tissue culture, viral assays) to high school student, L. Castro, in the Howard Hughes Medical Institute Program in the Microbiology & Immunology Department at the University of Texas Health Science Center at San Antonio.

Individual Instruction

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06/2013 - Present Res Associate II Medical Research Division/Regional Academic Health Center/UTHSCSA and UTRGV SOM Dept of Biomedical Sciences

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I supervise Fang-Mei Chang, B.S., Research Associate II in my laboratory. I teach and provide guidance for laboratory skills (Western blot, protein assays, flow cytometry, cell/tissue culture, tissue processing, real time RT-PCR) and interpretation of data analyses.

08/2011 - 12/2011 Postdoctoral Fellow

Supervision Medical Research Division/Regional Academic Health Center/UTHSCSA

1

I supervised and mentored the education of Yinghao Zhang, Ph.D., postdoctoral fellow in my laboratory. Dr. Zhang’s project involved elucidating the role of innate immunity in insulin resistance.

08/2011 – 08/2015 Research Assistant Medical Research

Division/Regional Academic Health Center/UTHSCSA

1

I supervise and mentor Daniel Acevedo, M.D., Research Assistant in my laboratory. I teach and provide guidance for laboratory skills (Western blot, protein assays, flow cytometry, cell/tissue culture, tissue processing, real time RT-PCR) and interpretation of data analyses.

06/2011 - 06/2011 Individual Instruction

Texas Diabetes Institute 1

Taught the glucose transport assay and provided guidance in data analyses to Sangeeta Ghosh, Ph.D. (Instructor, UTHSCSA/Medicine/Diabetes)

06/2011 - 06/2011 Individual Instruction


Taught the glucose transport assay and cell culture of THP-1 cells, and provided guidance in data analyses to Sophie Hussey, Ph.D. (Post-doctoral Fellow, UTHSCSA/Medicine/Diabetes)

04/2011 - 06/2012 Research Assistant Medical Research

Division/Regional Academic Health Center/UTHSCSA

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Provided training and guidance to Fang-Mei Chang, B.S. in (1) the culture of a monocytic cells line (THP-1), (2) flow cytometry assays, (3) real time RT-PCR assay, (4) isolation of primary human mononuclear cells and monocytes from peripheral blood, and (5) differentiation of primary human monocytes to macrophages.

01/2010 - 01/2010 Research Assistant Medical Research

Division/Regional Academic Center/UTHSCSA

1

I spent 40 hours teaching and advising Erika Valera, B.S., Research Associate, how to perform Western blots, protein assays, and tissue homogenization.

01/2009 - 12/2009 Postdoctoral Fellow Supervision


During 2009, I taught postdoctoral fellow, Hanyu Liang, Ph.D., how to perform Western blots, cell/tissue culture, mononuclear cell and monocyte isolation from peripheral blood.

01/2008 - 01/2009 Laboratory Coordinator


Between 2008 and 2009, I mentored the education of laboratory techniques, project design, data analyses and interpretation to Xiaojing Xu, Laboratory Coordinator at Texas Diabetes Institute.

01/2007 - 01/2008 Postdoctoral Fellow Supervision


Between 2007 through 2008, I taught Postdoctoral Fellow, Sangeeta Ghosh, Ph.D., laboratory techniques (transductions, cell culture, glucose transport assays) and advise her on data analyses and interpretation.

01/2006 - 12/2006 Visiting Medical Student


During the year of 2006, I supervised and taught laboratory techniques and data analyses to visiting medical student from Mexico, Juan Rosas.

05/2003 - 08/2003 Visiting Scientist Department of Medicine/Division

of Diabetes/University of Texas Health Science Center at San Antonio

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Participated in the education of laboratory techniques, data analyses, data interpretation to visiting scientist from Mexico, Rebeca Garcia-Macedo, Ph.D.

01/2003 - 12/2003 Research Associate Supervision

Department of Medicine/Division of Diabetes/University of Texas

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Health Science Center at San Antonio

During the Spring and Fall of 2003, I supervised and taught laboratory techniques (cell culture, transfections, transformations, enzyme digestions, DNA purifications, molecular techniques) to Research Associate, Andrea Barrentine, M.S.

Masters' Thesis Directed


05/1997 - 12/1997 Masters‘ Thesis

Directed Department of Microbiology and Immunology. University of Texas Health Science Center at San Antonio

1

Mentored the education of laboratory techniques (RT-PCR, tissue culture, viral assays) and analysis and interpretation of data to Cathie Murein, M.S. candidate in the Department of Microbiology and Immunology at UTHSCSA.

Visiting Graduate Students


06/2011 - 08/2011 Graduate Student

Supervision Medical Research Division/Regional Academic Health Center/UTHSCSA

1

During the summer of 2011, I mentored Ibdanelo Cortez, M.S., Ph.D. graduate student from the University of Texas Medical Branch at Galveston, in learning bench skills such as Western blot analysis and cell culture.

RESEARCH EXPERTISE:

The Molecular Mechanisms of Insulin Resistance - insulin resistance, type 2 diabetes, cardiovascular disease, skeletal muscle, macrophages, innate immunity, insulin signaling pathway, inflammatory signaling pathways

PUBLICATIONS: ('* ' indicates Peer Reviewed)

Abstract

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* 1. Chang F-M, Slaga TJ, Guerra J, Reyna SM. Inhibition of NFκB-induced inflammation by the synthetic triterpenoid CDDO-EA. 2017. (UTRGV SOM Research Symposium)

* 2. Acevedo D, Varela E, Guerra J, Banu J, Reyna SM. Nigella sativa influences GLUT4 through the AMPK pathway. 2015. (American Society for Nutrition. Experimental Biology Scientific Meeting).

* 3. Chang F-M, Acevedo D, Reyna SM. Inhibition of ERK blocks TLR4 endocytosis and pro-inflammatory responses in macrophages. 2015. (Maximizing Opportunities in Research and Education (MORE) for Better Health at UTPA, University of Texas Pan American).

* 4.Chang F-M, Acevedo D, and Reyna SM. ERK regulates TLR4 endocytosis and pro- inflammatory responses in macrophages. 2014. (American Diabetes Association (ADA) 74th Scientific Sessions).

* 5.Reyna, SM. Cellular mechanisms of insulin resistance. 2014. (MORE at

UTPA). * 6.Reyna, SM. Phytonutrients activate insulin signaling in skeletal muscle.

2013. (MORE at UTPA).

* 7. Guerra J, Varela E, Reyna SM, Banu J. Nigella sativa shows bone

protective properties against postmenopausal bone loss in an animal model 2012. (The American Society of Bone and Mineral Research).

* 8. Cersosimo E, Garduno-Garcia J, Xu X, Rajlakshmi U, Reyna S, Solis C, Joya

J, Triplitt C, DeFronzo R, Musi N. Potential Role of Insulin Signaling Pathways in Vascular Smooth Muscle Cell Migration Proliferation and Inflammation 2011. (71st ADA Scientific Sessions).

* 9. Reyna SM, Tantiwong P, Sriwijitkamol A, Xu X, Cersosimo E, DeFronzo RA,

Musi N. Elevated TLR4 content in mononuclear cells from individuals with type 2 diabetes 2009. (ADA 69th Scientific Sessions).

* 10. Joya J, Fernandez M, Cervera A, Reyna SM, Ghosh S, Triplitt C, Musi N, DeFronzo R, Cersosimo E. Despite differences in vascular and glucose metabolism insulin and oral therapy exert comparable effect on muscle inflammatory markers in type 2 diabetic Hispanic subjects 2009. (ADA 69th Scientific Sessions).

* 11. Monroy A, Federici M, Chavez A, Kamath S, Reyna SM, Palomo M, Musi N, Tripathy D, DeFronzo RA, Folli F.. Impaired regulation of TACE/TIMP3


proteolytic system in skeletal muscle of obese type 2 diabetic subjects. a new mechanism of insulin resistance in humans 2009. (International Symposium on Atherosclerosis.).

* 12. Reyna SM, Tantiwong P, Sriwijitkamol, Xu X, Cersosimo E, DeFronzo RA,

Musi N. Elevated Toll-like receptor 4 content in mononuclear cells from individuals with type 2 diabetes 2009. (Department of Medicine Research Day. University of Texas Health Science Center at San Antonio).

* 13. Ghosh SA, Reyna SM, Meka CR, Tantiwong P, Musi N. Palmitate increases

TLR4 content and stimulates expression of inflammatory genes in human myotubes. 2008. (ADA 68th Scientific Sessions).

* 14. Reyna SM, Sriwijitkamol A, Scarpace PJ, Zhang S, Musi N. Chronic

hypothalamic leptin overexpression stimulates AMPK in white adipose tissue 2007. (ADA 67th Scientific Sessions).

* 15. Reyna SM, Ghosh S, Tantiwong P, Reddy Meka CS, Eagan P, Jenkinson CP, Cersosimo E, DeFronzo RA, Coletta DK, Sriwijitkamol A, Musi N. Elevated TLR4 expression and signaling in muscle from insulin resistant subjects 2007. (Department of Medicine Research Day. University of Texas Health Science Center at San Antonio).

* 16. Yi Z, Luo M, Reyna SM, Weintraub ST, Langalis P, Mandarino LJ.

Quantification of serine phosphorylation of IRS-1 by HPLC-ESI-MS/MS 2006. (ADA 66th Scientific Sessions).

* 17. Luo M, Reyna SM, Carroll CA, Dong L, Weintraub ST, Mandarino LJ. Novel

serine phosphorylation sites in insulin receptor substrate-1: determination using high pressure liquid chromatography electrospray ionization mass spectrometry 2004. (ADA 64th Scientific Sessions).

* 18. Hoefling K, Pirruccello, Lane PH, Reyna SM, Tracy S, Gauntt CJ. Group B

coxsackievirus myocarditis and pancreatitis: linkage between viral virulence phenotypes. 2000. (Fourth Annual Cardiovascular Research Symposium. University of Nebraska Medical Center).

* 19. Reyna SM and Krolick KA. Possible role of chemokines in myasthenia

gravis 1999. (Society for the Advancement of Science and Native Americans in Science).

* 20. Reyna SM and Krolick K. The production of chemokines by myocytes in

myasthenia gravis. 1998. (Society for the Advancement of Chicanos and Native Americans in Science.).

* 21. Gauntt CJ, Wood JH, Lee CH, Reyna SM, Maull EA, Tracy SM, Chapman NM, Cunningham MW. A role for molecular mimicry in coxsackievirus-


induced myocarditis 1997. (Keystone Symposia: Immunologic Aspects of Cardiovascular Disease).

22. Castro L, Meurin C, Gauntt CJ, Wood J, Reyna SM. Recombinant

coxsackievirus B3 strains induce cytokines in murine cardiac fibroblasts 1997. (St. Mary's University Student Research Symposium. San Antonio, TX).

23. Castro L, Meurin C, Gauntt CJ, Wood J, Reyna SM. Recombinant

coxsackievirus B3 strains induce cytokines in murine cardiac fibroblasts 1997. (Science 1997 EXPO. University of Texas Health Science Center at San Antonio).

* 24. Reyna SM, Wood JH, Karaganis AG, Gauntt CJ. C3H/HeJ mice challenged

with cardiovirulent and noncardiovirulent strains of coxsackieviruses group B developed hypoglycemia and hyperglycemia 1996. (American Society for Microbiology).

* 25. Reyna SM, Wood JH, Karaganis AG, Gauntt CJ. C3H/HeJ mice challenged

with cardiovirulent and noncardiovirulent strains of coxsackieviruses group B developed hypoglycemia and hyperglycemia. 1995. (Texas Branch American Society for Microbiology).

Dissertation/ Thesis

1. Reyna SM. Monocyte chemotactic protein-1 in experimental autoimmune

myasthenia gravis 2002. Electronic/ Web Publication

1. Reyna SM, Ghosh S, DeFronzo RA, Jenkinson CP, Musi, N. Response to

comment on: Reyna et al (2008) elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57:2595-2602. 2009

Journal Article

* 1. Muscoquiuri G, Salmon AB, Aquayo-Mazzucato C, Li M, Balas B, Guardado-

Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, DeFronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs beta-cell function. Diabetes 2013 Dec;62(12):4201-4207.

* 2. Reyna SM, Tantiwong P, Cersosimo E, DeFronzo RA, Sriwijitkamol A, Musi

N. Short-term exercise training improves insulin sensitivity but does not


inhibit inflammatory pathways in immune cells from insulin-resistant subjects. J Diabetes Res 2013 Mar;2013:1-8.

* 3. Chang FM, Reyna S, Granados JC, Wei SJ, Innis-Whitehouse W, Maffi SK,

Rodriguez E, Slaga TJ, Short JD. Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells. J Biol Chem. 2012 Oct;287(42):35756-35767.

* 4. Joya-Galeana J, Fernandez M, Cervera A, Reyna SM, Ghosh S, Triplitt C, Musi N, DeFronzo R, Cersosimo E. Effects of insulin and oral antidiabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects Diabetes/Metabolism Research and Reviews2011;27(4):373-382.

* 5. Guigas B, Sakamoto K, Taleux N, Reyna SM, Musi N, Viollet B, Hue L.

Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life 2009 Jan;61(1):18-26.

* 6. Monroy A, Kamath S, Chavez AO, Centonze VE, Veerasamy M, Barrentine A, Wewer JJ, Coletta DK, Jenkinson C, Jhingan RM, Smokler D, Reyna S, Musi N, Khokka R, Federici M, Tripathy D, DeFronzo RA, Folli F. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Diabetologia 2009;52(10):2169-2181.

* 7. Reyna SM, Ghosh S, Tantiwong P, Reddy Meka CS, Eagan P, Jenkinson

CP, Cersosimo E, DeFronzo RA, Coletta DK, Sriwijitkamol A, Musi N. Elevated TLR4 expression and signaling in muscle from insulin resistant subjects. Diabetes2008;27:2595-2602.

* 9. Sriwijitkamol A, Coletta DK, Wajoberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan PA, Jenkison CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N. Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study Diabetes 2007;56:836-848.

* 10. Ochoa O, Sun D, Reyes-Reyna SM, Waite LL, Michalek JE, McManus LM,

Shireman PK. Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration Am J Physiol Regul Integr Comp Physiol 2007;293:R651-R661.

* 11. Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C,

Deng C, Reyna S, Musi N, Dong LQ, DeFronzo RA, Liu F. Peripheral disruption of Grb10 gene enhances insulin signaling and sensitivity in vivo Mol Cell Biol 2007;27:6497-6505.


* 12. Shireman PK, Contreras-Shannon V, Reyes-Reyna SM, Robinson SC,

McManus LM. MCP-1 parallels inflammatory and regenerative responses in ischemic muscle. Journal of Surgical Research 2006;134:145-157.

* 13. Yi Z, Luo M, Mandarino LJ, Reyna SM, Carroll CA, Weintraub ST.

Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS J Am Soc Mass Spectrom 2006;17:562-567.

* 14. Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub

ST and Mandarino LJ. Identification of insulin receptor substrate-1 serine/threonine phosphorylation sites using mass spectrometry-analysis: regulatory role of serine 1223 Endocrinology 2005;146:4410-4416.

* 15. Reyes-Reyna SM, Stegal T, and Krolick KA. Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte chemoattractant protein-1: a chemokine with the potential to influence the severity and course of experimental myasthenia gravis Journal of Immunology 2002;169:1579-1586.

* 16. Reyes-Reyna SM and Krolick KA. Chemokine Production by Rat Myocytes Exposed to Interferon-gamma Clinical Immunology 2000;94:105-113.

1

* 17. Tracy S, Hofling K, Pirruccello S, Lane PH, Reyna SM, and Gauntt CJ.

Group B coxsackievirus myocarditis and pancreatitis: connections between viral virulence phenotypes in mice J Med Virol 2000;62:70-81.

* 18. Gauntt CJ, Busbee D, Wood HJ, Reyna S, Mouneimnel R, Burghardt R, McAnalley W, and McDaniel HR. A glyconutritional (Ambrotose) provides some amelioration to mice with coxsackievirus-induced pancreatitis Age 1999;22:149-158. Journal Articles in Preparation: 1. Chang, FM, Acevedo D, Slaga T, and Reyna SM. The synthetic triterpenoid, CDDO-EA, inhibits NFkappaB in skeletal muscle. 2017. In preparation. 2. Chang, FM, Acevedo D, Reyna SM. ERK signaling regulates TLR4 endocytosis in macrophages. In preparation.

Book Chapter 1. Reyna SM and Banu J. “Obesity and Natural Products.” In: Anti-Obesity Drug

Discovery and Development. 2nd Edition. Eds. Atta-Ur-Rahman and M. Iqbal Choudhary. 2014.

Review Article


* 1. Gauntt CJ, Wood HJ, Reyna SM, McDaniel HR. Coxsackieviruses and

inflammatory diseases of the pancreas and heart in mouse models: a review. Proceedings of the Fisher Institute 1997;1:16-19.p

PRESENTATIONS: 05/2016 The Synthetic Triterpenoid, CDDO-EA, Inhibits NFkappaB-induced Inflammation. UTRGV, STDOI/ERAHC Retreat (Invited Speaker) 05/2016 Putting It into Perspective. UTRGV, Resilience Showcase 04/2015 Inhibition of ERK Blocks TLR4 Endocytosis and Pro-Inflammatory Responses in Macrophages. Maximizing Opportunities in Research and Education (MORE) for Better Health at UTPA, University of Texas Pan American, Edinburg, TX (Invited Speaker)

03/2014 Cellular Mechanisms of Insulin Resistance, Maximizing Opportunities in Research and

Education for Better Health at UTPA, University of Texas Pan American, Edinburg, TX (Invited Speaker)

04/2013 Phytonutrients Activate Insulin Signaling in Skeletal Muscle, Maximizing Opportunities in

Research and Education for Better Health at UTPA, University of Texas Pan American, Edinburg, TX (Invited Speaker)

03/2013 Cellular Mechanisms of Insulin Resistance, Translational Research Seminar Series,

Department of Biomedicine and School of Public Health, University of Texas at Brownsville, Brownsville, TX (Invited Speaker)

05/2011 Immunity and Insulin Resistance, Medicine Research Seminar Series, University of Texas Health Science Center at San Antonio, San Antonio, TX (Sole Presenter)

10/2009 Toll like Receptor 4 in Insulin Resistance, Medical Research Division, Regional Academic Health Center, Edinburg, TX (Invited Speaker)

05/2007 Elevated Toll-like Receptor 4 in Insulin Resistant Subjects, Research Day, Department of Medicine, UTHSCSA, San Antonio, TX (Invited Speaker)

10/2002 Role of TNF-alpha in IRS-1 Serine Phosphorylation, Biology Department, University of Texas at Brownsville, Brownsville, TX (Invited Speaker)

10/1999 Role of Chemokines in Experimental Myasthenia Gravis, SACNAS National Conference,

Society for the Advancement of Chicanos and Native Americans in Science, Portland, OR (Invited Speaker)

01/1998 Graduate School and Science Careers, South Texas Border Initiative Medical Education Program, San Antonio, TX (Sole Presenter)

01/1998 Graduate School and Science Careers, Alamo Health Education Center Program, San Antonio, TX (Sole Presenter)

01/1998 Thoughts of a Graduate Student on the Present and Future of Science Research,

Groundbreaking of the South Texas Biomedical Research Center, UTHSCSA, San Antonio, TX (Invited Speaker)


01/1997 Graduate School and Science Careers, National Migrant Health Farm Workers, San Antonio, TX (Sole Presenter)

PATENT: DiGiovanni J, Junco J, Liang H, Reyna SM, and Slaga TJ. “Methods and Compositions Comprising Ursolic Acid and/or Resveratrol for Treating Obesity, Diabetes, or Cancer. 2017. Publication #: US20170056414 A1 RESEARCH GRANTS: Current: Project: Institutional Seed Research Program Award Funding Agency: UTRGV Office of Research, Innovation, & Economic Development Title: Protective Mechanisms of the Synthetic Triterpenoid CDDO-EA (2-cyano-3,12-

dioxoolena- 1,9(11)-dien-28-oate ethyl amide) in Insulin Resistance. Status: Current $19,780 01/2017 – 08/2018 Role: Principal Investigator

Grant Detail: The overall goal of the proposed project is to understand the molecular mechanisms of action by CDDO-EA in protecting skeletal muscle from inflammation and preventing the development of skeletal muscle insulin resistance. Project: Support of Competitive Research (SCORE) Pilot Project Award Funding Agency: National Institutes of Health/NIGMS Title: Macrophage ERK Signaling and Its Application in Modulating Skeletal Muscle Insulin Resistance Status: pending $300,000 04/2018 – 03/2021 Role: Principal Investigator Grant Detail: The goal of the proposed project is to clarify the ERK signaling pathways activating macrophages and regulating TLR4 endocytosis and determine if ERK deficiency protects from skeletal muscle inflammation and insulin resistance. Project: CONACYT Research Grant Funding Agency: ConTex Title: Binational Network of Biobanks Status: pending $150,000 07/2017 – 06/2019 Role: Co-Principal Investigator (Dr. Claudia Maribel Luna-Aguirre, Ph.D. is the Co-PI from NNBM) Grant Detail: The goal of the proposed project is to develop a UTRGV biobank, create a cooperation between UTRGV and the National Network of Biobanks of Mexico (NNBM) headquarters in Autonomous University of Nuevo Leon (UANL) and establish a Binational Network of Biobanks (BNB) between both institutions.

Completed: Project #: F32 HL086089 Funding Agency: National Institutes of Health/NHLBI Title: Individual NRSA Status: Complete


Period: 12/2006 - 04/2009 Role: Principal Investigator

Grant Detail: The goal of this study is to determine the role the inflammatory

NFkappaB signaling pathway in endothelial dysfunction in type 2 diabetes. Project #: T32 HL07446 Funding Agency: National Institutes of Health/NHLBI Title: Institutional NRSA Status: Complete Period: 01/2005 - 11/2006 Role: Postdoctoral Fellow

Grant Detail: The role of this study was to determine the role of inflammatory

mediated mechanisms in the pathogenesis of insulin resistance. Project #: SRO1DK4793608 Funding Agency: NIH/NIDDK Title: NIH Postdoctoral Minority Supplement Award Status: Complete Period: 06/2002 - 01/2005 Role: Postdoctoral Fellow

Grant Detail: The goal of this study was to identify serine phosphorylation sites on

insulin substrate protein-1 induced by pro-inflammatory mediators. Project #: SRO1NS3631302 Funding Agency: NIH/NIAMS Title: NIH Predoctoral Minority Supplement Award Status: Complete Period: 05/1999 - 04/2000 Role: Graduate Student

Grant Detail: The goal of this study was to determine the role of pro-inflammatory

mediators in the pathogenesis of myasthenia gravis. Project #: T32 A1007271 Funding Agency: NIH/NIA Title: NIH Predoctoral Training Award Status: Complete Period: 09/1994 - 07/1997 Role: Graduate Student

Grant Detail: The goal of this study was to elucidate the role of CVB3 in myocarditis

accompanied by pancreatitis and hypoglycemia. SERVICE


SERVICE TO THE INSTITUTION (UTHSCSA): Dates Type Description

Role

07/2013-08/2015 University Assistant Radiation Safety Officer Faculty Representative

Assist with the Texas Department of State Health Services (TDSHS) laboratory inspections at the Medical Research Division/Regional Academic Health Center

05/2009-08/2011 School Medical Student Research Review Committee

Reviewer

Medical School. UTHSCSA. Combined, the committee reviews 30 - 80 applications for medical student summer research projects.

08/1999-07/2000 University University of Texas Health Science Center at

San Antonio-Graduate Student Association (GSA)

Treasurer

Kept detailed records of the association‘s budget. Reported the budget, available funds, and expenditures to the GSA President and members of the association during monthly meetings.

08/1997-07/1998 University University of Texas Health Science Center at

San Antonio-Microbiology & Immunology Department Representative-Graduate Student Association

Representative

Attended monthly GSA meetings and reported news and updates to the graduate

students of the Microbiology and Immunology Department.

SERVICE TO THE INSTUTION (UTRGV): Date Type Description Role 03/2016-Pres School Faculty Assembly Secretary/Treasurer Transcribe and submit the meeting minutes to the SOM Faculty Assembly Chair Faculty Assembly and Executive Committee meetings. Assist in the recommendation of revisions of the SOM faculty by-laws, policies, and guidelines for SOM faculty. 05/2015-Pres University DIET 4257 Research Methods Judge Judge scientific posters (10-15) presented by undergraduate students in the class DIET4257 Research Methods in Dietetics in the College of Health Affairs.


SERVICE TO THE PROFESSION: Dates Type Description

Role

10/2013-2014 International Diabetes Spectrum Journal Reviewer

Review manuscripts submitted for publication

09/2013-2014 International Diabetes Care Journal Reviewer

Review manuscripts submitted for publication 08/2011-Present National NIH LRP Ambassador

Member

As a past participant of the NIH LRP Award, I selected to serve in the NIH LRP Ambassador Network. As an Ambassador, I help potential applicants by responding to questions about the NIH LRP Program, sending program announcements to colleagues, posting notices, or hosting LRP information sessions.

07/2011-Present National Society for the Advancement of Chicanos and Native Americans in Science

Judge

I serve as a judge where I critique scientific abstracts (10 – 15) from undergraduate students attending the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) National Scientific Conference. My role as a reviewer in this setting serves two purposes: first, I judge the abstracts to be selected for poster and/or oral presentations, and second, I provide review comments on how the students can improve their abstracts.

05/2008-12/2010 International Nutrition, Metabolism & Cardiovascular Diseases Journal

Reviewer

Review manuscripts submitted for publication.

06/1999-10/1999 National Graduate Students in Microbiology-Society for

the Advancement of Chicanos and Native Americans in Science

Chair

Chaired the scientific session "Graduate Students in Microbiology" where graduate students from the Department of Microbiology and Immunology presented their dissertation projects at the Society for the Advancement of Chicanos and Native Americans in Science National Conference, Portland, OR

06/1998-10/1998 National State of the Art Microbiology Research-Society

for the Advancement of Chicanos and Native Americans in Science

Co-Chair

Co-chaired the scientific session "State of the Art Microbiology Research" where investigators from different organizations presented their research interests. The session was sponsored by the American Society for Microbiology at the Society for the


Advancement of Chicanos and Native Americans in Science National Conference at Washington, D.C.

PROFESSIONAL AFFILIATIONS:

Dates 03/2015-Present

Organization Women’s Faculty Network, UTRGV

01/2009-Present American Heart Association 01/2003-Present American Diabetes Association

01/1997-Present EDUCATIONAL WORKSHOPS (UTRGV SOM) 2015 - present 1. Constructing Written Test Questions for the Basic and

Clinical Sciences Workshop

2. Small Group Facilitation Skills Workshop presented by Dr. Oma Morey

3. The Neurobiology of Learning presented by Dr. John Pelley

4. Learning with iPad, Apple Professional Learning Workshop

5. Thinking Outside the Box-Creative Use of Clickers in the Classroom presented by Turning Technologies

6. Undergraduate Research Learning Community (01/2017-05/2017) directed by Dr. Ming-Tsan Pierre Lu, UTRGV, Dept of Teaching and Learning, Center for Teaching Excellence

Society for the Advancement of Chicanos and Native American in Science

COMMITTEES (UTRGV)

Dates Committee Role


01/2017-Present School of Medicine Scientific Planning Subcommittee Member Committee meets every two weeks for the planning of the first School of Medicine’s Scientific Symposium. The committee generates the title of the symposium and a list of speakers, develops the scientific abstract outline and the agenda for the symposium. 12/2015-12/2016 Search Committee, Associate Dean for Diversity Member Committee evaluates applications for candidates for the position of Associate Dean for Diversity, School of Medicine, UTRGV 12/2015-7/2016 Search Committee, Biomedical Sciences Faculty Member Committee evaluates applications for candidates for the positions of faculty in the Department of Biomedical Sciences, School of Medicine, UTRGV. 07/2015-08/2016 Search Committee, Chair of Dept of Biomedical Sci Member Committee evaluates applications for candidates for the position of Chair of the Department of Biomedical Sciences, School of Medicine, UTRGV 05/2015-Present School of Medicine, Admissions Committee Member Committee evaluates applications for incoming medical students. The committee selects applicants for interview based on their holistic review of their applications and the balance in both academic and non-academic qualifications.

05/2015-Present School of Medicine, Interview Sub-Committee Member Committee interviews for potential incoming medical students. 08/2014-04/2015 LCME Faculty Sub-Committee Member

Committee meets weekly to for two hours to develop policies for appointment, renewal, promotion and tenure, conflict of interest policies related to academic responsibility, and policies for feedback and evaluation on academic performance of faculty in the URTRGV/College of Medicine. The committee reviews the LCME data collection instrument for the purpose of obtaining LCME preliminary status.

03/2017 – Present LCME Medical Student Sub-Committee Member Committee evaluates the UTRVG SOM criteria for medical student admissions and recruitment, medical student health and counseling services, and medical student academic support and career advising.

COMMITTEES (UTHSCSA Standing Committees):


Dates Committee Role 07/2013-08/2015 Radiation Safety

Committee Member

Committee meets bi-monthly to review and approve 4 - 6 proposals for the use of radioactive material by principal investigators for their proposed research studies.

COMMUNITY INVOLVMENT:

Dates Institution Role 02/27/2015 Career Day, Canterbury Elementary, Edinburg, TX Presenter Gave presentation about the career of a scientist to second through fifth grade students. Our lab set up stations for students to practice pipetting, vortexing, understanding the concept of a procedure for measuring protein concentration in a solution, and visualizing two types of cells (myocytes and macrophages) in culture using a microscope. Students had ample opportunities to ask questions.

Sara Magdalena Reyna, Ph.D. GENERAL INFORMATION … · 2020-06-01 · 3 CV Reyna, Sara M. Details:...

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