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POSITIONS OPEN

ASSISTANT PROFESSORNEUROBIOLOGY

Section of NeurobiologyYale University School of Medicine

The Section ofNeurobiology at Yale University Schoolof Medicine invites applications for a tenure-track facultyappointment at the rank ofASSISTANT PROFESSORin Neurobiology beginning fall of 1995. Existing facultyin the Section of Neurobiology have strong interests inthe physiology, anatomy, and development of the cere-bral cortex and related structures and new faculty will beselected to complement the strengths of these faculty.The candidate should have a Ph.D., substantial post-

doctoral training, and a proven record of research accom-plishment. The successful applicant will establish an inde-pendent, externally funded research program. Research-ers with interest in the physiology, structure or develop-ment of the cerebral cortex, using the techniques ofmolecular neurobiology or cellular physiology (in vitro orin vivo), are especially encouraged to apply.

Applicants should submit before May 1, 1995, a cur-rent curriculum vitae, description of research directions,and name, address and telephone numbers of three refer-ences to: Search Committee, Section ofNeurobiology,Yale University School of Medicine, 333 CedarStreet, New Haven, CT 06510. Yale Umiversity is an EqualOpportuntiity/Affirnmative Action Employer.

ASSISTANT PROFESSORPLANT CELL BIOLOGIST

The Department of Biology invites applications for atenure-track position at the ASSISTANT PROFES-SOR level in the area of plant cell biology. Evidence ofproficiency in both teaching and research will be used asselection criteria. Applicants must have a Ph.D. and wvillbe expected to establish an externally funded researchprogram. Preference will be given to applicants using mo-lecular techniques to address cellular questions in higherplant cells and whose research interests complement ex-isting departmental research programs. Utah State Uni-versity is a Carnegie 1 Research Institution, and the Biol-ogy Department (http://www.biology.usu.edu) offersboth Ph.D. and M.S. degrees. There are interdisciplinaryprograms in Molecular Biology, Toxicology, and Ecolo-gy, support facilities and services from the BiotechnologyCenter, and association with the Utah Agricultural Exper-iment Station. Logan is situated on the western edge ofthe Rocky Mountains and offers excellent recreationalopportunities. Candidates should submit a curriculumvitae, a description of research and teaching interest, andrepresentative reprints. Three letters of recommendationshould be sent to: Dr. Keith Mott, Plant Cell BiologistSearch Committee, Biology Department, Utah StateUniversity, Logan, UT 84322-5305. (801-797-3563(office); 801-797-1575 (FAX), Email: mott~cc.usu.edu, electronic submissions are not allowed.) Review ofapplications will begin immediately and will continue un-til the position is filled. Utali State University is an EqualOpportunity1Affirviative Action Employer. Wo1/men and tninoritiesare especially encouraiged to apply.

ASSISTANT/ASSOCIATE PROFESSORMARINE MICROBIOLOGIST/BIOCHEMIST

BIOLOGICAL OCEANOGRAPHER

Ph.D. with thesis research in microbiology or a closelyrelated field, and training in molecular biology or bio-chemistry are required prior to hiring. Emphasis is onbacteria and viruses; prostistology is of lesser importance.Preference may be given to candidates with the following:postdoctoral research experience in marine microbes andtheir activities; potential to participate in the GraduateSchool of Oceanography's new global and coastal re-search initiatives; demonstrated excellence in teachingand advising graduate students. For the rank of associateprofessor, the applicant must have a demonstrated recordof strong, independent research, including grants and/orcontracts and publications. This is a calendar year, tenure-track position. Review of applications will begin April 3,1995, and continue until the position is filled. Pleasesubmit a curriculum vitae, the names of four references,and a summary ofyour research interests to: Elijah Swift,Search Committee Chair, Log. No. 091150, P.O. BoxG. URI, Kingston, RI 02881. The University ofP-- ideIsland is an Affirmative Action/Equal Employnient OpportunityEmployer and is conitnitted to increasitng the diversity of its faculty,staff and studentis. People fromt underrepresented groups are encour-aged to apply.

POSITIONS OPEN

BIOCHEMISTRY/MOLECULAR BIOLOGYMEHARRY MEDICAL COLLEGE

Faculty positions are available in 1995 in the Depart-ment of Biochemistry, at the level of ASSISTANT orASSOCIATE PROFESSOR Applicants must have aPh.D. or M.D. degree, or both, and appropriate formalpostdoctoral research experience. Joint appointments inclinical science are possible. We are seeking individualswho have potential or demonstrated competence in theuse of molecular biological or biophysical approaches toconduct research in molecular medicine, or on fundamen-tal biochemical/cell biological problem(s). Selected indi-viduals must also be capable of, and committed to makingsignificant contributions to teaching and administrativefunctions of the Department of Biochemistry. Successfulapplicants will be expected to develop/maintain a fundedresearch program of high quality and to substantiallyparticipate in the graduate and professional (medical,dental and allied health) school teaching programs ofthe Department. Applicants should send curriculum vi-tae, a statement on teaching interests, names of four in-dividuals who may be contacted for reference, and asummary (not exceeding four pages) of potential re-search project(s) to: Ifeanyi J. Arinze, Ph.D., Chair-man, Department of Biochemistry, Meharry MedicalCollege, Nashville, TN 37208. An Equal Opportu-nity/Affirnative Action Eniployer.

FACULTY POSITIONBowman Gray School of Medicine

The Departments of Obstetrics and Gynecology andPhysiology and Pharmacology invite applications for atenure-track position at the ASSISTANT/ASSOCI-ATE PROFESSOR level in the general area ofmolecularendocrinology with interests in developmental physiolo-gy. Expertise in molecular biology and an active researchprogram or the ability to develop a research programcompetitive for extramural funding desirable.

Applicant should have a Ph.D. or M.D. degree andpostdoctoral experience. Send a curriculum vitae, state-ment of research interests and plans and names of threereferences to:

Dr. James C. RoseDepartment of Obstetrics and Gynecology

Bowman Gray School of MedicineMedical Center BoulevardWinston-Salem, NC 27157

The Bowmian Cray School of Medicine is an Affirnative Action /Equal Opportunity Emtiployer. Womnen and tinPon.ties are enc,,ur-aged to apply.

ASSISTANT PROFESSORTENURE-TRACK

Georgetown University School of MedicineDepartment of Pharmacology

The Department of Pharmacology at GeorgetownUniversity invites applications for a tenure-track positionat the level of ASSISTANT PROFESSOR. A strongpreference will be given to individuals with molecular andcellular approaches to signal transduction in one of thefollowing areas: neuroscience, cancer biology, cardiovas-cular sciences, or developmental biology.

Candidates should forward their curriculum vitae, asummary of research interests with an indication of futureresearch directions, and arrange for three letters of rec-ommendation to be sent to: Dr. Barry B. Wolfe, Chair,Pharmacology Search Committee, Georgetown Uni-versity School of Medicine, 3900 Reservoir Road,NW, Washington, DC 20007. Georgetowtn University is anEqual OpportuniitylAffirtnative Action Employer.

ASSISTANT PROFESSOR of Ecology/General Bi-ology. Full-time, twvo-year replacement position; beginsFall Term 1995. Teaching duties in first year will includeone-semester Principles of Ecology course and one-se-mester introductory biology course. Second year will in-clude the ecology course and an advanced elective formajors that emphasizes animal ecology and could include,but need not be limited to, ethology, populations, phys-iological ecology or conservation biology. Space/equip-ment available for research. Ph.D. and commitment toliberal arts education and cultural diversity required. Priorteaching experience preferred. Submit interest letter, resume and three reference letters by March 8, 1995, to:Biology Search, University ofPuget Sound, P.O. Box7297, Tacoma, WA 98407.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995

CONDITIONS: The AAAS encouragesemployers to actively recruit andemploy underrepresented minoritygroups. Science reserves the right, atits discretion, to edit or decline topublish advertisements submitted to it.

914

A~t PfizErwe'r~e~taikingIAeclicineto newfVftiers.

The scientists of Pfizer Central Research are at the forefront of development in innova-tive medicines, meeting our commitment to breakthrough pharmaceutical interventionsfor major unmet needs. The Genetic Technologies group in our Fortune 100 company'sDepartment of Molecular Sciences is now pursuing research initiatives to discover newdrug targets in major therapeutic areas. We seek Ph. D. and BS/MS scientists with 2-plusyears of postdoctoral or postgraduate experience in these areas:

Molecular Biology Work closely with discovery biology, protein science,and high-throughput screening groups as part of a multi-disciplinary team determin-ing the function of novel genes using in vitro and in vivo approaches. We requirecDNA library construction and cloning experience, genomic cloning and analysis,express and transgene vector construction, and message expression analysis.Experience with computational sequence analysis tools a must, transgenics, map-ping, automated DNA sequencing helpful.

Computational Biology You will join a growing team effort to develop andapply computational tools for molecular biology. This work requires expertise in currentcomputational sequence analysis methods for database searching, gene/protein struc-ture prediction, and pattern discrimination, as well as a strong background in databaseand utility programming in a UNIX/Macintosh environment. Experience with molecularmodeling tools and VAXNVMS, coupled with background in molecular biology research,

would be helpful.At Pfizer, you will have opportunities to interact with one of the world's finest

corporate scientific communities, in a setting that offers the exemplarycultural, recreational, and educational advantages of Southeast

Connecticut. Relocation assistance is available. Please senddetailed resume to: Employee Resources Department,

Pfizer Inc, Eastern Point Road, Groton, CT 06340.We are an equal opportunity employer M/F/D/V

Central Research

FRED

HUTCHINSON Director

RESEARCH Division of Molecular MedicineCENTER

The Fred Hutchinson Cancer Research Center seeks applicants for theposition of Director of the newly established Division of MolecularMedicine. The current eight full time faculty have interests in genetherapy, virology, human and mammalian genetics, immune responsesand cancer biology, and an overall interest in biological processesrelevant to human health and disease. The Division has full access toCenter resources for new appointments, post-doctoral fellows andgraduate students. The Director has administrative responsibility forappointments and promotions, management, budgets, and assignmentof space and resources.

Molecular Medicine bridges scientific disciplines and approaches repre-sented in the divisions of Basic Sciences, Clinical Research and PublicHealth Sciences. The Molecular Medicine director is expected to serveas the principle focus for further expansion of translational research atthe Center. Supportforthese activities will come from both the regularlyappointed and affiliate division membership, and broadlyfrom within theCenter.Qualifications include major interest and experience in human biologyand disease, translational research, suitable educational and academicbackground, scientific reputation, and experience equivalent to a seniorleader in a major research organization.Anticipated appointment at the Full Member (Professor) level. Salarynegotiable.Please send letter of application and curriculum vitae to Dr. Robert W.Day, President and Director, Fred Hutchinson Cancer Research Center,1124 Columbia Street, LY-301, Seattle, WA 98104. Deadline for receiptof applications is April 15, 1995.

We offer a smoke-free work environment. Fred Hutchinson CancerResearch Center is an Equal Opportunity Employer Committed to WorkForce Diversity.

* Dean of the Science Faculty MCollege of Arts and Science

Nominations and applications are invited for the position of Dean of the ScienceFaculty of the College of Arts and Sciences at the University of MassachusettsBoston. Three Deans collaborate in administering the College ofArts andSciences: the Dean of Science, Dean of Liberal Arts, and Dean ofUndergraduate Education.

The Dean exercises line authority in personnel and budget matters for the sci-ences: more than 100 full-time faculty in Biology, Chemistry, Engineering,Environmental Sciences, Geography, Mathematics and Computer Sciences andPhysics. The Dean provides curricular direction, stimulates research and grantdevelopment, is active in fund-raising, and works with the science departmentsand other departments in the College ofArts and Sciences on general educationin sciences.

Candidates must have an earned Doctorate in one of the sciences and a record ofteaching and scholarship appropriate for appointment as tenured Full Professor.The successful candidate should have administrative experience including fiscalmanagement and grant development in a department or college offering doctoraldegrees. Familiarity with trends in mathematics and science education, includ-ing the use of instructional technology, is desirable.

The University offers doctorates in Environmental Biology and EnvironmentalSciences. Approval for a Ph.D. in Computer Science is expected shortly.Master's degrees may be earned in Biology, Chemistry, and Physics.

Send nominations and applications to: Chair, Dean of Science Faculty SearchCommittee, do Provost's Office, University of Massachusetts Boston, 100Morrissey Blvd., Boston, MA 02125-3393. Applications should include cur-rent vitae, names and addresses of at least three references, and letter describinginterest in and qualifications for the position. The Search Committee will beginreview of applications immediately and continue until the position is filled. AnAffirmative Action, Equal Opportunity, Title IX employer.

University of MassachusettsBoston

mow~

POSITIONS OPEN

DIVISION OF BIOLOGYCALIFORNIA INSTITUTE OF TECHNOLOGY

The California Institute of Technology Biology Divi-sion is accepting applications for a tenure-track ASSIST-ANT PROFESSOR position in the area ofimmunology.Exceptionally woell qualified applicants may also be consid-ered at the associate or full professor level. Initial tenure-track faculty appointment is normally for four years. Suc-cessful applicants are expected to participate in immunol-ogy teaching as w%,ell as to generate a creative and produc-tive research program that will interface with the diversescientific interests represented in the Biology Division.

Applicants should submit a curriculum vitae, list ofpublications and a brief statement of research interestsand plans. In addition, the candidate should arrange tohave three letters of reference sent to the search commit-tee to coincide with receipt of the application. All mate-rials should be sent to: Professor P. H. Patterson, Im-munology Search Committee, Division of Biology216-76, California Institute of Technology, Pasade-na, CA 91125. The California lstitute of Technology is atEqual Opportiunity Affirmiative Action Employer. 1'1 otmeni andminorities, eterans, and disabled persons are etnoura ed to apply.

ASSISTANT/ASSOCIATEFULL PROFESSOR

The Center of Marine Biotechnologv of the Universityof Maryland Biotechnology Institute seeks to fill a tenure-track faculty position with a highly qualified researcher inaquaculture and fisheries biotechnology and molecularbiology. Preference will be given to exceptional candi-dates who have established research programs in the areasof marine transgenics, vertebrate molecular neuroendo-crinology, immunology, or developmental biology. Ap-plications will be accepted at the ASSISTANT, ASSO-CIATE, or FULL PROFESSOR levels, and the startingrank of the position Xsill be commensurate with the qual-ifications of the successful candidate. Individuals whohave demonstrated outstanding research ability shouldforsvard a curriculum vitae, a short description of researchplans, and names of three referees by February 28, 1995,to: Chairman, Search Committee for AquacultureBiotechnology, Center of Marine Biotechnology,University of Maryland Biotechnology Institute, 600East Lombard Street, Baltimore, MD 21202. Tlhe pui-versity of Maryland is ant Equal Opportuntity Affirntiative ActionEmployer. lIu'mitte and iminorities are enicouraged to apply.

Environmental Scientists: Two full-time, tenure-trackpositions, likely ASSISTANT PROFESSOR rank, be-ginning fall 1995. Ph.D. degree required. Postdoctoralresearch experience preferred. In addition to introductorycourses, teaching responsibilities may include: 1) AquaticEcologist-limnology, water quality, fisheries ecology,population biology, biostatistics; 2) Terrestrial Ecologist-terrestrial ecology, conservation biology, landscape ecol-ogv, biostatistics. Individuals will mentor student re-search in the environmental science M.S. degree program.Expanded position descriptions available by FAX 360-650-7284. Review will begin March 15, 1995, and con-tinue until the positions are filled. Send full resume, state-ment of interest, and evidence of teaching effectivenessto: Aquatic Search or Terrestrial Search (specif6), Hux-ley College of Environmental Studies, Western Wash-ington University, Bellingham, WA 98225-9181.47ecstern Washingttoni University is ali Affiniativ~e ActionliEqualOpportunity Employer.

The University of Pennsylvania, Department of Psychi-atry, has open position for RESEARCH ASSISTANTPROFESSOR, non-tenure-track. Candidate must be aPh.D. with fellowship training in neuroscience/neurobi-ology and research interest in mammalian circadianrhythms. Please send letter and curriculum vitae to: AvaPlotnick, Department of Psychiatry, University ofPennsylvania, 305 Blockley Hall, 418 GuardianDrive, Philadelphia, PA 19104-6021. Aim Equal Oppor-tutiit)' Affirmmiatii'e Action Emmployer.

The University of Pennsylvania, Department of Psychi-atry, has open position for RESEARCH ASSISTANTPROFESSOR, non -tenure -track. Candidate must be aPh.D. with interest and some experience in research re-lated to sleep disorders and ability to attract extramuralsupport. Please send curriculum vitae and letter to: AvaPlotnick, Department of Psychiatry, University ofPennsylvania, 305 Blockley Hall, 418 GuardianDrive, Philadelphia, PA 19104-6021. Ami Equal Oppur-ttiuiityl.4ffirmmuatite Actiomn Emmuployer.

POSITIONS OPEN

CELL BIOLOGIST

The Department of Biology at the University of Min-nesota-Duluth invites applications for a tenure-track AS-SISTANT PROFESSOR position beginning Septem-ber 1, 1995. The position requires a Ph.D. in a biologicalscience and postdoctoral research experience. Responsi-bilities include: teaching cell biology, introductory biolo-gy, and advanced specialty courses; advisement of under-graduate students; participation in graduate education(M.S. emphasis); and establishment of a strong extramu-rally funded research program in an area of cell biology.Collaborative research with faculty in one of three Uni-versity, of Minnesota, Duluth School of Medicine depart-ments (Anatomn and Cell Biology, Medical Microbiologyand Immunology, Medical and Molecular Physiology)strongly encouraged. Send curriculum vitac, copies ofundergraduate and graduate transcripts, statement ofteaching and research interests, up to three reprints, andthree letters of recommendation that address teachingand research potential to: Dr. Conrad E. Firling, CellBiology Search Chair, Department of Biology, Uni-versity of Minnesota, 10 University Drive, Duluth,MN 55812-2496. The application deadline is March 20,1995. T7w L iiitrsity of Minnticsota is an Equal OpportunityEducator and Employer.

Male Reproductive Phvsiologist: A tenure-track AS-SISTANT (ASSOCIATE) PROFESSORSHIP isavailable for a reproductive physiologist whose researchinterests complement those of 15 faculty in the AnimalReproduction and Biotechnology Laboratory, and focuson spermatogenesis, epididymal function, influence of ex-current ducts and accessory sex gland fluids on spermfunction, or regulation of male reproductive function.The successful candidate must have a Ph.D., preferably beon site by December 1995, teach systemic physiology orrelated courses, and establish an extramurally supportedresearch program. Start-up funds will be available. Dead-line for applications is April 14, 1995. A letter of applica-tion should include current and long-term research inter-ests as well as teaching experience or interest. Provide acurriculum vitae, transcripts, and names, addresses andtelephone numbers of four individuals who were asked toprovide references. Send to: Dr. G. D. Niswender,Search Committee Chair, Department of Physiology,Colorado State University, Fort Collins, CO 80523.Colorado State t)muuuercity is ami Equal Employmmuemut OpportumlitylAffirmmuatiuve Actiom Employer. Ilo)mmucmi anid cthnmiuc mmimorities arestrommgly umyccli tio apply. Equal Emmploymmet Opportumnity Qffice:314 Stidemt Services Building, Colorado State Umuiversity, FortCollimns, CO 8052.3.

ASSISTANT PROFESSOR IN BIOLOGY

Applications are invited for a three-year faculty positionat the ASSISTANT PROFESSOR level starting August1995. There is a possibility for renewal with tenure-trackstatus. Applicants should have a strong commitment toteaching and the independent university tradition. Teach-ing responsibilities will include Human Anatomy andPhysiology for pre-physical therapy, nursing, and exercisescience students, and a course in introductory biology. APh.D. is required, and preference wsill be given to a can-didate with experience in anatomy and physiology labo-ratonr development including the use of computer-basedinstructional technology. The candidate will also be ex-pected to serve as an advisor to students pursuing the B.S.degree in Exercise Science and to engage in professionaldevelopment and University service. Pay will be commen-surate with education and experience. Applicants shouldsend curriculum vitae, official transcripts, a statement de-scribing their commitment to undergraduate teaching,and three letters of reference to: Karen Ott, Chair, De-partment of Biology, University of Evansville, Evans-ville, IN 47722. Applications must be received by March31, 1995.

The Um'tivetrcity of Eu'amusmile ciperates umudur a nuonudiscriimiatorypolicy wuith regard ti race, color, agi', religticom, Hiamdicap amid nuationalorigiui.

ASSISTANT PROFESSOR or ASSOCIATE PRO-FESSOR expert in cellular and molecular biology. Appli-cant should have independent program and cooperate^sith colleagues within and outside the department. Sendcurriculum vitae to: Dr. Dale E. Bockman, Departmentof Cellular Biology and Anatomy, Medical College ofGeorgia, Augusta, GA 30912-2000. Ami Equal Opportu-miity Allirinsi tiiui Action Inustitutionmu.

POSITIONS OPEN

ASSISTANT PROFESSORUNIVERSITY OF VERMONT

Department of Medical Technology seeks a full-time,TENURE-TRACK FACULTY member to teach un-dergraduate students and establish an active research pro-gram. A doctorate in a field related to microbiology andexperience in clinical microbiology are required. Certifi-cation as a generalist/specialist is preferred. Starting date:August 1995. Deadline for application: April 30, 1995.Please send cover letter and curriculum vitae to: SearchCommittee, University of Vermont, 302 RowellBuilding, Burlington, VT 05405. The University of Ver-miont is an Affirmatiiee Action Emiployer. W1onjemi and imnnorities areencouraged to apply.

FACULTY POSITION IN PHARMACOLOGY

The Department of Pharmacology, at Louisiana StateUniversity Medical Center (LSUMC) in Shreveport in-vites applications from accomplished researchers for a ten-ure-track ASSOCIATE PROFESSOR position. Appli-cants must have a M.D. or Ph.D. degree and five years ofpostdoctoral experience. The applicants' research shouldcomplement ongoing research in the Department. Theappointee will be expected to establish a strong researchprogram supported by extramural funding, and to partic-ipate in the teaching of graduate and medical students.Applications must include a curriculum vitae, a list ofpublications, selected reprints, a briefsummary ofcurrentand future research plans, and the names ofthree referees.Send applications to: Adrian J. Dunn, Ph.D., Depart-ment of Pharmacology, LSUMC, P.O. Box 33932,Shreveport, LA 71130-3932. LSUMC is an Equal Emi-ploytnent Opportunity Ettiployer.

COASTAL MARINE/ESTUARINE BIOLOGYUNIVERSITY OF FLORIDA

Applications are invited for a 12-month, tenure-trackfaculty position at the ASSISTANT PROFESSOR lev-el. A Ph.D. in a biological discipline and expertise perti-nent to fish or shellfish is required. The successful appli-cant will be expected to develop a vigorous research pro-gram and teach at the undergraduate and graduate levels.Send letter ofapplication, curriculum vitae, and the names,addresses and telephone numbers of five references byMarch 31, 1995, to: Chair, Search Committee, Depart-ment of Fisheries and Aquatic Sciences, University ofFlorida, 7922 NW 71st Street, Gainesville, FL 32653.An Equal Opportutnity/Affirtnative Action Institution.

Invertebrate Zoologist. The Department of Biology atIllinois Wesleyan University has a one-year opening, withthe possibility of becoming tenure-track, at the ASSIST-ANT PROFESSOR level in invertebrate zoology for the1995-96 academic year. The candidate should have aPh.D., a broad background in biology and a strong com-mitment to undergraduate excellence. Responsibilities forthe academic year include teaching invertebrate zoology(introductory and upper-level), invertebrate lectures ofgeneral biology course (six lectures), two general biologylabs each semester, and non-majors course. Applicantsshould submit a letter of application, curriculum vitae,transcripts, a one-page statement of teaching philosophyand three letters of recommendation (including com-ments on teaching effectiveness) to: Dr. Bruce B. Criley,Chair, Biology Department, Illinois Wesleyan Uni-versity, P.O. Box 2900, Bloomington, IL 61702. Re-view of applications begins immediately and will continueuntil position is filled. An Equal Opportunity Emiployer; iom-en and ininonties are encouraged to apply.

Twvo tenure-track faculty positions at the ASSISTANTPROFESSOR level available no later than September 1,1995, in the Department of Pharmacology, University ofWisconsin Medical School, Madison, Wisconsin as part ofa Departmental growth program. Applications are invitedfrom individuals who possess the Ph.D. and/or M.D.degree and who will develop a vigorous research programin molecular and/or cellular pharmacology. Submit cur-riculum vitae and at least three letters of reference to: Dr.Arnold Ruoho, Chair, Search Committee, Depart-ment ofPharmacology, University ofWisconsin Med-ical School, 1300 University Avenue, Madison, WI53706. The first-round deadline for this advertisement isApril 15, 1995; however, the position will remain openuntil filled. -flie Unitiersity of Wiscotnsin -Aadisoti is an EqualOpportuntiity Affirttmativoe Action Employer.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995916

DROSOPHILANEUROBIOLOGYINSECT CONTROLMerck Research Laboratories is seek-ing applicants for two positions in theArthropod Control Research Group.The group focuses on mechanism-based drug research in Drosophilaneurobiology and physiology aimedat insect control. The successfulcandidates will join an insect controlresearch group with areas of interestincluding ion channel structure/func-tion, neuronal signaling, neuronaldevelopment and insect hormones.The Drosophila Research Group ispart of a team of 30 researchers inthe department of Genetics andMolecular Biology.

Senior Research Biologist: To performresearch in Drosophila neurobiologyusing classical and molecular geneticapproaches. The qualified individualwill be part of a research teamfocusing on mechanism-based drugdevelopment for insect control. Thesuccessful candidate will have a Ph.D.or equivalent degree and strongresearch training in Drosophilagenetics, biochemistry and/ormolecular biology.

Staff Biologist: To perform research inthe Drosophila Research Group oninsect control. Research experiencewith Drosophila is essential and famil-iarity with molecular biology or insectphysiology is desirable. The success-ful candidate will have an M.S. or

equivalent degree in biology, or aB.S. degree or equivalent with atleast 1 year of experience workingwith Drosophila.

Salary, benefits and growth potentialfor these positions are excellent. Thework location is in Rahway, NewJersey, approximately 25 miles fromNew York City. Please send resume,no later than March 1, with an outlineof research interest and names ofthree references addressed to Dr. JeffWarmke, cdo Human ResourcesManager, Merck & Co., Inc., AD 158-S,P.O. Box 2000, RY80-A-3, Rahway, NJ07065. EEO/AA/VH Employer.

MERCKResearch Laboratories

FACULTY POSITION IN NMR SPECTROSCOPYThe University of Texas Medical Branch * Galveston, Texas

Continuing development of Structural Biology at UTMB leads to an additional junior, tenure-track faculty position in the area of application of Nuclear Magnetic Resonance (NMR) to solvingstructures of biological macromolecules. The University of Texas Medical Branch has made amajor commitment to create a strong Structural Biology Program on campus to enhance ourexisting capabilities. The NMR facility, directed by Dr. David Gorenstein, consists of new 400and 600 MHz Varian spectrometers with a 750 MHz instrument contracted for delivery inJanuary 1995. Endowed foundations, the Medical Branch and NIH funding have provided excel-lent equipment, a newly renovated facility, and ample additional space in support of StructuralBiology. The Unit consists not only ofNMR spectroscopists, but also other disciplines relevant toStructural Biology, including computational chemistry and x-ray crystallography.

The successful candidate must have outstanding potential for independent research andrecord in the field of NMR, will be expected to attract funding from national agencies and tofully participate in graduate education at the departmental level. Affiliation with the SealyCenter for Molecular Science or other relevant academic departments will be available.

Applications should include a complete curriculum vitae, a summary of research interestsand names and addresses of at least three references. Review of applications will continueuntil the position is filled. Applications should be addressed to:

Dr. James C. LeeStructural Biology Search Committee

Department of Human Biological Chemistry and Geneticsand

The Sealy Center for Molecular ScienceUniversity of Texas Medical Branch * Galveston, Texas 77555-1055

UTMB is an equal opportunity affirmative action employer M/F/D/V. UTMB is a smoke-free, drug-free workplace.UTMB hires only individuals authorized to work in the United States.

The FASEB JournalEditor-in-Chief

The Federation of American Societies for Experimental Biology (FASEB) seeks an Editor-in-Chief of The FASEB Journal. The first and current Editor-in-Chief, Dr. William J.Whelan, plans to retire from this position in June 1996 after 10 years ofdistinguished service.The Federation of American Societies for Experimental Biology (FASEB) is a coalition ofnine biomedical research societies in the disciplines of physiology, biochemistry andmolecular biology, pharmacology and experimental therapeutics, investigative pathology,nutrition, immunology, cell biology, biophysics and anatomy. The FASEB Journal is anofficial publication of the Federation designed to report on rapidly changing developmentsin the life sciences, and publishes state-of-the-art reviews and briefresearch communicationsin areas of interest to members of the FASEB Societies. Reviews focus on interdisciplinaryaspects of growth points in life sciences research, and research communications emphasizeinnovative advances in methodology. In addition, the Journal features articles on publicaffairs and news items about research funding; people and institutions; acalendar of scientificmeetings; and, lists of currently released books and new products.The FASEB Journal has a circulation of about 8,000. Impact factor data compiled by theInstitute for Scientific Information indicates that The FASEB Journal ranks first out of 59journals in the biology category, and 1 1th out of 173 journals in the category ofbiochemistryand molecular biology.The Editor-in-Chief is responsible for the development and implementation of editorialpolicy, for solicitation and quality control of content, and for liaison with production staff. Itis anticipated that the Editor-in-Chief will recruit a core clerical staffto assist with manuscripthandling at the home institution.Candidates should be scientists of international stature. They should have a broad knowledgeas well as interest in the scientific disciplines ofconcern to members ofthe FASEB Societies.Editorial experience, administrative skills and an interest in innovation are also essential.Applications and nominations may be submitted to:

Editor-in-Chief Search CommitteeExecutive Office

FASEB9650 Rockville Pike

Bethesda, Maryland 20814-3998

Closing date for receipt of applications is April 15, 1995

FASEB is an Equal Employment Opportunity/Affirmative Action Employer

m -1

POSITIONS OPEN

PROFESSOR AND CHAIRDepartment of Medicinal Chemistry

University of Utah College of Pharmacy

The University of Utah seeks an outstanding scientistto fill the position ofCHAIR of the Department of Me-dicinal Chemistry in the College of Pharmacy. Responsi-bilities include providing leadership for the department;conducting a successful research program that comple-ments others in the department, college and university;supporting pharmacy education and graduate education;and establishing productive interactions with othergroups on campus, and within the college. Candidatesshould hold a doctoral degree, have an outstandingrecord in research, have a national and international rep-utation commensurate with appointment at the level ofProfessor, and have demonstrated administrative skills.

Applications will be accepted until April 1, 1995, oruntil a suitable candidate is identified. Selection of candi-dates for interview will begin immediately.Send application (including curriculum vitae, state-

ment of professional goals, three letters of recommenda-tion) to: Medicinal Chemistry Search Committee,University of Utah College of Pharmacy, 201 SkaggsHall, University of Utah College of Pharmacy, SaltLake City, UT 84112 USA.

The University of Utah is an Equal Opportunity/AffirmativeAction Employer. Applications from women and minority candidatesare encrouraged.

The College of Medicine at the University of Floridaseeks a Professor/Associate Professor and CHAIRPER-SON for the Department of Biochemistry and MolecularBiology. The Chair will be expected to participate in thedevelopment and expansion of the department's researchand graduate training programs. The department has ex-cellent facilities and strong collaborative relationshipswith other departments, research centers and programswithin the University, including: Structural Biology,Mammalian Genetics, Gene Therapy, and Diabetes. Inaddition, opportunities exist for the development of co-ordinated research programs with the College's GeneralClinical Research Center, the National High Field Mag-net Laboratory, the University of Florida Brain Institute,the University of Florida Cancer Center, and the Inter-disciplinary Center for Biotechnology Research. Mini-mum qualifications include a Ph.D. and/or M.D. degree,a distinguished record of creative scientific productivity, acommitment to enhance graduate and medical education,and a dedication to faculty development. The salary isnegotiable. Deadline for applications is April 2, 1995,with an anticipated start date of October 1, 1995. Replywith a letter of interest, curriculum vitae and the names/addresses/telephone numbers ofthree or more referencesto: Dr. Douglas Barrett, M.D., Chair of Biochemistryand Molecular Biology Search Committee, P.O. Box100296, University of Florida College of Medicine,Gainesville, FL 32610.

Women and members of minority groups are encouraged to apply.Equal Employment Opportunity/Affirmative Action Employer.

EXECUTIVE OFFICERAMERICAN ASSOCIATION OF ANATOMISTS

The American Association of Anatomists is seeking anEXECUTIVE OFFICER to represent the Association'sinterest at the office of the Federation of American Soci-eties for Experimental Biology (FASEB) at Bethesda. TheExecutive Officer reports to the Association's ExecutiveCommittee. Individuals interested in the position shouldsend a letter of interest, a curriculum vitae and the namesof three individuals willing to provide letters of reference.Preferential consideration will be given to individuals withmanagement experience, formal training and experiencein Biomedical Science, and residency in the Washington,DC vicinity. Please send applications by March 10, 1995,to: Robert D. Yates, Chairman, Tulane Medical Cen-ter, Department of Anatomy SL 49, 1430 TulaneAvenue, New Orleans, LA 70112.

INSTRUCTOR of Biology: Southwestern OklahomaState University is accepting applications for an individualto teach general biology and introductory zoology. Mas-ter's degree plus college level teaching experience re-quired. To apply forward letter of application, resume,transcripts and three letters of reference to: SWOSU,Attn. Human Resources, 100 Campus Drive,Weatherford, OK 73096. Review of applications willbegin March 1, 1995, and continue until the position isfilled. The expected start date is fall 1995. Equal Employ-mjent OpportunttitylAffirmtative Action Employer.

POSITIONS OPEN

BIOLOGICAL FIELD STATIONDIRECTOR

The University of Mississippi invites applications for atenure-track, twelve-month position as DIRECTOR ofthe Biological Field Station and ASSOCIATE PRO-FESSOR/PROFESSOR of Biology. Salary and rankcommensurate with qualifications. The Field Station islocated 10 miles from campus and includes streams,springs, wetlands, and over 200 experimental ponds.Plans are underway for a multimillion dollar developmentof the Field Station's facilities. Responsibilities: The Di-rector is expected to conceptualize and develop a multi-faceted program of research and education at the FieldStation. Candidates are sought with broad views ofAquatic/Terrestrial Biology, with proven ability to com-pete for research funds, and with a dedication to developthe Field Station. The Director must have experience inadministration and will be expected to teach and establisha strong research program in his/her specialty. A Ph.D.and the ability to work with a diverse constituency and acommitment to environmental education are required.Deadline for application: Applications will be reviewedstarting February 28, 1995. Position open until filled.Starting date July 1, 1995 preferred. Send letter of appli-cation, description of teaching qualifications and inter-ests, description of current and future research program,complete curriculum vitae and the names, addresses, andtelephone numbers of three references to: Dr. James A.Kushlan, Chair, Department of Biology, Universityof Mississippi, University, MS 38677. Telephone:601-232-7203.

The Utiiversity of Mississippi is an Affirmative Action/Amen-cants ivith Disabilities Act/Equal Opportunity Employer.

ASSISTANT-IN-INSTRUCTIONENVIRONMENTAL SCIENCE

Middlebury College, Middlebury, Vermont: the Pro-gram in Environmental Studies is accepting applica-tions for a three-year position as ASSISTANT-IN-INSTRUCTION in Environmental Science to begin 15June 1995. The position involves developing lab/fieldexercises for an introductory environmental sciencecourse offered in both fall and spring semesters, teachinglabs, grading, and coordinating undergraduate teachingassistants. We seek candidates with a strong backgroundin the natural sciences, experience in teaching environ-mental science with an interdisciplinary perspective, andat least a Master's degree in a natural science or scienceeducation. Submit a letter of application, curriculum vi-tae, statement of teaching interest, transcripts, and namesand telephone numbers of three references by March 10,1995, to: Chair, Environmental Science Search Com-mittee, Program in Environmental Studies, FarrellHouse, Middlebury College, Middlebury, VT 05753.Middlebury College is an Equal Opportunity Employer and en-courages applications from women and members of minority groups.

BIOLOGY FACULTY

Colby-Sawyer College, an independent, coeducationalcollege noted for its high quality New Hampshire life, hasbeen repeatedly cited by US News and World Report as one ofthe top small colleges in its category. Growing enrollmentsand innovative new programs have created openings forFACULTY who are dedicated to excellence in teachingand a personalized approach to undergraduate liberal artseducation. This full-time, nine-month appointment be-gins September 1995. Doctorate or near completion re-quired, as well as demonstrated excellence in teaching andadvising. Responsibilities include advising students, teach-ing anatomy and physiology courses to Nursing, SportsScience, and Biology majors, teaching in the general edu-cation program and teaching upper-level courses in biolo-gy. Experience directing undergraduate research projectspreferred. Send current curriculum vitae, and names ofthree references to: Human Resources Department,Colby-Sawyer College, 100 Main Street, New Lon-don, NH 03257. Equal Opportunity Employer.

A FACULTY POSITION is available for a Ph.D. inBioengineering to maintain a 3T and develop a 6T humanNMR imaging and spectroscopy system. Significant expe-rience (more than five years) in Rf coil design and imple-mentation, and experience with meter bore high fieldsystems is required. Please send curriculum vitae to: Dr.Thomas J. Brady, Director, MGH-NMR Center,Building 149, 13th Street, Room 2301, Charlestown,MA 02129.

POSITIONS OPEN

DOROTHY OTTO KENNEDY ENDOWEDPROFESSOR in Pharmaceutical Sciences. The Wash-ington State University College of Pharmacy, Depart-ment of Pharmaceutical Sciences is inviting applicationsand/or nominations for an annual, tenured appoint-ment at the PROFESSOR level. A Ph.D. and/or M.D.and research emphasis in cancer is required with desiredexperience in pharmacology/toxicology, pharmaceu-tics, or medicinal chemistry. The candidate must have astrong extramurally funded research program and a na-tional/international reputation. Duties include sustain-ing an independent extramurally funded research pro-gram, taking a leadership role in facilitating interactionbetween researchers in the College of Pharmacy and theCancer Prevention and Research Center, teaching anddirecting graduate students in the Pharmacology/Tox-icology graduate program, and providing limited in-struction to pharmacy students in the professional doc-torate program. Application deadline is June 1, 1995, oruntil the position is filled. Applications should include acurriculum vitae, the names and addresses of three ref-erences and a statement of research interests and profes-sional goals. Send nominations and applications to:Gary G. Meadows, Ph.D., Chair, Search Commit-tee, College of Pharmacy, Washington State Univer-sity, Pullman, WA 99164-6510. Telephone: 509-335-4753. Washington State University is an Equal Oppor-tunity/Affirmative Action Educator and Employer. Members ofethnic minorities, u'omen, Vietnam-era or disabled veterans, per-sons of disability, and/or persons age 40 and over are encouragedto apply.

FACULTY POSITIONTHE WEIZMANN INSTITUTE OF SCIENCE

The Department of Biochemistry at The WeizmannInstitute of Science, Rehovot, Israel is seeking applicantsfor a tenure-track position at the SENIOR SCIENTIST(ASSISTANT PROFESSOR) level starting in the fall of1995 or later. The Department of Biochemistry providesan excellent and stimulating research environment withgroups conducting research in Molecular Genetics (geneexpression, DNA replication and repair) and Bioenergetics(membrane transport systems and photosynthesis). Can-didates are sought in these and other areas of biology,preferably with a background in protein-DNA interac-tions, molecular or developmental genetics, enzymology,or protein structure and biophysical methods. The suc-cessful candidate is expected to establish an independentand creative research group. Applications should includeresearch plans, curriculum vitae, list of publications andthe names ofthree references, and should be sent to: Prof.Zvi Livneh, Head, Department ofBiochemistry, Weiz-mann Institute of Science, Rehovot 76100 Israel.

ASSISTANT MEMBERSLOAN KETTERING INSTITUTEMOLECULAR BIOLOGY PROGRAM

The Molecular Biology Program at Sloan KetteringInstitute is seeking candidates for a tenure-track positionat the ASSISTANT MEMBER level to undertake re-search studying developmental processes. The successfulcandidates will have demonstrated outstanding potentialfor a research career in studying developmental processes.Sloan Kettering Institute offers an interactive researchenvironment, with a number of research groups workingin areas of molecular biology, developmental biology, cellbiology and structural biology. Prospective candidatesshould send their application to: Development/Molec-ular Biology Search Committee, c/o P. Besmer, Box46, Memorial Sloan Kettering Cancer Center, 1275York Avenue, New York, NY 10021. Please submit acurriculum vitae, a research statement including presentand future research activities, and three letters of recom-mendation by March 15, 1995. Sloan Kettering Institute/Memorial Sloan Kettering Cancer Center is an Equal Opportunity/Affirmative Action Employer.

Department of Psychiatry, University of Pennsylvania,has two FACULTY POSITIONS available for programin neurobiology and behavior. Positions are at either thejunior or senior level depending on candidates' qualifica-tions. Candidates must be M.D., Ph.D. with training ingenetics and experience in endocrinology, molecularpharmacology and neuroanatomy. Please send letter ofintent and curriculum vitae to: Peter C. W~hybrow,M.D., Chairman, Department of Psychiatry, Univer-sity of Pennsylvania, 305 Blockley Hall, 418 Guard-ian Drive, Philadelphia, PA 19104-6021. Equal Oppor-tunity/Afirnmative Action Employer.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995918

Procter&G amble

* The successful candidate will work on the role in teratogenesis oftoxicant-induced metallothioncin synthesis and/or hepatic acute phaseresponse in the pregnant animal; or effects of tcratogens on the cxpres-sion ofpattern formation genes. The laboratory takes a diverse approach(molecular, biochemical, physiological, cmbryological) to the study ofteratogenic mechanisms. Candidates with experience in toxicology ordevelopmental biology arc preferred. Our laboratory is part of a largegroup carrying out basic research in toxicology in a collegial atmospherewhere publishing results is stressed.

FL Procter & GambleR&PD Technical Recruiting, Dept. GD

P.O. Box 538707 * Cincinnati. OH 45253-8707 1T 1l

Applications are invited forthe position ofDIRECTOR of the Whitney Laboratory,a research institute of the University ofFlorida. The Whitney Laboratory is dedi-cated to exploiting the advantages of ma-rine animals as models in basic biologicalresearch; facilitating the application ofthese results to problems ofhuman health,natural resources and the environment;training futureexperimental biologists, andcontributing to public education. TheWhitney Laboratory is located 18 milessouth of St. Augustine, Florida. Appli-cants for Director should have an earneddoctorate, an active research program inthe physiology, cell biology or develop-mental biology of marine animals, anddemonstrated ability to provide adminis-trative and scientific leadership for a mul-tidisciplinary marine biological labora-tory. The Director will have a facultyappointment in an academic unit of theUniversity ofFlorida. Salary is negotiableand dependent upon qualifications. Appli-cants should send their curriculum vitaeand the names of three professional refer-ences by March 30, 1995 to: AndrewSorensen, Provost, 235 Tigert Hall, Uni-versity of Florida, Gainesville, Florida32611-2073. The University ofFlorida isan Affirmative Action/Equal EmploymentOpportunity Employer. The selectionpro-cess will be conducted under the provi-sions of Florida 's "Government in theSunshine " and Public Records laws.

TheextracellularMatrix in Invasion,

Friday, Meta6ta&i6,March 10, 1995 and AngiogeneMi6

MAYER AUDITORIUMUniversity of Southern California Health Sciences Campus

ProgramWelcome

PETER A. JONES, PHDUniversity ob Southern Calibornia

IntroductionYVES A. DE CLERCK, MDUniversity ot Southern Calitornia

ERKKI RUOSLAHTI, MDLa Jolla Cancer Research Foundation

Integrins as Signaling Moleculesin Cell Proliferation, Migrationand Apoptosis

DAVID A. CHERESH, PHDThe Scripps Research Institute

Role of Integrin av0f3 inAngiogenesis of Human Tumors

LYNN M. MATRISIAN, PHDVanderbilt University

Metalloproteinases inTumor Progression

BONNIE F. SLOANE, PHDWayne State University

Cathepsins in Cellular Invasion

JAMES P. QUIGLEY, PHDState University ot Newyork at Stony BrookThe Plasminogen Activator Systemin Tumor Invasion and Metastasis

YVEs A. DE CLERCK, MDUniversity ob Southern Calibornia

Tissue Inhibitors ofMetalloproteinases in TumorInvasion and Metastasis

ZENA WERB, PHDUniversity ol Calibornia.San Francisco

Proteolytic Degradation of theExtracellular Matrix DuringPhysiological Invasion

DANIEL B. RIFKIN, PHDNewyork University Medical Center

Interplay Between GrowthFactors, Matrix and Proteasesin Angiogenesis

HELENE SAGE, PHDUniversity ob Washington

Positive and Negative Regulators ofAngiogenesis: Sparc and Angiostatin

Symposium organized by USC/Amgen Inc.No registration fee * Information: (213) 764-0816

I9 Assistant Professor -Tenure track (anticipated)

Protein Biochemistry/EnzymologyDepartment of BiochiemistryLouisiana State University

The Department of Biochemistry at Louisi-ana State University seeks applicants forthe position of Assistant Professor. Candi-dates must have a Ph.D. or equivalent de-gree in biochemistry or closely related dis-cipline and a record of post-doctoral expe-rience and publications that engender con-fidence in the applicant's ability to establishan extramurally funded independent re-search program in protein structure/func-tion, modemenzymologyorenzymemecha-nisms. The department has excellentfacili-ties to support studies of proteins includingdichroism, two-dimensional NMR and apremiersynchrotronfacilitywhich providesintense X-rays upto 10 KeV. The synchro-tron is presently being equipped for X-raydiffraction and EXAFS capability. Candi-dates will be expected to participate in thedepartment's undergraduate and graduateteaching programs. Send curriculum vitae,description of proposed research and namesand addresses of three references to:Protein Biochemistry Search Committee

Room 322 Choppin HallLouisiana State University

Baton Rouge, Louisiana 70803-1806Phone: (504) 388-1556

Fax: (504)388-5321Application deadline:

March 1, 1995 or until filled.An Affirmatve Action!

Equal Opportunity Employer

POSTDOCTORALRESEARCHASSOCIATE

Postdoctoral Research Associate po-sition is available for a recently quali-fied Ph.D. to join a productive researchgroup involved in the study of growthregulation and differentiation of myo-genic tumor cells. Studies will involveelucidating the role of insulin-likegrowth factors in cellular growth andin abrogating the function of myogenicregulatory proteins. A strong back-ground in molecular biology and ex-perience with use of viral vector sys-tems would be advantageous.Send c.v. and names of three refer-ences to:

Dr. Peter J. HoughtonDepartment of Molecular

Pharmacology

___ St. Jude Children'sResearch Hospital332 N. Lauderdale

_ > Memphis, TN 38105

An equal opportunity/affirmative action employer

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5.M

m

POSITIONS OPEN

The Department of Pediatrics, Wright State UniversitySchool ofMedicine, and The Children's Medical Center,Dayton, Ohio, seek a third gastroenterologist in the Di-vision of Gastroenterology and Nutrition. This is a fullyaffiliated faculty position at the ASSISTANT or ASSO-CIATE PROFESSOR level. Applicants must be Board-eligible or Board-certified in pediatric gastroenterologyand licensable to practice medicine in Ohio and havecompleted a three year fellowship in pediatric gastroen-terology. Preferred experience in patient care, teachingand research, concentrating in pediatric gastrointestinal,hepatic and nutritional disease process. The candidateshould have a record ofsuccess and be capable ofperform-ing independent basic science or clinical research and willhave related protected time. He/she must manifest evi-dence of potential or demonstrable qualities requisite forexcellence in teaching and research. The Division of Gas-troenterology and Nutrition is rapidly growing with anewv 750 square foot research lab located within our 155bed pediatric hospital. A significant amount of internalfunding is designated for use in basic or clinical research.Salary commensurate with professional experience andlocal standards. Qualified candidates should contact: Dr.Adam G. Mezoff, Director, Division of Gastroenter-ology and Nutrition, Department of Pediatrics, TheChildren's Medical Center, One Children's Plaza,Dayton, OH 45404-1815. Closing date for receipt ofapplications is April 30, 1995. First consideration of ap-plications is February 27, 1995, and will continue untilthe position is filled. Wrghlt State University and The Clil-dren 's Medical Center are Equal Opportunity Affirnmative ActionEmployers.

Biology Faculty: The College of Mount St. Joseph, aCatholic co-educational college of2,600 students locatedin suburban Cincinnati, invites applications for the fol-lowing faculty position available August 1995: Full-timeASSISTANT PROFESSOR specializing in physiologyand embryology. Candidates must have a Ph.D. and astrong commitment to teaching and undergraduate re-search. Duties may include teaching anatomy and physi-ology, embryology, general biology, developing a coursein physiology, and supervising student research. Appli-cants should provide a letter of application, curriculumvitae, statements ofteaching and research philosophy, andthree letters of reference addressed to Dr. Gene Kritsky,Chair, Department of Biology by March 15, 1995, to:Office of Personnel Services, College of Mount St.Joseph, 5701 Delhi Road, Cincinnati, OH 45233-1670. Tie College ofMount St.Joseph is an Equal Opportunity/Affirmative Actiio Employer.

ASSISTANT/ASSOCIATE PROFESSOR

A TENURE-TRACK POSITION is available for astructural biologist using multi-nuclear NMR techniquesto study biomolecule structure and function. A fullyequipped NMR spectroscopy laboratory with a VarianVXR 500S NMR Spectrometer is available as well as sub-stantial institutional support to expand/upgrade this fa-cility. Dedicated molecular modeling computers and on-line access to the University of Kentucky IBM 3090 su-percomputer are also in place. The successful candidatewill be expected to pursue an independently funded re-search program and to play a substantial role in theplanned development of a major nesw program in Struc-tural Biology. Appointment and teaching responsibilitieswvill be in the University ofKentucky College ofMedicineDepartment of Biochemistry. Interested persons shouldsubmit a curriculum vitae, a summary of present and fu-ture research interests and three letters of recommenda-tion to: NMRFaculty Search Committee, Departmentof Biochemistry, University of Kentucky MedicalCenter, Lexington, KY 40536-0084. An Equal Oppor-tunity1Afiniative Action Employer.

HUMAN GENETICS DEPARTMENTUNIVERSITY OF UTAHFACULTY POSITIONS

TENURE-TRACK - ANY LEVELCurrent faculty interests include: Genetics of Human

Disease; Developmental Genetics; Human GenomeProject; Molecular Genetics of Gene Regulation; andPopulation Genetics. Send curriculum vitae and brief de-scription of research interests to: Raymond F.Gesteland, Department of Human Genetics, Univer-sity of Utah School of Medicine, Salt Lake City, UT84112. FAX: 801-585-3910. Tfle University of Utah is anEqual Eniploynient Opportuntity Affirniatii'e Action Employer andenrcoutrages applications from u'onien and niinorities.

POSITIONS OPEN

VASCULAR BIOLOGY CENTERMEDICAL COLLEGE OF GEORGIA

Applications are invited for twvo full-time ASSISTANTPROFESSOR positions in the ten-member, interdisci-plinary Vascular Biology Center at the Medical College ofGeorgia. Each position carries appointment to an appro-priate academic department. Qualifications includeearned M.D. and/or Ph.D. degrees, postdoctoral experi-ence and demonstrated excellence in Vascular Biology.Attractive salary, competitive start-up funds and labora-tory space will be provided. Send curriculum vitae and thenames of three references to: Dr. John D. Catravas,Director, Vascular Biology Center, CB3601, MedicalCollege of Georgia, Augusta, GA 30912-2300. Tele-phone: 706-721-6338; FAX: 706-721-2347. 71eMedical College of Georgia is an Equal OpportutnitylAffirmnativeAction Employer.

ASSISTANT PROFESSOR of Molecular Biologyand Biochemistry: The University of Idaho is seeking tofill a tenure-track position for an assistant professor. Weare interested in candidates capable of establishing a na-tionally competitive research program to study the mo-lecular biology of plants or fungi in one of two areas: 1)molecular mechanisms of development or 2) responses toabiotic and biotic stimuli. The research program shouldcomplement existing departmental programs in plant mo-lecular biology and biochemistry, microbial developmen-tal genetics, medical/pathogenic microbiology and envi-ronmental microbiology. The successful candidate musthave a strong commitment to teaching excellence and willbe responsible for a one-semester undergraduate lecture/laboratory course in basic biochemistry to be taught eachyear and a graduate-level course in his/her area of exper-tise in alternate years. Applicants should have a Ph.D. inMolecular Biology, Biochemistry or related field and post~doctoral research experience using contemporary molecu-lar techniques. Send curriculum vitae, statement of re-search interests and three letters of reference by March 24,1995, to: Bruce L. Miller, Search Committee Chair,Department of Microbiology, Molecular Biology andBiochemistry, Life Sciences Building, University ofIdaho, Moscow, ID 83844. FAX: 208-885-6518. AnAffirmiative ActionlEqual Opportunity Employer.

ASSISTANT PROFESSORNEUROSCIENCE

A TENURE-TRACK POSITION available begin-ning July 1995 in the Department of Neuroscience, Uni-versity of California, Riverside. We seek an outstandingneuroscientist, preferably one using cellular/molecular/genetic approaches to topics such as neural developmentand who has a strong commitment to excellence in teach-ing and research. Ph.D. or equivalent degree required.Postdoctoral experience strongly preferred. It is expectedthat the successful candidate will develop collaborativerelations with existing neuroscience faculty while estab-lishing a vigorous, independent research program. Teach-ing duties of department faculty include both graduateand undergraduate courses in neuroscience. Applicationdeadline: 31 March 1995. Applicant should send a cur-riculum vitae, copies of publications, statement of re-search and teaching interests, and name, address, tele-phone and FAX numbers for at least three potential ref-erees to: Glenn I. Hatton, Chairman, Department ofNeuroscience, University of California, Riverside, CA92521-0146. Api Equal Opportuinity/Affirnative Action Emn-ployer.

UNIVERSITY OF PENNSYLVANIADepartment of Biochemistry and Biophysics

The Department of Biochemistry and Biophysics at theUniversity of Pennsylvania is seeking a senior facultymember with established international reputation for aTENURE-TRACK POSITION in the area of mito-chondrial respiration and energy conversion mechanisms,dysfunction and associated disease. The successful appli-cant will have a strong background in molecular biophys-ics and well-established links with molecular biologistsand clinically oriented studies. Candidates should forwardtheir curriculum vitae, a summary of research interests,and arrange for three letters of recommendation to besent to: Ms. Ruth Keris, Staff to Search Committee,Department of Biochemistry and Biophysics, Univer-sity of Pennsylvania School of Medicine, Philadel-phia, PA 19104-6059.

The University of Pennisylvamiia is an Equal OpportunitylAffimnative Action Employer amd emicourages applications from mi-miinnties amid wiomnii.

POSITIONS OPEN

EAST STROUDSBURG UNIVERSITYBiological Sciences

Full-time, continuing ASSISTANT PROFESSORposition for a Molecular Biologist/Geneticist for fall1995 to teach Introductory Biology and Genetics alsoincluding Human Anatomy and Physiology Labs. Thesuccessful candidate will have an opportunity to developcourses in their specialty and direct undergraduate/grad-uate research. Ph.D. required. The applicant should haveprevious teaching experience and a strong commitmentto teaching undergraduates. Salary Range: $35,661 to$43,346 including excellent benefits.

Half-time temporary INSTRUCTOR position for the1995-96 academic year to teach Introductory Biologyand Human Anatomy and Physiology Labs. Ph.D. pre-ferred. The applicant should have previous teaching ex-perience and a strong commitment to teaching under-graduates. Salary Range: $29,338 to $35,661 includingexcellent benefits.Send curriculum vitae and three letters of reference by

February 24, 1995, to: Dr. Raymond Milewski, Chair,Search Committee, Department of Biological Scienc-es, East Stroudsburg University, East Stroudsburg,PA 18301.

East Stroudsburg University is an Affirniative Action/EqualEmployment Opportunity Employer/Minority/Feniale/Dis-ablediVeterans. A Pennsylvania State System of Higher Educa-tios University.

POSTDOCTORAL POSITIONHarvard Medical School

Brigham and Women's Hospital

Biochemistry of transcription activation by RNA poly-merase II (see Parvin et al., Cell, 68:1135, 1992; Parvinand Sharp, Cell, 73:533, 1993). Requires background inbiochemistry, protein purification and molecular biologytechniques. Available immediately. Send curriculum vitaeand names of three references to: Dr. Jeffrey Parvin,Department of Pathology, Brigham and Women'sHospital, 75 Francis Street, Boston, MA 02115.Brigham and Women's Hospital is an Equal OpportuntitylAffir-mative Action Employer.

MOLECULAR PHARMACOGENETICSPOSTDOCTORAL FELLOWSHIPMAYO MEDICAL SCHOOL

POSTDOCTORAL FELLOWSHIP positions areavailable beginning immediately to participate in ongoingNIH-funded studies of the molecular basis of geneticpolymorphisms for drug metabolizing enzymes that alterdrug toxicity and/or therapeutic efficacy. Candidatesshould have a Ph.D. and/or an M.D. degree with expe-rience in pharmacology, molecular biology and/or mo-lecular genetics. Experience in cDNA cloning, gene clon-ing and DNA polymorphism detection would be helpful.Send curriculum vitae and list of three references to: Dr.Richard Weinshilboum, Department of Pharmacolo-gy, Mayo Medical School/Mayo Clinic, Rochester,MN 55905. Mayo Foundation is an Affirmative Action andEqual Opportunity Educator and Employer.

POSTDOCTORAL TRAINING in Clinical Chem-istry. One position available on July 1, 1995, for basicscientist or physician interested in career as laboratorydirector in academic Laboratory Medicine. Our two-yearprogram provides practical experience in clinical chemis-try laboratories and extends relevant basic scientificknowledge. Deadline: 1 April 1995. Write to: MargaretA. Kenny, Ph.D., Co-Director, Chemistry Postdoc-toral Program, Department of Laboratory MedicineSB-10, University of Washington, Seattle, WA98195. The University of Washington is ant Equal Opportunity!Affirmative Action Employer.

POSTDOCTORAL/RESEARCH ASSOCIATE

We seek an outstanding individual to work with a mul-tidisciplinary group studying mechanisms of carcinogen-esis and novel anticarcinogen agents. Special area ofinter-est is the study of human breast malignancies. Qualifiedcandidates should have a Ph.D. with experience in molec-ular biology, protein chemistry/analysis and cell culture.Interested candidates should send their curriculum vitaeand statement of research interest to: Leoncio Garrido,Ph.D., Massachusetts General Hospital, NMR Cen-ter, Building 149 (2301), 13th Street, Charlestown,MA 02129 by March 27, 1995. Al Equal Opportunity/Affirniative Action Einployer.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995920

ENAS1 THE NATIONALINAE RESEARCHIQM COUNCIL

announces aResident Research

AssociateshipAward

to be offered inCell Bilg and

at theNAVAL MEDICAL

RESEARCH INSTITUTEBethesda, MD

The National Research Council(NRC) is accepting applicationsfor a Research Associateshipaward at the Naval MedicalResearch Instue, Bethesda,Maryland.Research opportunity availablein the area of cell biology andultrastructural pathology ofinflammation. Interest andexperience in adhesion mole-cules and cytokines involvedin neutrophil induced tissueinjury are desirable.

The NRC awardee will work inthe above project area as aguest investigator at the NavalMedical Research Institute.Annual stipend for recent Ph.D.recipients is $32,000 and isappropriately higher for seniorresearchers. Award is for oneyear, renewable for a total tenureof three years. Support is provid-ed for relocation and professionaltravel, and a health insuranceprogram is offered.For furter infonraton contact:Yuan-Hsu Kang, Ph.D.National Naval Medical CenterNAVAL MEDICAL RESEARCHINSTITUTEBthesda, Maryland 20889-5607Fax: (301) 295-0535

Applications, submitted direcdyto the NRC, areaccepted on acontinuous basis throughoutthe year. Those postmarked byApirll 15 will be reviewed in June,and by August 15 in October.

FOR APPLICATION MATERIALS CONTACT:NATIONAL RESEARCH COUNCILAssociateship Programs

(TJ-2094/NK)2101 Constitution AvenueWashington, DC 20418FAX: (202) 334-2759

Research Scientists and Specialist: Tree BiotechnologyWestvaco, a major manufacturer of pulp, paper and specialty chemicals is seeking four research scientists and aspecialistin our Forest Research organization. Majoremphasiswill beon hardwood research whichwill complementan existing pine biotechnology program. These individuals will be located atWestvaco's Forest Science Laboratoryin Summerville, South Carolina.Westvaco's world-class Forest Research program emphasizes forest genetics, biotechnology, productivity, biomet-rics, harvesting, and environmental protection. Research is conducted using an interdisciplinary team approach tomeet the objectives of specific missions. The selected individuals will be expected to integrate, contribute andcommunicate effectively with other colleagues in this team research environment.Four Ph.D. scientists and one B.S. or M.S. specialist are needed. Both advanced and entry-level candidates areencouraged to apply. Additional requirements for the positions are as follows:Scientists: TransformationlTissue CultureTwo Scientists to develop research programs for highly efficient tissue culture and genetic transformation ofhardwood species. Experience in planttissueculture and/or plant genetictransformation required. Background withwoody plants is desirable, but not essential.Scientist: Genetic Engineering of SterilityScientist to develop research program on the physiological, biochemical and molecular basis of flowering with thegoal of engineering sterility into trees. Strong background in molecular biology required. Background in molecularbiology of sterility in plants desirable.Scientist: Genetic Engineering of Herbicide/Stress ResistanceScientist to develop research program on genetic engineering of herbicide and stress resistance into trees. Strongbackground in plant physiologyand/ormolecular biology required. Experience in one or more of thefollowing areasis desirable: mode of action of plant stress resistance, plant transformation, and greenhouse or field testing oftransgenic plants.Specialist: Application of DNA MarkersSpecialisttodevelop DNAmarkersforthe identification ofselectedclonesofforesttrees. Experience in DNAanalysisincluding DNA isolation (preferably from plants) and handling, restriction digestion, DNA amplification and gelelectrophoresis required. The successful applicant should have a M.S. degree in Biology (or related field) or a B.S.degree with equivalent experience.Salary commensurate with experience and training. Interested individuals should send a letter of intent specifyingposition title(s), a resume, transcripts, and a list of references to:

Ms. C. L. McCordWestvaco-Forest Research

P. 0. Box 1950Summerville, SC 29484

Closing date for receipt of applications: April 15, 1995 or until suitable candidates are found.Westvaco is an equal opportunity employer, MIF.

U.S. EPA Office of Research and DevelopmentBiologically-Based Dose Response Models for Developmental Toxicity

Request for PreproposalsThe U.S. EPA Environmental Protection Agency Office of Health and Environmental Assess-

ment(OHEA) and Health Effects Research Laboratory (HERL) is seeking PREPROPOSALSFORFINANCIAL ASSISTANCE BY COOPERATIVE AGREEMENT with non-profit or not-for-profit research organizations for research on biologically-based dose-response modelling fordevelopmental toxicity. Such agreements require a minimum oft5% cost sharing by the recipientorganization. A high degree of collaboration with the EPA researchers involved in these activitiesis anticipated (e.g., joint planning and conduct of most tasks and co-authored publications).

The primary goal of the project is to conduct research aimed at understanding the fundamentalmechanisms of abnormal development and developing mathematical models of mechanism-baseddose-response relationships in conjunction withEPA bio-modelers and researchers. Potential focalareas include: (1) segmentation disruption; (2) nucleotide pool imbalances; (3) second/thirdmessengerperturbations. Proposals may address one ormore ofthese areas, orentirely independentand novel areas. Proposals addressing concentration-time (CxT) relationships will be given priorityfor funding.

Proposals will be evaluated by expert review panels. The review will be based on the preposer'sexperience with similarresearch activities, qualifications oftheproposed staffand their understand-ing of appropriate research approaches and technologies, the relevancy to the mission ofEPA, andthe cooperative nature of the proposed working arrangement with EPA staff. The applicant'sproposed budget will also be considered in the selection process. The yearly share of resources forthis research area is expected to be $170,000 for each of 3 years, and EPA anticipates making oneor two awards.

ONLY STATE AND LOCAL GOVERNMENTS, NONPROFIT RESEARCH INSTITU-TIONS OF HIGHER EDUCATION, INDIVIDUALS, OR NOT-FOR-PROFIT RESEARCHORGANIZATIONS THAT ARE ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDERTHE FOLLOWING ACT SHOULD APPLY: Statute authority for this cooperative agreement isfound in the Clean Air Act, 42 U.S.C. §7401 04(a) (2). Interested applicants must be eligible toreceive Federal Assistance under the Code of Federal Regulations (CFR) Part 30 GeneralRegulations for Assistance Programs, and Part 40-Research and Demonstration Grants. Thegovernment reserves the right to not make awards in the research area described in this solicitation.Additional technical instructions and appropriate application materials will be provided uponrequest. Technical instructions for preparation of preproposals and proposals should be obtainedfrom: Barbara Blackwell, Health Effects Research Laboratory (MD-51), U.S. EnvironmentalProtection Agency, Research Triangle Park, NC 27711; Tel 919-541-2886; Fax 919-541-4324.Responses to this advertisement must be received by close of business (COB) March 31, 1995.Responses should be sent to Barbara Blackwell, Health Effects Laboratory (MD-51), U.S.Environmental Protection Agency, Research Triangle Park, NC 27711.I I

POSITIONS OPEN

POSTDOCTORAL POSITION-MassachusettsGeneral Hospital and Harvard Medical School, Boston.Postdoctoral position in antibody engineering for candi-dates with appropriate experience in molecular biology,immunochemistry, protein chemistry. Research involvesstructural and functional characterization of mutant anti-body combining sites at protein and DNA level. Sendcurriculum vitae, statement of research interests, andnames of three references to: Dr. Michael N. Margolies,Jackson 1421, Massachusetts General Hospital, Bos-ton, MA 02114. Telephone: 617-726-8552; FAX:617-726-4811 or 726-6802.

POSTDOCTORAL POSITIONS

Three POSTDOCTORAL POSITIONS are avail-able to study: 1) PKC isozymes and binding proteins/substrates in carcinogenesis; 2) domain mapping andfunction of a novel diacylglycerol kinase; and 3) the reg-ulation of the vitamin D dependent calcium binding pro-tein, calbindin D-28K in kidney cells. The latter projectwill focus on modulation ofvitamin D receptor mediatedevents by growth factor signaling pathways and reversiblephosphorylation.

Applicants should submit their curriculum vitae and thenames and addresses of three references. Applications forpositions 1 or 2 should be addressed to: Dr. Susan Jaken,c/o Personnel Department, and Position 3 to: Dr.JoEllen Welsh, c/o Personnel Department, W. AltonJones Cell Science Center, 10 Old Barn Road, LakePlacid, NY 12946. An Affirmative Action/Equal OpportunityEmployer.

POSTDOCTORAL SCHOLAR or Research Assist-ant. Immediate opening. Requires strong biophysicsbackground. Structure-function studies of the 1) channelactivity of tumor necrosis factor (Science, 255; 1427,1992) and 2) DNase activity of diphtheria toxin (Science,246: 1165, 1989). Send curriculum vitae plus recom-mendations to: Dr. B. J. Wisnieski, M&MG, 1602Molecular Science Building, UCLA, Los Angeles, CA90024. Email: berniew~microbio.lifesci.ucla.edu;FAX: 310-206-5231.

POSTDOCTORAL POSITIONSGENE TRANSFER

POSTDOCTORAL POSITIONS are available tostudy gene transfer and expression in vitro and in vivo (CNSand lung). A Ph.D. and relevant experience is required.An interest in viral vectors (AAV, adenovirus) and expe-rience with vector delivery to the CNS is desired. Submitcurriculum vitae including the names of three referencesto: Dr. Philip R. Johnson or Dr. Warren Lo, Chil-dren's Hospital Research Foundation, Room W309,700 Children's Drive, Columbus, OH 43205. FAX:614-722-2716.

POSTDOCTORAL POSITION available immedi-ately to participate in NIH-sponsored research on the roleof complement regulatory proteins in immunological re-nal disease. Background in molecular biology (molecularcloning, recombinant DNA methodology, analysis ofmRNA) required. Send curriculum vitae, a brief state-ment of research interests, and names and telephonenumbers of three references to: Dr. Richard J. Quigg,Nephrology Section, The University of Chicago,5841 South Maryland Avenue, MC 5100, Chicago,IL 60637. FAX: 312-702-4816. Affirmative Action/EqualOpportunity Employer.

Neurobiology RESEARCH TRACK POSITIONSfor integrative and/or cellular neuroscientists to join amultidisciplinary research group studying cellular actionsof monoamines, functional organization of the locus co-eruleus, olfactory bulb and brainstem autonomic and no-ciceptive circuits. Applicants should possess a Ph.D. and/or M.D. or equivalent and demonstrated experience inone or more of the following techniques: (i) in vivo or invitro extracellular/intracellular recording, (ii) axonal tracttracing, and (iii) immunohistochemistry and in situ hy-bridization. Send curriculum vitae and names, addressesand telephone numbers of three references to: Dr. M. T.Shipley/Dr. M. Ennis, Department ofAnatomy, Uni-versity of Maryland School of Medicine, 655 WestBaltimore Street, Baltimore, MD 21201. The Universityof Maryland is an Affirmative Action/Equeal Employment Oppor-tunity/ADA Employer.

POSITIONS OPEN

POSTDOCTORAL POSITION

Available immediately to study (1) the molecular mech-anisms in human carcinogenesis, and (2) the mechanisticapproach in cancer chemoprevention. Target organ sitesfor chemoprevention are: breast, lung, head and neck,and colon. Specific research interest: drug metabolism,detoxification, DNA damage/repair, and cell prolifera-tion. Candidate should have strong background in bio-chemistry, molecular biology, or cytopathology. Experi-ence in cell culture, PCR, flow cytometry, ELISA, andcomputers. Applicants should send curriculum vitae, asummary of research interest/experience, a list of names,addresses, and telephone numbers of three references to:Dr. Jennifer J. Hu, Lombardi Cancer Center, S-level,3800 Reservoir Road NW, Georgetown UniversityMedical Center, Washington, DC 20007.

POSTDOCTORAL POSITION for TransgenicStudies in Cellular and Molecular Neurobiology-TheDepartment of Neurobiology has postdoctoral positionsavailable to study various aspects of molecular, cellularand developmental neurobiology. Some major areas ofinterest are cell-cell and cell-substratum adhesion mole-cules, neurite outgrowth and nerve regeneration. Specificstudies include: analysis of overexpression, mutation ordeletion of adhesion molecules in animals, analysis ofgenes such as Hox and Pax, that control the expression ofadhesion molecules and their subsequent roles in the for-mation of morphogenetic pathways during neural devel-opment; identification of signal transduction pathwaysand the gene programs activated by adhesion moleculebinding. Applicants should have a strong background incellular and/or molecular biology. Send curriculum vitaeand three letters of reference to: Dr. Gerald M. Edel-man, Chairman, Department of Neurobiology, TheScripps Research Institute, 10666 North TorreyPines Road SBR14, La Jolla, CA 92037. AffirmativeAction/Equal Opportunity Employer.

POSTDOCTORAL POSITION: Available immedi-ately to participate in ongoing cellular, biochemical andmolecular biology studies on soluble T cell receptor mol-ecules and their role and function in immune regulation.Training in cellular immunology and molecular biology isrequired and experience in biochemistry/protein purifi-cation is desired. Send curriculum vitae, statement of re-search interests and names of three references with tele-phone numbers to: Dr. John W. Moorhead, Depart-ment of Immunology, Campus Box B-164, Universi-ty of Colorado Health Sciences Center, 4200 EastNinth Avenue, Denver, CO 80262. FAX: 303-270-7642.

The University of Colorado is comnmitted to Equal Opportunityand Affirmative Action. Applications from twomen and minontygroups are encouraged.

POSTDOCTORAL POSITION to study tumori-genesis based upon the overexpression of casein kinasello, as described in this issue of Science. Experiments onthis and related models will involve the use of transgenicand knock-out mice. Background in molecular biology/biochemistry is required. Please submit a curriculum vi-tae, a summary of research interests, and the names andtelephone numbers of three references to: David C. Sel-din, M.D., Ph.D., Department of Hematology-On-cology, Boston University Medical Center, 88 EastNewton Street, Boston, MA 02118.

POSTDOCTORAL POSITIONS in Antisense Oli-gonucleotide Research: Positions available immediatelyto study the transport of antisense oligonucleotides incells and tissues. A good background in cell biology isessential and experience with digital imaging techniqueswould be helpful. Applicants should send curriculum vitaeand names of two references to: R. L. Juliano, Depart-ment ofPharmacology, University ofNorth Carolina,Chapel Hill, Chapel Hill, NC 27599-7365. FAX:919-966-5640. An Equal Opportunity/Affirmative ActionEmployer.

POSTDOCTORAL POSITION at the University ofVirginia in Kinases and Cell Signaling in laboratory of T.W. Sturgill, for biochemist with background and interestin protein phosphorylation research, protein chemistry,protein purification (FPLC), or MAP kinases. Send cur-riculum vitae, description of research training and careergoals, and three references to: Dr. Thomas W. Sturgill,University of Virginia Medical Center, Markey Cen-ter for Cell Signalling, Box 577, Charlottesville, VA22908. FAX: 804-924-9659.

POSITIONS OPEN

POSTDOCTORAL POSITION supported by NIHtraining grant available immediately to study tyrosinephosphorylation signaling pathways at focal adhesions(see Proc. Natl. Acad. Sci. U.S.A., 89: 8487-8491, 1992;Mol. Cell. Biol., 15: 954-963, 1995). Candidate shouldhave recent Ph.D. and interest in regulation of cell growthand differentiation. Experience in molecular biology andmammalian cell culture desired. Send curriculum vitaeand names of three references to: Dr. Steven K Hanks,Department of Cell Biology, Vanderbilt UniversitySchool of Medicine, Nashville, TN 37232. An Affirma-tive Action/Equal Opportunity Employer.

ANALYTICAL TOXICOLOGY

The National Center for Toxicological Research(NCTR) seeks a research chemist at the POSTDOC-TORAL level ($35,578 per year; sponsored by Inter-agency Agreement with the EPA). The research effortswill involve analytical and mass spectrometry methodsdevelopment for multiple residue analysis of aromaticamine and polycyclic hydrocarbon-DNA adducts and af-ford incumbent an opportunity to participate in a multi-laboratory, interdisciplinary approach to analytical toxi-cology. The research chemist will participate in the bio-monitoring studies and develop analytical techniques forcorroboration of 32P-postlabeling results. Applicantsshould submit curriculum vitae and the names and ad-dresses of at least three references to: Fred F. Kadlubar,Ph.D., HFT-100, NCTR, 3900 NCTR Road, Jeffer-son, AR 72079.NCTR is an Equal OpportiunitylAffirmative Action Employer.

POSTDOCTORAL FELLOWSHIPS INMOLECULAR VIROLOGY

POSTDOCTORAL TRAINEESHIPS are availablethrough NIH training grants in the broad areas of ViralOncology and basic Molecular Virology. Research pro-grams include virus structure, replication mechanisms,assembly, immune recognition, protein structure andfunction, oncogenesis, viral vectors, and vaccine/drugdevelopment. Viruses under study are: retroviruses, in-cluding HIV and SIV (preceptors include E. Hunter, B.Hahn, G. Shaw, P. Fultz, C. Morrow), influenza virus(G. Air, M. Luo), picornaviruses (M. Luo, C. Morrow),phage P22 (P. Prevelige), VSV and respiratory syncytialvirus (G. Wertz), nodarvirus and vaccinia virus (L. A.Ball), adenovirus (J. Engler), papilloma virus (T. Broker,L. Chow), and herpesviruses (R. Whitley, W. Britt).These fellowships are only available to U.S. citizens orpermanent residents and we regret that we cannot processapplications from foreign nationals. Applications and in-quiries should be sent to: Dr. G. Air or Dr. E. Hunter,Department of Microbiology, University of Alabamaat Birmingham, UAB Station, Birmingham, AL35294. An Affirmative Action/Equal Opportunity Employer.

POSTDOCTORAL FELLOWS. Three positionsavailable immediately. NIH and major pharmaceuticalcompany funded projects to study molecular genetics ofsulfotransferases, UDP-glucuronosyltransferases anddipeptide transporters, and regulation of gene expressionby xenobiotics (Chemico-Biol Interact, 92:161, 1994 andPharm Res, 12:317, 1995). Background in drug transport,cellular/molecular biology, or biochemistry is required.Send curriculum vitae and the names of three referencesto: Tony Ah-Ng Kong, Ph.D., Director, Laboratoryof Molecular Pharmaceutics and Toxicology, Depart-ment of Pharmaceutics and Pharmacodynamics(M/C 865), College of Pharmacy, University of Illi-nois at Chicago, 833 South Wood Street, Chicago, IL60612. The University of Illinois at Chicago is an AffimiativeAction/Equal Opportunity Eniployer.

UNDERGRADUATE RESEARCH

The Center for Reproduction ofEndangered Species atthe San Diego Zoo is seeking five outstanding undergrad-uates for NSF/Bonner STUDENT RESEARCH PO-SITIONS during summer 1995. Applications from mi-nority and female students are strongly encouraged. Stu-dents will participate in biological research on topics in-volving genetics, physiology, pathology, infectiousdiseases, virology, endocrinology, and behavior. Fullsummer stipend ($3,255) and travel are paid. To apply,send letter of application, transcript, a statement of re-search interests, and two letters of recommendation to:Summer Research Program, CRES, San Diego Zoo,Box 551, San Diego, CA 92112, by March 15, 1995.The Zoological Society of San Diego is an Equal OpportunityEmployer.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995922

Tenure-TrackAnd Postdoctoral

Listed below are a few of the outstanding opportunities forconducting research that are now available at the National Institutesof Health.

Tenure-TrackPositionAssistant ProfessorEquivalent

Gene TransferTherpyAlan N. Schechter, MD

Candidates are being sought to initiate an independent re-search program using modem techniques of molecular genetics,especially gene transfer, to develop new therapies for human disease.Areas of special research interest include stem cell biology, vectordevelopment and gene expression control. Relevant research train-ing and a strong publication record is required. A two-page state-ment of research interests and goals should be submitted in additionto three letters of recommendation. Laboratory of Chemical Biology(OE-67), NIDDK, Building 10, Room 9N307, 10 CENTERDRMSC 1822, BETHESDA MD 20892-1822.

PostdoctoralPositionsCell Biology ofAntigen Prentation

Paul A. Roche, PhDAntigen processing and presentation is being investigated using

a variety of cell and molecular biology approaches. Emphasis is onelucidating the intracellular transport route taken by newly synthe-sized MHC glycoproteins and in identifying the signals that mediatedelivery of these proteins to antigen processing compartments.Applicants must have less than five years of postdoctoral experience.Experimental Immunology Branch, (OE-67), NCI, Building 10,Room 4B17, 10 CENTERDRMSC 1360, BETHESDAMD20892-1360.

Cytosleton and Antineoplastic DrugsErnest Hamel, MD, PhD

Mitosis and cytokinesis are key cell cycle events. Controlmechanisms are of intrinsic interest and relevant targets for antican-cer drug development. Current research areas include interactionsof small ligands and of proteins in microtubule structure and func-tion and drug interactions with actin microfilaments. Applicantsmust have less than five years postdoctoral experience. Priorcytoskeletal research experience is highly desirable. Laboratory ofMolecular Pharmocology, (OE-67), NCI, Building 37, Room5C25, 37 CONVENT DRMSC 4255, BETHESDAMD 20892-4255.

Larngeal NeurophysiologyChristyL Ludlow, PhD

The inhibition of laryngeal reflexes and their integrative controlduring vocalization is being investigated. The central effects ofperipheral nerve stimulation and heightened laryngeal stimulationare studied. The chronic effects of peripheral nerve injury and sub-sequent reinnervation on the modulation of such reflexes and theircontrol is of interest. Applicants should have less than five yearspostdoctoral experience. Voice and Speech Section (OE-67),

NIDCD, Building 10, Room 5D38, 10 CENTER DRIVE MSC1416, BETHESDA MD 20892-1416.

Molecular BiologyAmy P. Paterson,MD

Thomas L. EggeRman, MD, PhDThe molecular basis for the regulation of apolipoproteins, lipids

and the development of atherosclerosis is being investigated both invitro and in vivo. Specific areas of interest include ontogeny/phylog-eny, hormonal, heavy metal and cytokine regulation, particularly asaffecting apoB mRNA editing. Experience in molecular biology, cellculture and less than five years of post doctoral training are required.Division of Cellular and Gene Therapy (OE-67), FDA/CBERHRM515 1401 Rockville Pike, Rockville, MD 20852-1448.

Molecular Biology ofReceptorsJUrgen Wess, PhD

A position is available to study the molecular mechanismsgoverning the function, regulation, assembly, and intracellular traf-ficking of muscarinic acetylcholine and other G protein-coupledreceptors by molecular biological and biochemical techniques.Background in molecular biology, cell biology, biochemistry, ormolecular modelling is desirable. Applicants must have less than fiveyears of postdoctoral experience. Laboratory of Bioorganic Chemis-try (OE-67), NIDDK, Building 8A, Room B1A09, 8 CENTERDRIVE MSC 0820, BETHESDAMD 20892-0820.

Additional Postdoctoral Fellowship OpportunitiesFor an on-line listing of additional postdoctoral openings, you

may access the NIH EDNET Bulletin Board POSTDOC confer-ence via Internet (wylbur.cu.nih.gov) or modem (1,301-402-2221or 1,800-358-2221) with parameters set at "7,Even,1". When con-nected to NIH, type in ",vtlOO" for terminal emulation, "F5E" forinitials, and "AJL1" for account number.

The Postdoctoral Research Fellowship Opportunities catalog,which describes intramural laboratories at the NIH, is also availableby request. An electronic version of the catalog may be accessed viathe Intemet using either the Gopher Information System(gopher.nih.gov) or the World Wide Web (http:lkwww.nih.govl).When connected, select Research Opportunities at the NIH Office ofEducation. Ifyou would like to request a catalog or have furtherquestions, please contact the Office of Education, Building 10,Room 1C129, 10 CENTERDRMSC 1158, BETHESDAMD20892-1158, 301-402-1603, Fax 301-402-0483.

To ApplyIf you hold a doctoral degree (e.g., PhD, MD/PhD, MD, DO,

DDS, DMD or DVM) accompanied by previous laboratory researchexperience, and would like to be considered for one of these posi-tions, please send a cover letter, currinulum vitae, bibliog-raphy, and statement of research interests to the ad- A Adodress listed with each position. In addition, please °)arrange to have letters of recommendation sent fromthree scientists who can provide an evaluation of your oqualifications. HE V

*AFIUh~iT~i INTWT1OfficeOfEducation

The NIH is an Equal Opportunity Employer

POSITIONS OPEN

POSTDOCTORAL/RESEARCH FACULTYTheoretical, Computational, and

Experimental Chemistry and Physics

We are looking for exceptionally able (1) theoretical/computational chemists or physicists with a strong back-ground in quantum or classical dynamics, intense light-matter interactions, quantum control ofchemical dynam-ics, or related areas, (2) experimentalists, particularly witha background in one or more of the following: ultrafastlasers, atomic and molecular beams, laser generated X-rays, charged particle beams, or X-ray physics. Currentresearch interests in our group include (1) theoretical andexperimental quantum control ofchemical dynamics withfemtosecond lasers, (2) development of multi-terasattfemtosecond lasers and their application to high fieldchemistry and physics, (3) ultrafast, short waelengthelectron and X-ray; diffraction as applied to imaging mo-lecular quantum dyniamics. For a description of currentgroup activities and personnel see our World Wide Website, http://www-wilson.ucsd.edu/ or send Emailwith no text to "wilsjob~ucsd.edu." To apply, pleasesend a curriculum vitae to: Prof. Kent R. Wilson, De-partment of Chemistry 0339, University of Califor-nia, San Diego, La Jolla, CA 92093-0339. Affinniati'~eActionlEqual Opportunity Employer.

POSTDOCTORAL and RESEARCHER POSI-TIONS available immediately in structural studies ofpeptides and proteins. Postdoctoral applicants must havebackground in one of the following areas: (1) molecularmodeling ofprotein and peptide structure and computer-aided drug design; (2) synthesis and structure of pep-tides and peptidomimetics. The Researcher position re-quires a Bachelor's or Master's degree. Knowkledge inorganic chemistry and peptide synthesis is preferred.Competitive salary and benefits. Send curriculum vitaeand arrange for three letters of reference to be sent to:Professor Ziwei Huang, Department of Pharmacol-ogy, Jefferson Cancer Institute, Thomas JeffersonUniversity, Philadelphia, PA 19107. FAX: 215-923-2117; Email: zhuanglcalvin.jci.tju.edu. Affir-mative ActionlEqual Opportunity Eniployer.

RESEARCH ASSOCIATE position available imme-diately to study micro-mechanical properties of contrac-tile cells and molecular motile forces using atomic forcemicroscopy and other biophysical techniques. Experi-mental scientist with a Ph.D. and experience in biochem-istry and biophysics is preferred. Send curriculum vitaeand names of three references to: Dr. Sanjeev G. Shroff,The University of Chicago, 5841 South MarylandAvenue, Chicago, IL 60637. FAX: 312-702-1034.Email: sshroff@medicine.bsd.uchicago.edu. AffirnativeAction Equal Opportioiity Eniployer.

Neurobiology POSTDOCTORAL POSITIONS forintegrative and/or cellular neuroscientists to join a mul-tidisciplinary research group studying cellular actions ofmonoamines, functional organization of the locus coer-uleus, olfactory bulb and brainstem autonomic and noci-ceptive circuits. Applicants should possess a Ph.D. and/orM.D. or equivalent and demonstrated experience in oneor more of the following techniques: (i) in vivo or it vitroextracellular/intracellular recording, (ii) axonal tract trac-ing, and (iii) immunohistochemistrv and inl situ hybridiza-tion. Send curriculum vitae and names, addresses andtelephone numbers of three references to: Dr. M. T.Shipley/Dr. M. Ennis, Department ofAnatomy, Uni-versity of Maryland School of Medicine, 655 WestBaltimore Street, Baltimore, MD 21201. flie Universityof Maryland is anl Affirniatii'e Action Equal Eniploymnent Oppor-ttunitylADA Etnployer.

POSTDOCTORAL RESEARCH POSITIONS.Molecular biologists to study HIV- 1 replication andpathogenesis. Please send curriculum vitae and names ofreferees to: Dr. Jeremy Luban, Columbia University,Department of Medicine, 701 West 168th Street,New York, NY 10032. Colunibia tUniversity is an EqualOpportioiiity ASfirmpiati'e Action Enmployer.

Seeking a Product Development BIOCHEMIST wsithbackground in purification including affinityr chromatog-raphy, electrophoresis, ion exchange, HPLC, SDS-PAGEand blot analysis required. Need conjugation/antibodyqualification experience. Master's or Ph.D. with three ormore years ofindustrial experience in test kit developmentmandatory. Full benefits package and Seattle location.Send resume to: BioControl Systems, Inc., 19805North Creek Parkway, Bothell, WA 98011.

POSITIONS OPEN

RESEARCH ASSOCIATE

Regulation of nitric oxide synthase expression in fieldsof male reproductive biology. Ph.D. in molecular/cellbiology, or related areas. Strong experience with genecloning and expression, cell culture, etc. A knowledge ofgene therapy in animal models and protein purificationwill be a plus. Salary ($36,000 to $45,000 plus fringebenefits), commensurate with experience. Available im-mediately. Send curriculum vitae and three reference let-ters to: Nestor G. Cadavid, Ph.D., Harbor-UCLAMedical Center, Department of Surgery, Division ofUrology, Building F-6, 1000 West Carson Street,Torrance, CA 91107.

RESEARCH ASSOCIATE: Investigate experimentaland analytical data pertaining to seismic performance ofearthquake-resisting structures with specific reference toReinforced Concrete Structures. Publish technical reportsand conference papers in Engineering and technical jour-nals. Serve as an in-house consultant to teaching andresearch staffin the department. Requirements: Ph.D. inCivil (Structural and Earthquake) Engineering. Threeyears of experience in the area of Shake-Table testing ofkC structural elements and mechanical/mathematicalmodeling of RC joints. Experience in conducting staticand dynamic testing. Solid background in nonlinear FEManalysis of Reinforced Concrete Structures. Ability to for-mulate mathematical models for design and carry throughdesigning. Salany: $610.00 per week; 40 hours per week;Job/Interviexv site: Los Angeles, California. Send this adand a resume to: Job No. DG4178, P.O. Box 269065,Sacramento, CA 95826-9065.

NEWLY FORMED DEPARTMENT OFMOLECULAR BIOLOGY

The Masonic Medical Research Laboratory (MMRL), anot-for-profit independent basic biomedical research in-stitute located in the foothills of the Adirondack Moun-tains, invites applications for an individual to head itsnewvly formed Department of Molecular Biology. Posi-tion is at a rank of RESEARCH SCIENTIST I or II,equivalent to Assistant or Associate Professor. Ph.D./M.D. candidates with experience and interest in molecu-lar biology aspects of the electrical function of the heartwill be given preference. Appointee will be expected tocollaborate with the wvell-established cardiac electrophys-iology and immunology programs at the MMRL. A dis-tinguished record of scientific achievement and a solidtrack record of extramural grant support are a must. Toapply, send a letter of application, a curriculum vitae, andnames and addresses of three references to: Dr. CharlesAntzelevitch, Director, Masonic Medical ResearchLaboratory, 2150 Bleecker Street, Utica, NY 13501.Ant Equal OpportuntitylAftirmative Action Einployer.

CLINICAL APPLICATIONS CELL BIOLO-GIST-University of California at San Diego/GeneTherapy Program. In collaboration with the Director ofthe Clinical Applications Laboratory, vill be responsiblefor developing/coordinating large multidisciplinaryprojects; contributing to gene delivery protocols and de-veloping methodologies to transition research into clini-cal grade processes and products. Requires Ph.D. in Bio-logical Science or equivalent combination of education/experience; knowledge of the field to contribute to orig-inialitv/innoxvation in research results. Prefer workingknowledge of process engineering and the appropriatelasts governing the manufacture of human pharmaceuti-cals. Supervisory skills desirable. Salary commensuratewith experience. Apply by February 27, 1995, referencingJob No. 106855-S, to: UCSD Human Resources,10280 North Torrey Pines Road, Suite 266, La Jolla,CA 92093-0967. Affirmative Action Equal Opportinity Em-ployer.

SENSORY PSYCHOPHYSICISTNEUROPHYSIOLOGIST

The John B. Pierce Laboratory, Center for Research inHealth and the Environment, an affiliate of Yale Univer-sity, seeks independent INVESTIGATOR, at any level,preferably in chemosensation or somatosensation. Sendcurriculum vitae, three reprints, and names of three refer-ences by April 1, 1995, to: Sensory Search, John B.Pierce Laboratory, 290 Congress Avenue, New Ha-ven, CT 06519. An Equal Opportunity Affirmmiatii'e ActionEinployer.

POSITIONS OPEN

MOLECULAR EPIDEMIOLOGY/BIOMARKERS

The National Center for Toxicological Research(NCTR) seeks an EPIDEMIOLOGIST and a MO-LECULAR BIOLOGIST at the GS- 12/13 level (full-time permanent; $42,641 to $50,706 per year) to carryout both independent and collaborative studies aimed atassessment of human exposure and individual susceptibil-ity to chemical carcinogens of regulatory or public healthconcern to the U.S. Food and Drug Administration. Theepidemiologist should have experience with transitional/biomarker studies; and the molecular biologist should befamiliar with genotyping and DNA sequencing methods.Appropriate technical/postdoctoral support and start-upfunding wvill be provided. Interested applicants (must beU.S. citizens) should submit curriculum vitac and thenames and addresses of at least three references to: FredF. Kadlubar, Ph.D., Office of Research, NCTR, 3900NCTR Road, Jefferson, AR 72079.NCTR is an Equal OpportuntiitylAflinntative Actiomi Emnployer.

RESEARCH SCIENTISTPOSTDOCTORAL RESEARCH SCIENTISTS

are being recruited by the Division of Medical Oncologyto study the interaction of antisense oligodeoxynucleo-tides with prostate cancer cells. The ultimate objective isto optimize the use of these compounds as clinical ther-apeutic agents. Expertise in molecular biology, and ex-perience with confocal microscopy and/or flow cytom-etry is preferred. Other positions available to study themechanism of action ofsuramin and other polyanions asantineoplastic agents. Candidates should have expertisein molecular biology. Ph.D. or M.D. required. Sendcurriculum vitae and the names of three references to:C. A. Stein, M.D., Ph.D., Columbia University, 630West 168 Street, New York, NY 10032. FAX: 212-305-7438; Email: stein@cuccfa.ccc.columbia.edu.An Affirmative Actioi /Eqtal Opportimmity Employer.

ANNOUNCEMENTS

REQUEST FOR APPLICATIONS AVAILABLE

The Center for Indoor Air Research, sponsor of scien-tific research on a broad range of indoor air topics, hasavailable its 1995 Request for Applications booklet. Ap-plications for January 1, 1996 funding must be receivedby June 1, 1995. For more information on the Center forIndoor Air Research and/or a copy of the Request forApplications booklet, call or write:

Center for Indoor Air Research1099 Winterson Road, Suite 280

Linthicum, MD 21090Telephone 410-684-3777

FAX: 410-684-3729

COURSES AND TRAINING

JOHNS HOPKINS UNIVERSITYSCHOOL OF HYGIENE AND PUBLIC

HEALTHNIH-Sponsored Training Program in Molecular

andCellular Biology of Infectious Diseases

The Department of Molecular Microbiology and Im-munology at the Johns Hopkins University School ofPublic Health invites applications for fully funded PRE-and POSTDOCTORAL POSITIONS for training inthe molecular and cellular biology ofinfectious diseases ofglobal public health importance. This NIH-sponsoredtraining program is restricted to citizens and permanentresidents of the United States and comprises course workand research in the areas of immunology, bacteriology,virology and parasitology. Applications for September1995 must be submitted by March 15, 1995. For moreinformation, please contact: Dr. Noel R. Rose, Direc-tor, Molecular and Cellular Biology of Infectious Dis-eases Training Program, Department of MolecularMicrobiology and Immunology, 615 North WolfeStreet, Baltimore, MD 21205. FAX: 410-955-0105.Fize Johns Hopkins Umiiversity actively enictuirages interest from

u'otieti anid miniorities and is ani Equal OpportunityAffirntiativeAction Eniployer.

SCIENCE * VOL. 267 * 10 FEBRUARY 1995924

GIVFE YOUJR CAIREEIRA STIRONG ]DGSE OF WOIRILID -CLASS IR&]DSmithKline Beecham, a worldwide leader in the pharmaceuticals industry, has excellent opportunities for

serious scientists in our Drug Metabolism & Pharmacokinetics Department. This department focuses on theabsorption, distribution, metabolism and elimination of candidate drugs to support safety and efficacy studies.Currently, the following positions are available:

Investigator/Contract OperationsInteracting with scientists from other areas such as Toxicology, Regulatory Affairs and external contract

houses, this candidate will be responsible for designing, contracting and reporting preclinical ADME and pro-

tein binding studies; contracting cytochrome P450 studies; and preparing preclinical sections of MAA/NDAs andresponses to preclinical questions from regulatory agencies. Qualifications will.l incluidea. PhD. -with 5+ years'relevant experience; excellent communication skills, especially the ab^i~l~iWtto wrt; cocse -reports;extensive experience in preclinical drug metabolism and ph~armacok.ineis adexreneipepigrgua

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or/In Vitro BiotransformationWithin... the.. ofhspsition, this candidate will utilize, implement and develop model in vitro test

............................... .....1.................sytes` eauating drug"" biotransformation and for predicting drug-drug interactions, species differences in...

and metabolic stability of drug development candidates. In a team-focused environment, the

candidate will quantitatively analyze drugs and metabolites in biological media using HPLC and associateddetection techniques. Responsibilities will include protocol/report and manuscript preparation. The successfulcandidate will have a D.V.M. or Ph.D. in Pharmacology, Toxicology or related area, 1-6 years' relevant experi-ence, proven research ability in the field of drug metabolism in particular, and demonstrated skills with in vitrotest systems. Refer to Job Code L0194.

Located in our state-of-the-art research facility in suburban Philadelphia, SmithKline Beecham offers a com-

petitive compensation/benefits/relocation package. Qualified candidates should send CV/resume, indicatingdesired Job Code, to: SmithKline Beecham Pharmaceuticals, Job Code , PO Box 679, Conshohocken, PA19428. We are an Equal Opportunity Employer, M/F/DIN.

SB3SmithKItne Beecham

Pharmaceuticals

Challenginrg the natural limits.

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SAVE 25%Running your recruitment ad once

may not be enough. Place the same adagain within the next eight issues andget 25% off your second insertion.

* Get more attention* Get more value* Get more applicants

Reach the global scientific communityyou need to maximize your recruitmentefforts. SCIENCE does it bigger, better andat greater savings for you.

In the U.S., callJanis Crowley (212) 496-7704

or fax (202) 682-0816In Europe, callGordon Clark

+44 01223 302 067or fax +44 01223 302 068

MOLECULAR

BIOLOGISTS

Cardiovascular Research

Ciba Pharmaceuticals, a world renowned innovator in the research, devel-opment and manufacture of pharmaceutical products, has a firm commit-ment to enhancing the quality of life. To that end, our CardiovascularResearch team is applying tremendous creativity and realizing significantadvancement in the treatment of cardiovascular disease.We are seeking two PhD-level Molecular Biologists to work on projectteams to determine functions of novel gene products as drug discoverytargets. Qualifications include a strong technical background (cloning,DNA sequencing, recombinant protein expression, etc.) and demonstra-ble experience in gene isolation, gene regulation and/or characteriza-tion of gene function. A background in vascular endothelial or smoothmuscle cell biology would be helpful. One position will require an ad-ditional 4-5 years of related industrial experience.We offer salaries commensurate with your experience and education, a

generous benefits package, and a unique opportunity to play an integralrole in the future of cardiovascular medicine. For confidential consider-ation, please send your resume, indicating salary history and require-ments, to: Staffing Center, Department JN-390, Ciba PharmaceuticalsDivision, 556 Morris Avenue, Summit, New Jersey 07901. We are an

equal opportunity employer.

Preparing for the future

Leading Edge ResearchArris Pharmaceutical Corporation is a growing biopharmaceutical company dedicated to therapid development of novel human therapeutics. We are committed to an innovative multi-disciplinary & team oriented approach that encourages both creativity and collaboration. Wecurrently have two exceptional Molecular Pharmacology opportunities.

Senior Position in Molecular PharmacologyWorking closely with synthetic chemists and molecular biologists, the selected candidate willassist with the discovery of novel therapeutics by designing, developing and implementing HTSscreening protocols for both biochemical & whole cell assays. The position requires a Ph.D.; apost-doctoral in molecular pharmacology, enzymology, molecular biology or biochemistry; andat least 2 years' experience running HTS in a pharmaceutical environment. An interest inmacromolecular & protein-ligand interactions and familiarity with automation & data handlingare desired. (Job Code: SNP)

Scientist Position in Molecular BiologyThe chosen candidate will need a Ph.D. in molecular biology, biochemistry or related disciplineand at least 2 years' academic or industrial post-doctoral experience. The position requiresexperience with the purification of native & recombinant serine proteases; demonstrated abilityin the areas of cloning, expression, and purification of recombinant proteases; sound expressionvector construction skills; experience with one or more expression systems (E. coli, yeast,mammalian cells, or baculovirus), and a broad purification/characterization background, whichincludes affinity, ion exchange, gel filtration and hydrophobic chromatography. (job Code:SCT)Arris offers generous salaries & benefits, the potential for career advancement and the opportu-nity to make significant scientific contributions. For consideration, please send resume & coverletter to:

Arris Pharmaceutical Corp. iHuman Resources, Attn: Job Code385 Oyster Point Blvd., Suite 3South San Francisco, CA 94080.

Equal Opportunity Employer C o R P 0 R A T I 0 N

At PfizerW. Pe

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Postdoctoral Positions In TheBiological Sciences

Molecular and Biochemical Mechanismsof Macrolide ResistanceJoyce A. Sutcliffe, Ph.D., Infectious Diseases, Pfizer Central ResearchPatrice Courvalin, Unite des Agents Antibacteriens, Institut Pasteur, Paris, FranceNovel strains of staphylococci resistant to erythromycin by cleavage of themacrocyclic nucleous have recently been detected. In addition, these strains alsoefflux 14-and 1 5-membered macrolides. The initial aim of the work is to char-acterize the genes encoding the macrolide esterase and the macrolide effluxsystem after cloning in Escherichia coli or Staphylococcus aureus. Biochemi-cal characterization of these resistance mechanisms includes the develop-ment of a macrolide efflux assay in gram-positive cocci.

Signal Transduction-CancerNeil Gibson, Ph.D., Cancer, Pfizer Central ResearchRuth Halaban, Department of Dermatology, Yale UniversityThe project's goals are to investigate the signaling pathway mediated by thefibroblast growth factor receptor in normal human melanocytes and malig-nant melanoma cells. Ph.D. in molecular biology with experience in signaltransduction preferred.

Signal Transduction/lInsulin ActionE. Michael Gibbs, Ph.D., Metabolic Diseases, Pfizer Central ResearchGustav E. Lienhard, Department of Biochemistry, Dartmouth Medical SchoolThe aim of this joint project is to elucidate at the molecular level pathwaysof signaling that emanate from the insulin receptor and are mediated byphosphatidylinositol 3-kinase. The research strategy will involve the inter-ruption of the normal signaling pathway from the insulin receptor to thekinase and assessing the effects on insulin's metabolic actions. Experi-ence with a variety of biochemical and molecular techniques and/ortransgenic animals is preferred.

_ > Molecular ImmunologyJeff Hanke, Ph.D., Molecular Immunology, Pfizer Central Research

Research will focus on the development of novel transgenic models ofhuman autoimmune disease. Applicants will be expected to carry forwardan independent research project. An emphasis is placed on publicationand individual scientific development. Several options exist for the co-sponsoring University laboratory on this project. Candidates will have com-pleted a Ph.D. program with training in molecular biology. Experience

with either transgenic animals or Immunology is a plus.In addition to a stimulating research environment, we offer a com-petitive compensation and benefits package, including relocationassistance to our southeastern shoreline community. If you hold a

doctoral degree with 0-2 years of postdoctoral experience andwould like to be considered for one of these positions, please

submit resume suitable for electronic scanning, i.e.eliminate italics, bullets, bolds, underlines and sta-

ples, laser printed preferred. Send to EmployeeResources, AD 1003, Pfizer lnc, Central Research

DDMsion, Eastern Point Road, Groton, CT 06340.

We are an equal opportunity em-ployer. M/F/D/V

Central Researcha

InEm-

loomm-

M

SCIENTISTS

Integrin Signaling

COR Therapeutics, Inc. is a publicly-held biopharma-ceutical company located in the San Francisco Bay Area.We specialize in the discovery and development of novelpharmaceutical products for the treatment and preventionof severe cardiovascular disease. We currently have anexceptional opportunity for experienced Scientists to forma research team focused on basic mechanisms in integrinsignaling. A Ph.D. and 2-8 years of relevant researchexperience are required. Individuals will be hired at thepositions of Scientist I, Scientist II, or Senior Scientist,depending on experience and qualifications. Threepositions are available.

Molecular BiologyCloning, expression, and functional characterization ofsignaling proteins. This position requires broad experi-ence in molecular biology, including developing strategiesfor doning and expression of proteins. Preference will begiven to individuals with a background utilizing the yeasttwo hybrid system to characterize signaling proteins(ob Code R47-95).

Biochemistry/Protein ChemistryCharacterization of integrin signaling pathways. Priorexperience in the characterization of cytoplasmic signaling,including structure-function analysis of signaling proteins,is required Uob Code R48-95).

Cell BiologyIdentification of integrin binding proteins throughexpression cloning. Extensive experience in cell biologytechniques used to characterize and quantitate cellularactivation is required, with preference given to individualswith experience in developing strategies for expressioncloning Uob Code R49-95).

COR Therapeutics, Inc. offers competitive salaries, benefits,and attractive equity positions to its employees, combinedwith the challenge and opportunity to make significantresearch contributions. To apply, please reference job codeand send curriculum vitae to: COR Therapeutics, Inc.,Human Resources, 256 East Grand Avenue, South SanFrancisco, CA 94080. COR is an equal opportunity employer.

COR THERAPEUTICS, INC.

EVELOPMENT BIOCHEMISTSContribute to a better world!

That's what you'll do when you work with DuPont.We are a global leader in technologicalachievements and products that create a betterworld.

We currently have exciting and challengingopportunities in our Diagnostics Division in Glasgow,Delaware for Development Biochemists. In this role,your primary responsibility will be to develop assays,calibrators and control products for use in in-vitrodiagnostics.

The ideal candidate will have a PhD in Biochemistry,Clinical Chemistry or Immunochemistry withexperience in protein chemistry, enzymology orrelated field.

DuPont offers an excellent compensation andbenefits package. To be considered, please forwardyour resume to: DuPont Human Resources,PSS-0096, Wilmington, DE 19898. An EqualOpportunity Employer.

I)U Medical Products

The University of Zurich (Switzer-land), Faculty of Sciences, invites

((i z applications for a

e v ~~Professorship inAnimal Behaviour

Applicants should have an excellent research record inareas concerning physiological or other proximate as-pects of behaviour, especially in vertebrates (preferablymammals). The candidate is expected to establish astrong independent research programme and to interactwith existing groups in neurobiology and behaviouralecology. He/she is required to participate in the teachingprogramme of the Institute of Zoology and to deliverlectures in German within two years.Depending on the qualifications and age of the appli-cant, the position will be tenurable (Assistant Professor)or tenured (Associate or Full Professor).Applicants should submit their curriculum vitae, briefsummaries of previous research and future researchplans, list of publications, copies of up to five majorpublications, and the names of three potential refereesto the following address: Dekan der PhilosophischenFakultat 11, Professor Dr. H. Fischer, Winterthurerstr.190, CH-8057 Zurich, Switzerland. Applications will beaccepted until March 15, 1995.Informal enquiries concerning the position may be ad-dressed to the Head of the Institute of Zoology, Profes-sor Dr. R. Wehner (phone +41 1 257-4831, FAX +41 1257-5716).

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North American Vaccine, Inc. a rapidly expanding company aeaicatea Ioresearch, development and manufacturing of vaccines, has an immedi-ate opening in our process development area.Qualified candidate will have a Ph.D. in Biochemistry with a minimum of

3 years postdoctoral experience. The selected candidate will be involvedin protein and polysaccharide purification process development andchemicaVimmunological assay development. Working knowledge of pro-tein chemistry and column chromatography is required. Experience incarbohydrate chemistry is a plus.We offer a competitive salary and benefits package and an environ

.. ment ideal for professional growth. We're located in Beltsville,i. Maryland- 20 minutes north of Washington D.C. Qualified candidates

should send a resume and/or CV indicating position number to:

N̂ T Human Resources ManagerORTH AMERICAN VACCINE, INC.

an IUAMAVA I3MC 1 )1fl2 Inhinan Crarp'k ourt

At Amgen, you'll discover a research environment thatemphasizes collaboration, intellectual honesty, scientificintegrity, and a supportive culture. This unique approachhas helped us grow into a global biotechnology leader injust thirteen years.

MAMMALIAN CELL MOLECULAR BIOLOGY

Research Scientist

The successful candidate will initiate and develop researchprograms focusing on novel factors regulating cell growthand transformation. Requirements include a Ph.D. with atleast 3 years of post-doctoral experience in tumor biology.Candidates must have a broad knowledge of oncogenes,tumor suppressors, growth factors and receptors, and hands-on experience in at least one of these areas. The ability todirect independent research and familiarity with certaintumor models are highly preferred.(Job Code: OXP-SC-2261)

CELL BIOLOGY

Research Associate

The successful candidate will maintain established cell linesand primary endothelial cell cultures. Other duties includecarrying out cell-based functional assays such as the analysisof proliferation, migration, and adhesion. Candidates musthave a BS/MS in Cell Biology or related field, at least 2 years'research experience, and some degree of computerproficiency. Experience in immunohistochemistry orreceptor-ligand interactions is a plus.(Job Code: OXP-SC-2240)

At Amgen, you'll find our approach to scientific researchas rewarding as it is effective. We offer a highlycompetitive compensation and benefits package thatincludes a retirement and savings plan, an on-site fitnesscenter, and three weeks' vacation. Please mail yourresume/c.v. to: Amgen Inc., Staffing, Job Code:(see above), Amgen Center, Thousand Oaks, CA 91320-1789. Principals only, please. For information on otherresearch opportunities available at Amgen, please call1-800-446-4007. EEO-Affirmative Action EmployerMIFID/V. We recognize that diverse perspectives are akey factor in the process of discovery.

AMOEN

Senor Staff Scientist/Engineer($71,664-$93,166)

The U.S. Nuclear Regulatory Commission's mission is to protect America'shealth, safety, and environment in the civilian use of nuclear materials.We are currently seeking a qualified individual with knowledge of theprinciples associated with radioactive waste disposal and nuclearmaterial safety for a Senior Staff Scientist/Engineer position at ourNuclear Waste Branch in Rockville, MD.Responsibilities include coordinating and participating in activities ofthe Advisory Committee for Nuclear Waste (ACNW) in connection withthe committee's review of activities associated with the managementand disposal of radioactive waste. In addition, you will provide an expertoverview of work on the engineering and/or performance assessment(risk analysis) asp of both high and low level radioactive waste disposal.To qualify, you must have knowledge of computer-based codes todescribe the performance of disposal facilities, as well as the ability toassess and functional knowledge of probabilistic methods and calcu-lations. In addition, you must have at least one year of experience in thefield as well as a sound understanding of related theories, principles andpractices. Knowiedge of radioactive waste regulations, standards, policies,and long-term performance is essential. Excellent written and verbalcommunication skills are a must.This highly visible position could be your opportunity to make a significantcontribution to safety standards in the nuclear industry. For consideration,please send your resume or SF-171 by February 17, 1995 to: U.S.Nuclear Regulatory Commission, Office of Personnel, Attn: SherylE. Dunn, Mall Stop T-2 D32 (Dept. A-95020), Washington, D.C. 20555.

*+^^9>=U.S. NUCLERJREGULATORYCOMMISSION

An equal opportunity employer, M/F/DNU.S. citizenship required

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