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Advancing Animal Nutrition
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SM021003
A Yeast-Derived Source of Mannanoligosaccharides and Beta-Glucans
safmannan™
PAGRI PRODUCTS, INC.
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Advancing Animal Nutrition
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SM021003
Contains 19 - 24% mannan & 24 - 26% beta-glucanContains no carriers and is extremely consistentIs water-dispersible (milk replacers)Research is available on binding of certain bacteria to the lining of the digestive tractResearch is available on yeast cell wall and stimulation of the immune systemFood grade product derived from primary S. cerevisiae yeastProduced in France under strict physical, microbial and chemicalstandards by Lesaffre company Bio-Springer
Yeast Cell WallMannanoligosaccharides of Saccharomyces cerevisiae
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Advancing Animal Nutrition
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SM021003
Research shows D-mannose containing mannanoligosaccharides may bind to bacterial lectins, reducing colonization of the gut by enteropathogens such as salmonellae and E. Coli
Research shows that feeding MOS results in increased villus height in the small intestine that provides more surface area for nutrient absorption.
Yeast Cell WallProposed Mode of Action
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Advancing Animal Nutrition
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SM021003
Lesaffre Research
(Dr. B. Gedek, Univ. of Munich, 1992)
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Advancing Animal Nutrition
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SM021003
Potential Binding
CellCell Cell
Bacteria
Mannanoligosaccharides
Lectin
CHO in thesurface
DrugLectin
(Saf Agri, 2001)
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Advancing Animal Nutrition
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SM021003 KSU
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Advancing Animal Nutrition
P
SM021003KSU
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Advancing Animal Nutrition
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SM021003
Design
1200 turkey hens,
30 per pen, 6 weeks, 10 reps
MOS 1 @ 1 lb/ton
MOS 2 @ 2 lb/ton 012345
Day 42Bird Wt.
(lb)
Day 42F:G (lb)
F:GAdjustedto 5 lb wt.
(lb.)
Day 42Mortality(# birds)
MOS 1 MOS 2
Poultry Trial - Virginia Scientific
Poultry Performance
(Virginia Scientific, 2001)
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Advancing Animal Nutrition
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SM021003
Intestinal Villa (Santin, et. al., 2000)
a = without MOS
b = with a quality MOS
Duodenum
Jejunum
Ileum
a
a
a
b
b
b
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Advancing Animal Nutrition
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168 pigs (13.2 lb./21 d), 6/pen, 5 wks, 7 reps
MOS 1 @ 2 lb/ton
MOS 2 @ 4 lb/ton
0
100
200
300
400
500
600
700
800
gram
s
ADG d 0-35 ADFI d 0-35 (g) G:F (g/kg)
5.45.55.65.75.85.9
66.1
Fecal Coliforms (log 10)
ControlMOS 1MOS 2
Swine Research - Kansas State University
Pig Performance
(Hancock, et. al., 2001)
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Advancing Animal Nutrition
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SM021003
Somatic Cell Counts in Lactating Holsteins Comparing Yeast Culture and P-7
509
462.9
430
440
450
460
470
480
490
500
510
(P < 0.001)
YC P-7
Som
ati c
Cel
l Cou
nt(1
,000
)(Higginbotham, et. al., 2000)
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Advancing Animal Nutrition
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MOS Source
Be sure of the quality and consistency of the mannanoligosaccharide (MOS) source you use in your product
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Advancing Animal Nutrition
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SM021003
Research Results for Use of MOS in Mycotoxin Challenge
Evaluation of live yeast or MOS with mycotoxinsAflatoxin, Ochratoxin A and T-2 Toxin in chickens.
Animals fed diets with 0.2% yeast, showed reduced effects of the mycotoxin challenge.Animals fed diets with 0.1% MOS showed amelioration of the negative effects on gain from mycotoxins.Animals fed yeast and MOS exhibited fewer pathogenic lesions.
(Marques, Rene - INIFAP, 2000)
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Advancing Animal Nutrition
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SM021003
Location
Canada IA VA SD NC MN
%
DM 96.5 95.8 96.9 95.3 95.3 95.1
Total N 3.4 3.3 3.9 4.6 4.5 3.7
Glucans 21.6 14.0 21.7 12.8 22.3 29.5
Mannans 5.2 20.3 12.5 2.6 6.9 8.6
Products were obtained from different areas within the U.S. and Canada
• 6 random samples were taken of the same competitive MOS product
Competitive Product Inconsistency
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Advancing Animal Nutrition
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SM021003
• 3 samples from 3 different lots were obtained, since Safmannan™ is produced in only one location
Lot # 3103 Lot # 3261 Lot # 2953
DM (%) 96.6 95.7 95.7
Total N (%) 3.1 3.0 2.6
Glucans (%) 24.3 27.4 26.1
Mannans (%) 21.0 19.8 20.5
safmannan Consistency
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Advancing Animal Nutrition
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General RecommendationsSpecie safmannan MOSDairy 5- 10 g/h/d 10-20 g/h/d
Beef 5- 10 g/h/d 10-20 g/h/d
Calves 2- 5 g/h/d 5 - 10 g/h/d
Swine - Starters 2 lbs/t Complete Feed 4 lb/t Complete Feed
Swine - Growers 1 lb/t Complete Feed 2 lb/t Complete Feed
Turkeys 1 lb/t Complete Feed 2 lb/t Complete Feed
General Use 0.5 - 1 lb/t Complete Feed 1 -2 lb/t Complete Feed
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Advancing Animal Nutrition
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SM021003
More concentrated mannan and beta-glucancontentExtremely consistentPure yeast cell wall, no carrierUse at half the recommended inclusion rate of most competitive MOS productsProduced by Lesaffre, world’s largest yeast manufacturer
Safmannan is consistent - Any order, Anywhere, Any time!
safmannan Advantages