SAFETY DATA SHEET · 2020-07-20 · MammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1),...

SAFETY DATA SHEETMammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282

Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II, as amended by Commission Regulation (EU)2015/830 - United Kingdom (UK)

SECTION 1: Identification of the substance/mixture and of the company/undertaking

MammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282Product name :

1.1 Product identifier

1.3 Details of the supplier of the safety data sheet

e-mail address of personresponsible for this SDS

: [email protected]

1.2 Relevant identified uses of the substance or mixture and uses advised against

Part no. : Agendia NGS Nuclease-Free Water

931282-07

Agendia NGS Hyb 1 931282-01Agendia NGS Hyb 2 931282-02Agendia NGS Hyb 4 931282-03Agendia NGS Binding Buffer

931282-04

Agendia NGS Wash Buffer 1

931282-05


931282-06

Agendia NGS Elution Buffer

931282-08

Agendia NGS Neutralization Buffer

931282-09

1.4 Emergency telephone number

Emergency telephone number (with hours of operation)

: +31 (0)20 462 1510

Agendia NV Science Park 406 1098 XH Amsterdam The NetherlandsTelephone:+31 (0)20 462 1510

Part no. (chemical kit) : 931282

Analytical chemistry.

Agendia NGS Nuclease-Free Water 3 mlAgendia NGS Hyb 1 0.480 mlAgendia NGS Hyb 2 1.5 mlAgendia NGS Hyb 4 1.5 mlAgendia NGS Binding Buffer 15.5 mlAgendia NGS Wash Buffer 1 10 mlAgendia NGS Wash Buffer 2 29 mlAgendia NGS Elution Buffer 0.96 mlAgendia NGS Neutralization Buffer 0.96 ml

Material uses :

Date of issue/Date of revision : 1/4220/01/2020 Date of previous issue : 13/02/2018 Version : 2

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MammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282


SECTION 2: Hazards identification

See Section 11 for more detailed information on health effects and symptoms.

Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

2.1 Classification of the substance or mixture

Product definition : Agendia NGS Nuclease-Free Water

Mono-constituent substance

Agendia NGS Hyb 1 MixtureAgendia NGS Hyb 2 MixtureAgendia NGS Hyb 4 MixtureAgendia NGS Binding Buffer

Mixture


Mixture


Mixture


Mixture


Mixture

See Section 16 for the full text of the H statements declared above.

Ingredients of unknown toxicity

:

Ingredients of unknown ecotoxicity

:

2.2 Label elements

Agendia NGS Hyb 1H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 2H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2

Agendia NGS Elution BufferH290 CORROSIVE TO METALS - Category 1

Agendia NGS Neutralization BufferH315 SKIN CORROSION/IRRITATION - Category 2H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 1 Percentage of the mixture consisting of ingredient(s) of unknown acute dermal toxicity: 1 - 10%Percentage of the mixture consisting of ingredient(s) of unknown acute inhalation toxicity: 10 - 30%

Agendia NGS Hyb 2 Percentage of the mixture consisting of ingredient(s) of unknown acute dermal toxicity: 10 - 30%

Agendia NGS Hyb 4 Percentage of the mixture consisting of ingredient(s) of unknown acute dermal toxicity: 1 - 10%Percentage of the mixture consisting of ingredient(s) of unknown acute inhalation toxicity: 1 - 10%

Agendia NGS Binding Buffer

Percentage of the mixture consisting of ingredient(s) of unknown acute inhalation toxicity: 1 - 10%


Percentage of the mixture consisting of ingredient(s) of unknown acute dermal toxicity: 10 - 30%Percentage of the mixture consisting of ingredient(s) of unknown acute inhalation toxicity: 10 - 30%Percentage of the mixture consisting of ingredient(s) of unknown acute oral toxicity: 10 - 30%

Agendia NGS Hyb 4 Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 1%


Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 15.8%


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SECTION 2: Hazards identificationHazard pictograms : Agendia NGS Hyb 1

Agendia NGS Hyb 2



Signal word :

Hazard statements :

Prevention :

Precautionary statements

Agendia NGS Nuclease-Free Water

No signal word.

Agendia NGS Hyb 1 WarningAgendia NGS Hyb 2 WarningAgendia NGS Hyb 4 No signal word.Agendia NGS Binding Buffer

No signal word.


No signal word.


No signal word.


Warning


Warning


No known significant effects or critical hazards.

Agendia NGS Hyb 1 H319 - Causes serious eye irritation.Agendia NGS Hyb 2 H373 - May cause damage to organs through prolonged or

repeated exposure.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer







H290 - May be corrosive to metals.


H319 - Causes serious eye irritation.

H315 - Causes skin irritation.


Not applicable.

Agendia NGS Hyb 1 P280 - Wear eye or face protection.P264 - Wash hands thoroughly after handling.

Agendia NGS Hyb 2 P260 - Do not breathe vapour.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Not applicable.


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Response :

Storage :

Disposal :

BufferAgendia NGS Wash Buffer 1

Not applicable.


Not applicable.


P234 - Keep only in original packaging.


P280 - Wear protective gloves. Wear eye or face protection.

P264 - Wash hands thoroughly after handling.


Not applicable.

Agendia NGS Hyb 1 P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Agendia NGS Hyb 2 P314 - Get medical attention if you feel unwell.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


P390 - Absorb spillage to prevent material damage.


P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


P406 - Store in corrosive resistant container with a resistant inner liner.


Not applicable.


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 P501 - Dispose of contents and container in accordance

with all local, regional, national and international regulations.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


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Supplemental label elements

Tactile warning of danger


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

:

: Agendia NGS Nuclease-Free Water

Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Safety data sheet available on request.Agendia NGS Binding Buffer

Safety data sheet available on request.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

Special packaging requirements

Hazardous ingredients :

2.3 Other hazards

Annex XVII - Restrictions on the manufacture,placing on the market and use of certain dangerous substances,mixtures and articles


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 - Disodium dihydrogen ethylenediaminetetraacetateAgendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


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:Other hazards which do not result in classification


None known.

Agendia NGS Hyb 1 None known.Agendia NGS Hyb 2 None known.Agendia NGS Hyb 4 None known.Agendia NGS Binding Buffer

None known.


None known.


None known.


None known.


None known.

PBT

Agendia NGS Nuclease-Free WaterNot applicable (Inorganic)

N/A N/A N/A Not applicable (Inorganic)

N/A N/A

P B T vPvB vP vBProduct meets the criteria for PBT or vPvB according to Regulation (EC) No.1907/2006, Annex XIII

:

Agendia NGS Hyb 1 This mixture does not contain any substances that are assessed to be a PBT or a vPvB.




This mixture does not contain any substances that are assessed to be a PBT or a vPvB.









SECTION 3: Composition/information on ingredientsAgendia NGS Nuclease-Free Water

Mono-constituent substance

Agendia NGS Hyb 1 MixtureAgendia NGS Hyb 2 MixtureAgendia NGS Hyb 4 MixtureAgendia NGS Binding Buffer MixtureAgendia NGS Wash Buffer 1 MixtureAgendia NGS Wash Buffer 2 MixtureAgendia NGS Elution Buffer MixtureAgendia NGS Neutralization Buffer Mixture

:3.1 Substances


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SECTION 3: Composition/information on ingredients

There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.

[1] Substance classified with a health or environmental hazard[2] Substance with a workplace exposure limit[3] Substance meets the criteria for PBT according to Regulation (EC) No. 1907/2006, Annex XIII[4] Substance meets the criteria for vPvB according to Regulation (EC) No. 1907/2006, Annex XIII[5] Substance of equivalent concern[6] Additional disclosure due to company policy

Type

[A] Constituent[B] Impurity[C] Stabilising additive

Product/ingredient name

Agendia NGS Nuclease-Free WaterWater REACH #: Annex IV

EC: 231-791-2CAS: 7732-18-5

100 Not classified. [A]

Agendia NGS Hyb 1Sodium chloride EC: 231-598-3

CAS: 7647-14-5≥10 - ≤25 Eye Irrit. 2, H319 [1]

Agendia NGS Hyb 2Disodium dihydrogen ethylenediaminetetraacetate

EC: 205-358-3CAS: 139-33-3

≥10 - ≤25 Acute Tox. 4, H302Acute Tox. 4, H332STOT RE 2, H373 (respiratory tract) (inhalation)

[1]

Agendia NGS Hyb 4Sulfuric acid monododecyl ester sodium salt (1:1)

CAS: 8012-56-4 ≤3 Acute Tox. 4, H302 [1]

Agendia NGS Binding BufferSodium chloride EC: 231-598-3

CAS: 7647-14-5<10 Eye Irrit. 2, H319 [1]

Agendia NGS Neutralization Buffer2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride

EC: 214-684-5CAS: 1185-53-1

≥10 - <20 Skin Irrit. 2, H315Eye Irrit. 2, H319STOT SE 3, H335

[1]

Identifiers % TypeRegulation (EC) No. 1272/2008 [CLP]

See Section 16 for the full text of the H statements declared above.

SECTION 4: First aid measures


Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.

Agendia NGS Hyb 1 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention.

Agendia NGS Hyb 2 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.

4.1 Description of first aid measures

Eye contact :


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SECTION 4: First aid measuresGet medical attention following exposure or if feeling unwell.

Agendia NGS Hyb 4 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.








Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention if irritation occurs.


Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention.


Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 2 Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention following exposure or if feeling unwell. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed.The exposed person may need to be kept under medical surveillance for 48 hours.

Agendia NGS Hyb 4 Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur.








Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be

Inhalation :


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Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as

Skin contact Agendia NGS Nuclease-Free Water

Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Agendia NGS Hyb 2 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention following exposure or if feeling unwell. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Agendia NGS Hyb 4 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.








Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse.


Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing before reuse. Clean shoes thoroughly before reuse.

dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.


Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed.The exposed person may need to be kept under medical surveillance for 48 hours.

Ingestion

:

:


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SECTION 4: First aid measuresvomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 2 Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention following exposure or if feeling unwell. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 4 Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.








Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.


Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed


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SECTION 4: First aid measuresand the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Protection of first-aiders : Agendia NGS Nuclease-Free Water

No action shall be taken involving any personal risk or without suitable training.

Agendia NGS Hyb 1 No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

Agendia NGS Hyb 2 No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

Agendia NGS Hyb 4 No action shall be taken involving any personal risk or without suitable training.








No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.


No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

4.2 Most important symptoms and effects, both acute and delayed

Potential acute health effects

Inhalation : Agendia NGS Nuclease-Free Water


Agendia NGS Hyb 1 No known significant effects or critical hazards.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer




Agendia NGS Wash No known significant effects or critical hazards.



Agendia NGS Hyb 1 Causes serious eye irritation.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer









Causes serious eye irritation.

:Eye contact


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SECTION 4: First aid measuresBuffer 2Agendia NGS Elution Buffer
















:Ingestion

Skin contact : Agendia NGS Nuclease-Free Water











Causes skin irritation.

Over-exposure signs/symptoms

Eye contact : Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 Adverse symptoms may include the following:pain or irritationwateringredness

Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


No specific data.


No specific data.


No specific data.


Adverse symptoms may include the following:

pain or irritationwateringredness


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Notes to physician Agendia NGS Nuclease-Free Water

Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Agendia NGS Hyb 1 Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Agendia NGS Hyb 2 In case of inhalation of decomposition products in a fire,symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

Agendia NGS Hyb 4 Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.



Agendia NGS Wash Treat symptomatically. Contact poison treatment specialist

:

Skin contact

Ingestion

Inhalation Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 No specific data.Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.



irritationredness

:

:

:

4.3 Indication of any immediate medical attention and special treatment needed


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SECTION 4: First aid measuresBuffer 1 immediately if large quantities have been ingested or inhaled.Agendia NGS Wash Buffer 2





In case of inhalation of decomposition products in a fire,symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

Specific treatments Agendia NGS Nuclease-Free Water

No specific treatment.

Agendia NGS Hyb 1 No specific treatment.Agendia NGS Hyb 2 No specific treatment.Agendia NGS Hyb 4 No specific treatment.Agendia NGS Binding Buffer










:

SECTION 5: Firefighting measures


Use an extinguishing agent suitable for the surrounding fire.

Agendia NGS Hyb 1 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Hyb 2 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Hyb 4 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Binding Buffer










5.1 Extinguishing media


None known.

Agendia NGS Hyb 1 None known.Agendia NGS Hyb 2 None known.Agendia NGS Hyb 4 None known.Agendia NGS Binding Buffer

None known.


None known.


None known.


None known.


None known.

Suitable extinguishing media

:

Unsuitable extinguishing media

:

5.2 Special hazards arising from the substance or mixture


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SECTION 5: Firefighting measures


Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Agendia NGS Hyb 1 Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Agendia NGS Hyb 2 Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Hazardous combustion products

Hazards from the substance or mixture


No specific data.

Agendia NGS Hyb 1 Decomposition products may include the following materials:phosphorus oxideshalogenated compoundsmetal oxide/oxides

Agendia NGS Hyb 2 Decomposition products may include the following materials:carbon dioxidecarbon monoxidenitrogen oxidesmetal oxide/oxides

Agendia NGS Hyb 4 Decomposition products may include the following materials:carbon dioxidecarbon monoxidesulfur oxidesmetal oxide/oxides


Decomposition products may include the following materials:

halogenated compoundsmetal oxide/oxides


No specific data.


No specific data.


No specific data.


Decomposition products may include the following materials:

carbon dioxidecarbon monoxidenitrogen oxideshalogenated compounds


In a fire or if heated, a pressure increase will occur and the container may burst.

Agendia NGS Hyb 1 In a fire or if heated, a pressure increase will occur and the container may burst.













:

:

5.3 Advice for firefighters

Special precautions for fire-fighters

:


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SECTION 5: Firefighting measuresAgendia NGS Hyb 4 Promptly isolate the scene by removing all persons from the

vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.












Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.

Agendia NGS Hyb 1 Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.










Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full

Special protective equipment for fire-fighters

:


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SECTION 5: Firefighting measuresface-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.



SECTION 6: Accidental release measures6.1 Personal precautions, protective equipment and emergency procedures

For non-emergency personnel


No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Put on appropriate personal protective equipment.

Agendia NGS Hyb 1 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.

Agendia NGS Hyb 2 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.

Agendia NGS Hyb 4 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Put on appropriate personal protective equipment.








No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.


No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.


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SECTION 6: Accidental release measures

6.2 Environmental precautions


Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Agendia NGS Hyb 1 Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).





Agendia NGS Wash Avoid dispersal of spilt material and runoff and contact with

For emergency responders

:

Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.


If specialised clothing is required to deal with the spillage,take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".

Agendia NGS Hyb 1 If specialised clothing is required to deal with the spillage,take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".













:


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SECTION 6: Accidental release measuresBuffer 1 soil, waterways, drains and sewers. Inform the relevant

authorities if the product has caused environmental pollution (sewers, waterways, soil or air).








Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.

Agendia NGS Hyb 1 Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.










Stop leak if without risk. Move containers from spill area.Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations. Absorb spillage to prevent material damage.Dispose of via a licensed waste disposal contractor.


Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose

Methods for cleaning up :

6.3 Methods and material for containment and cleaning up


M-ROW-144-V4



SECTION 6: Accidental release measuresof via a licensed waste disposal contractor.

6.4 Reference to other sections

See Section 1 for emergency contact information.See Section 8 for information on appropriate personal protective equipment.See Section 13 for additional waste treatment information.

:

SECTION 7: Handling and storage7.1 Precautions for safe handling

Protective measures :

Advice on general occupational hygiene

:


Put on appropriate personal protective equipment (see Section 8).

Agendia NGS Hyb 1 Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.

Agendia NGS Hyb 2 Put on appropriate personal protective equipment (see Section 8). Do not breathe vapour or mist. Do not ingest.Avoid contact with eyes, skin and clothing. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.

Agendia NGS Hyb 4 Put on appropriate personal protective equipment (see Section 8).








Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Keep away from acids. Empty containers retain product residue and can be hazardous. Do not reuse container.Absorb spillage to prevent material damage.


Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.


Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 1 Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 2 Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.


M-ROW-144-V4



SECTION 7: Handling and storage


Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Hyb 1 Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

7.2 Conditions for safe storage, including any incompatibilities

Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 4 Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.











Storage :


M-ROW-144-V4



SECTION 7: Handling and storageAgendia NGS Hyb 2 Store in accordance with local regulations. Store in original

container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Hyb 4 Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.








Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store in corrosive resistant container with a resistant inner liner. Separate from acids.Keep away from metals. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Store in accordance with local regulations. Store in original


M-ROW-144-V4



SECTION 7: Handling and storageNeutralization Buffer container protected from direct sunlight in a dry, cool and

well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

7.3 Specific end use(s)

Recommendations :

:Industrial sector specific solutions


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Industrial applications, Professional applications.

Agendia NGS Hyb 1 Industrial applications, Professional applications.Agendia NGS Hyb 2 Industrial applications, Professional applications.Agendia NGS Hyb 4 Industrial applications, Professional applications.Agendia NGS Binding Buffer










SECTION 8: Exposure controls/personal protection

Recommended monitoring procedures

If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to monitoring standards, such as the following: European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042 (Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents) Reference to national guidance documents for methods for the determination of hazardous substances will also be required.

:

8.1 Control parameters

Occupational exposure limits

No exposure limit value known.


M-ROW-144-V4




Agendia NGS Hyb 1Sodium chloride DNEL Short term Oral 126.65 mg/

kg bw/dayGeneral population

Systemic

DNEL Long term Oral 126.65 mg/kg bw/day

General population

Systemic

DNEL Short term Dermal 126.65 mg/kg bw/day

General population

Systemic

DNEL Long term Dermal 126.65 mg/kg bw/day

General population

Systemic


Workers Systemic


Workers Systemic

DNEL Short term Inhalation

443.28 mg/m³

General population

Systemic

DNEL Long term Inhalation

443.28 mg/m³

General population

Systemic


2068.62 mg/m³

Workers Systemic


2068.62 mg/m³

Workers Systemic



0.6 mg/m³ General population

Local


1.2 mg/m³ General population

Local


1.5 mg/m³ Workers Local


3 mg/m³ Workers Local

DNEL Long term Oral 25 mg/kg bw/day

General population

Systemic

Agendia NGS Binding BufferSodium chloride DNEL Short term Oral 126.65 mg/

kg bw/dayGeneral population

Systemic

DNEL Long term Oral 126.65 mg/kg bw/day

General population

Systemic


General population

Systemic


General population

Systemic


Workers Systemic


Workers Systemic


443.28 mg/m³

General population

Systemic


443.28 mg/m³

General population

Systemic


2068.62 mg/m³

Workers Systemic


2068.62 mg/m³

Workers Systemic

Product/ingredient name Exposure Value Population Effects

PNECs

No PNECs available

DNELs/DMELs

Type


M-ROW-144-V4




Hand protection

Based on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Respirators must be used according to a respiratory protection program to ensure proper fitting, training, and other important aspects of use.

Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary.

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields.

Eye/face protection

Respiratory protection :

:

:

Skin protection

Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

:

Environmental exposure controls

: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Appropriate engineering controls

: Good general ventilation should be sufficient to control worker exposure to airborne contaminants.

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period.Appropriate techniques should be used to remove potentially contaminated clothing.Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

8.2 Exposure controls

Hygiene measures :

Individual protection measures

Body protection :

Other skin protection Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

SECTION 9: Physical and chemical properties

Physical state Agendia NGS Nuclease-Free Water

Liquid.

Agendia NGS Hyb 1 Liquid.Agendia NGS Hyb 2 Liquid.Agendia NGS Hyb 4 Liquid.Agendia NGS Binding Buffer

Liquid.


Liquid.


Liquid.


Liquid.


Liquid.


Colourless.

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 Not available.Agendia NGS Binding Buffer

Not available.

Colour

:

:

9.1 Information on basic physical and chemical properties

Appearance


M-ROW-144-V4




Melting point/freezing point Agendia NGS Nuclease-Free Water

0°C

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 0°CAgendia NGS Binding Buffer

Not available.


0°C


Odourless.


Not available.


Not available.


Not available.


Not available.


Not available.

Odour

pH


Not available.


Not available.


Not available.


Not available.


7

Agendia NGS Hyb 1 7.4Agendia NGS Hyb 2 8Agendia NGS Hyb 4 5.2 to 6.2Agendia NGS Binding Buffer

7.1 to 8.1


6.5 to 7.5


6.8 to 7.8


12.2 to 13.4


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Odour threshold

:

:

:

:


M-ROW-144-V4





100°C

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 100°CAgendia NGS Binding Buffer

Not available.


100°C


100°C


100°C


Not available.

Initial boiling point and boiling range


0°C


0°C


Not available.

Evaporation rate Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


7.3 (butyl acetate = 1)


Not available.


Not available.

Flash point Agendia NGS Nuclease-Free Water

Not applicable.


Not available.


Not available.


Not available.


Not available.


Not available.

:

:

:

Flammability (solid, gas) : Agendia NGS Nuclease-Free Water

Not applicable.


Not applicable.


Not applicable.


Not applicable.


M-ROW-144-V4




Vapour pressure

Relative density

Vapour density


1.0 [@ 3.98°C (39.16°F)]


Not available.


Not available.


Not available.

Agendia NGS Elution Not available.


0.62 [Air = 1]


Not available.


Not available.


Not available.


Not available.


Not available.


3.2 kPa [room temperature]


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Upper/lower flammability or explosive limits

:

:

:

:


Not applicable.


Not applicable.


M-ROW-144-V4




Solubility(ies)

BufferAgendia NGS Neutralization Buffer

Not available.


Easily soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 1 Soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 2 Soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 4 Easily soluble in the following materials: cold water and hot water.








Not available.


Soluble in the following materials: cold water and hot water.

Auto-ignition temperature Agendia NGS Nuclease-Free Water

Not applicable.


Not available.


Not available.


Not available.


Not available.


Not available.


-1.38


Not available.


Not available.


Not available.


Not available.


Not available.

Partition coefficient: n-octanol/water

:

:

:

Decomposition temperature : Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


Not available.


M-ROW-144-V4





Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Viscosity Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Explosive properties :

:


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Oxidising properties :

9.2 Other information


Not available.


Not available.

No additional information.


M-ROW-144-V4



SECTION 10: Stability and reactivity

10.4 Conditions to avoid Agendia NGS Nuclease-Free Water

No specific data.


No specific data.


The product is stable.

Agendia NGS Hyb 1 The product is stable.Agendia NGS Hyb 2 The product is stable.Agendia NGS Hyb 4 The product is stable.Agendia NGS Binding Buffer










10.2 Chemical stability :

:

10.3 Possibility of hazardous reactions


Under normal conditions of storage and use, hazardous reactions will not occur.

Agendia NGS Hyb 1 Under normal conditions of storage and use, hazardous reactions will not occur.













10.1 Reactivity : Agendia NGS Nuclease-Free Water

No specific test data related to reactivity available for this product or its ingredients.

Agendia NGS Hyb 1 No specific test data related to reactivity available for this product or its ingredients.














M-ROW-144-V4



SECTION 10: Stability and reactivity

10.6 Hazardous decomposition products


No specific data.


No specific data.


No specific data.


No specific data.


Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Agendia NGS Hyb 1 Under normal conditions of storage and use, hazardous decomposition products should not be produced.













:

10.5 Incompatible materials


May react or be incompatible with oxidising materials.

Agendia NGS Hyb 1 May react or be incompatible with oxidising materials.Agendia NGS Hyb 2 May react or be incompatible with oxidising materials.Agendia NGS Hyb 4 May react or be incompatible with oxidising materials.Agendia NGS Binding Buffer







Reactive or incompatible with the following materials:

acidsmetals



SECTION 11: Toxicological information

Acute toxicity

Agendia NGS Hyb 1Sodium chloride LD50 Oral Rat 3000 mg/kg -


LD50 Oral Rat 2 g/kg -

Agendia NGS Binding BufferSodium chloride LD50 Oral Rat 3000 mg/kg -

Product/ingredient name Result Species Dose Exposure

11.1 Information on toxicological effects


M-ROW-144-V4




Carcinogenicity

Mutagenicity

Conclusion/Summary : Not available.

Irritation/Corrosion

Agendia NGS Hyb 1Sodium chloride Eyes - Moderate irritant Rabbit - 24 hours 100

milligrams-

Eyes - Moderate irritant Rabbit - 10 milligrams -Skin - Mild irritant Rabbit - 24 hours 500

milligrams-

Agendia NGS Binding BufferSodium chloride Eyes - Moderate irritant Rabbit - 24 hours 100

milligrams-

Eyes - Moderate irritant Rabbit - 10 milligrams -Skin - Mild irritant Rabbit - 24 hours 500

milligrams-

Product/ingredient name Result Score Exposure Observation

Sensitiser


Species

Acute toxicity estimates


Teratogenicity


Reproductive toxicity



Not available.

Agendia NGS Hyb 1 Routes of entry anticipated: Oral, Dermal, Inhalation.Agendia NGS Hyb 2 Routes of entry anticipated: Oral, Dermal, Inhalation.Agendia NGS Hyb 4 Not available.Agendia NGS Binding Buffer

Not available.


Not available.


Not available.

Agendia NGS Elution Routes of entry anticipated: Oral, Dermal, Inhalation.

Information on likely routes of exposure

:


Agendia NGS Hyb 1Sodium chloride 3000 N/A N/A N/A N/A

Agendia NGS Hyb 2Agendia NGS Hyb 2 13698.6 N/A N/A N/A 10.3Disodium dihydrogen ethylenediaminetetraacetate 2000 N/A N/A N/A 1.5

Agendia NGS Hyb 4Agendia NGS Hyb 4 128800 N/A N/A N/A N/ASulfuric acid monododecyl ester sodium salt (1:1) 1288 N/A N/A N/A N/A

Agendia NGS Binding BufferSodium chloride 3000 N/A N/A N/A N/A

Oral (mg/kg)

Dermal (mg/kg)

Inhalation (gases)(ppm)

Inhalation (vapours)

(mg/l)

Inhalation (dusts

and mists)(mg/l)


M-ROW-144-V4




Potential acute health effects

BufferAgendia NGS Neutralization Buffer

Routes of entry anticipated: Oral, Dermal, Inhalation.

Inhalation : Agendia NGS Nuclease-Free Water
























:Ingestion

Skin contact : Agendia NGS Nuclease-Free Water











Causes skin irritation.



Agendia NGS Hyb 1 Causes serious eye irritation.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer






Agendia NGS Elution No known significant effects or critical hazards.

:Eye contact


M-ROW-144-V4



SECTION 11: Toxicological informationBufferAgendia NGS Neutralization Buffer

Causes serious eye irritation.

Symptoms related to the physical, chemical and toxicological characteristics

Skin contact

Ingestion

Inhalation Agendia NGS Nuclease-Free Water

No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.



irritationredness

:

:

:

Eye contact : Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 Adverse symptoms may include the following:pain or irritationwateringredness

Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


M-ROW-144-V4




Potential chronic health effects



Agendia NGS Hyb 1 No known significant effects or critical hazards.Agendia NGS Hyb 2 May cause damage to organs through prolonged or

repeated exposure.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer










General :













Carcinogenicity :


No specific data.


No specific data.


No specific data.



pain or irritationwateringredness

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Short term exposure

Long term exposure

Potential immediate effects

Potential delayed effects

:

:

Potential immediate effects

Potential delayed effects

:

:

Not available.

Not available.

Not available.

Not available.


M-ROW-144-V4



SECTION 11: Toxicological informationAgendia NGS Nuclease-Free Water












Mutagenicity :













Teratogenicity :

Developmental effects : Agendia NGS Nuclease-Free Water












Fertility effects : Agendia NGS Nuclease-Free Water













M-ROW-144-V4



SECTION 12: Ecological information

Mobility Not available.:

LogPow BCF Potential

12.3 Bioaccumulative potential


Agendia NGS Nuclease-Free WaterWater -1.38 - low


-4.3 1.8 low

Product/ingredient name Aquatic half-life Photolysis Biodegradability

Agendia NGS Nuclease-Free WaterWater - - Readily

12.1 Toxicity

Agendia NGS Hyb 1Sodium chloride Acute EC50 4.74 g/L Fresh water Algae - Chlamydomonas

reinhardtii96 hours

Acute EC50 519.6 mg/l Fresh water Crustaceans - Cypris subglobosa

48 hours

Acute IC50 6.87 g/L Fresh water Aquatic plants - Lemna minor 96 hoursAcute LC50 1000000 μg/l Fresh water Fish - Morone saxatilis - Larvae 96 hoursChronic LC10 781 mg/l Fresh water Crustaceans - Hyalella azteca -

Juvenile (Fledgling, Hatchling,Weanling)

3 weeks

Chronic NOEC 6 g/L Fresh water Aquatic plants - Lemna minor 96 hoursChronic NOEC 0.314 g/L Fresh water Daphnia - Daphnia pulex 21 daysChronic NOEC 100 mg/l Fresh water Fish - Gambusia holbrooki -

Adult8 weeks

Agendia NGS Binding BufferSodium chloride Acute EC50 4.74 g/L Fresh water Algae - Chlamydomonas

reinhardtii96 hours

Acute EC50 519.6 mg/l Fresh water Crustaceans - Cypris subglobosa

48 hours

Acute IC50 6.87 g/L Fresh water Aquatic plants - Lemna minor 96 hoursAcute LC50 1000000 μg/l Fresh water Fish - Morone saxatilis - Larvae 96 hoursChronic LC10 781 mg/l Fresh water Crustaceans - Hyalella azteca -

Juvenile (Fledgling, Hatchling,Weanling)

3 weeks

Chronic NOEC 6 g/L Fresh water Aquatic plants - Lemna minor 96 hoursChronic NOEC 0.314 g/L Fresh water Daphnia - Daphnia pulex 21 daysChronic NOEC 100 mg/l Fresh water Fish - Gambusia holbrooki -

Adult8 weeks

Product/ingredient name SpeciesResult Exposure

12.2 Persistence and degradability

Not available.

12.4 Mobility in soil

Soil/water partition coefficient (KOC)

Not available.:


M-ROW-144-V4



SECTION 12: Ecological information

12.6 Other adverse effects No known significant effects or critical hazards.

12.5 Results of PBT and vPvB assessment

:

PBTProduct/ingredient name

Agendia NGS Nuclease-Free WaterWater Not

applicable (Inorganic)

N/A N/A N/A Not applicable (Inorganic)

N/A N/A

P B T vPvB vP vB

SECTION 13: Disposal considerations

Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 2008/98/EC.

Hazardous waste :

The generation of waste should be avoided or minimised wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.

:Methods of disposal

13.1 Waste treatment methods

Product

Packaging

Methods of disposal :

Special precautions :

The generation of waste should be avoided or minimised wherever possible. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible.

This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers.

SECTION 14: Transport information

14.6 Special precautions for user

: Transport within user’s premises: always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.

Additional information

-

-

-

-

-

-

Not regulated. Not regulated.

ADR/RID IMDG IATA

14.1 UN number

14.2 UN proper shipping name

14.3 Transport hazard class(es)

14.4 Packing group

14.5 Environmental hazards

No. No. No.

Not regulated.

-

-

-


M-ROW-144-V4



SECTION 14: Transport information14.7 Transport in bulk according to Annex II of Marpol and the IBC Code

: Not available.

SECTION 15: Regulatory information

Other EU regulations


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer Not applicable.Agendia NGS Wash Buffer 1 Not applicable.Agendia NGS Wash Buffer 2 Not applicable.Agendia NGS Elution Buffer Not applicable.Agendia NGS Neutralization Buffer

Not applicable.

Annex XVII - Restrictions on the manufacture,placing on the market and use of certain dangerous substances,mixtures and articles

:

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

EU Regulation (EC) No. 1907/2006 (REACH)

Annex XIV - List of substances subject to authorisation

Substances of very high concern

None of the components are listed.

Seveso Directive

This product is not controlled under the Seveso Directive.

Annex XIV

None of the components are listed.

Ozone depleting substances (1005/2009/EU)

Not listed.

Prior Informed Consent (PIC) (649/2012/EU)

Not listed.

International regulations

Chemical Weapon Convention List Schedules I, II & III Chemicals

Montreal Protocol (Annexes A, B, C, E)

Not listed.

Stockholm Convention on Persistent Organic Pollutants

Not listed.

Rotterdam Convention on Prior Informed Consent (PIC)

Not listed.

UNECE Aarhus Protocol on POPs and Heavy Metals

Not listed.

Europe : Not determined.

Inventory list

Australia : Not determined.

Canada : Not determined.

China : Not determined.

Japan : Japan inventory (ENCS): All components are listed or exempted.Japan inventory (ISHL): All components are listed or exempted.

New Zealand : Not determined.

Not listed.


M-ROW-144-V4



SECTION 15: Regulatory information

15.2 Chemical safety assessment

This product contains substances for which Chemical Safety Assessments might still be required.

:

Republic of Korea : Not determined.

Philippines : Not determined.

Taiwan : Not determined.

United States : Not determined.

Turkey : Not determined.

Thailand : Not determined.

Viet Nam : Not determined.

SECTION 16: Other informationIndicates information that has changed from previously issued version.

Abbreviations and acronyms

:

Full text of abbreviated H statements

Procedure used to derive the classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

Classification Justification

Agendia NGS Hyb 1Eye Irrit. 2, H319 Calculation method

Agendia NGS Hyb 2STOT RE 2, H373 Calculation method

Agendia NGS Elution BufferMet. Corr. 1, H290 Expert judgment

Agendia NGS Neutralization BufferSkin Irrit. 2, H315 Calculation methodEye Irrit. 2, H319 Calculation method

Agendia NGS Hyb 1H319 Causes serious eye irritation.

Agendia NGS Hyb 2H302 Harmful if swallowed.H332 Harmful if inhaled.H373 (inhalation) May cause damage to organs through prolonged or repeated

exposure if inhaled.H373 May cause damage to organs through prolonged or repeated

exposure.

Agendia NGS Hyb 4H302 Harmful if swallowed.

Agendia NGS Binding BufferH319 Causes serious eye irritation.


ATE = Acute Toxicity EstimateCLP = Classification, Labelling and Packaging Regulation [Regulation (EC) No.1272/2008]DMEL = Derived Minimal Effect LevelDNEL = Derived No Effect LevelEUH statement = CLP-specific Hazard statementN/A = Not availablePBT = Persistent, Bioaccumulative and ToxicPNEC = Predicted No Effect ConcentrationRRN = REACH Registration NumbervPvB = Very Persistent and Very Bioaccumulative


M-ROW-144-V4



SECTION 16: Other information

Date of issue/ Date of revision

Version

Notice to reader

Date of previous issue

:

:

:

20/01/2020

13/02/2018

2

To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

Full text of classifications [CLP/GHS]

H290 May be corrosive to metals.

Agendia NGS Neutralization BufferH315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.

Agendia NGS Hyb 1Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 2Acute Tox. 4, H302 ACUTE TOXICITY (oral) - Category 4Acute Tox. 4, H332 ACUTE TOXICITY (inhalation) - Category 4STOT RE 2, H373 (inhalation) SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE

(inhalation) - Category 2STOT RE 2, H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE

- Category 2

Agendia NGS Hyb 4Acute Tox. 4, H302 ACUTE TOXICITY (oral) - Category 4

Agendia NGS Binding BufferEye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Elution BufferMet. Corr. 1, H290 CORROSIVE TO METALS - Category 1

Agendia NGS Neutralization BufferEye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2STOT SE 3, H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE

(Respiratory tract irritation) - Category 3


M-ROW-144-V4

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