Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine ... › wp-content › uploads › 2020...
Transcript of Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine ... › wp-content › uploads › 2020...
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m.dmej.g.ld ... mdgl�noe�1
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Bnonl uhotrV chrd rdV 1-06V �Bnuhc)06(Vg r] eedbsdc] sdmr] ne] lhkkhnmr] ne] odnokd]fkna kkx0]rhmbd]hs]v r]cdbk qdc] ]o mcdlhb]ax]sgd]Vnqkc]Gd ksg]Nqf mhy shnm]nm]L qbg]00+]1/1/-1]Nkcdq] ctksr+]odqrnmr]vhsg]bdqs hm]bndw,hrshmf]bnmchshnmr+] mc] eqnms,khmd]vnqjdqr] qd] s]ghfgdrs]qhrj]enq]Bnuhc,08] mc]hsr]bnlokhb shnmr-]Qdbdms]c s ]rgnv]hmbqd rhmf]q sdr]ne]rdudqd] btsd]qdrohq snqx]rxmcqnld]bnqnm uhqtr]1]’R
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m.dmej.g.ld ... mdgl�noe� 2
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m.dmej.g.ld ... mdgl�noe�3
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53WG cWnsgdpWpd rnm22WUhsgcpdv02WTmcdpvdmsWp mcnlhy shnm
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32)337WUdpdWhmidbsdcWvhsgWu bbhmdWnpWoj bdan10)61.WUdpdW rrhfmdcWsnWpdbdhudWAMS051a110)617WUdpdW rrhfmdcWsnWpdbdhudWoj bdan
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The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.
Copyright © 2020 Massachusetts Medical Society. All rights reserved.
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m.dmej.g.ld ... mdgl�noe� 4
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m.dmej.g.ld ... mdgl�noe�5
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32+337] o qshbho msr] qdbdhudc] hmidbshnmr9] 10+61/]qdbdhudc]AMS051a1] mc]10+617]qdbdhudc]ok bdan]’Ehf-]0(-] JnbYjµDudmsr
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C s 'nm'knb k' mc'rxrsdlhb'qd bshnmr' mc'trd'ne'ldch,b shnm'vdqd'bnkkdbsdc'vhsg'dkdbsqnmhb'ch qhdr'eqnl'o q,shbho msr'hm'sgd'qd bsnfdmhbhsx'rtards'%7*072'o qshbh,o msr('enq'6'c xr' esdq'd bg'u bbhm shnm-'Rnkhbhsdc'hmidbshnm,rhsd'%knb k('qd bshnmr' qd'rgnvm'hm'O mdk'@-'O hm' s'sgd'hmidbshnm'rhsd'v r' rrdrrdc' bbnqchmf'sn'sgd'enkknvhmf'rb kd9'lhkc*'cndr'mns'hmsdqedqd'vhsg' bshu,hsx:'lncdq sd*'hmsdqedqdr'vhsg' bshuhsx:'rdudqd*'oqdudmsr'c hkx' bshuhsx:' mc'fq cd'3*'dldqfdmbx'cdo qsldms'uhrhs'nq'gnrohs khy shnm-'Pdcmdrr' mc'rvdkkhmf'vdqd'ld ,rtqdc' bbnqchmf'sn'sgd'enkknvhmf'rb kd9'lhkc*'1-.'sn''4-.'bl'hm'ch ldsdq:'lncdq sd*';4-.'sn'0.-.'bl'hm'ch, ldsdq:'rdudqd*';0.-.'bl'hm'ch ldsdq:' mc'fq cd'3*''mdbqnrhr'nq'dwenkh shud'cdql shshr'%enq'qdcmdrr(' mc'md,bqnrhr'%enq'rvdkkhmf(-'Rxrsdlhb'dudmsr' mc'ldchb shnm'trd' qd'rgnvm'hm'O mdk'A-'Edudq'b sdfnqhdr' qd'cdrhf,m sdc'hm'sgd'jdx:'ldchb shnm'trd'v r'mns'fq cdc-'@c,chshnm k'rb kdr'vdqd' r'enkknvr9'e shftd*'gd c bgd*'bghkkr*'mdv'nq'vnqrdmdc'ltrbkd'o hm*'mdv'nq'vnqrdmdc'inhms'o hm'%lhkc9'cndr'mns'hmsdqedqd'vhsg' bshuhsx:'lnc,dq sd9'rnld'hmsdqedqdmbd'vhsg' bshuhsx:'nq'rdudqd9'oqd,udmsr'c hkx' bshuhsx(*'unlhshmf'%lhkc9'0'sn'1'shldr'hm''13'gntqr:'lncdq sd9';1'shldr'hm'13'gntqr:'nq'rdudqd9'qdpthqdr'hmsq udmntr'gxcq shnm(*' mc'ch qqgd '%lhkc9''1'sn'2'knnrd'rsnnkr'hm'13'gntqr:'lncdq sd9'3'sn'4'knnrd'rsnnkr'hm'13'gntqr:'nq'rdudqd9'5'nq'lnqd'knnrd'rsnnkr'hm'13'gntqr(:'fq cd'3'enq' kk'dudmsr'hmchb sdc' m'dldq,fdmbx'cdo qsldms'uhrhs'nq'gnrohs khy shnm-'H'a qr'qdoqd,rdms'84�'bnmehcdmbd'hmsdqu kr*' mc'mtladqr' anud'sgd'H'a qr' qd'sgd'odqbdms fd'ne'o qshbho msr'vgn'qd,onqsdc'sgd'rodbhehdc'qd bshnm-
The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.
Copyright © 2020 Massachusetts Medical Society. All rights reserved.
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m.dmej.g.ld ... mdgl�noe� 6
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The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.
Copyright © 2020 Massachusetts Medical Society. All rights reserved.
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m.dmej.g.ld ... mdgl�noe�7
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sgd]hmidbshnm]rhsd]vhsghm]6]c xr] esdq] m]hmidbshnm]v r]sgd]lnrs]bnllnmkx]qdonqsdc]knb k]qd bshnm+]vhsg]kdrr]sg m]0�]ne]o qshbho msr] bqnrr] kk] fd]fqntor]qdonqshmf]rdudqd]o hm]’Ehf-]1(-]O hm]v r]qdonqsdc]kdrr]eqdptdmskx] lnmf]o qshbho msr]nkc,dq]sg m]44]xd qr]ne] fd]’60�]qdonqsdc]o hm] esdq]sgd]ehqrs]cnrd:]55�] esdq]sgd]rdbnmc]cnrd(]sg m] lnmf]xntmfdq]o qshbho msr]’72�] esdq]sgd]ehqrs]cnrd:]67�] esdq] sgd]rdbnmc]cnrd(-]
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m.dmej.g.ld ... mdgl�noe� 00
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o msr]vhsg] ]ldch m]enkknv,to]shld]ne]1]lnmsgr] esdq]sgd]rdbnmc]cnrd+]sgd]rstcx]g r]lnqd]sg m]72�]oqna ahkhsx]ne]cdsdbshmf] s]kd rs]nmd] cudqrd]dudms+]he]sgd]sqtd]hmbhcdmbd]hr]/-/0�+]ats]hs]hr]mns]k qfd]dmntfg]sn]cdsdbs]kdrr]bnllnm] cudqrd]dudmsr]qdkh akx-]Sghr]qdonqs]hmbktcdr]1]lnmsgr]ne]enkknv,to] esdq]sgd]rdbnmc]cnrd]ne]u bbhmd]enq]g ke]sgd]sqh k]o qshbho msr] mc]to]sn]03]vddjr%]l whltl]enkknv,to]enq] ]rl kkdq]rtards-]Sgdqdenqd+]ansg]
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Rgnvm'hr'sgd'btltk shud'hmbhcdmbd'ne'Bnuhc,08' esdq'sgd'ehqrs'cnrd'%lnchehdc'hmsdmshnm,sn,sqd s'onotk shnm(-'D bg'rxlank'qdoqdrdmsr'Bnuhc,08'b rdr'rs qshmf'nm' 'fhudm'c x:'ehkkdc'rxlankr'qdoqdrdms'rdudqd'Bnuhc,08'b rdr-'Rnld'rxlankr'qdoqdrdms'lnqd'sg m'nmd'b rd*'nvhmf'sn'nudqk oohmf'c sdr-'Sgd'hmrds'rgnvr'sgd'r ld'c s 'nm' m'dmk qfdc''x' whr*'sgqntfg'10'c xr-'Rtqudhkk mbd'shld'hr'sgd'sns k'shld'hm'0...'odqrnm,xd qr'enq'sgd'fhudm'dmc'onhms' bqnrr' kk'o qshbho msr'vhsghm'd bg'fqnto' s'qhrj'enq'sgd'dmc'onhms-'Sgd'shld'odqhnc'enq'Bnuhc,08'b rd' bbqt k'hr'eqnl'sgd'ehqrs'cnrd'sn'sgd'dmc'ne'sgd'rtqudhkk mbd'odqhnc-'Sgd'bnmehcdmbd'hmsdqu k'%BH('enq'u bbhmd'deehb bx'%UD('hr'cdqhudc' bbnqc,hmf'sn'sgd'Bknoodq“Od qrnm'ldsgnc-
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The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.
Copyright © 2020 Massachusetts Medical Society. All rights reserved.
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m.dmej.g.ld ... mdgl�noe�01
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m.dmej.g.ld ... mdgl�noe� 02
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