Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine ... › wp-content › uploads › 2020...

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Transcript of Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine ... › wp-content › uploads › 2020...

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    The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.

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    sgd]hmidbshnm]rhsd]vhsghm]6]c xr] esdq] m]hmidbshnm]v r]sgd]lnrs]bnllnmkx]qdonqsdc]knb k]qd bshnm+]vhsg]kdrr]sg m]0�]ne]o qshbho msr] bqnrr] kk] fd]fqntor]qdonqshmf]rdudqd]o hm]’Ehf-]1(-]O hm]v r]qdonqsdc]kdrr]eqdptdmskx] lnmf]o qshbho msr]nkc,dq]sg m]44]xd qr]ne] fd]’60�]qdonqsdc]o hm] esdq]sgd]ehqrs]cnrd:]55�] esdq]sgd]rdbnmc]cnrd(]sg m] lnmf]xntmfdq]o qshbho msr]’72�] esdq]sgd]ehqrs]cnrd:]67�] esdq] sgd]rdbnmc]cnrd(-]

  • m.dmej.g.ld ... mdgl�noe� 8

    R edsvV lcVDeehb bvVneVsgdVAMS021a1VT bbhld

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  • m.dmej.g.ld ... mdgl�noe�0�

    Rg d 9mdu9dmej mc9 inrom j 9 n e 9ldcgagmd

    shnm]odqhnc]ne]4]c xr+0/]hmchb shmf]sgd]d qkx]nmrds]ne] ]o qsh kkx]oqnsdbshud]deedbs]ne]hlltmhy shnm-]Sgd]rstcx]v r]mns]cdrhfmdc]sn] rrdrr]sgd]deehb bx]ne] ] rhmfkd,cnrd] qdfhldm-] Mdudqsgdkdrr+] hm] sgd]hmsdqu k]adsvddm]sgd]ehqrs] mc]rdbnmc]cnrdr+]sgd]nardqudc] u bbhmd] deehb bx] f hmrs]Bnuhc,08]v r]41�+] mc]hm]sgd]ehqrs]6]c xr] esdq]cnrd]1+]hs]v r]80�+]qd bghmf] etkk]deehb bx] f hmrs]chrd rd]vhsg]nmrds] s]kd rs]6]c xr] esdq]cnrd]1-]Ne]sgd]0/]b rdr]ne]rdudqd]Bnuhc,08]sg s]vdqd]nardqudc] esdq]sgd]ehqrs]cnrd+]nmkx]0]nbbtqqdc]hm]sgd]u bbhmd]fqnto-]Sghr]ehmchmf] hr]bnmrhrsdms]vhsg]nudq kk]ghfg]de,ehb bx] f hmrs] kk]Bnuhc,08]b rdr-]Sgd]rdudqd]b rd]rokhs] oqnuhcdr] oqdkhlhm qx] duhcdmbd] ne] u bbhmd,ldch sdc] oqnsdbshnm] f hmrs] rdudqd] chrd rd+] k,kduh shmf]l mx]ne]sgd]sgdnqdshb k]bnmbdqmr]nudq]u bbhmd,ldch sdc]chrd rd]dmg mbdldms-00

    Sgd] e unq akd]r edsx]oqnehkd]nardqudc]ctqhmf]og rd]0]sdrshmf]ne]AMS051a13+7]v r]bnmehqldc]hm]sgd]og rd]1.2]onqshnm]ne]sgd]sqh k-]

  • m.dmej.g.ld ... mdgl�noe� 00

    R edsvV lcVDeehb bvVneVsgdVAMS021a1VT bbhld

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    o msr]vhsg] ]ldch m]enkknv,to]shld]ne]1]lnmsgr] esdq]sgd]rdbnmc]cnrd+]sgd]rstcx]g r]lnqd]sg m]72�]oqna ahkhsx]ne]cdsdbshmf] s]kd rs]nmd] cudqrd]dudms+]he]sgd]sqtd]hmbhcdmbd]hr]/-/0�+]ats]hs]hr]mns]k qfd]dmntfg]sn]cdsdbs]kdrr]bnllnm] cudqrd]dudmsr]qdkh akx-]Sghr]qdonqs]hmbktcdr]1]lnmsgr]ne]enkknv,to] esdq]sgd]rdbnmc]cnrd]ne]u bbhmd]enq]g ke]sgd]sqh k]o qshbho msr] mc]to]sn]03]vddjr%]l whltl]enkknv,to]enq] ]rl kkdq]rtards-]Sgdqdenqd+]ansg]

    Ehftpd—2-—DeehbVbx—ne—AMS051a1—VfVhmrs—Bnuhc,08—Vesdp—sgd—Ehprs—Cnrd-

    Rgnvm'hr'sgd'btltk shud'hmbhcdmbd'ne'Bnuhc,08' esdq'sgd'ehqrs'cnrd'%lnchehdc'hmsdmshnm,sn,sqd s'onotk shnm(-'D bg'rxlank'qdoqdrdmsr'Bnuhc,08'b rdr'rs qshmf'nm' 'fhudm'c x:'ehkkdc'rxlankr'qdoqdrdms'rdudqd'Bnuhc,08'b rdr-'Rnld'rxlankr'qdoqdrdms'lnqd'sg m'nmd'b rd*'nvhmf'sn'nudqk oohmf'c sdr-'Sgd'hmrds'rgnvr'sgd'r ld'c s 'nm' m'dmk qfdc''x' whr*'sgqntfg'10'c xr-'Rtqudhkk mbd'shld'hr'sgd'sns k'shld'hm'0...'odqrnm,xd qr'enq'sgd'fhudm'dmc'onhms' bqnrr' kk'o qshbho msr'vhsghm'd bg'fqnto' s'qhrj'enq'sgd'dmc'onhms-'Sgd'shld'odqhnc'enq'Bnuhc,08'b rd' bbqt k'hr'eqnl'sgd'ehqrs'cnrd'sn'sgd'dmc'ne'sgd'rtqudhkk mbd'odqhnc-'Sgd'bnmehcdmbd'hmsdqu k'%BH('enq'u bbhmd'deehb bx'%UD('hr'cdqhudc' bbnqc,hmf'sn'sgd'Bknoodq“Od qrnm'ldsgnc-

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    The New England Journal of Medicine Downloaded from nejm.org on December 14, 2020. For personal use only. No other uses without permission.

    Copyright © 2020 Massachusetts Medical Society. All rights reserved.

  • m.dmej.g.ld ... mdgl�noe�01

    Rg d 9mdu9dmej mc9 inrom j 9 n e 9ldcgagmd

    sgd]nbbtqqdmbd]ne] cudqrd]dudmsr]lnqd]sg m]1]sn]2-4] lnmsgr] esdq] sgd] rdbnmc] cnrd] mc] lnqd]bnloqdgdmrhud] hmenql shnm] nm] sgd] ctq shnm] ne]oqnsdbshnm] qdl hm] sn] ad] cdsdqlhmdc-]

  • m.dmej.g.ld ... mdgl�noe� 02

    R edsvV lcVDeehb bvVneVsgdVAMS021a1VT bbhld

    ,oodlchvSgd] tsgnqr%] eehkh shnmr] qd] r]enkknvr9]Etmc bhnm]HME