S1475 as703026
1
Product Information AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 inhibited growth and survival of MM cells (cell IC50 ranging from 0.005 to 2 μM) and cytokine-induced osteoclast differentiation more potently (9- to 10-fold) than AZD6244. Inhibition of proliferation induced by AS703026 was mediated by G0-G1 cell cycle arrest and was accompanied by reduction of MAF oncogene expression. Importantly, AS703026 sensitized MM cells to a broad spectrum of conventional (dexamethasone, melphalan), novel or emerging (lenalidomide, perifosine, bortezomib, rapamycin) anti-MM therapies. [1] Biological Activity [1] Kim K et al. Br J Haematol. 2010 May; 149(4):537-49 References Novel Kinase Inhibitors for cell signaling & oncology research S1475 AS703026 Technical Data: M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 431.20 C15H15FIN3O3 Unknown 99% at -20℃ 2 years 1236699-92-5 Notes NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE. Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem. Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must be received from our customer service team. Returns accepted will be subject to a 30% restocking charge. For all product returns and product replace- ments,please contact Selleck directly by [email protected] or +1-713-922-4115. Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt. Fax: +1-713-796-9816 Toll Free: (877)796-6397 -- USA and Canada only -- © Copyright 2010 Selleck chemicals. Orders +1-713-922-4115 [email protected] Web www.selleckchem.com Tech Support [email protected] (chemistry support) [email protected] (bio support) Please visit www.selleckchem.com to download MSDS and CoA. MSDS & CoA Return Policy Selleck Overnight Delivery Service Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 .Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet. ℃ Synonyms: MSC1936369B » MEK I F H N N H N O OH OH
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Transcript of S1475 as703026
Product Information
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 inhibited growth and survival of MM cells (cell IC50 ranging from 0.005 to 2 µM) and cytokine-induced osteoclast differentiation more potently (9- to 10-fold) than AZD6244. Inhibition of proliferation induced by AS703026 was mediated by G0-G1 cell cycle arrest and was accompanied by reduction of MAF oncogene expression. Importantly, AS703026 sensitized MM cells to a broad spectrum of conventional (dexamethasone, melphalan), novel or emerging (lenalidomide, perifosine, bortezomib, rapamycin) anti-MM therapies. [1]
Biological Activity
[1] Kim K et al. Br J Haematol. 2010 May; 149(4):537-49
References
Novel Kinase Inhibitors for cell signaling & oncology research
S1475 AS703026
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
431.20C15H15FIN3O3
Unknown99%at -20℃ 2 years1236699-92-5
Notes
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
Please inspect packages immediately upon
receipt and notify customer service within
3 days of delivery of any damage or
discrepancies.Our team will take quick and
appropriate action to correct any problem.
Goods ordered in error can only be accepted
for return if made within 3 days of delivery,
are unopened,have been stored correctly and
are in good condition. Should you wish to
return any item(s), prior authorization must
be received from our customer service team.
Returns accepted will be subject to a 30%
restocking charge.
For all product returns and product replace-
ments,please contact Selleck directly by
+1-713-922-4115.
Please have on hand, the invoice number,
purchase order number,air bill number and
approximate date of shipment/receipt.
Fax: +1-713-796-9816
Toll Free: (877)796-6397-- USA and Canada only --
© Copyright 2010 Selleck chemicals.
Orders+1-713-922-4115
Webwww.selleckchem.com
Tech [email protected](chemistry support)
[email protected](bio support)
Please visit www.selleckchem.com to download MSDS and CoA.
MSDS & CoA
Return Policy
Selleck Overnight Delivery Service
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under
the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended
storage temperature,most are recommended stored at -20 .Many products are stable in the short-term at temperatures that differ from that
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save
you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage
recommendations on the product data sheet.
℃
Synonyms: MSC1936369B
» MEK
I
FHN
N
HNO OH
OH
