RxQuotient Jan09 Final

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    JJ AANNUUAARRYY22000099

    Pharma Perception Research

    RxQuotient

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    Brand India has in the past few years gained significant

    recognition globally, due to pre-dominant contributions from

    two driving sectors of the Indian economy- Information

    Technology and Pharmaceuticals. While Pharmas muchtouted cousin IT, has catapulted its synergies to surge ahead,

    the Indian Pharmaceutical industry, seems to be in a state of

    perpetual quandary, ever since the turn of the new

    millennium.

    Circa 2005 was expected to change the rules of the Pharma

    business. For survival in the patent era post-2005, New Drug

    Discovery and Exports were prescribed as the panacea - in

    contrast to the 1970s patent regulation that gave Indian

    Pharma the fillip to have global operations as also ability to

    manufacture medicines at low cost.

    To understand what the industry observers- analysts and

    journalists- perceive of Indian Pharma and its future outlook,

    RxQuotient - the Healthcare Research Initiative of Adfactors

    PR conducted a perception study in December 2006

    constituting Mumbai journalists. Following it-up is the current

    study in November 2008 comprising Mumbai based analysts as

    well as journalists.

    RxQuotient observes a positive perception change vis--vis

    2006 doubt about Indian Pharmas ability to discover a new

    drug is replaced with confidence in 2008 - confidence that is

    the outcome of number of molecules in the clinical stage and

    out-licensing deals struck by Indian companies. Indian

    companies capability to take the product to the market on

    their own is an obstacle some feel which, if overcome can

    boost the image of the country and industry. Earlier, Indian

    pharma companies brought Brand India on the global stage

    based on cost advantage and quality products: Can Indian

    Pharma repeat the same feat in New Drug Discovery Research?

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    RxQuotient is not presenting a statistical view of the two key

    stakeholders perceptions based on the responses to the

    structured questionnaire. What it does present, are theexpectations and understanding of Indian Pharma by analysts

    and journalists- two stakeholders, key audience for the Indian

    Pharma industry.

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    is a positive development for the industry and opened up

    opportunities for collaboration with multinational players.

    It established Indias reputation for scientific (chemistry)

    capability. Yet the CRAMS business is being seen as a short

    term advantage; the Eastern European or Far Eastern

    companies might soon catch up on the cost advantage.

    Competitive advantage for the Indian companies would

    rest on the capability to add value.

    RENEWED INTEREST IN THE DOMESTIC MARKETThe Indian domestic market growing at around 15% is

    under the radar again. Companies like Mankind, whichhave gained strength in the domestic market, are being

    watched.

    THE BIG SURPRISEThat the countrys largest pharma company would be the

    first one to sell out was a big surprise to many. Earlier,

    people assumed that Company below a certain size would

    find the going tough and eventually sell out, but withRanbaxy gone, people believe size does not matter.

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    There are thousands of pharmaceutical firms in India but only

    a few gain immediate recall, regard and are tracked by the

    analysts and journalists with no prompts being solicited.

    RxQuotient identifies the stars in the Indian Pharma Galaxy companies that the observers are watching- constantly!

    DR. REDDY SIf there is one company that seems to have been instrumental

    in shaping the learning curve of Indian Pharma, it is Dr.

    Reddys. Be it making a mark in the generics market of

    regulated countries, New Drug Discovery Research, Out-

    licensing deals, unique financing model for research, among a

    host of other initiatives, Dr. Reddys seems to have led the

    pack. The industry observers admire the company and its

    mentor Dr. Anji Reddy.

    CIPLAThis company proves the adage, actions speak louder thanwords. Analysts complain that the management meets and

    talks only once a year- at the AGM. Yet they have their eyes

    set on this company. Reason- the massive expansion that the

    company has undertaken, gives an impression that the

    company is poised for enormous growth. The non-confronting,

    partnership model of the company is perceived advantageous.

    DISHMANSilently executing its CRAMS business and without making

    much noise, Dishman has manages to draw everybodys

    attention.

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    An analyst succinctly captured Indian Pharmas state of

    innovative research thus: t he work of Indian pharma in

    innovati ve research is l ike learning to ride a bicycle- fall ing is

    part of t he learning process . The recent incident of two

    multinationals returning the molecules of an Indian company

    is perceived as a setback- not a downturn.

    While the news of out-licensing deals takes the stock price

    soaring, any hint of negative development plunges stocks.

    Industry observers attribute two reasons to this phenomenon-

    a) The markets dont understand research

    b) Companies build very high expectations

    To tackle the first issue, observers feel, pharma companies

    hived-off their R&D units to attract serious investors (apart

    from cleaning the balance sheet). To deal with the second

    issue, companies management need to bring an attitudinal

    change viz. generate understanding about the research

    process than tom-toming successful closure of out-licensing

    deals.

    Out-licensing may be a good revenue generator it however,

    limits the Indian companys control in the progress of the

    molecule. The experience of multinationals returning the

    molecule to Indian companies has led to the thought whether

    Indian companies can develop capabilities to take their

    molecules beyond the clinical stage to the end market??

    As more companies join the innovative research bandwagon

    and the number of molecules in clinical trials increase,

    confidence in discovery research is growing steadily. Indian

    Pharma and India urgently need an India discovered drug to

    up their credentials in Global Pharma. Not only will this feat

    build Indian Pharmas confidence in innovative research but

    also gain respect for Indian scientific innovations.

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    CRAMS

    Changes in the global pharmaceutical business contributed to

    the advancement of CRAMS opportunities among IndianPharma. Indian biggies like Ranbaxy & Dr. Reddy proved their

    mettle in the US market, garnering confidence in Indian

    Pharmas scientific capabilities. The phenomenal growth in

    International business boosted Indian Pharmas confidence to

    the extent to challenging patents. Convinced about Indian

    Pharmas expertise and to avoid generic companies that were

    posing a challenge, Global MNCs started to deal with

    companies in the CRAMS business, thus opening up a newbusiness segment for Indian Pharma.

    Globally, CRAMS, is not a new business segment; it is new,

    however for Indian Pharma. With the introduction of the IPR

    regime in 2005, outsourcing to India by MNCs gained

    momentum. Indian Pharma equipped with infrastructure and

    scientific skills, which was at crossroads following the patent

    regime, now found MNCs knocking its doors.

    Indian Pharmas growth in the CRAMS business could be

    attributed to three factors:

    Cost control measures by MNCs Environmental concerns in the developed world The IPR regime post 2005

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    GENERICS

    For generics, 2011-12 would be a landmark year for Indian

    Pharma. A number of drugs will go off-patent and the

    generics market will reach its peak. Also, there will be pricing

    pressure on generic players. Growth in the US market will

    start diminishing with more players entering the fray. Infact,

    profitability in the US market has been low, from 2005 itself.

    The emerging markets look more attractive. In the near

    future, Generic exports will continue to be a growth driver for

    Indian Pharma.

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    R e s e a r c h l e d c o m p a n i e s n e e d t o b u i ldu n d e r s t a n d in g a b o u t r e s ea r c h r a t h e r t h a n

    bu i ld ing expec t a t ions on f ina nc i a l s

    F ir s t In d i a r e sea r ched d r ug wi ll give a f il li p t ot h e I n d i a n P h a r m a s r e s e a r c h e ffo r t

    I n d i a n P h a r m a n e e d s t o t h in k a b o u t b r i n g in g an e w d r u g to t h e m a r k e t , r a t h e r t h a n ju s t

    r e s t r i c t ing t o ou t - li cens in g

    U S a n d E u r o p e a n m a r k e t s a r e p e r c e ive d h i gh l ycomp et i ti ve and op por tun i ti e s fo r gr owth

    l imi ted

    B u s in e s s r e a c h i n e m e r g in g m a r k e t s w illi n t e r e s t t h e o b s e r v e r s

    CRAMS is a p r o f it ab l e bus ines s , bu t no t a l ongt e r m p l a y. In d i a n P h a r m a w i ll h a v e to m a i n t a in

    sc ien t i fi c knowledge a dvan t age , no t j u s t cos t

    a d v a n t a g e

    Com pan ies to wa t ch ou t fo r (ob se r ver s v i ew) :CRAMS - Dishm an , Divis an d J ub i lan t

    Gener i cs - S un , P ira m al and Cip la

    MNCs- GSK, Avent is a nd Pfizer

    20 11-12 wi l l be l an dm ar k yea r fo r t h e In d i anp h a r m a i n d u s tr y

    U lt im a t e ly, I n d i a n P h a r m a s r e s e a r c h

    capa b i li t y w i ll de t e r m i ne it s f u t u r e t r a jec t o r y !!!

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    The markets dont understand science. You see stock price goes up with an

    announcement in the R&D space. But people are realizing that there is lot of hype

    surrounding research deals. Eventually, they will start looking at the deals impact

    on net revenue.

    CRAMS is another fashionable word these days. But to be honest, not everyone can

    do CRAMS: maybe just contract manufacturing. Chemistry is difficult.

    Manufacturing capabilities are in place and people are getting orders.

    Q) Tell us something about your interactions with industry leaders?

    CEOs want to give less (information) and talk more. They have become extra

    cautious in dealing with the media maybe because of the regulatory considerations.

    Not much knowledge is shared. Scientific discussions are lacking. Even in press

    releases, there is not much scientific content about products/ research. One needs

    to understand whether the journalist in front of one is a fresher or someone who

    has been tracking the sector for over a decade. One should also remember that the

    journalist meets top people in the industry. Restructuring, plans, etc. are all very

    exciting for your internal employees, but a journalist wants news.

    Q) So, what makes news, for you?

    The surprise element makes news. If you are doing something which someone else

    has done six months back, its not news for the journalist. There has to be a crucial

    element, something new. The size of the company doesnt matter if there is

    something new happening- whether it really has precedence in the world.

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    RxQuotient

    Pharma Perception Research

    RxQuotient is a Research initiative of Adfactors PR Healthcare Team.

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