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![Page 1: Running ‘on-line’ classes to teach (and also assess) how students can retrieve pertinent information on new drugs from the World Wide Web Bevyn Jarrott.](https://reader036.fdocuments.in/reader036/viewer/2022081603/5697c0131a28abf838ccc9a5/html5/thumbnails/1.jpg)
Running ‘on-line’ classes to teach (and also assess) how
students can retrieve pertinent information on new drugs from
the World Wide Web
Bevyn Jarrott and Elizabeth Davis,Department of PharmacologyMonash University, Melbourne,
Australia
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Modern Drug Development
(“better, faster, cheaper”)
3rd Year B.Sc. subjectConsists of 4 Units:
1. Drug Discovery
2. Modern drugs
3. Modern Preclinical Development
4. Clinical Development of drugs
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One of the objectives of the subject (worth 10 % of
marks) is:
• To develop skills in obtaining, evaluating and using scientific information
• to deliver both a written report (= 7%) and a verbal report on new drugs (= 3%)
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Practical session in the Modern Drugs Unit -
Internet searching on new drugs
• Each student uses an Internet connected computer in a 3 hour session
• Students are given one of 8 modern drugs to research
• Students search the WWW for information in a structured way using a proforma
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Internet searching on new drugs
• Drugs are chosen that are generally still in Phase III
• Drugs chosen in 2001:Anakinra Etanercept Herceptin
Inhaled InsulinInfliximab Myocet PEG-Intron Zovant
• Best source of potential new drugs: www.newmedicines.org
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www.newmedicines.org
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Internet searching on new drugs
Drug being researched: ETANERCEPT (Enbrel)1. Manufacturer’s website: www.immunex.com
2. No. of websites found by Google = 5990
3. Most informative websites:
4. Best graphics website:
5. Site for clinical use:
6. Site describing drug’s pharmacokinetics:
7. Site describing drug’s Mechanism of action:
8. Sites describing present status as a drug:
9. Site discussing drug’s pharmacoeconomics:
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Results with Google search engine
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anakinra
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anakinra
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anakinra
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enbrel
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Protocol to compare inhaled Vs subcut
insulin
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Response to inhaled insulin Vs subcut.
insulin
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Results with Google search engine
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SCIRUS - the most comprehensive science-specific search engine on the Internet
• Focuses only on web sites containing scientific content (~90 million web pages
• Delves deeper into Web sites by reading vital pdf and Postscript files
• ~1 million US patents
• Peer reviewed journal articles
• ~600K Beilstein abstracts
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SCIRUS - in contrast to GOOGLE
• Filters out non-scientific sites• Finds peer-reviewed articles from
access-controlled databases with 17 million records such as Science Direct, BioMed Central, Ideal, Neuroscion.
• Searches and ranks by relevance (no. of words and no.of hyperlinks) or ranks by date
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Search options – by disease, by drug name, by
drug company
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Receive news on new drugs by e-mail
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Sharing the results found ?
• The best report of each drug could be posted on the IUPHAR Website as:
New Drug of the Month an idea, proposed by Dr Ewen
MacDonald, University of Kuopio, an IUPHAR Teaching Section committee member.
• Independent refereeing of the report would be necessary