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PROCEEDING BOOK

BALI ENDOCRINE UPDATE

(BEU Xl l l )

"EndocrinologY and BeYond"

EDITOR

Prof. Dr. dr. Ketut Suastika, SpPD-KEMD, FINASIM

Prof. Dr. dr. AA. Gd. Budiar:tha, Sp.PD-KEMD, FINASIM

Dr. dr. Wira Gotera, Sp'PD-KEMD, FlNAS|M

Dr. dr. Made Ratna Saraswati, Sp.PD-KEMD, FINASIM

dr. I Made Pande Dwipayana, Sp.PD-KEMD, FINASIM

Aula Nusantara Gedung Agrokompleks

Universitas UdaYana

16-17 APril2016

KATALOG DALAM TERBITAN

BAU ENDOCR|NOTOGT UPDATE (BEU Xilt)

Endocrinology and Beyond

Denpasar, PT. Percetakan Bali

xiv + 138 hlm; 16,5 x24 cm

f SBN : 97 8-602-L672-48-8

BAL| ENDOCRTNOLOGT UPDATE (BEU XiltlEndocrinology and Beyond

EDITOR

Prof. Dr. dr. Ketut Suastika, SpPD-KEMD, FINASIMProf. Dr. dr. AA. Gd. Budiartha, Sp.PD-KEMD, FtNASIMDr. dr. Wira Gotera, Sp.PD-KEMD, FINASIMDr. dr. Made Ratna Saraswati, Sp.PD-KEMD, FINASIMdr. I Made Pande Dwipayana, Sp.pD-KEMD, FtNASIM

Penerbit:

PT. Percetakan Bali, Jl. Gajah Mada l/1 Denpasar gOLlZ,

Telp. (0361) 234723, 23521L

Bali Endocrine Update (BEU) Xlll 2016

DAFTAR ISI

KATA PENGANTAR

DAFTAR ISI

JADWATACARA

SUSUNAN PANITIA

MATERI

DIABETES TREATMENT: PAST, PRESENT, FUTURE

Anak Agung Gde Budiartha

NEW CI-ASSES OF ANTIHYPERGLICEMIC AGENT

I Made Pande Dwipayana

PENGHAMBAT SODIUM GLUCOSE CO-TRANSPORTER 2

(SGLT2 TNHTBTTOR):

OBAT ANTI HIPERGIIKEMIK ORAI YANG TIDAK BERGANTUNG

tNsuuNMade Ratna Saraswati

BENEFIT OF ONCE DAIIY IEVEMIR foT TYPE 2 DM MANAGEMENT


A NEWTHERAPY: ROIE OF GLP-1IN TYPE 2 DM MANAGEMENT

Wira Gotera

KEUNTUNGAN TERAPI BERBASIS INKRETIN PADA DIABETES MELTITUS

TIPE 2: BUKTI DARI BEBERAPA UJI KtlNtS


xill

L2

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20

22

Bali Endocrine Update {BEU} Xlll2015

TRIAT EVALUATING CARDIOVASCU IAR OUTCOM ES WITH

SITAGUffiN (TECOS): CARDIOVASCULAR SAFETY TRIAI .........

Made Ratna Saraswati

HIDDEN FACES OF DIABETES : UNMASKING DIABETIC DYSI'IPEDEMIA &

NEWEST LIPID GUIDETINE ON DM ...............


STATIN THERAPHY IN DIABETES AND CKD : FRIEND OR FOE ?

Wira Gotera

DIAGNOSIS AND TREATMENT OF HYPOGONADISM IN MAIE

A. A. Gede Budhitresna

HIPOGONAD PADA REMAJA .................

I Made Arimbawa

Surgical Endocrinology

Nyoman P. Riasa

PENATALAKSANAAN KAKI DIABETES


THE ROLE OF HYATURONIC ACID PIUS SITVER SUTFADIAZINE IN

THE TREATMENT OF DIABETIC WOUND ............. ............,........ ir........

lNyoman Semadi

sHoutD sutFoNytuREA (su) REMATN AN ACCEPTABIE l't UNE ADD ON

TO METFORMIN THERAPY IN T2DM ? ON FOCUS ON GTIMEPIRTDE

PLUS METFORMTN ..........

SriMurtiwi

INISIASI DAN TITRASI INSUTIN BASAT PADA DIABETES MELTITUS TIPE 2:

FOKUS INSULIN GIARGtNE

Ketut Suastika

DIAGNOSIS DAN TERAPI MEDIK NODULTIROID

Ketut Suastika

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Bali Endocrine Update (BEU) Xlll 2015

SET YOURSETF FREE FROM THYROID DISORDERS .................

Risa Anwar

WORKSHOP: MONITORING GTUKOSA DARAH MANDIRI

Made Ratna Saraswati

SINDROM CUSHING

Ketut Suastika

MANAGEMENT PRE & POST HYPOPHYSECTOMY IN PITUITARYADENOMA .."

Wira Gotera

LAMPI RAN P R ESE NTASI P OSTER

ANAIISIS MASATAH TERKAIT OBAT/DRUG RETATED PROBLEMS (DRPs) pada

PASIEN DIABETES MELTITUS TIPE II NON KOMPTIKASI

Made Ary Sarasmita, Ni Wayan lka Himawari

IDENTIFI KASI MASATAH TERKAIT OBAT/DRUG RELATED PROBLEMS ( DRPS)

PADA PASIEN DIABETES METTITUSTIPE II DENGAN DW..............

Made Ary Sarasmita, Ni Wayan lka Himawari, NKND Jayanthi,

DMA Kencanasari

EVIDENCE BASED MEDICINE PENGGUNAAN ANTIPTATELET SEBAGAI

RHEOLOGIC VASCULAR AGENT PADA PASIEN DIABETES MEILITUS

DENGAN GANGGUAN VASCUTAR

Made Ary Sarasmita

HUBUNGAN STATUS SOSIAT EKONOMI KELUARGA DENGAN KEGEMUKAN

PADA REMAJA SMA DI DENPASAR

Anak Agung Gede Ari Nanda Bhaswara

HUBUNGAN OBESTTAS PADA ORANG TUA DENGAN TERJADINYA OBESITAS

PADA ANAK REMAJA SMA DI KOTA DENPASAR PROVINSI BALI

Theodorus Onesiforus Gozali

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Bali Endocrine Update {BEU) Xlll 2016

HUBUNGAN SINDROM METABOLIK DENGAN KEJADIAN DISFUNGSI EREKSI

PADA PASIEN DIABETES MELTITUS TIPE 2 DI POLIKTINIK PENYAKIT

DALAM RSUP SANGTAH DENPASAR

Ni Putu Tesi Maratni

ASOS|AS| ANTARA PARAMETER ANTROPOMETR|, KADAR SERUM

TRtGtfsERf DA {TG}, DAN GAMMA GLUTAMYL TRANSFERASE (GGT}

DENGAN STEATOSIS HEPAR PADA PEREMPUAN MUDA DENGAN

OBESITAS DI PROVINSI BALI

Tjokorda lstri Pramitasuri, Arya Krisna Manggala

OBESITAS TIDAK TERBUKTI MEMPENGARUHI PENURUNAN TEKANAN

DARAH PADA KETOMPOK PASIEN DENGAN HIPERTENSIDI RUMAH SAKIT

DR. HAUTUSY AMBON TAHUN 2014

Leonard Kencana

GLYCATED ALBUMIN SEBAGAI PENANDA KONTROT GTIKEMIK PADA

PENDERITA DIABETES METITUS TIPE 2

Anselmus Ake, Made Ratna Saraswati, I Gde Raka Widiana

HUBUNGAN ANTARA POLA MAKANAN DENGAN OBESITAS REMAJAPADA S|SWA-SISW| SEKOTAH MENENGAH ATAS (SMA) Dt DENPASAR

Nyoman Arya Shridewi Abhigamika, Made Ratna Saraswati

THE CHARCOAT OSTEOARTHROPATHY (COA) tN 64 YEARS OtD FEMATE

PATIENT WITH DIABETES METIITUS WPE 2

I Gede Agus Aprianta

Atrial Fibrilasi pada Penyakit lantung Tiroid

Ayuningtyas.A.S, D.C.Wulandari, K.Suryana

GRAVES' DISEASE AS A LATE MANIFESTATION OF IMMUNE

RECONSTITUTION INFAMMATORY SYNDROME AFTER HIGHTY ACTIVE

ANTIRETROVIRAL THERAPY IN HIV INFECTED PATIENT

Putu Ayu Sri Saraswati

vill

Bali Endocine Update (BEU) Xffi 2016

SEORANG PENDERITA KRISIS TIROID AI(IBAT STRUMA MUTTINODULAR

TOKSIK YANG DIPICU INFEKSI VIRUS DENGUE

lda Bagus Aditya Nugraha

PROGRAM KEGIATAN CLUB DIAMED,,

HIDUP NYAMAN BERSAMA DIABETES"

I Ketut Pasek, Team PKRS RS BaliMed

PROGRAM KEGIATAN ROYAT DTABETES CIINIC

Doddy, Bali Royal Hospital

EDUKASI MEDIS DAN KONSUTTASI GIZI DI KTINIK SAHABATSEBAGAI

BENTUK KEPEDUTIAN DIABETES

Putu Arya Nugraha, RS Kertha Usada Slngaraja

MENINGKATKAN PERAN AKTIF "CAREGIVER" DALAM PENATATAKSANAAN

DIABETES METITUS

Dewi Catur Wulandari, RSUD Wangaya

PERANAN TOMBA SETFIE MELALUI FACEBOOK SEBAGAI MEDIA EDUKASI

KESEHATAN DATAM UPAYA MENINGKATKAN PUBTIC AWARENESS

TENTANG DIABETES METLITUS DI KABUPATEN SIKA,

PROVINSI NUSA TENGGARA TIMUR

lvan Banjuradja, Asep Purnama, RSUD T.C. Hil lers

KOLABORASI 3P diPUSKESMAS BULETENG II SEBAGAI IMPTEMENTASI

COLLABORATIVE CARE DATAM TATATAKSANA DIABETES METITUS

IGA Raka Mahasadu, Puskesmas Buleleng ll Slngaraja

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IX

Bali Endogine Update (BEU) Xlll2016

THE ROIE OF HYALURONIC ACID PLUS SILVER SULFADIAZINE IN THE

TREATMENT OF DIABETIC WOUND

I Nyoman Semadi

Cardiothoracic and Vascular Division, Department of Surgery,

Faculty of Medicine Udayana University/ Sanglah General Hospital Denpasar

Absffact

fn united states, there are about 23.6 million children and adults or 7'8% of the

population who suffer from diabetes. ln canada an estimated 25% Canadians with

diabetes who develop foot complications and 1 in 15 end up having a limb amputation

during their lifetime. Diabetic foot ulcer (DFUs) is a major complication of diabetes

melfitus and the prevalence of DFUs: !2%to 15%. DFUs patients need lower extremity

amputation (LEA) is t2%. Conva-lateral amputation after 3-5 years is 50 %' Three

years mortality rate is 20-50%. Major increase of morbidity and mortality due to

failure of the wound healing process. A key feature of wound healing is stepwise repair

of lost extracellular matrix {ECM) that forms the largest component of the dermal skin

layer. Non-heqling chronic diabetic ulcers are often treated with extracellular matrix

replacement therapy. lt is a common trend to use such advanced moist wound

therapy, bio-engineered tissue or skin substitute, growth factors, and other' Moist

wound therapy is known to promote fibroblast and keratinocyte proliferation and

migration, collagen synthesis, early angiogenesis and wound contraction. The porpuse

of wound care in manage of diabetic wound is to give optimum protection of

environment wound healing (Hailey, 2007; Pinzur, 2009). Wound was covered,

dressing and bandaging properly to keep optimum environment and prevent bacteria

contamination (Espensen, 2O07; Pinzur, 2009). Moist environment of the wound can

elevate reepitelial and wound healing prosess in a whole body (Barros et al, 2007)'

Hyaloronic acid (HA) is an extracellular matrix component of connective tissue to

have role of wound healing by moist of an environment to grow the tissue and

reepitelisation. Hyaluronic acid has been use long time ago for opthalmology,

connective tissue disease, joint inflamation and rhematoid' Topical aplicatian of HA

give the good result in chronic wound of the diabetic patient (Barrois, 2007; Ballard ,

2009). Coupling the considerations regarding HA activity on the tissue repair in

:=

==a

Bali Endocrine Update (BEU) Xlll2016

diabetic with those supporting SSD application in various types of wounds to control

microbial proliferation, it appaers that simultaneous application of SSD and HA rnay be

rational choice for thetreatment of chronic lesion affecting diabetic'patients. The

available evidence fully support the rationale for clinical use of the formulation here

described in diabetic patient, on the basis of the preclinical data available for each

component in microorganisms, in experimental animal and in human cells.

Key word: hyaluronic acid and silrier sulfadiazine, topical application, wound care

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