Root deep absolute advance iii - clinical backbone

Clinical Backbone

4 Nourishing oils

10 Phytonutrientextracts

17 Keratin resembling plantamino acids

Fall ReductionRoot EnergizingBlockage Clearing

Anti Scalp AgeingDandruff Removal

Shaft StrengtheningVolumizingInstant ShineSmootheningFrizz Control

10 Actions against all 5 concerns of hair fall and decreased

hair density / growth on all 3 parts of hair.

The Everything (Hair) Therapy

Concern Active Ingredient Efficacy data Formulation details

Fall Reduction Pisum sativum sproutextract

Increase of growth coefficient (A/T) by 78% in 12 weeks with improvementin hair and scalp quality by more than 80%

Root Deep Hydroil

Ocimum basilicum hairyroot culture extract

23% increase in dermal papilla cells after 1 month30.7% decrease in hair fall in 2 months

Root Deep Hydroil

Pterocarpus marsupiumbark extract

Reduction of hair fall in male volunteers with androgenic alopecia:Frontal zone – 33% in 4 monthsOccipital zone – 46% in 4 months

Root Deep HydroilRoot Deep Shampoo

Root Energizing Plant extracts withHexapeptides-11

Around 20% decrease in hair removal due to enlargement of hair bulb after5 applications

Elementi PuroRoot Recharge synergy

Vanillyl Butyl Ether 66.4% increase in scalp microcirculation(10 Minutes after application)Increase in IGF-1 production that will lead to increase in Anagen hair density

Elementi PuroRoot Recharge synergy

Blockage Clearing Ocimum basilicum hairyroot culture extract

Upto 80% reduction in sebum as compared to 70% with Finasteride after 72hours

Root Deep Hydroil

Zinc PCA +65% of Anti 5-α reductase activity compared to positive control in 28 days Elementi PuroRoot Recharge synergy

Anti Scalp Aging Pterocarpus marsupiumbark extract

54% of reduction in glycation after 15 days78% of free radical inhibition in spot laboratory studies (in tubo)

Root Deep HydroilRoot Deep Shampoo

Dandruff Removal Piper nigrum fruit extractand Inga alba bark extract

Effective against dandruff-causing bacterial strain at low MICAround 40% reduction in dandruff after 42 daysAround 50% reduction in sebum 42 days

Root Deep HydroilRoot Deep ShampooRoot Deep Intenso Fluid

ShaftStrengthening

Hydrolyzed Pea Protein +4.0 % increase in tensile strength of Hair after each application+4.3 % increase in Cross section area of Hair after each application+5.71 % increase in Hair moisture after each application

Root Deep ShampooRoot Deep Intenso Fluid

++++++++Proven Hair Fall reduction

Pisum sativum sprout extractPisum sativum sprout extract++++++ ++++++

Study design I• Study period of 12 weeks used twice daily

• 20 volunteers of age 21-37

• 17 females with hair in telogen phase > 15%

• 3 males with hair in telogen phase > 20%

Incorporated inRoot Deep Hydroil

ResultsResults++++++ Effect on hair fallEffect on hair fall

ResultsResults++++++ Reduction of Hair fallReduction of Hair fall

ResultsResults++++++ Effect on A/T ratioEffect on A/T ratio

ResultsResults++++++ Response from volunteersResponse from volunteers

++++++ ++++++

Study design II

• Study period of 14 days used twice daily

• 10 volunteers of age 46-60

• 4 females

• 6 males

Pisum sativum sprout extractPisum sativum sprout extract


ResultsResults++++++ Effect on the expression of dermal papilla signaling moleculesEffect on the expression of dermal papilla signaling molecules

• Noggin – A protein that shortens the telogen phase• FGF-7 - Fibroblast growth factor – 7 that initiates new anagen phase

Ocimum basilicum hairy root culture extractOcimum basilicum hairy root culture extract++++++ ++++++

Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starvinghair roots & promotes fuller, denser hair.

5α reductase is the key target enzyme in the inhibition ofhair loss. Basil root Culture extract inhibit 5α reductase.Testosterone will not convert into dihydrotestosterone(DHT) in absence of 5α reductase.

The results showed a clear concentration dependentinhibition of 5α reductase. Consequently, Basil rootCulture extract was able to reduce hair loss in people withandrogenic alopecia.


ResultsResults++++++ Increased proliferation of Dermal papilla cellsIncreased proliferation of Dermal papilla cells


• Study period of 2 months used once daily

• 21 volunteers of age 25-67 with daily hair loss

> 100 strains

• 19 females

• 2 males

Study design


ResultsResults++++++ ++++++

Pterocarpus marsupium bark extractPterocarpus marsupium bark extract++++++ ++++++

• Study period of 6 months used once dailyagainst placebo

• 40 male volunteers of with androgenicalopecia

Study design

Incorporated inRoot Deep HydroilRoot Deep Shampoo

++++++++Proven Root Energizing

Plant extracts with Hexapeptides-11Plant extracts with Hexapeptides-11++++++ ++++++

• Plant extracts like sugar cane extract, Lemonfruit extract, Apple fruit extract, green tealeaf extract along with Hexapetides-11restores hair and scalp vitality at cellularlevel and energizing hair bulb

Incorporated inElementi PuroRoot Recharge Synergy

Plant extracts with Hexapeptides-11Plant extracts with Hexapeptides-11++++++ ++++++

• Study period of 5 days used once daily• 15 volunteers of age 30-60 with hair length

of not less than 12 inches

Study design

Vanillyl Butyl EtherVanillyl Butyl Ether++++++ ++++++

• Enhances microcirculation of blood flowwith lesser irritation and warming sensation Incorporated in

Elementi PuroRoot Recharge Synergy

ResultsResults++++++ Increase in Blood flowIncrease in Blood flow

ResultsResults++++++ Effect on the production of IGF-1Effect on the production of IGF-1

++++++++Proven Blockage Clearing


Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starvinghair roots & promotes fuller, denser hair.

5α reductase is the key target enzyme in the inhibition ofhair loss. Basil root Culture extract inhibit 5α reductase.Testosterone will not convert into dihydrotestosterone(DHT) in absence of 5α reductase.

The results showed a clear concentration dependentinhibition of 5α reductase. Consequently, Basil rootCulture extract was able to reduce hair loss in people withandrogenic alopecia.


Inhibition of 5α reductase


Zinc PCAZinc PCA++++++ ++++++

• Zinc salt of pyrrolidone carboxylic acid, adouble acting complex that optimally alliesthe beneficial effects of zinc and L-PCA,physiological components of the organism.

Incorporated inElementi PuroRoot Recharge Synergy


Inhibition of 5α reductase• Pre-incubation of human Dermal fibroblasts in presence of Zinc PCA / Zinc

chloride and Addition of radioactive (titrated) Testosterone and incubation for 24hours / preparation of cellHomogenates by sonication and Radioactivitymeasurement

• Anti 5-alpha reductase activity of Zinc PCA (+65%) much higher than Zinc chloride(+45%)

• Intrinsic activity of Zinc PCA greater than equimolar quantity of Zinc chloride.

Study design


Inhibition of 5α reductase


Seboregulatory activity• Sebometric study on 2 groups of 16 volunteers after 28 daily application on the

half forehead with a cream containing 1% Zinc PCA vs Placebo and non-treatedzone

Study design

ResultsResults


Antimicrobial activity• Minimum Inhibitory Concentration of Zinc PCA was identified and optimized for

various bacterial and fungal strains.

Study design

ResultsResults

++++++++Proven Anti scalp Aging


• Anti glycation activity• Against aminoguanidine as positive control

Study design

Incorporated inRoot Deep HydroilRoot Deep Shampoo

ResultsResults


• Anti free radical activity


• Test on Keratinocytes:• On the model of UVB induced inflammation against positive control of Aspirin• Incubation period of 72 hours

Anti-inflammatory effect:Study design I

ResultsResults


• Test on Polymorphonuclear neutrophilic granulocytes (PMN):• On the model of UVB induced inflammation against positive control of Minocyclin• Incubation period of 24 hours

Anti-inflammatory effect:Study design II

ResultsResults

++++++++Proven Dandruff Removal

Piper nigrum fruit extract and Inga alba bark extractPiper nigrum fruit extract and Inga alba bark extract++++++ ++++++

• Study period of 6 months used once dailyagainst placebo

• Against Bacterial strains Malassezia globosaand Malassezia furfur, responsible for dandruff,inflammation and irritation

• Incubation period of 48 hours

Anti microbial activity:Study design

Incorporated inRoot Deep HydroilRoot Deep ShampooRoot Deep Intenso Fluid

ResultsResults


• On human keratinocytes on the model of UVBinduced inflammation against positive controlof Aspirin

• Incubation period of 48 hours

Anti inflammatory activity:Study design

ResultsResults


• To evaluate the scalp conditions (dandruff, sebum) against a shampoo with 1%zinc pyrithione, after 4 weeks of treatment and 2 weeks of remanence period

Improvement of Scalp properties:Study design


Reduction in Dandruff:


Reduction in Sebum:


Response of Volunteers:

++++++++Proven Shaft strengthening

Hydrolyzed Pea ProteinHydrolyzed Pea Protein++++++ ++++++

• 17 keratin resembling plant amino acids• Improves hair strength lost by damages• Restores hair moisture and prevents dry hair• Smoothens hair surface

Incorporated inRoot Deep ShampooRoot Deep Intenso Fluid


Tensile strength measurement:


Cross-section measurement:


Hair moisture measurement:

Natural is the most over utilized but perhaps the least specified term in personal care creations.Whenever you make a choice of using natural products, the question is "how much nature does itactually hold"? Subtracting the water part, nature score indicates the exact percentage of naturalingredients in your selected Brillare science product. So the next time when you read our score, countyour nature proximity & be assured of our constant endeavor to keep you as close as possible-tonature.

When it comes to cleaning, sensitive skin/hair possesses the common phenomena of over sensitivitytowards traditional cleansers.Let's clean it with sulphate free, biodegradable cleansers.It's your body & it's your world.Stand By The Environment.

++++++ ++++++

Personal care cosmetics are formulated with dual purpose of action. One is for the concern specificefficacy and other is for the wellness feel it imparts on human body and soul. Active score is brillareresearch laboratory's conscious effort to formulate the personal care cosmetics which carries higherpercentage of concern specific active ingredients. These active ingredients are carefully combinedwith organoleptic advancements in cosmetic base. It brings better efficacy, enhanced nourishmentand greater cosmetic wellness.

The Difference

++++++ ++++++The Difference

Patented#

Anti hair fall andHair regrowth promoting

Nature quantified formulations

India first – World first

# Patent pending for deep penetrating micro-emulsion techniques of Hydroil & Root Recharge Synergy

Root deep absolute advance iii - clinical backbone

Health & Medicine

Transcript of Root deep absolute advance iii - clinical backbone