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Transcript of RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov,...
![Page 1: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/1.jpg)
RNA nanotechnology for computer design and in vivo computation
by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B. Leontis, and Peixuan Guo
Philosophical Transactions AVolume 371(2000):20120310
October 13, 2013
©2013 by The Royal Society
![Page 2: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/2.jpg)
Comparison of the electronic computer and a molecular-scale computer.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 3: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/3.jpg)
Logic-gate systems with Ag+ and Hg2+ ions as inputs and electrochemical signals as output detected by differential pulse voltammetry (DPV).
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 4: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/4.jpg)
Historical outline of RNA nanotechnology.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 5: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/5.jpg)
Significance and uniqueness of RNA nanotechnology.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 6: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/6.jpg)
Fabrication of RNA nanoparticles.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 7: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/7.jpg)
Workflow diagram of functional RNA construction based on the pRNA molecule.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 8: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/8.jpg)
Illustration of toolkits to obtain RNA nanoparticles.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 9: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/9.jpg)
Application RNA nanotechnology for computer design.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 10: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/10.jpg)
AFM images of pRNA nanoparticles obtained by ‘hand-in-hand’ interaction following toolkit no. 1 [87].
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 11: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/11.jpg)
AFM images of pRNA nanoparticles obtained by ‘foot-to-foot’ interaction following toolkit no. 2 [87].
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 12: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/12.jpg)
AFM images of pRNA nanoparticles obtained by ‘foot-to-foot’ interaction following toolkit no. 3 [87].
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society
![Page 13: RNA nanotechnology for computer design and in vivo computation by Meikang Qiu, Emil Khisamutdinov, Zhengyi Zhao, Cheryl Pan, Jeong-Woo Choi, Neocles B.](https://reader035.fdocuments.in/reader035/viewer/2022062802/56649ebc5503460f94bc5824/html5/thumbnails/13.jpg)
The development path of molecular-scale computing.
Meikang Qiu et al. Phil. Trans. R. Soc. A 2013;371:20120310
©2013 by The Royal Society