Risk Factors for Podoconiosis: Kamwenge District, Uganda ... · Podoconiosis in Kamwenge...
Transcript of Risk Factors for Podoconiosis: Kamwenge District, Uganda ... · Podoconiosis in Kamwenge...
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Public Health Fellowship Program – Field Epidemiology Track
Risk Factors for Podoconiosis:
Kamwenge District, Uganda
September 2015
Christine Kihembo, MBchB, MIPH
Fellow, Cohort 2015
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Podoconiosis in Kamwenge
Podoconiosis: Non-filarial elephantiasis
Contact with
irritant soils: red
clays from
alkaline volcanic
rock
Areas >1000m
(330ft), Annual
rainfall of
1000mm
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Disease process
Mineral particles
penetrate skin
Taken up by macrophages
in lymphatics
Inflammation:
(Genetically predisposed)
Lymphatic Fibrosis
and Blockade
Disabling
Lymphedema
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Podoconiosis in Kamwenge
Podoconiosis not documented in
Kamwenge district
Kamwenge
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Podoconiosis in Kamwenge
Events leading to investigation
2014 Early 2015 Aug 2015 Sept 2015
WHO,VCD alerted of
increased cases of
“elephantiasis”
2nd Alert
Investigation
Lymphatic Filariasis
Mapping by MOH, VCD
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Podoconiosis in Kamwenge
Objectives
Identify risk factors for Podoconiosis in
Kamwenge district
Provide evidence for public health action
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Podoconiosis in Kamwenge
Case definition
Suspected Case: Asymmetrical lower limb swelling
(non-pitting oedema) for ≥1mon, plus ≥1 of: – Itching of skin, burning sensation – Plantar-oedema (swelling of sole of foot) – Lymph ooze – Prominent skin markings – Hyperkeratosis(skin hardening) – Formation of moss-like papillomata/nodules – Rigid toes in a Kamwenge resident.
Probable Case: Suspected case with negative microfilaria antigen immunological card test
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Podoconiosis in Kamwenge
Active Case finding in collaboration with:
District health team
Village health team
Office of the RDC
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Podoconiosis in Kamwenge
Case count
52 Suspected cases
40 Probable Cases
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Podoconiosis in Kamwenge
Age distribution of cases
0
4
8
12
16
20
0 20 40 60 80
Attack rate (/1000)
• Cases <13y: 0
• Mean age: 48 (range: 13-80) yrs
Age (years)
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Podoconiosis in Kamwenge
Epidemic curve shows stable number of
cases over time
0
2
4
6
8
10
1980 1990 2000 2010
Year of Onset
Case count
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Podoconiosis in Kamwenge
Higher attacker rates in Busiriba sub-county
Attack Rate/1,000
Overall 1.0
Busiriba Sub-county 1.3
Kamwenge Sub-county 0.65
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Podoconiosis in Kamwenge
Higher attacker rates among females
Attack Rate/1,000
Population
Overall 1.0
Female 1.2
Male 0.29
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Podoconiosis in Kamwenge
Cases spread over 27 villages in two
sub-counties
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Podoconiosis in Kamwenge
Hypothesis generation interview
Risk factor %
(n=24)
Farmers
(growing crops)
100
Never wore shoes at
work
60
Washed feet at end
of day
65
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Podoconiosis in Kamwenge
Case-control study
40 cases
80 controls: Asymptomatic Kamwenge
residents
Matched by Age, Sex and Village of
residence
Foot exposures at home and work:
wearing shoes, type of shoes, washing
feet, floor type/cover.
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Podoconiosis in Kamwenge
Not wearing shoes significantly associated
with disease
Wearing shoes
before
disease onset
Exposure rate (%)
ORM-H
(95% CI)
Cases
n=40
Controls
n= 75
Not wearing
shoes at work 93 31 6.7 (1.7-26)
Not wearing
shoes at home 80 55 4.4 (1.5-13)
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Podoconiosis in Kamwenge
Stratified analysis
Wearing shoes at: ORkiu
95% Cl
Work and home Ref
Work only 4.2 0.74- 24
Home only 5.5 0.32- 87
Neither at work nor
home
8.8 1.9- 40
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Podoconiosis in Kamwenge
Delay in washing feet significantly associated
with disease
Washing feet
after work
OR 95% CI
<2 hours Ref
2-4 hours
4.8
0.89-26
End of Day
11
2.1- 57
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Podoconiosis in Kamwenge
Study area is at high altitude,
rich in volcanic soils
Altitude: 1163-
1328m above sea
level
Deep rich volcanic
fertile soils:
Assessment by
Paulos Chanie
(2014)*
*Innovative Water Resource use & Management for
Poverty Reduction in Sub-saharan Africa
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Podoconiosis in Kamwenge
Differentiation from filarial elephantiasis
Clinical
– Bilateral oedema
– Assymetrical
– Below knee oedema
– No genital involvement
Lab
– Negative filarial test in
40 cases tested
Geographical
– Altitude
– Volcanic soils
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Podoconiosis in Kamwenge
Conclusions
This is non-filarial elephantiasis
consistent with Podoconiosis
Prolonged foot exposure to volcanic
soils is a risk factor for Podoconiosis
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Podoconiosis in Kamwenge
Recommendation
Health education on foot protection and
prompt washing of feet after work
Provision of gumboots to Kamwenge
farmers
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Podoconiosis in Kamwenge
Acknowledgement
Epidemiology & Surveillance Division
– Ben Masiira, PHFP-FET Fellow
– Dr. Monica Musenero
– Dr. Opar Bernard
Vector Control Division
– Gabriel Matwale
World Health Organization
– Dr.Miriam Nanyunja
– William Z.Lari
PHFP
– Dr. Bao-Ping Zhu
– Dr. Ario Alex
– Dr Frank Kaharuza
Kamwenge District Local Government,
District Health Team
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Podoconiosis in Kamwenge
Foot protection ( wearing of shoes)
Odds Ratio
P value
95% CI
Wearing shoes while at work and
home
Reference
Wearing shoes while at work only 4.2 0.104
0.74-23.7
Wearing shoes while at home only
5.5 0.247
0.32-86.7
Not Wearing at all 8.8 0.005 1.91-40.1
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Risk Factors
Cases
Controls
Exposure
rate
Cases
Control
s
Adjusted
Mantel-Hanszel
odds ratio (95%
CI)
Wearing shoes while
at work:
No
37
23
93
31
6.7(1.7-25.8)
Yes 3 52 8 69 Reference
Wearing shoes while
at home
No
32
39
80
55
4.4 (1.5-12.9)
Yes 8 36 20 48 Reference
Family history of
illness similar to
podoconiosis
Yes
22
10
69
31
13.6(3.0-62.3)
No
18
65
45
87
Reference
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Podoconiosis in Kamwenge
Podoconiosis a neglected tropical disease
4million people affected worldwide
5% population in endemic areas: Tropical
Africa, South America, India
Eliminated from North Africa, Europe
High Prevalence 10%
– E. Africa: Ethiopia, Kenya, TZ, Uganda, Rwanda, E.Guinea,
Cameroon
Podoconiosis in Uganda:
–Kapchorwa
–Kabale
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Podoconiosis in Kamwenge
Symptoms among Poconiosis Case-patients
22
75
79
82
85
85
93
98
100
0 20 40 60 80 100 120
Others
Prominent Skin Markings
Rigid Toes
Burning Sensation
Hyperkeratosis
Papillomata Formation
Itchy Skin
Plantar Oedema
Bilateral lower limb swelling
Percentage
(%)
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Podoconiosis in Kamwenge
Distribution of cases by age group
6 8
55
31
0
10
20
30
40
50
60
10-18 19-30 31-60 Above 60
Percentage (%)
Age group (%)