Rifampicin Induced Thrombocytopenia Ppt
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Transcript of Rifampicin Induced Thrombocytopenia Ppt
Sunday, April 9, 20231
RIFAMPICIN INDUCED THROMBOCYTOPENIA
(Rajiv Garg, V. Gupta, S. Mehra, R. Singh and R.Prasad)[Indian J Tuberc 2007]
-Rishikesh H. Autade M.Sc.
(IV Sem)
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“It happens every time! Doc. When I eat Anti-tubercular Drug, immediately develop this nasty rasher on all over my body. My wife thinks that I m Alien.”
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Tuberculosis Mycobacterium
tuberculosis. Transmission. How does
bacteria enters in to Macrophage?
How lesions are formed?
Symptoms.
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Treatment of Tuberculosis Isoniazid -Catalase oxidase Rifampicin -DNA dependent RNA polymerase. Streptomycin -30s Ribosome Ethanmbutanol -Bacterial cell wall Pyraziamide -DNA Replication.
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Rifampicin(1967)
Amycolaptosis rifacolatopsis.
Metabolism
C43H58N4O12
Mycolic acid And Peptidoglycan
How does bacteria get resistance to Rifampicin?
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Adverse Effect (Thrombocytopenia)
Thrombocytopenia is the term used for a reduced platelet (Thrombocyte) count.
150 to 400 million/ml
Platelet- Blood clotting
What is the effect of reduced platelet count?
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Rifampicin
Glycoprotein
Platelet Platelet removed from blood
Drug dependent AntibodyConf. Change in
Glycoprotein
How does rifampicin causes thrombocytopenia?
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Case Study Prpura means
bleeding is seen on the skin in the form of tiny pin prick hemorrhages.
1st evidence of Rafampicin induced thrombocytopenia.
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Discussion
Criteria's for Thrombocytopenia Differentiation.
Major bleeding
-Intracranial and Retroperitoneal
Minor bleeding
-Excessive menstrual bleeding
Trivial bleeding
-Purpurae all over body, Epistaxis.
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Thrombocytopenia
- Ethambutanol, Pyrazinamide. Keep eye on platelet count during
treatment. Use new drugs while restarting the
therapy. Offending drug should not be used again.
Discussion Cont….
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Ethical Issues
Rifampicin was given to the patient with informed consent.
Ethical concerns would have arisen if- - New drug - Without Patients permission.
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Current Research In T.B.
Project - 2001 with EU And WHO.
Gatifloxacin-Reduces treatment period.
Phase II trials- South Africa.
public and private partners.
Expected to come- End of 2009.
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An Apple a day keep Dr. away.
Sunday, April 9, 202314
References
James N George et al. Drug induced thrombocytopenia a systematic review of published case reports. Ann Intern
Med 1998; 129: 886-890. Rifampicin – Sister Mary Gabriel,
Ruttonjee Snatorium, Hong Kong. Pg no. 47-54(the bulletin of hong Kong Medcal Association Vol.25, 1973).