Ribozyme Catalysis of Metabolism in the RNA World

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2007 Biochemistry Z 0250 Ribozyme Catalysis of Metabolism in the RNA World — [81 refs.]. — (CHEN, X.; LI, N.; ELLINGTON*, A. D.; Chem. Biodiversity 4 (2007) 4, 633-655; Dep. Chem. Biochem., Univ. Tex., Austin, TX 78712, USA; Eng.) — Nuesgen 26- 267

Transcript of Ribozyme Catalysis of Metabolism in the RNA World

Page 1: Ribozyme Catalysis of Metabolism in the RNA World

2007

BiochemistryZ 0250 Ribozyme Catalysis of Metabolism in the RNA World — [81 refs.]. —

(CHEN, X.; LI, N.; ELLINGTON*, A. D.; Chem. Biodiversity 4 (2007) 4, 633-655; Dep. Chem. Biochem., Univ. Tex., Austin, TX 78712, USA; Eng.) — Nuesgen26- 267

A Novel General Methodology for Ribozyme-Mimetic Synthesis ... · concludes in the easier hydrolysis of RNA at mild acidic and alkali conditions, due to the participation of 2’-OH

A Novel General Methodology for Ribozyme-Mimetic Synthesis ... · concludes in the easier hydrolysis of RNA at mild acidic and alkali conditions, due to the participation of 2’-OH

ASHA S V BCH-10-05-05. Ribozyme, or RNA enzyme, is a RNA molecule that act as enzymes, often found to catalyze cleavage of either its own or other RNAs.

ASHA S V BCH-10-05-05. Ribozyme, or RNA enzyme, is a RNA molecule that act as enzymes, often found to catalyze cleavage of either its own or other RNAs.

Enzymes - Univerzita Karlovavyuka-data.lf3.cuni.cz/CVSE1M0001/enzymes 21 10 2011...Enzyme structure • Enzymes are mostly proteins (exception: ribozyme - catalytic active RNA). •

Enzymes - Univerzita Karlovavyuka-data.lf3.cuni.cz/CVSE1M0001/enzymes 21 10 2011...Enzyme structure • Enzymes are mostly proteins (exception: ribozyme - catalytic active RNA). •

Antibiotic Inhibition of RNA Catalysis: Neomycin B … · Antibiotic Inhibition of RNA Catalysis: Neomycin B Binds to the Catalytic Core of the td Group I Intron Displacing Essential

Antibiotic Inhibition of RNA Catalysis: Neomycin B … · Antibiotic Inhibition of RNA Catalysis: Neomycin B Binds to the Catalytic Core of the td Group I Intron Displacing Essential

RNA Chemistry & Structure...• proteins Catalysis • everywhere • classic enzymes • RNA • less common / well established • ribosome, hammerhead, … Regulation • Proteins

RNA Chemistry & Structure...• proteins Catalysis • everywhere • classic enzymes • RNA • less common / well established • ribosome, hammerhead, … Regulation • Proteins

Expanding Biohybrid-mediated Asymmetric Catalysis into the ... · Expanding Biohybrid-mediated Asymmetric Catalysis into the Realm of RNA Nicolas Duchemin,a Erica Benedetti,a Lucas

Expanding Biohybrid-mediated Asymmetric Catalysis into the ... · Expanding Biohybrid-mediated Asymmetric Catalysis into the Realm of RNA Nicolas Duchemin,a Erica Benedetti,a Lucas

THE SPLICEOSOME IS A RIBOZYME

THE SPLICEOSOME IS A RIBOZYME

RNA catalysis

RNA catalysis

1 The Chemical Principles of RNA Catalysis

1 The Chemical Principles of RNA Catalysis

Combinatorial RNA libraries - Heidelberg University · 2010-07-08 · (Abzymes) catalytic RNA (Ribozymes) Abzyme 1E9 1.– SO2 2. [Ox.] 1E9 + TSA + + Ribozyme •hydrophobic interactions

Combinatorial RNA libraries - Heidelberg University · 2010-07-08 · (Abzymes) catalytic RNA (Ribozymes) Abzyme 1E9 1.– SO2 2. [Ox.] 1E9 + TSA + + Ribozyme •hydrophobic interactions

RNA catalysis: ribozymes, ribosomes, and riboswitches ... · RNA catalysis: ribozymes, ribosomes, and riboswitches Strobel and Cochrane 637 Figure 1 Group I intron splicing promoted

RNA catalysis: ribozymes, ribosomes, and riboswitches ... · RNA catalysis: ribozymes, ribosomes, and riboswitches Strobel and Cochrane 637 Figure 1 Group I intron splicing promoted

Structural basis of viral RNA-dependent RNA polymerase ...Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Bo Shua,b and Peng Gonga,1 aKey Laboratory

Structural basis of viral RNA-dependent RNA polymerase ...Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Bo Shua,b and Peng Gonga,1 aKey Laboratory

ANTISENSE AND RIBOZYME TECHNOLOGY

ANTISENSE AND RIBOZYME TECHNOLOGY

Predicting RNA Structure and Function. Ribozyme The Ribosome : The protein factory of the cell mainly made of RNA.

Predicting RNA Structure and Function. Ribozyme The Ribosome : The protein factory of the cell mainly made of RNA.

In-ice evolution of RNA polymerase ribozyme activityphyshiggsp/4S03/Attwater2013.pdf · of ribozymes based on the R18 RNA polymerase ribozyme9–11. R18 is a ribozyme, approximately

In-ice evolution of RNA polymerase ribozyme activityphyshiggsp/4S03/Attwater2013.pdf · of ribozymes based on the R18 RNA polymerase ribozyme9–11. R18 is a ribozyme, approximately

Protein-responsive ribozyme switches in eukaryotic cellsauthors.library.caltech.edu/50209/13/Nucl. Acids... · NucleicAcidsResearch,2014,Vol.42,No.19 12309 RNA device characterization

Protein-responsive ribozyme switches in eukaryotic cellsauthors.library.caltech.edu/50209/13/Nucl. Acids... · NucleicAcidsResearch,2014,Vol.42,No.19 12309 RNA device characterization

Evolution of Biological Catalysis: Ribozyme to RNP Enzymesymposium.cshlp.org/content/early/2009/10/22/sqb.2009.74.024.full.pdf · Ribozyme to RNP Enzyme T.R. C ECH Howard Hughes Medical

Evolution of Biological Catalysis: Ribozyme to RNP Enzymesymposium.cshlp.org/content/early/2009/10/22/sqb.2009.74.024.full.pdf · Ribozyme to RNP Enzyme T.R. C ECH Howard Hughes Medical

Self-splicing intronRNAs: ribozymes, parasites and agents ... · The “Tetrahymena ribozyme” and the discovery of RNA catalysis •Primary significance: a first example of RNA

Self-splicing intronRNAs: ribozymes, parasites and agents ... · The “Tetrahymena ribozyme” and the discovery of RNA catalysis •Primary significance: a first example of RNA

HiScribe T7 High Yield RNA Synthesis Kit - NEB · of high yield RNA transcripts and for incorporation of modified ... ribozyme biochemistry, ... HiScribe T7 High Yield RNA Synthesis

HiScribe T7 High Yield RNA Synthesis Kit - NEB · of high yield RNA transcripts and for incorporation of modified ... ribozyme biochemistry, ... HiScribe T7 High Yield RNA Synthesis

RNA Synthetic Biology using the Hammerhead Ribozyme ...

RNA Synthetic Biology using the Hammerhead Ribozyme ...