RHEUMATOLOGY · 2018. 10. 30. · 2 THE GW SCHOOL OF MEDICINE AND HEALTH SCIENCES FOCUSING ON NEW...

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The George Washington University School of Medicine and Health Sciences Division of Rheumatology provides state-of-the-art rheumatologic care in the heart of Washington, D.C. Our faculty focuses on the future of rheumatology, including mentoring and educating students, residents, and fellows. Our team conducts research into scleroderma, lupus, hidradenitis suppurativa, myositis, immunology, education and health care transitions. The GW Rheumatology Division also hosts the internationally recognized Cure JM Myositis Center, which is focused on care and research into myositis.

1DIVISION OF RHEUMATOLOGY

These are exciting times for GW Rheumatology. The division continues to grow and expand clinical operations, while we focus on our mission to advance clinical care, education, and research in the field of rheumatology.

GW Rheumatology faculty members are engaged in educating GW students, residents, and fellows both in small group and didactic formats, as well as providing bedside clinical experiences in the rheumatology elective.

Philanthropic support has been incredibly important for our growth. The inaugural Stuart S. Kassan, MD ’72, Endowed Lecture in Rheumatology has allowed us to start a new tradition at GW. Through this annual lecture, we hope to educate our students and colleagues about our exciting field. Other philanthropic donations have been used to support faculty development and research.

Moving forward, our division priorities are focused on ongoing growth. Rheumatologic disease remains the number one cause of disability in the United States. By educating future physicians, advancing research, and excelling in clinical care in rheumatology, we hope to improve outcomes for our patients.

Victoria K. Shanmugam, MRCP, MBBS, FACR, FACPDirector, Rheumatology

DIRECTOR’S MESSAGE

2 THE GW SCHOOL OF MEDICINE AND HEALTH SCIENCES

FOCUSING ON NEW FACULTY

A graduate of our own GW Rheumatology Fellowship Program, we were delighted to promote Marc Phillpotts, MD to assistant professor of medicine. He is actively engaged in teaching our fellows, residents, and medical students, and has a special interest in seronegative spondyloarthritis and inflammatory eye disease.

New faculty member Gelareh Atefi, MD completed a research fellowship at the University of Michigan, and her clinical rheumatology fellowship at the Harvard University Beth Israel Deaconess Medical Center Rheumatology Program in Boston. Dr. Atefi specializes in osteoarthritis, inflammatory arthritis, and osteoporosis.

Marc Phillpotts, MD

Gelareh Atefi, MD


Saira Bilal, MD recently received the coveted American College of Rheumatology Musculo-skeletal Ultrasound Certification. Dr. Bilal is an assistant professor of medicine at the George Washington University School of Medicine and Health Sciences. She is engaged in teach-ing in the Clinical Skills and Reasoning course and focuses her clinical and research interests on musculoskeletal ultrasound in the diagno-sis and management of rheumatoid arthritis, seronegative arthritis, gout, and osteoarthritis.

SAIRA BILAL, MD CERTIFIED IN ULTRASOUND

Catherine Hood, DNP, FNP-C, received her Bachelors of Science in Nursing from the University of North Carolina, Chapel Hill, and her Doctor of Nursing Practice degree from the University of Maryland. She enjoys helping patients with complex rheumatic diseases through their lifespan.

WELCOME CATHERINE HOOD, DNP, FNP-C

CONGRATULATIONS TO OUR TEAM


Derek Jones, PhD, is a postdoctoral fellow in the Division of Rheumatology. He completed his PhD in biomedical engineering at Case Western Reserve University, and is involved in research in Myositis, Hidradenitis Suppu-rativa, Scleroderma and Systemic Lupus Ery-thematosus. Among his current projects, Dr. Jones is investigating the use of mass spec-trometry to study metabolomics in Hidradeni-tis Suppurativa.

Post Doctoral Research Fellow

The GW Rheumatology Fellowship is a two-year ACGME-accredited training program that prepares physicians to become board certified in Rheumatology. As a senior fellow, Erica McBride, MD is currently receiving dedicated training in musculoskeletal ultrasound. Junior fellow, Ishita Aggarwal, MD joins us this year from California and is enjoying teaching our residents and medical students.

RHEUMATOLOGY FELLOWSHIP

TRAINEE SUCCESSES


The Mark Millen Award is presented annually to a member of the SMHS graduating class who has demonstrated exceptional proficiency in the field of Rheumatology. Spencer Frost was an en-thusiastic and engaged participant in the Rheu-matology Elective and we hope he considers a career in the field of Rheumatology.

MARK MILLEN AWARD IN RHEUMATOLOGY

This year, internal medicine resi-dent Mayce Haj Ali, MD won several awards for her work investigating prognosis in patients with ANA neg-ative scleroderma. This work was presented at the D.C. Rheumatism Society meeting, the D.C. chapter of the American College of Physicians meeting, and will be presented at the American College of Rheumatology annual meeting in October 2018.

RESIDENT AWARD

As a testament to her boundless enthusiasm for education and passion for rheumatology, the 2018 class of graduating residents selected Eri-ca McBride, MD, senior fellow in rheumatology, to be the 2018 Fellow of the Year. The award was presented during the SMHS Department of Med-icine’s annual award ceremony.

FELLOW OF THE YEAR


BUILDING GW RHEUMATOLOGY

EDUCATION

Joint Injection Training for

Students

Rheumatology Elective

Rheumatology Student-Faculty

Publications

Rheumatology Student Interest

Group

1 Patent Application

DISCOVERY

21 Publications

9 Presentations

at National Meetings

9 Active Research Studies

4 New Proposals Submitted


BUILDING GW RHEUMATOLOGY

Joint Injection

Training for Students

Rheumatology Student Interest

Group

Hidradenitis Patient Support

Group

SERVICE

Scleroderma Patient Education

Day

Cure JM Myositis Patient

Conference

Faculty Service on National Committees

Faculty Service on GW

Committees

Focused Ultrasound

Guided Procedures

CLINICAL CARE

Dedicated Administrative Support Team

Specialist Rheumatology

Nurse Practitioner

Expert Clinical Care


The inaugural Stuart S. Kassan, MD ’72, Endowed Lecture in Rheumatology featured V. Michael Hollers, MD, presenting on Genetics and the Environment in Rheuma-toid Arthritis. Through his generosity and support, Kassan established this endowed fund to further education and awareness into the field of rheumatology.

THE STUART S. KASSAN, MD ’72, ENDOWED LECTURE IN RHEUMATOLOGY

INVESTING IN GW RHEUMATOLOGY


My GW medical training basically changed my life and launched my career in rheuma-tology. Funding this endowed lecture series in rheumatology is the perfect way for me to give back. Dr. Shanmugam has created an outstanding Division of Rheumatology at GW. I am thrilled to support their work and to promote and enhance this important discipline at GW. As a graduate of the George Washington University School of Medi-cine and Health Sciences, and as a rheumatologist, I could not think of a better way to promote and enhance this important discipline for patient care and teaching than by funding the endowed lecture series in rheumatology at GW.

- Stuart S. Kassan, MD ‘72

Philanthropic donations to the Rheumatology Research Fund support investiga-tions into autoimmune disease, educational research, and faculty development. Many of these donations come from grateful patients, whose lives have been changed by our work.

When we give to Dr. Shanmugam and her research team, we know exactly how our contribution is being used and its importance to helping others who live with Lupus and other autoimmune diseases. Research funding is so important. Because of cutting-edge research, my doctors have been able to develop an amazing treatment plan. My hus-band and I strongly believe in funding Lupus research, not just because it helps me and my family, but because it benefits so many others who have autoimmune issues. We give to the GW program because we believe this research will be life changing for many.

- Ceci and Dennis Wraase, MS ’75

PHILANTHROPY ADVANCING RESEARCH


Directed by Rodolfo Curiel, MD, the Cure JM Myositis Center is a multidisciplinary clinical center focused on the evaluation and treatment of inflammatory muscle diseases. The center provides clinical consultation to patients with established or suspected inflammatory muscle diseases, and conducts research into Juvenile Der-matomyositis.

Gulnara Mamyrova, MD present-ed research from the Cure JM study at the 62nd Annual General Assembly and Scientific Meeting of the Japanese College of Rheu-matology. Her presentation was titled: Distinguishing Features of Clinically Hypomyopathic and Amyopathic Juvenille Dermato-myositis.

In 2018, the Cure JM team hosted the Annual Patient Education Conference at GW and the conference drew almost 100 participants and experts from the United States and Canada.

MYOSITIS CENTER


SCLERODERMA STUDIES

Scleroderma is an immune disease characterized by inflammation, vasculopathy, and fibrosis. Our team is working to understand the causes of scleroderma so that we can identify new treatments for this debilitating disease.

Through the STOP Scleroderma study we are investigating various biomarkers that predict disease progression in scleroderma, and trying to understand factors that predict prognosis in patients with early disease.

COllaborative, National QUality and Efficacy Registry for Tracking Disease Progres-sion in in scleroderma is supported by the Scleroderma Research Foundation. This multicenter collaborative study focuses on investigating multiple disease features and correlating them with molecular predictors to investigate response to thera-pies in a cohort of patients with early scleroderma.


The GW Lupus Study was initiated with philanthropic support from our patients and their families. The goal of this study is to investigate predictors of Lupus activity and outcomes. Systemic Lupus Erythematosus is a chronic autoimmune disease in which the immune system becomes active against parts of our own cells. The causes of Lupus are not well understood, and there is a great need to improve outcomes for patients with Systemic Lupus Erythematosus.

Studies conducted at GW Rheumatology have shown that opiate use is associated with delayed wound healing. This work was funded by the National Institutes of Health and was selected as a plenary presentation at the Wound Healing Society National Meeting.

IMMUNOLOGIC DISCOVERIES IN HIDRADENITIS SUPPURATIVAThrough the Wound Etiology and Healing Study, we have de-veloped a longitudinal cohort of patients with Hidradenitis

Suppurativa (HS). We are investigating the interplay of the host immune response with the microbiome in HS. Our work has found that the bacteria Prevotella is com-monly found in HS lesions. We have also found that skin from HS patients shows reduced expression of the naturally occurring antimicrobial peptide Dermcidin. This suggests that defective innate immune responses may play a role in pathogenesis of HS and identifies potential new treatments for this devastating condition.

Our translational research program focuses on taking observations from the clinic and inves-tigating disease pathogenesis to help identify novel biomarkers and therapeutic targets for au-toimmune diseases. Supported by philanthropic donations and federal funding, our team of phy-sicians and post-doctoral scientists collaborate on synergistic projects that advance scientific discovery and translate discoveries into action.

TRANSLATIONAL RESEARCH

PUBLICATIONS1. Choi Y, Banerjee A, McNish S, Couch KS, Torralba MG, Lucas S, Tovchigrechko A, Madupu R, Yooseph S, Nelson KE, Shanmugam VK, Chan AP. Co-occurrence

of Anaerobes in Human Chronic Wounds. Microb Ecol. 2018 Aug 23.2. Uribe JA, Aggarwal I, Witthayaweerasak J, Liao YJ, Berry GJ, Sab UK, Weyand CM. Refractory Giant Cell Arteritis Complicated by Vision Loss From Optic

Atrophy and Maculopathy Associated With Pachymeningitis. J Neuroophthalmol. 2018 Mar;38(1):17-23. 3. Matthew M Hitchcock, Ishita Aggarwal, Amy Chang, Julianna J Weiel, John D Szumowski; A 36-Year-Old Woman From West Africa With Newly Diagnosed

AIDS and a Spinal Cord Mass, Clinical Infectious Diseases, Volume 66, Issue 7, 19 March 2018, Pages 1148–1149.4. Mulani S, McNish S, Jones D, Shanmugam VK. Prevalence of antinuclear antibodies in hidradenitis suppurativa. Int J Rheum Dis. 2018 May;21(5):1018-

1022. doi: 10.1111/1756-185X.13312.5. Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA Jr, Steen VD,

Ramos PS, Silver RM, Korman B, Varga J, Schiopu E, Khanna D, Hsu V, Gordon JK, Saketkoo LA, Gladue H, Kron B, Criswell LA, Derk CT, Bridges SL Jr, Shan-mugam VK, Kolstad KD, Chung L, Jan R, Bernstein EJ, Goldberg A, Trojanowski M, Kafaja S, Maksimowicz-McKinnon KM, Mullikin JC; NISC Comparative Sequencing Program, Adeyemo A, Rotimi C, Boin F, Kastner DL, Wigley FM. Whole-Exome Sequencing to Identify Rare Variants and Gene Networks that Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018 May 6. doi: 10.1002/art.40541.

6. Morgan ND, Shah AA, Mayes MD, Domsic RT, Medsger TA Jr, Steen VD, Varga J, Carns M, Ramos PS, Silver RM, Schiopu E, Khanna D, Hsu V, Gordon JK, Gladue H, Saketkoo LA, Criswell LA, Derk CT, Trojanowski MA, Shanmugam VK, Chung L, Valenzuela A, Jan R, Goldberg A, Remmers EF, Kastner DL, Wigley FM, Gourh P, Boin F. Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore). 2017 Dec;96(51):e8980. doi: 10.1097/MD.0000000000008980.

7. Boortalary T, Misra K, McNish S, Jones D, Shanmugam VK. Prevalence of positive QuantiFERON gold in-tube testing in hidradenitis suppurativa. J Dermato-log Treat. 2018 Sep;29(6):637-640. doi: 10.1080/09546634.2018.1425360.

8. Shanmugam VK, Mulani S, McNish S, Harris S, Buescher T, Amdur R. Longitudinal observational study of hidradenitis suppurativa: impact of surgical inter-vention with adjunctive biologic therapy. Int J Dermatol. 2018 Jan;57(1):62-69. doi: 10.1111/ijd.13798.

9. Jones D, Banerjee A, Berger PZ, Gross A, McNish S, Amdur R, Shanmugam VK. Inherent differences in keratinocyte function in hidradenitis suppurativa: Evidence for the role of IL-22 in disease pathogenesis. Immunol Invest. 2018 Jan;47(1):57-70. doi: 10.1080/08820139.2017.1377227.

10. Shanmugam VK, Zaman NM, McNish S, Hant FN. Review of Current Immunologic Therapies for Hidradenitis Suppurativa. Int J Rheumatol. 2017;2017:8018192. doi: 10.1155/2017/8018192. Epub 2017 Aug 20. Review.

11. Shanmugam VK, Angra D, Rahimi H, McNish S. Vasculitic and autoimmune wounds. J Vasc Surg Venous Lymphat Disord. 2017 Mar;5(2):280-292. doi: 10.1016/j.jvsv.2016.09.006. Epub 2016 Dec 14. Review.

12. Sabbagh S, Ronis T, White PH. Pediatric Rheumatology: Addressing the transition to adult-oriented healthcare. Open Access Rheumatol. 2018; 10:83-95.13. Spencer D, McManus M, Call K, Turner J, Harwood C, White P, Alarcon G. Health care coverage and access among children, adolescents, and young adults,

2012-2015: Implications for future health reforms. Journal of Adolescent Health 62 (2018) 667–673.14. Lestishock L, Daley AM, White P. Pediatric nurse practitioners’ perspectives on health care transition from pediatric to adult care. Journal of Pediatric Health

Care. 2018. 32(3): 263-27215. Hickam T, White P, Modrin A, McManus M, Cox K. Implementing a nationally recognized pediatric-to-adult transitional care approach in a major children’s

hospital. Health and Social Work. 2018; 43(1): 3-516. White P, Schmidt A, McManus M, Irwin C: Incorporating Health Care Transition Services into Preventive Care for Adolescents and Young Adults: A Toolkit for

Clinicians. Washington DC Got Transition, June 2018.17. McManus M, White P, Schmidt A, Moltini R, Kantor D, Salus T: 2018 Coding and Reimbursement Tip Sheet for Transition from Pediatric to Adult Health Care.

Washington DC: Got Transition, May 201818. Hudack M, Helm M, White P, and committee on Child Health Financing. Principles of Child Health Care Financing. Pediatrics 2017; 140(3): 1-8.19. Mamyrova G, Rider LG, Ehrlich A, Jones OY, Miller FW, Katz JD. Environmental factors associated with disease flare in juvenile and adult dermatomyositis.

Rheumatology (Oxford) 2017 Apr 21. doi: 10.1093/rheumatology/kex162.20. Mamyrova G, Kishi T, Targoff IN, Ehrlich A, Curiel RV, Rider LG with the Childhood Myositis Heterogeneity Study Group. Features distinguishing clinically amyo-

pathic juvenile dermatomyositis (CAJDM) from juvenile dermatomyositis (JDM). Rheumatology (Oxford) 2018 Jul 16. doi:10.1093/rheumatology/key190.21. Kishi T, Bayat N, Ward MM, Huber AM, Wu L, Mamyrova G, Targoff IN, Warren-Hicks WJ, Miller FW, Rider LG with the Childhood Myositis Heterogeneity

Study Group. Medications received by patients with Juvenile Dermatomyositis. Semin Arthritis Rheum. 2018 Mar 28. pii: S0049-0172(17)30753-9. doi: 10.1016/j.semarthrit.2018.03.016.

BOOKS/CHAPTERS1. White P, McManus M. Historical perspectives, current priorities, and health care transition evidence and measurement. In: Hergenroeder A, Wie-

mann C, eds. Health Care Transition for Adolescents and Young Adults with Chronic Illness and Disability. Switzerland: Springer International Pub-lishing, pgs. 233-238. 2018

2. McManus M, White P. Payment for transition services. In: Hergenroeder A, Wiemann C, eds. Health Care Transition for Adolescents and Young Adults with Chronic Illness and Disability. Switzerland: Springer International Publishing, pgs. 233-238. 2018

3. Shanmugam, Victoria K. Vasculitis and Other Uncommon Arteriopathies. In: Rutherford’s Vascular Surgery 9th edition. Pgs 1795-1808. 2018

S C I E N T I F I C PUBLICATIONS

Division of Rheumatology

The GW School of Medicine and Health Scinecessmhs.gwu.edu/medicine/divisions/rheumatology

Thank you for your support of the GW Division of Rheumatology.

This year we have been honored to receive significant gifts supporting the WE-HEAL Study, the GW Lupus Study, the STOP Scleroderma Study, and the Cure JM Myositis Center. Philanthropy is critically important for the growth of GW Rheumatology and helps us focus on the future. We want to thank all of our supporters including alumni, faculty, and grateful patients as we continue to focus on improving care for patients with rheumatic disease and educating the future rheumatology workforce.

Donations to support the GW Division of Rheumatology may be made online at:

go.gwu.edu/Give2Rheumatology

YOU MAKE A DIFFERENCE

RHEUMATOLOGY · 2018. 10. 30. · 2 THE GW SCHOOL OF MEDICINE AND HEALTH SCIENCES FOCUSING ON NEW...

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