“revolutionising healthcare through continuously improving diagnostic solutions”
-
Upload
hugo-crawford -
Category
Documents
-
view
220 -
download
1
Transcript of “revolutionising healthcare through continuously improving diagnostic solutions”
![Page 1: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/1.jpg)
“revolutionising healthcare through continuously improving diagnostic solutions”
![Page 2: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/2.jpg)
Randox Laboratories Limited
• Privately owned diagnostic and instrument company
• UK and Ireland’s largest indigenous diagnostic company
• Established in 1982
• Employs 850 people
• 200 scientists and engineers
![Page 3: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/3.jpg)
We supply quality products to:• Hospitals, clinical laboratories and veterinary and research
laboratories
• Over 130 countries
• An estimated 60,000 clients using Randox products.
In 2009:• 4 billion diagnostic tests manufactured by Randox.
![Page 4: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/4.jpg)
Our facilities may have been basic but we developed
excellent diagnostic
products, many of which we still
manufacture today!
![Page 5: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/5.jpg)
![Page 6: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/6.jpg)
Princess Royal Visit 1987
![Page 7: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/7.jpg)
![Page 8: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/8.jpg)
Staff Levels..
0
100
200
300
400
500
600
700
800
900
NU
MB
ER
OF S
TA
FF
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 992000200120022004200520062007200820092010
![Page 9: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/9.jpg)
Current Product Range
• Biochip Array Technology (Including Molecular)
• Clinical Chemistry analysers and reagents
• Quality Control systems
• Life Sciences Department
• Randox Testing Services
• Randox Health Checks
![Page 10: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/10.jpg)
We now have
60,000 customers worldwide
and have achieved significant market share
![Page 11: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/11.jpg)
Miami-Dade CountyCalifornia, USA
“We are very happy with the huge advantages that the Evidence Investigator has brought to our death investigation abilities.”
Dr Lee Hearn
![Page 12: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/12.jpg)
Planned Population Federation of Korea (PPFK)Seoul, South Korea
“I am very happy with the performance of the Imola as my QC results from Korea's national EQA scheme are always perfect on the RX Imola.”
![Page 13: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/13.jpg)
![Page 14: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/14.jpg)
![Page 15: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/15.jpg)
Randox Offices and Distributors
![Page 16: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/16.jpg)
Collaborations Network
Randox has an extensive network of international collaborations
~
We collaborate with 35 universities and hospitals in 7 different countries
~
Including Queen’s University Belfast and the University of Ulster
![Page 17: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/17.jpg)
20th position out of the estimated 20th position out of the estimated 1,850 diagnostic companies worldwide1,850 diagnostic companies worldwide
![Page 18: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/18.jpg)
4th in QC serum and calibrators4th in QC serum and calibrators
![Page 19: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/19.jpg)
Number 1 in supply to Number 1 in supply to
international EQA schemesinternational EQA schemes
![Page 20: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/20.jpg)
Randox manufactures 8% of all clinical Randox manufactures 8% of all clinical chemistry tests in the worldchemistry tests in the world
![Page 21: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/21.jpg)
Randox provides the reagents for 11% of Randox provides the reagents for 11% of all HDL Cholesterol tests executed all HDL Cholesterol tests executed
world wideworld wide
![Page 22: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/22.jpg)
Last year we manufactured our Last year we manufactured our
40 billionth test40 billionth test
is a world class manufacturer !is a world class manufacturer !
![Page 23: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/23.jpg)
Innovation
Our mission statement:
“Revolutionising healthcare through continuously improving diagnostic
solutions”
PRODUCT PORTFOLIO
![Page 24: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/24.jpg)
Innovation
Products are designed and developed with the customer and patient in mind
~
Our rigorous design and development process ensures that all products are fit for purpose
PRODUCT PORTFOLIO
![Page 25: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/25.jpg)
Biochip Array Technology
![Page 26: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/26.jpg)
Primary research High throughput
Huge versatility of technology
Expanding portfolio
Complimentary clinical chemistry
Excellent QC throughout
Clinical
![Page 27: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/27.jpg)
Randox has spent $225million
developing Biochip Array Technology
![Page 28: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/28.jpg)
Randox Sales Conference October 2008
. . with over 400 new tests in development – more than any other company in the world
Highly innovative…
![Page 29: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/29.jpg)
Randox in Cardiology
Randox has developed tests to
save 20% of patients lives
Cutting edge technology and novel biomarkers to
accurately diagnose patients with suspected
heart attacks
![Page 30: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/30.jpg)
Respiratory Pathogen Biochip
Human coronavirus 229E/NL63Human coronavirus 229E/NL63
Streptococcus pneumoniaeStreptococcus pneumoniae
Haemophilus influenzaeHaemophilus influenzae
Moraxella catarrhalisMoraxella catarrhalis Influenza AInfluenza A
Influenza BInfluenza B
Chlamydophila pneumoniaeChlamydophila pneumoniae
Legionella pneumophilaLegionella pneumophila
Human bocavirus 1/2/3Human bocavirus 1/2/3
Human enterovirus A/B/CHuman enterovirus A/B/C
Human rhinovirus A/BHuman rhinovirus A/B
Human adenovirus B/C/EHuman adenovirus B/C/E
Mycoplasma penumoniaeMycoplasma penumoniae
Human parainfluenzavirus 1Human parainfluenzavirus 1
Human Respiratory Syncytial virus AHuman Respiratory Syncytial virus A
Human metapneumovirusHuman metapneumovirus
Staphylococcus aureusStaphylococcus aureus
Human Respiratory Syncytial virus BHuman Respiratory Syncytial virus B
Human parainfluenzavirus 2Human parainfluenzavirus 2
Human parainfluenzavirus 3Human parainfluenzavirus 3
Human parainfluenzavirus 4Human parainfluenzavirus 4
Human coronavirus OC43/HKU1Human coronavirus OC43/HKU1
![Page 31: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/31.jpg)
Randox 10-plex STI Biochip
Mycoplasma genitalium (MG)Mycoplasma genitalium (MG)Neisseria gonorrhoea (NG)Neisseria gonorrhoea (NG)
Chlamydia trachomatis (CT)Chlamydia trachomatis (CT)
Trichomonas vaginalis (TV)Trichomonas vaginalis (TV)
Treponema pallidum (TP)Treponema pallidum (TP)
Herpes simplex 1 (HSV1)Herpes simplex 1 (HSV1) Herpes simplex 2 (HSV2)Herpes simplex 2 (HSV2)
Mycoplasma hominis (MH)Mycoplasma hominis (MH)
Haemophilus ducreyi (HD)Haemophilus ducreyi (HD)
Ureaplasma urealyticum (UU)Ureaplasma urealyticum (UU)
10 pathogens detected in one PCR reaction!
10 pathogens detected in one PCR reaction!
9 patient samples hybridized in one carrier
Up to 54 samples run simultaneously
9 patient samples hybridized in one carrier
Up to 54 samples run simultaneously
![Page 32: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/32.jpg)
Bladder Cancer
Development of diagnostic
algorithm to remove the
need for cystoscopy
![Page 33: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/33.jpg)
Breast Cancer RNA/cDNA array
Low density chip-based cDNA
arrays, using a molecular
signature panel that can
divide breast tumours into
clinically relevant sub-types
![Page 34: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/34.jpg)
• One in nine women will be affected by breast cancer• Complex disease involving a number of sub groups • Sub-groups have treatment & prognostic significance• Current IHC methodology is not standardised• Interpretation of IHC can be problematic• IHC relies on small number of targets for diagnosis
Aim: to accurately subtype breast cancer and
predict outcome using a gene expression array
![Page 35: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/35.jpg)
Metabolic SyndromeDefined as the Clustering of Cardiovascular Risk Factors
with 20-25% of adults affected
![Page 36: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/36.jpg)
Metabolic Syndrome ArraysI II
Adiponectin C-Peptide
C-reactive Protein (CRP) Ferritin
Cystatin C Insulin
Interleukin-1 alpha (IL-1α)
Interleukin-6 (IL-6)
Leptin
Plasminogen Activator Inhibitor-1 (PAI-1)
Resistin
Tumour Necrosis Factor-alpha (TNFα)
![Page 37: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/37.jpg)
Co-morbidities of Metabolic Syndrome
• Cardiomyopathy• Coronary Heart Disease• Atherogenic Dyslipidemia• Peripheral and Cerebrovascular Disease• Calcific Aortic Valvular Disease• Type 2 Diabetes• Polycystic Ovary Syndrome (PCOS)• Non-Alcoholic Fatty Liver Disease (NFALD)• Cognitive Impairment• Cancer• Chronic Kidney Disease• Mental Health Conditions
![Page 38: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/38.jpg)
Applicability of other arrays to metabolic conditions
– Adhesion molecules array– Cardiac arrays– Cerebral arrays– Cytokine arrays– Endocrine array
Synergy with other biochip arrays available
![Page 39: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/39.jpg)
Ovarian Cancer RNA/cDNA array
Low density chip-based
cDNA arrays, using a
molecular signature panel
that can predict responders
and non-responders to
chemotherapy (Taxol and
Platinum-based)
![Page 40: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/40.jpg)
Ovarian Cancer RNA/cDNA array
•Low density chip-based cDNA array
• Predicts responders and non-responders to platinum and taxol
chemotherapies (using Ovarian tumours as models)
• Provides a rapid (1 day) test prior to treatment
• Ensures the patient gets the best treatment at the right time
• Standardised and easy to use protocols
![Page 41: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/41.jpg)
Disease prediction – Cardiac disease risk• Cardiovascular disease (CVD) is a complex multifactorial and polygenic disorder
• Results from interaction between genetic makeup and environment
• Identification of SNPs in known CVD genes may therefore aid in the identification of individuals at risk
• Use with Framingham score to better gauge patient risk
• This will permit lifestyle changes or target therapy
• Includes the best 20-SNP combination for prediction of cardiac disease – derived from GWAS and meta analyses
![Page 42: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/42.jpg)
Randox TxB Cardio® Assay
![Page 43: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/43.jpg)
Randox Health Checks
Due to the slowness of uptake of new tests by the health service, we decided to
set up Randox Health Checks, our own clinic
![Page 44: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/44.jpg)
Randox Health Checks
![Page 45: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/45.jpg)
Conclusion
With the unravelling of the Human Genome Project – the potential for life changing inventions is immense
~
We, at Randox, have developed the world’s most revolutionary technology – in fact a disruptive technology in Laboratory
Medicine
~
We can help improve the lives of many people in this world
![Page 46: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/46.jpg)
Belfast is as good a place to do this as anywhere in the world
~
We have a highly educated workforce open to the world
~
All we need is entrepreneurial leadership to overcome hurdles and problems put in our way
~
Remember that Belfast has been the source of many inventions and significant entrepreneurial endeavours
![Page 47: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/47.jpg)
Henry George Ferguson
Ferguson designed and built a new plough which was coupled to the tractor in
three-point linkage, so that both formed a single unit. This 'Ferguson System',
building on the earlier two-point linkage patented in 1919, was patented in 1928. Together with many other inventions, it
was to revolutionise farming.
![Page 48: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/48.jpg)
John Dunlop
Dunlop’s great invention, of the inner tube for cycle tyres, came about more or less
by chance. In 1888 his small son was prescribed cycling as cure for a heavy cold; Dunlop hit on the idea of making the boy's tricycle more comfortable by
fitting it with inflated tubes, made of canvas and bonded together with liquid rubber. He patented this idea, using the word 'pneumatic' for the first time, in the
same year.
![Page 49: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/49.jpg)
Invention is in our genes!
![Page 50: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/50.jpg)
Thank you for listening…
![Page 51: “revolutionising healthcare through continuously improving diagnostic solutions”](https://reader036.fdocuments.in/reader036/viewer/2022062516/56649d965503460f94a7eb75/html5/thumbnails/51.jpg)
“revolutionising healthcare through continuously improving diagnostic solutions”