Review of Rectal MRI Technique, Protocol, and …...Review the utility of MRI as the primary...
Transcript of Review of Rectal MRI Technique, Protocol, and …...Review the utility of MRI as the primary...
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“Bottoms Up”Review of Rectal MRI Technique, Protocol,
and InterpretationAn Educational Session for Technologists and Radiologists
ZAHRA KASSAMSouthwest Regional Lead Cancer Imaging Program, Cancer Care Ontario
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Objectives
Review the utility of MRI as the primary pre-surgical staging modality for rectal cancer.
Discuss MRI protocol, relevant anatomy, and sequence planning
Discuss pearls and pitfalls in interpretation, utility of MCCs
Synoptic Reporting – why do we have it, and what’s new in 2016?
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Why is MRI staging important?
• Stratifies patients for neoadjuvant CRT vs. surgical management
• Evaluates local extent of disease
• Assesses sphincter involvement
– Is the patient a candidate for sphincter-sparing surgery?
Graphic courtesy of www.radiologyassistant.nl
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• Achieve consistency and high interobserver agreement
Accuracy of Staging
• Avoid repeating MRI prior to surgery
Streamlined treatment planning
• Referrals, technique, and reporting
• Ontario Cancer Plan
Establish standardization
The Radiologist’s Goal
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OCPIV Goals and CIP Priority Areas
5 5
Support providers/patients with tools for decision
making, communication
Patient-centred wait times (IR targets)
APPROPRIATENESS
TIMELY ACCESS
SYNOPTIC REPORTING
EVIDENCE-BASED PET
standardized protocols
synoptic/standardized referrals
Tools to help adherence to evidence-based guidance
PET QA best-practices
FOCAL ABLATION
Programs to improve access to specialized services
Standardized protocols
Assess, expand, enhance and utilize data
Strengthen system ability to ensure resources are most
optimally utilized
Leverage and expand evidence-based guidance
Enhanced communication for smoother transitions
Foundation (data) for quality improvement,
patient-specific indicators
CIP Priority Areas
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Background & Anatomy
Image used with permission from Amirsys Publishing
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Anatomy of the Rectum
• Appx. 16 cm in length
Extends from upper end of anal canal to rectosigmoid
junction
• Lower 1/3 = 0-5 cm
• Middle 1/3 = 6-10 cm
• Upper 1/3 = 11-16 cm
Divided into thirds
• Draw a line from sacral promontory to symphysis pubis
Low sigmoid vs. high rectal?
Graphic courtesy of www.radiologyassistant.nl
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Mesorectum
• Fatty tissue “envelope” surrounding rectum
– Contains lymph nodes, blood vessels, fat & fibrous septa
– Surrounded by mesorectalfascia
• For simplicity, corresponds to circumferential radial margin
• Low signal on T2
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Definitions
• Resection of tumor and surrounding fat
• Cure rate for low T-stage approaches 90% with surgery alone
TME = Total Mesorectal Excision
• Thin envelope containing perirectal fat, blood vessels, nerves and lymph nodes
MRF = Mesorectal Fascia
• Plane of resection used during surgery - often depends on tumor location
CRM = Circumferential Radial Margin
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Current Operative Management
• Transanal endoscopic microsurgery
• Transanal local excisionT1 lesions:
• Total mesorectal excision (TME)
T2 and early T3 lesions:
• Neoadjuvant therapy TME
Advanced T3/T4
lesions:
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Total Mesorectal Excision
Graphic courtesy of www.radiologyassistant.nl
Mesorectalfascia (MRF)
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Threatened Surgical Planes - MRF
• Presacral fascia
• Tumor extension anterior to Denonvillier’s fascia
• Lateral MRF separates mesorectum from neurovascular bundles
• Serosa above the peritoneal reflection covers bowel
Adapted from Dr. Blair MacDonald
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peritoneal
reflection
bare area
= radial
margin
shiny
peritoneal
covering
Anatomical Landmarks
C
A
B B
A
C C
B
A
circumferential
radial margin
CRM + serosal
surface (anterior)
non-circumferential
radial margin (posterior)
+ serosal surface (anterior)
anterior posteriorSlide Courtesy of Dr. D. Driman
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Slide courtesy of Dr. Blair MacDonald
Sg
CRT
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Graphic courtesy of www.radiologyassistant.nl
MRI Protocol
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Graphic courtesy of www.radiologyassistant.nl
Ordering and Sequence Planning
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What clinical information is needed?
• General tumor location, i.e. distance from anal verge– Important for planning
of the MR study
• Biopsy proven primary rectal cancer?
• Mucinous vs. non-mucinous – May change MR
protocol
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MR Protocol CCO recommendations 2015
Patient preparation Sequences
Required - High resolution, non-fat saturated T2-weighted
sequences perpendicular to the long axis of the rectum, using phased
array coil
Recommended* Antiperistaltics(buscopan)
-
Optional • Pre-procedure enema• Luminal distention• IV contrast
DWI+GdT1
Not routinely recommended
Fat saturated T2 sequences
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Optimal Protocol Specifications
22
22
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Sample MR Protocol
St. Joseph’s Hospital, London
• Buscopan 20 mg IV/IM, No Gd for routine cases
• Ax T1/T2 TSE whole pelvis
• Sag T2 TSE 240 mm FOV
• Axial oblique T2 TSE 220 mm FOV (3/0)
• Coronal oblique T2 TSE 220 mm (3/0)
• Axial whole pelvis DWI
• B values 0, 250, 500, 1000 + ADC map
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Sequence planning
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Pitfalls in Angulation
Improper angulation leads to overstaging,
with presumed extension beyond MRF
(T3)
Proper angulation reveals a T2 lesion
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A “C-shaped” TumorRequired 2 angles
2
1
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Troubleshooting: Endoluminal Contrast
Ultrasound gel distends rectum and displaces retroverted uterus anteriorly, thereby
eliminating extrinsic compression of tumor
Retroverted uterus, with fundus contacting and compressing rectal mass.
Difficult to stage
Fundus
Tumor
Fundus
Tumor
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Troubleshooting: Endoluminal Contrast
Without endoluminal contrast With endoluminal contrast
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Diffusion Weighted Imaging
Indications
• Useful to screen for small, difficult to visualize tumors
• Can provide information similar to IV contrast
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Example of DWI in Rectal Cancer
B = 0
B = 1000 ADC map
T2
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T2 ADC
PET mMR
Multiparametric Analysis
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MRI Interpretation:Pearls and Pitfalls
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What am I supposed to be looking at?
• Relationship to anal sphincter, verge
• Pelvic sidewall involved?Tumor location
• Signal intensity, surface ulceration
• Mucinous composition? (high T2 signal)
Tumor morphology
• T-stage, EMDI
• Disease outside circumferential radial margin
Local extent
• N-stage, adjacent tumor deposits, extramural vascular invasion
Metastatic spread & biomarkers
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Distance from anal verge
• Measure along a straight line (like rigid scope) to the lower, rolled border of the tumor
• The top of puborectalissling is 35 – 42 mm above the anal verge
Image courtesy of Dr. Blair MacDonald
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Anterior peritoneal reflection: Look for disappearing anterior fat
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T2 vs. T3 diseaseWhy is this so important?
T2/early T3 – surgical
T3 – prognosis worsens as extramural depth of invasion increases
• Some centres treat early T3 disease like T2
• Advanced T3 disease requires neoadjuvant chemoradiation
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T3 disease
• Extension of tumor into the perirectal fat
• Extension of the tumor should have a rounded or nodular border
• Should be continuous with the main tumor itself
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Pitfall: Desmoplastic T2 vs. T3
Linear spicules represent desmoplastic reaction in a T2 tumor. T3 lesion shows nodular, convex extension beyond the muscularis propria.
T2 lesion T3 lesion
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T2 vs. T3
Nodular tumor extensionFibrous, desmoplastic reaction
Adapted from Dr. Blair MacDonaldc
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T2 vs. T3
• Tumor bulge into perirectal fat
• PPV T3 = 99%
• Nodular growth into perirectal fat
• PPV T3 = 94%
Definite T3
• Spiculation in perirectal fat
• PPV T3 = 51%
“Advanced T2/early T3”
G. Brown et al. Radiol 1999;211(1):215-222.
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T2 vs. Early T3MR stage T2; pT3a
MRI stage – T2 Final stage – pT3a
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Deciding between T2 & T3 – Pearl
• When T-staging, look at the deepest part of the ulcer
• Invasion should occur there first (less protection)
• If fat is clean deep to the ulcer, more likely T2
Ulcerated masses
• “T2 vs. early T3”
• Management may not change
If still unsure
T3b Ulcerated Tumor
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Extramural Depth of Invasion (EMDI) and T3 disease
T3a: <1 mm EMDI (prognosis similar to T2)
T3b: 1-5 mm EMDI – good prognosis
T3c: 5-15 mm EMDI – poor prognosis
T3d: >15 mm EMDI – worse prognosis
T3b
T3c
T3d
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Measuring EMDI and distance to MRF
EMDIDistance to MRF
Images courtesy of Dr. Blair MacDonald
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Measuring distance to MRFAlways measure the shortest distance
at the tumor/fat interface
Images courtesy of Dr. Blair MacDonald
Incorrect
Correct
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Distinction: CRM+ or CRM-
• 1 mm between tumor and MRF highly predictive for positiveCRM
• ≥5 mm between tumor and MRF highly predictive for negativeCRM
Graphic courtesy of www.radiologyassistant.nl
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Low rectal tumors
• Lower extent of tumor is at or below the top border of the puborectalis
• Worse prognosis– Higher rate of recurrence
because mesorectal fat tapers inferiorly
– Less inherent protection– Involvement of anal sphincter
complex not currently included in TNM classification
• Need to see – Levators– Sphincter complex– Intersphincteric plane– Relationship to rectal wall
Graphic courtesy of www.radiologyassistant.nl
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Anatomy of the Low Rectum
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Reporting of low rectal cancer in 2015Provide a “level” rather than a “T-stage”
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Involvement of the levator and intersphincteric plane – Level 4
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N+ disease in rectal Ca
• 25% measure <5 mm
“Suspicious” nodes
• Irregular border
• Mixed signal intensity
• Size > 5 mm (short axis)
• Sens 85%, Spec 97%
Pearls
• Look for “polka dots” of low signal inside node –even in nodes <5mm, this is suspicious
• +ve Nodes outside MRF – non-surgical
Pitfall – mucinous nodes
N-StagingPredictors of malignancy – what we use
Brown, G. et alRadiology. 2003; 227: 371-377
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Mucinous Tumor & Nodes
• “Watery”, bright on T2
• Easy to miss if you’re not looking
• IR or SPAIR helpful for detection
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The “Polka-Dot Node” Sign
Large nodes – 17 mm short axis “Normal” size node – 5 mm short axis
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Extramural Vascular Invasion
Presence of tumor cells beyond muscularis propria, in endothelium lined vessels
Vessel = tubular structure containing signal void on T2
Lack of signal void or enlarged vessel suggests
invasion
Biomarker of poor prognosis
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Liver Metastases in CRCNot necessarily “end stage” anymore…
50% patients with CRC will develop liver metastasis
Mean survival time for untreated liver metastases is 6-13 months
Liver resection increases 5-year survival rate from 0-1% to ≈ 50%
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Reporting liver mets - “Must-do’s”
• Number of lesions
• Affected & spared segments
• 2D/3D size of largest lesion
• Location relative to portal and hepatic veins
• Distance from liver capsule to liver lesion (depth)
Image credit: RadiologyAssistant.nl
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Synoptic MRI Reporting
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OCPIV Goals and CIP Priority Areas
5656
Support providers/patients with tools for decision
making, communication
Patient-centred wait times (IR targets)
APPROPRIATENESS
TIMELY ACCESS
SYNOPTIC REPORTING
EVIDENCE-BASED PET
standardized protocols
synoptic/standardized referrals
Tools to help adherence to evidence-based guidance
PET QA best-practices
FOCAL ABLATION
Programs to improve access to specialized services
Standardized protocols
Assess, expand, enhance and utilize data
Strengthen system ability to ensure resources are most
optimally utilized
Leverage and expand evidence-based guidance
Enhanced communication for smoother transitions
Foundation (data) for quality improvement,
patient-specific indicators
CIP Priority Areas
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Where do I find the synoptic
report?
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Slide courtesy of Dr. Blair MacDonald
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Synoptic reportWhat do the clinicians want to know?
Please give a T-stage and N-stage
State whether the CRM is positive or negative
Comment on whether there is extramesorectal disease
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Surgeon
Pathologist
Radiologist
Medical Oncologist
Radiation Oncologist
Palliative Care
Trainees
Multidisciplinary Case Conferences
(MCCs)
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Slide courtesy of Dr. Blair MacDonald
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• Rectal cancer MCC led to 30% change of initial treatment strategy– 7/42 changed to primary surgery– 5/42 changed to preCRT or chemotherapy– ~40% of changes were due to re-interpretation of the MRI
Please attend your local MCCs! They are an excellent vehicle for learning and CME.
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Summary
As the primary pre-surgical staging modality for rectal cancer, high quality, accurate MRI is crucial for staging.
Keys to success: (1) Consistent MRI protocol/reporting; (2) Dialogue between technologists and radiologists, and amongst
multidisciplinary team; (3) Follow-up of challenging cases.
Synoptic Reporting – new nomenclature for low rectal tumors. Clinicians want a high quality report with T&N stage clearly
indicated.
MCCs make all of us better radiologists, and improve patient outcomes.