16602 Royder Road College Station, TX 77845

Phone: 979-862-1434 (Work) 979-690-1345 (Home) 979-218-4796 (Cell) Fax: 979-862-4929 E-mail: gmartin@cvm.tamu.edu

Gregory G. Martin

Experience 2006-present Texas A&M University College Station, TX Assistant Research Scientist Analysis and elucidation of lipid binding protein structure/function Biochemical characterization of ligand binding parameters of key

intracellular lipid binding proteins

2000-2006 Texas A&M University College Station, TX Post-Doctoral Research Associate Biochemical purification of lipid binding proteins Biochemical/physiological characterization of liver fatty acid binding

protein gene-ablated mouse tissue

1993-2000 University of Southern Mississippi Hattiesburg, MS Graduate Research Assistant Purification of fungal hydrophobin protein and associated polysaccharide Analysis of surface behavior of purified fungal components Characterization of aqueous solution properties of purified fungal

components

1990-1993 Stringer Attendance Center Stringer, MS Teacher Taught high school (grades 9-12) biology, advanced biology, chemistry,

advanced chemistry, and physics

1986-1990 The Upjohn Company Kalamazoo, MI Biochemist Studied neurotransmitter receptors and related signal transduction

systems involved in schizophrenia

1985-1986 University of Illinois Urbana, IL Research Biochemist Studied the regulation of messenger RNA for a key enzyme involved in

cholesterol biosynthesis Managed accounts of the principal investigator’s research grants

1980-1985 University of Illinois Urbana, IL Graduate Research Assistant Studied the regulation of protein and messenger RNA for a key enzyme

involved in cholesterol biosynthesis

1979-1980 Argonne National Laboratory Argonne, IL Resident Student Aide Developed immunological tools for the detection and quantification of

tumor antigens from rat hepatomas

Education 1993-1999 University of Southern Mississippi Hattiesburg, MS Ph.D., Biochemistry; Minor, Polymer Science Dissertation Title: “Isolation and Characterization of a New Class of

Amphipathic Biopolymers Capable of Self-Assemby from Aqueous Media” Dissertation Advisor: Dr. Charles L. McCormick

1980-1985 University of Illinois Urbana, IL M.S., Biochemistry Thesis Title: “Regulation of 3-Hydroxy-3-Methylglutaryl Coenzme A

Reductase in Cultured Rat Liver Cells Thesis Advisor: Dr. David J. Shapiro

1975-1979 University of San Diego San Diego, CA B.A., Chemistry

Selected Publications

Ablating L-FABP in SCP-2/SCP-x null mice impairs bile acid metabolism and biliary HDL-cholesterol secretion. Martin GG, Atshaves BP, Landrock KK, Landrock D, Storey SM, Howles PN, Kier AB, Schroeder F (2014) American Journal of Physiology-Gastrointestinal and Liver Physiology 307, G1130-G1143

Structural and functional interactions of fatty acids with human liver fatty acid binding protein (L-FABP) T94A variant. Huang H, McIntosh AL, Martin GG, Landrock KK, Landrock D, Gupta S, Atshaves BP, Kier AB, Schroeder F (2014) FEBS Journal 281, 2266-2283

The human liver fatty acid binding protein T94A variant alters the structure, stability, and interaction with fibrates. Martin GG, McIntosh AL, Huang H, Gupta S, Atshaves BP, Landrock KK, Landrock D, Kier AB, Schroeder F (2013) Biochemistry 52, 9347-9357

High glucose potentiates L-FABP mediated fibrate induction of PPAR alpha in mouse hepatocytes. Petrescu AD, McIntosh AL, Storey SM, Huang H, Martin GG, Landrock D, Kier AB, Schroeder F (2013) Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1831, 1412-1425

Liver fatty acid binding protein gene ablation exacerbates weight gain in high-fat fed female mice. McIntosh AL, Atshaves BP, Landrock D, Landrock KK, Martin GG, Storey SM, Kier AB, Schroeder F (2013) Lipids 48, 435-448

Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPAR alpha-regulated beta-oxidative enzymes. Petrescu AD, Huang H, Martin GG, McIntosh AL, Storey SM, Landrock D, Kier AB, Schroeder F (2013) American Journal of Physiology-Gastrointestinal and Liver Physiology 304, G241-G256

Inhibitors of fatty acid synthesis induce PPAR alpha-regulated fatty acid beta-oxidative genes: synergistic roles of L-FABP and glucose. Huang H, McIntosh AL, Martin GG, Petrescu AD, Landrock KK, Landrock D, Kier AB, Schroeder F (2013) PPAR Research, Article Number 865604

Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes. Storey SM, McIntosh AL, Huang H, Martin GG, Landrock KK, Landrock D, Payne HR, Kier AB, Schroeder F (2012) American Journal of Physiology-Gastrointestinal and Liver Physiology 303, G837-G850

Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F (2012) American Journal of Physiology-Gastrointestinal and Liver Physiology 302, G824-G839

Loss of liver FA binding protein significantly alters hepatocyte plasma membrane microdomains. McIntosh AL, Atshaves BP, Storey SM, Landrock KK, Landrock D, Martin GG, Kier AB, Schroeder F (2012) Journal of Lipid Research 53, 467-480

Acyl-CoA binding proteins interact with the acyl-CoA binding domain of mitochondrial carnitine palmitoyl transferase I. Hostetler HA, Lupas D, Tan Y, Dai J, Kelzer MS, Martin GG, Woldegiorgis G, Kier AB, Schroeder F (2011) Molecular and Cellular Biochemistry 355, 135-148

Liver fatty acid-binding protein and obesity. Atshaves BP, Martin GG, Hostetler HA, McIntosh AL, Kier AB, Schroeder F (2010) Journal of Nutritional Biochemistry 21, 1015-1032

Effect of sterol carrier protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes. Storey SM, Atshaves BP, McIntosh AL, Landrock KK, Martin GG, Huang HA, Payne HR, Johnson JD, Macfarlane RD, Kier AB, Schroeder F (2010) American Journal of Physiology-Gastrointestinal and Liver Physiology 299, G244-G254

Hepatic phenotype of liver fatty acid binding protein gene-ablated mice. Martin GG, Atshaves BP, Huang H, McIntosh AL, Williams BJ, Pai P-J, Russell DH, Kier AB, Schroeder F (2009) American Journal of Physiology-Gastrointestinal and Liver Physiology 297, G1053-G1065

Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. Atshaves BP, McIntosh AL, Martin GG, Landrock D, Payne HR, Bhuvanendran S, Landrock KK, Lyuksyutova OI, Johnson JD, Macfarlane RD, Kier AB, Schroeder F (2009) Journal of Lipid Research 50, 1429-1447

Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice. Martin GG, Atshaves BP, McIntosh AL, Payne HR, Mackie JT, Kier AB, Schroeder F (2009) Molecular and Cellular Biochemistry 324, 101-115

Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F (2008) Journal of Nutrition 138, 1859-1865 Structure and function of the sterol carrier protein-2 N-terminal presequence. Martin GG, Hostetler HA, McIntosh AL, Tichy SE, Williams BJ, Russell DH, Berg JM, Spencer TA, Ball J, Kier AB, Schroeder F (2008) Biochemistry 47, 5915-5934 Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Schroeder F, Petrescu AD, Huang H, Atshaves BP, McIntosh AL, Martin GG, Hostetler HA, Vespa A, Landrock D, Landrock KK, Payne HR, Kier AB (2008) Lipids 43, 1-17 Selective cholesterol dynamics between lipoproteins and caveolae/lipid rafts. Storey SM, Gallegos AM, Atshaves BP, McIntosh AL, Martin GG, Parr RD, Landrock KK, Kier AB, Ball JM, Schroeder F (2007) Biochemistry 46, 13891-13906 A new N-terminal recognition domain in caveolin-1 interacts with sterol carrier protein-2 (SCP-2). Parr RD, Martin GG, Hostetler HA, Schroeder ME, Mir KD, Kier AB, Ball JM, Schroeder F (2007) Biochemistry 46, 8301-8314 Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice. Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F (2006) American Journal of Physiology-Gastrointestinal and Liver Physiology 290, G36-48 Liver fatty acid binding protein (L-FABP) gene ablation alters liver bile acid metabolism in male mice. Martin GG, Atshaves BP, McIntosh AL, Mackie, JT, Kier AB, Schroeder F (2005) Biochemical Journal 391, 549-560 Ablation of the liver fatty acid binding protein gene decreases fatty acyl-CoA binding capacity and alters fatty acyl-CoA pool distribution in mouse liver. Martin GG, Huang H, Atshaves BP, Binas B, Schroeder F (2003) Biochemistry 42, 11520-11532 Decreased liver fatty acid binding capacity and altered liver lipid distribution in

mice lacking the liver fatty acid binding protein gene. Martin GG, Danneberg H, Kumar LS, Atshaves BP, Erol E, Bader M, Schroeder F (2003) Journal of Biological Chemistry 278, 21429-21438 Sterol carrier protein-2 functions in phosphatidylinositol transfer and signaling. Schroeder F, Zhou M, Swaggerty CL, Atshaves BP, Petrescu AD, Storey SM, Martin GG, Huang H, Helmkamp GM, Ball JM (2003) Biochemistry 42, 3189-3202 Membrane charge and curvature determine interaction with acyl-CoA binding protein (ACBP) and fatty acyl-CoA targeting. Chao H, Martin GG, Russell WK, Waghela SD, Russell DH, Schroeder F, and Kier AB (2002) Biochemistry 41, 10540-10553 Sterol carrier protein-2: structure reveals function. Stolowich NJ, Petrescu AD, Huang H, Martin GG, Scott AI, and Schroeder F (2002) Cellular and Molecular Life Sciences 59, 193-212 Gene structure, intracellular localization, and functional roles of sterol carrier protein-2. Gallegos AM, Atshaves BP, Storey SM, Starodub O, Petrescu AD, Huang H, McIntosh AL, Martin GG, Chao H, Kier AB, and Schroeder F (2001) Progress in Lipid Research 40, 498-563 Sc3p hydrophobin organization in aqueous media and assembly onto surfaces as mediated by the associated polysaccharide schizophyllan. Martin GG, Cannon GC, McCormick CL (2000) Biomacromolecules 1, 49-60 Adsorption of a fungal hydrophobin onto surfaces as mediated by the associated polysaccharide schizophyllan. Martin GG, Cannon GC, McCormick CL (1999) Biopolymers 49, 621-633 Organization and regulated expression of rat-liver HMG-CoA reductase genes. Shapiro DJ, Gould L, Martin G, Williams D, Wolski R (1986) Journal of Lipid Research 27, 567-568 Regulation of rat-liver cell 3-hydroxy-3-methylglutaryl coenzyme-A reductase by methoxypolyoxyethylated cholesterol. Martin GG, Shapiro DJ (1985) Biochimica et Biophysica Acta 837, 163-172 Production and characterization of monoclonal-antibodies to rat-liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Clark RE, Martin GG, Barton MC, Shapiro DJ (1982) Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 79, 3734-3738