RESUMÉ dr Shakir Ahamad · Ahamad, A. K. Gupta, R. Kant, K. Mohanan, Org. Biomol. Chem. 2015, 13,...
Transcript of RESUMÉ dr Shakir Ahamad · Ahamad, A. K. Gupta, R. Kant, K. Mohanan, Org. Biomol. Chem. 2015, 13,...
Department of Chemistry
Aligarh Muslim University
Aligarh, 202002, India
shakirzaheer111
@gmail.com
+91-8410487966
To work with a reputed institution as an assistant professor/research scientist,
that will provide me a good platform to utilize my research, teaching and
administration skills.
AWARDS, DISTINCTIONS AND FELLOWSHIPS
2017: CSIR-CDRI Incentive award for publication-2017
2015: Senior research fellowship (SRF) from UGC, New Delhi
2013: Junior research fellowship (JRF) from UGC, New Delhi
2013: Qualified joint CSIR-UGC test for JRF and eligibility for lectureship
(NET), A IR-34.
2013: Qualified GATE-2013, AIR-221
EDUCATION
ALIGARH MUSLIMUNIVERSITY
M.ScOrganic Chemistry
2013
75.00 %
KURUKSHETRAUNIVERSITY
B.ScChemistry
2011
70.00%
HOBBIESCRICKET, BADMINTON, KABADDI, GYM
INSTRUMENTATION& IT SKILLS
MS OFFICE
ADOBE PHOTOSHOP
MestReNova
TOPSPIN
CHEM DRAW
Mass spectrometery, NMR, HPLC, UPLC
IR, UV, PXRD, X-Ray Crystallography, ITC,
DSC
RESEARCH DESCRIPTION
Worked as research scholar (Ph. D.) under the supervision of Dr. Kishor
Mohanan, (senior scientist at CSIR-central drug research institute, Lucknow)
from July 2013 to April 2018 in the area of organic synthesis and medicinal
chemistry.
Ÿ Heterocyclic Chemistry
Ÿ Development of metal-free domino multi-component reactions for the
synthesis of structurally diverse N-, O-, F- and P-based heterocycles by
employing diazo compounds.
Ÿ Development of new synthetic methods.
Ÿ Drug Discovery
Ÿ Design, synthesis and biological evolution of pyrazole-based nucleoside
as potential therapeutics for anti-HIV activity.
Ÿ Design, synthesis and biological profiling (in vitro and in vivo) of
aminopyridine derived PCSK-9 inhibitors as target drugs for anti-
hyperlipidemic activity.
Ÿ Design, synthesis and SAR study of 1-aminopropan-2-ole tethered
aminoazabenzimidazoles for anti-malarial activity.
RESUMÉ
dr Shakir Ahamad
Ÿ Doctor of Philosophy in Organic Chemistry: 20 December 2018
Ÿ Thesis entitled- “Domino reactions employing diazo compounds: an
efficient access to novel N-heterocycles” (Under the supervision of Dr.
Kishor Mohanan, Senior Scientist, Medicinal & Process Chemistry Division,
Central Drug Research Institute, Lucknow, India)
RESEARCH INTERESTS
Organic Synthesis, Host-Guest chemistry, Chemical Biology and Medicinal
Chemistry
SCIFINDER
OS - Windows, Linux
CDRILUCKNOW, INDIA
ChemicalScience
2013-18
Ph.D.
Assistant Pro fesso r, D epartm ent o f Ch em istry,
Ali garh M usli m U n iversity, Ali garh, 2020 02, I n d ia
RESEARCH APTITUDE
Ÿ Planning, organizing and implementation of research projects.
Ÿ Capable of performing both collaborative and independent research.
Ÿ Supervision of research work of graduate and post-graduate project trainees and junior Doctoral colleagues.
Ÿ Designing, synthesizing and lead optimization through SAR study for medicinal chemistry purpose.
RESEARCH AND TEACHING EXPERIENCE
Ÿ Junior Research Fellow: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute Lucknow-226031,
Uttar Pradesh, India, 2013-2015.
Ÿ Senior Research Fellow: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031,
Uttar Pradesh, India, 2015-2018.
Ÿ Project Assistant: Molecular & Structural Biology division, CSIR - Central Drug Research Institute, Lucknow -
Ÿ 226031, India (2018-2019)
Ÿ Assistant Professor: Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
Ÿ (since 02-08-2019)
RESEARCH SKILLS
Ÿ Experienced in performing multi-step organic synthesis from milligram to gram scale.
Ÿ Experienced in handling light and moisture sensitive compounds and performing reactions under inert atmosphere and
their proper purification.
Ÿ Strong knowledge and experienced in designing and synthesizing organic molecules of biological interest.
Ÿ Capable to handle sugar and nucleoside based molecules.
Ÿ Efficient in handling spectroscopic techniques and data interpretation (Mass, IR, UV, HPLC, UPLC and NMR).
Ÿ Adept in using general techniques for separation and purification of organic compounds.
Ÿ Skilled in using online databases such as Reaxys, Scifinder, Science direct, Google Scholar and PubMed.
Ÿ Softwares: ChemDraw, MS Word, MS Excel, MS PowerPoint, Adobe Photoshop, TOPSPIN, MestReNova, etc.
Ÿ Experienced in writing research articles and reviews.
PUBLICATIONS
Papers Published in International Journals
Organic Chemistry
1. Solubility enhancement of Ribociclib through host–guest interactions with cucurbiturils, D. Katiyar, T. S. S. Ahamad,
Thakur (Manuscript under preparation)
2. Bioavailability improvement of Tenofovir through inclusion with CB7. , D. Katiyar, T. S. Thakur (Manuscript S. Ahamad
under preparation)
3. ''Metal-catalysed regioselective synthesis of donor−acceptor CF3-containing cyclopropanes, and its nucleophilic ring
opening reactions.'' A. Kumar, , R. Kant, K. Mohanan. (Manuscript under preparation) S. Ahamad
4. ''Metal-catalyzed domino three-component reaction using trifluorodiazoethane: An approach towards the synthesis
of trifluoromethylpyrazoles.'' A. Kumar, S. Mathew, , R. Kant, K. Mohanan. (Manuscript under preparation) S. Ahamad
5. 'Silver-Catalyzed Three-Component Route to Trifluoromethylated 1,2,3-Triazolines Using Aldehydes, Amines, and
Trifluorodiazoethane.'' A. Kumar, , R. Kant, K. Mohanan. 2019, 21, 2962. S. Ahamad Org. Lett.,
6. Base-mediated 1,6-conjugate addition reaction of Seyferth-Gilbert reagent to para-quinone methides A. K. Gupta, S.
Ahamad, R. Kant, K. Mohanan 2018, 16, 4623. Org. Biomol. Chem.
7. Metal-Free three-component assembly of fully-substituted 1,2,3-triazoles .; K.; Kumar A.; Kant, R.; Mohanan, Ahamad, S
K. Asian J. , 2018, 7, 1698. Org. Chem
8. Three-component synthesis of 3,4-disubstituted pyrazoles using diazosulfone as a diazomethane surrogate. , S. Ahamad
R. K. Patidar, A. Kumar, R. Kant, K. Mohanan, 2017, 2, 11995. ChemistrySelect
9. Metal-Free three-component domino approach to phosphonylated triazolines and triazoles. , R. Kant, K. S. Ahamad
Mohanan, 2016, 18, 280. Org. Lett.
10. Three-component domino HWE olefination/1,3-dipolar cycloaddition/oxidation strategy for the rapid synthesis of
trisubstituted pyrazoles. , R. Kant, K. Mohanan, 2016, 1, 5276. S. Ahamad ChemistrySelect
11. Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-
derived olefins. A. K. Gupta, , E. Gupta, R. Kant, K. Mohanan, 2015, 13, 9783. S. Ahamad Org. Biomol. Chem.
12. Domino reaction involving the Bestmann–Ohira reagent and a,b-unsaturated aldehydes: efficient synthesis of
functionalized pyrazoles. , A. K. Gupta, R. Kant, K. Mohanan, 2015, 13, 1492. S. Ahamad Org. Biomol. Chem.
Medicinal Chemistry
Publications from medicinal chemistry part are awaited as further studies under process.
ORAL AND POSTERS PRESENTATION, AND PARTICIPATION IN CONFERENCES/ SYMPOSIA / WORKSHOP
1. Participated and delivered an oral talk in at CSIR-CDRI, Lucknow, “XII J-NOST Conference for Research Scholars”
th th24 to 27 November, 2016.
2. Participated and delivered an oral talk in at “International Conference on Recent Advances in Chemical Science”
th thAligarh Muslim Univetsity, 29 to 30 March, 2016
3. Participated and presented poster in One Day Symposium on “Drug Discovery in India: Past, Present and Future”
st at CSIR-Central Drug Research Institute, Lucknow, 1 January 2015.
th th4. Volunteered in , at CSIR-CDRI Lucknow, 15 -16 September, 2017.“The First CDRI and NRDC-Industry Conclave”
5. Volunteered in (CTDDR-2016) th“6 International Symposium On Current Trends In Drug Discovery And Research”
th thheld at CSIR-Central Drug Research Institute, 25 – 28 February, 2016, Lucknow.
6. Participated in organized by Waters India (p) Ltd., at SAIF, CSIR-CDRI, Lucknow, “HPLC/UPLC training programme”
th th 5 -6 September 2017.
7. Participated in Workshop on “The Application of MS and LC-MS/MS Instrument for Identification and
Characterization of Small Molecules” th st at SAIF, CSIR-CDRI, Lucknow 29 September to 1 October, 2015.
UNDERGRADUATE TRAININGS AND PROJECTS
Ÿ One month project on the “production of ethanol from sugarcane molasses'' at department of biotechnology, GNKC,
Yamuna nagar-135001, Haryana, India, 2011.
Ÿ One month training in pathology at city pathology lab, Saharanpur-247001, Uttar Pradesh, India 2010.
Ÿ One month industrial training on fermentation technology at Pilkhani Distillery & Chemical Works, Saharanpur-
247001, Uttar Pradesh, India, 2009.
EXTA-CURRICULAR
Ÿ Won gold medals in marathon, kabaddi, cricket and silver medal in badminton mixed doubles held at CSIR-CDRI
in the “Annual Sports 2018”.
Ÿ Won gold medal in cricket and silver medal in kabaddi held at CSIR-CDRI in the “annual sports 2017”.
Ÿ Won gold medal in kabaddi and silver medal in cricket held at CSIR-CDRI in the “annual sports 2016”.
Ÿ Won several prizes in competitions held at the school level.
Ÿ First (2007) and second (2008) level training certificates from ''Hindustan Scouts & guides'' Utter Pradesh, India.
PERSONAL DETAILS
Ÿ Father’s Name : Zaheer Ahamad
ŸthDate of Birth : 20 July 1991
Ÿ Nationality/Sex/Marital Status : Indian/Male/ Single
Ÿ Languages known : Hindi/Urdu/English
ACADEMIC REFEREES
Dr. Tejender S. Thakur
Senior Scientist
Molecular & Structural Biology
CSIR - Central Drug Research Institute, Lucknow - 226031, India
0522-2772450 EPABX-4481, Fax No.- +91-522-2771941
DECLARATION
I hereby declare that the
information given above is true
and I hold the responsibility of
its authenticity.
Date:
Place:
Shakir Ahamad
वैज्ञानिकऔरिवीकृतअिुसंधािअकादमी ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH
Summary of the Research Work
Organic Synthesis and Medicinal Chemistry
2
Synthetic Organic Chemistry
1. Silver-Catalyzed Three-Component Route to Trifluoromethylated 1,2,3-Triazolines Using
Aldehydes, Amines, and Trifluorodiazoethane
A. Kumar, S. Ahamad, R. Kant, K. Mohanan. Org. Lett., 2019, 21, 2962.
2. Base-mediated 1,6-conjugate addition reaction of Seyferth-Gilbert reagent to para-quinone
methides
A. K. Gupta, S. Ahamad, R. Kant, K. Mohanan Org. Biomol. Chem. 2018, DOI: 10.1039/C8OB01017J
3. Metal-Free three-component assembly of fully-substituted 1,2,3-triazoles
Ahamad, S.; K.; Kumar A.; Kant, R.; Mohanan, K. Asian J. Org. Chem, 2018, DOI: 10.1002/ajoc.201800340
3
4. Three-component synthesis of 3,4-disubstituted pyrazoles using diazosulfone as a diazomethane
surrogate
Ahamad, S.; Patidar R. K.; Kumar A.; Kant, R.; Mohanan, K. ChemistrySelect 2017, 2, 11995.
5. Metal-Free three-component domino approach to phosphonylated triazolines and triazoles
Ahamad, S.; Kant, R.; Mohanan, K. Org. Lett. 2016, 18, 280
6. Three-component domino HWE olefination/1,3-dipolar cycloaddition/oxidation strategy for the
rapid synthesis of trisubstituted pyrazoles
Ahamad, S.; Kant, R.; Mohanan, K. ChemistrySelect 2016, 1, 5276
4
7. Domino reaction involving the Bestmann–Ohira reagent and α,β-unsaturated aldehydes: efficient
synthesis of functionalized pyrazoles
Ahamad, S.; Gupta, A. K.; Kant, R.; Mohanan, K. Org. Biomol. Chem. 2015, 13, 1492.
8. Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-
unprotected isatin-derived olefins
A. K. Gupta, S. Ahamad, E. Gupta, R. Kant, K. Mohanan, Org. Biomol. Chem. 2015, 13, 9783.
9. Metal-catalyzed regioselective synthesis of donor−acceptor CF3-containing cyclopropanes, and its
nucleophilic ring opening reactions
A. Kumar, S. Ahamad, R. Kant, K. Mohanan. (Manuscript Communicated)
5
10. Metal-catalyzed domino three-component reaction using trifluorodiazoethane: An approach
towards the synthesis of trifluoromethylpyrazoles
A. Kumar, S. Mathew, S. Ahamad, R. Kant, K. Mohanan. (Manuscript Communicated)
Medicinal Chemistry
11. Design, Synthesis and Biological Evaluation of a Novel Class of Pyrazole Nucleosides as Antiviral
Agents
S. Ahamad, S. verma, R. Patidar, R. Kant, K. Mohanan. (Further studies are going on)
6
12. Design, synthesis and biological profiling of aminopyridine derived PCSK-9 inhibitors as
target drugs for anti-hyperlipidemic activity (liver LDL clearance)
S. Ahamad, A. Burman, K. Mohanan. (Further studies are going on)
PARAMETERS S-017-0594
Aqueous buffer solubility
(by Kinetic Method)
≥ 60µg/mL
SGF Stability (pH1.2)
(% remaining, 1 h)
90.86%
(Stable)
SIF Stability (pH7.4)
(% remaining, 2 h)
89.17%
(Stable)
Plasma Stability
(% remaining, 1.5 h)
83.34 ± 2.85%
(Stable)
Microsomal stability
(% remaining, 1h ) 54.96 ± 9.02%
K(1/min) 0.010 ± 0.002667
Half-Life (min) 81.4 ± 17.60
Intrinsic clearance
(mL/min×mg) 0.010 ± 0.002667
Hepatic clearance(L/h/kg) 16.965 ± 4.68
7
13. Design, synthesis and SAR study of 1-aminopropan-2-ole tethered aminoazabenzimidazoles for
anti-malarial activity
S. Ahamad, S. Mathew, K. Mohanan. (LEAD optimizationis going on)
8
14. Molecular Encapsulation of cyclin-dependent kinase 4/6 inhibitors by Cucurbit[7]Uril: An
Experimental and Computational Study
S. Ahamad, Tejender S. Thakur (Manuscript Communicated)
Supramolecular
Formulation
9
15. Bioavailability improvement of Tenofovir through inclusion with CB7.
S. Ahamad, D. Katiyar, T. S. Thakur (Manuscript under preparation)
10
16. Inclusion of Anti-bacterial drugs (Levofloxacin and ciprofloxacin) in Cucurbit[7]uril
S. Ahamad, D. Katiyar, T. S. Thakur (Manuscript under preparation)
17. Study to improve the thermal stability and aqueous solubility of CDRI developmental compound
S011-1599 (potent Anti Breast Cancer Lead)
We have prepared a new crystalline salt form of the S011-1559. The new crystalline phase possess high
thermal stability than the parent compound S011-1559, a low melting solid which exists as liquid at RT.
Further, we were also able to address the poor aqueous solubility the compound S011-1559 (practically
insoluble in water) by crystal engineering. The new salt for is highly soluble in water (~1-2 mg/mL).